According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of dir...According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of direction finding with interferometer for wideband signals and multiple signals scene,a frequency domain phase interferometer is proposed and the concrete implementation scheme is given.The proposed method computes the phase difference in frequency domain,and finds multi-target results with judging the spectrum amplitude changing,and uses the frequency phase difference to compute the arrival angle.Theoretical analysis and simulation results show that the proposed method effectively solves the problem of the angle estimation with phase interferometer for wideband signals,and has good performance in multiple signals scene with nonoverlapping spectrum or partially overlapping.In addition,the wider the signal bandwidth,the better direction finding performance of this algorithm.展开更多
To describe and analyze the current status of benefit-finding research in patients with chronic diseases and to provide a reference for clinical practice and future research in this field.Using Arksey and O’Malley’s...To describe and analyze the current status of benefit-finding research in patients with chronic diseases and to provide a reference for clinical practice and future research in this field.Using Arksey and O’Malley’s scoping review methodology as a framework,we searched PubMed,Web of Science,Science Direct,and CINAHL(4 English databases);and China National Knowledge Infrastructure,the VIP Database for Chinese Technical Periodicals,the Wan Fang Database and China Biomedical Database(4 Chinese databases)for literature on benefit finding in patients with chronic diseases,with a search time frame of construction to April 20,2024,and the literature was screened,extracted,and summarized.A total of 44 papers were included,comprising 18 in Chinese and 26 in English.Among them,a total of 19 assessment tools were used,and the influential factors investigated were categorized into socio-demographic characteristics,disease-related characteristics,psychological and behavioral characteristics,coping styles,and social support.Benefit finding is found to be a positive psychological experience and important for patients with chronic diseases,and the influencing factors are complex and diverse,with a wide range of assessment tools.However,domestic tools lack autonomy and specificity.Clinical caregivers and staff should develop relevant assessment tools and formulate a personalized research plan based on the characteristics of patients with chronic diseases in China to promote the adoption of healthy lifestyles by patients with chronic diseases,improve their self-management ability,and provide a practical basis for improving the quality of life of patients with chronic diseases.展开更多
Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected ...Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected to appear in several key benchmark physics processes.A Common Tracking Software was used to reconstruct the trajectories of long-lived particles,revealing that the track-finding performance of the widely used combinatorial Kalman filter is limited by its seeding algorithm.This limitation can be mitigated by guiding the combinatorial Kalman filter using initial tracks provided by the Hough transform.The track-finding performance of the combined Hough transform and combinatorial Kalman filter was evaluated using the process J∕ψ→Λ(→pπ−)Λ(→pπ+)at STCF.展开更多
AIM:To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency(CLD),an extremely rare condition.METHODS:A prospective,cross-sectional comparative study was perf...AIM:To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency(CLD),an extremely rare condition.METHODS:A prospective,cross-sectional comparative study was performed on six patients with CLD and 13 healthy age-and sex-matched controls.The central corneal thickness(CCT),anterior chamber depth(ACD),axial length(AL),keratometry(K1,K2),optical coherence tomography(OCT),and OCT angiography parameters were compared between the leptin and control groups at the baseline visit.The change in these measurements in leptin patients over a two-year period was analyzed.RESULTS:CLD patients had lower mean AL,ACD,and CCT(P≤0.012 for all).Mean K1,K2(P≤0.047 for both),choroidal thickness(P≤0.001),and central ganglion cell layer(GCL)thickness(P=0.029)were higher in the leptin group.Perifoveal superficial capillary plexus(SCP)density was decreased in all quadrants except the temporal region(P<0.05),and parafoveal deep capillary plexus(DCP)density was decreased in the superior hemisphere,temporal quadrant(P≤0.036 for both)and nasal quadrant(P=0.048)in the leptin group.During the two-year follow-up,no changes in anterior and posterior segment measurements were observed in the leptin patients,except for subfoveal choroidal thickness(P<0.001).CONCLUSION:CLD patients exhibit structural alterations in both the anterior and posterior segments of the eye,including notable changes in retinal and choroidal vasculature.However,there is limited evidence concerning the influence of leptin therapy on the eye.展开更多
BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have fo...BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have focused on the imaging findings of MEITL,which poses significant challenges for clinical diagnosis.A 78-year-old female with recurrent vomiting and abdominal distension was admitted to our hospital.Magnetic resonance and^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)examinations revealed multiple segmental malignant tumors in the small intestine with me-senteric lymph node metastasis.An endoscopic biopsy revealed MEITL.After three cycles of reduced-dose cyclophosphamide,vinorelbine,and prednisone che-motherapy,follow-up^(18)F-FDG PET/CT demonstrated a partial response to treatment.The patient was still alive after 6 months of follow-up.CONCLUSION Magnetic resonance imaging serves as a valuable tool in detecting malignant tumor lesions of MEITL,whereas^(18)F-FDG PET/CT offers additional assistance in tumor staging and assessing treatment efficacy.展开更多
As the number of automated guided vehicles(AGVs)within automated container terminals(ACT)continues to rise,conflicts have becomemore frequent.Addressing point and edge conflicts ofAGVs,amulti-AGVconflict-free path pla...As the number of automated guided vehicles(AGVs)within automated container terminals(ACT)continues to rise,conflicts have becomemore frequent.Addressing point and edge conflicts ofAGVs,amulti-AGVconflict-free path planning model has been formulated to minimize the total path length of AGVs between shore bridges and yards.For larger terminalmaps and complex environments,the grid method is employed to model AGVs’road networks.An improved bounded conflict-based search(IBCBS)algorithmtailored to ACT is proposed,leveraging the binary tree principle to resolve conflicts and employing focal search to expand the search range.Comparative experiments involving 60 AGVs indicate a reduction in computing time by 37.397%to 64.06%while maintaining the over cost within 1.019%.Numerical experiments validate the proposed algorithm’s efficacy in enhancing efficiency and ensuring solution quality.展开更多
Developmental and epileptic encephalopathies(DEEs)are neurological disorders generally involving medically intractable seizures and a diverse array of comorbid neuropsychiatric delays and deficits that may severely af...Developmental and epileptic encephalopathies(DEEs)are neurological disorders generally involving medically intractable seizures and a diverse array of comorbid neuropsychiatric delays and deficits that may severely affect cognition,mood,sleep,social behavior,movement control,learning,and/or memory.Dravet syndrome(DS),also known as Severe Myoclonic Epilepsy of Infancy.展开更多
The importance of Very Long Baseline Interferometry(VLBI)for pulsar research is becoming increasingly prominent and receiving more and more attention.We present the pathfinding pulsar observation results with the Chin...The importance of Very Long Baseline Interferometry(VLBI)for pulsar research is becoming increasingly prominent and receiving more and more attention.We present the pathfinding pulsar observation results with the Chinese VLBI Network(CVN)incorporating the Five-hundred-meter Aperture Spherical radio Telescope(FAST).On MJD 60045(11th April 2023),PSRs B0919+06 and B1133+16 were observed with the phase-referencing mode in the L-band using four radio telescopes(FAST,TianMa,Haoping,and Nanshan)and correlated with the pulsar binning mode of the distributed FX-style software correlator in Shanghai.After further data processing with the NRAO Astronomical Image Processing System(AIPS),we detected these two pulsars and fitted their current positions with accuracy at the milliarcsecond level.By comparison,our results show significantly better agreement with predicted values based on historical VLBI observations than those with previous timing observations,as pulsar astrometry with the VLBI provides a more direct and model-independent method for accurately obtaining related parameters.展开更多
BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of hyperglycemia.The relationship between SHR and acute coronary syndrome(ACS)prognosis remains unclear.This study was c...BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of hyperglycemia.The relationship between SHR and acute coronary syndrome(ACS)prognosis remains unclear.This study was conducted to identity the association between SHR and in-hospital outcomes in patients with ACS.METHODS A total of 12,010 patients were eventually enrolled in the study.The relationship between SHR and in-hospital major adverse cardiovascular events(MACEs)was then modeled by restricted cubic spline(RCS)curves,and all patients were divided into three groups according to the results.The multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes,described as odds ratios(ORs)and 95%confidence intervals(CIs).Subgroup analyses were also performed on different diseases.RESULTS The median age of this cohort was 63(54,71)years old,and 8942(74.5%)were male.Group 1 was defined as SHR<0.6(n=426),Group 2 was defined as SHR between 0.6 and 1(n=5821),and Group 3 was defined as SHR>1(n=5763).Compared with Group 2,Group 1(OR=1.891,95%CI:1.028-3.479,P<0.001)and Group 3(OR=1.868,95%CI:1.434-2.434,P<0.001)had higher risks of suffering from in-hospital MACEs.SHR was associated with higher risks of in-hospital MACEs in the subgroups of DM[OR=2.282,95%CI:1.477-3.524).CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital MACEs.Young males with DM,hypertension,and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.展开更多
BACKGROUND The association of cardiovascular risk burden with disability is unclear.We examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajector...BACKGROUND The association of cardiovascular risk burden with disability is unclear.We examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older adults.METHODS A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were included.FGCRS at baseline was assessed and categorized into tertiles.Physical function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects models.RESULTS At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,respectively.In the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05).CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in gait.Results suggest SPPB may provide a measure of cardiovascular health in older adults.展开更多
BACKGROUND Oxidative stress is closely associated with hypertensive outcomes.The oxidative balance score(OBS)measures oxidative stress exposure from dietary and lifestyle elements.The objective of this study was to in...BACKGROUND Oxidative stress is closely associated with hypertensive outcomes.The oxidative balance score(OBS)measures oxidative stress exposure from dietary and lifestyle elements.The objective of this study was to investigate the association between OBS and mortality in hypertensive patients.METHODS This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey(NHA-NES)1999-2014.Several models,including Cox regression,restricted cubic splines(RCS),Kaplan-Meier survival analysis,subgroup,and sensitivity analyses,were exploited to investigate the relationship between OBS and the risk of mortality.RESULTS Controlling for all potential confounders,a significantly inverse association was observed between elevated OBS and all-cause[hazard ratio(HR)=0.90,95%CI:0.85-0.95]and cardiovascular mortality(HR=0.85,95%CI:0.75-0.95).With adjustment for covariates,significant associations between lifestyle OBS and mortality risks diminished,whereas associations between dietary OBS and these mortality risks remained robust(all-cause mortality:HR=0.91,95%CI:0.86-0.96;cardiovascular mortality:HR=0.85,95%CI:0.76-0.96).RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk(P_(nonlinear)=0.088 and P_(nonlinear)=0.447,respectively).Kaplan-Meier curves demonstrated that the mortality rate was lower with a high OBS(P<0.001).The consistency of the association was demonstrated in subgroup and sensitivity analyses.RCS after stratification showed that among current drinkers,those with higher OBS had a lower risk of mortality compared with former or never drinkers.CONCLUSIONS In hypertensive individuals,there was a negative association between OBS and all-cause and cardiovascular mortality.Encouraging hypertensive individuals,especially those currently drinking,to maintain high levels of OBS may be beneficial in improving their prognosis.展开更多
Background: The community tuberculosis care program was started to reduce the impact of TB and increase successful treatment outcomes, thus contributing to meeting WHO targets on TB. According to the Botswana Ministry...Background: The community tuberculosis care program was started to reduce the impact of TB and increase successful treatment outcomes, thus contributing to meeting WHO targets on TB. According to the Botswana Ministry of Health, community tuberculosis care was introduced with the main goal of reducing tuberculosis-related morbidity and mortality among communities through the expansion of direct observed therapy and community involvement to community settings. The community caregivers were to support tuberculosis patients throughout their treatment period until they were cured or had completed their treatment. Settings: Two major cities of Botswana, Francistown and Gaborone, with more than twenty-two health clinics offering tuberculosis care. Objective: To investigate community caregivers’ experiences and identify programmatic strategies to improve active TB case findings under the community TB care (CTBC) program in Botswana during 2016-2021. Methods: We adopted a descriptive qualitative research design, followed by convenience purposive sampling. We obtained consent and interviewed 40 participants who met the inclusion criteria, 16 out of 73 in Gaborone and 24 out of 38 from Francistown. Results: We interviewed 40 caregivers with a mean age of 43.4 years. Accepting the caregiving role was identified as the main experience by more than two thirds of the caregivers. While at least more than two-fifth felt obligated to care for the patient at home due to personal relations. More than half of the respondents found caregiving difficult or frustrating due to some challenges encountered during the caregiving role. Behavioral modifications were suggested under different subthemes as strategies to improve active case finding. [-rId13-]Conclusion: Acceptance was the major experience in CTBC. Intensification of known programmatic strategies was suggested by caregivers to improve tuberculosis active case finding in CTBC.展开更多
In recent years,the path planning for multi-agent technology has gradually matured,and has made breakthrough progress.The main difficulties in path planning for multi-agent are large state space,long algorithm running...In recent years,the path planning for multi-agent technology has gradually matured,and has made breakthrough progress.The main difficulties in path planning for multi-agent are large state space,long algorithm running time,multiple optimization objectives,and asynchronous action of multiple agents.To solve the above problems,this paper first introduces the main problem of the research:multi-objective multi-agent path finding with asynchronous action,and proposes the algorithm framework of multi-objective loose synchronous(MO-LS)search.By combining A*and M*,MO-LS-A*and MO-LS-M*algorithms are respectively proposed.The completeness and optimality of the algorithm are proved,and a series of comparative experiments are designed to analyze the factors affecting the performance of the algorithm,verifying that the proposed MO-LS-M*algorithm has certain advantages.展开更多
TToo tthhee eeddiittoorr::Autism spectrum disorder(ASD)is believed to have a multifactorial aetiology involving both genetics and environmental factors.Evidence also emphasises that ASD is programmed during the in ute...TToo tthhee eeddiittoorr::Autism spectrum disorder(ASD)is believed to have a multifactorial aetiology involving both genetics and environmental factors.Evidence also emphasises that ASD is programmed during the in utero period,with multiple prenatal and postnatal factors influencing the epigenome and contributing to the onset of ASD.展开更多
With the improvement of living standards and changes in dietary habits,the non-alcoholic fatty liver disease(NAFLD)has become one of the most common metabolic diseases clinically,with a global prevalence exceeding 25%...With the improvement of living standards and changes in dietary habits,the non-alcoholic fatty liver disease(NAFLD)has become one of the most common metabolic diseases clinically,with a global prevalence exceeding 25%.NAFLD often presents as a multisystem disease characterized by excessive deposition of triglycerides within hepatocytes,with over 5%of hepatocytes exhibiting steatosis.The clinical progression of NAFLD can mainly be divided into two stages:non-alcoholic fatty liver(NAFL)and non-alcoholic steatohepatitis(NASH).NAFL represents the early stage,primarily characterized by hepatocellular steatosis(which can be reversed with early intervention)and further progression leading to NASH.Besides hepatocellular steatosis,NASH also exhibits hepatocyte inflammation,injury,and fibrosis.Research indicates that 25%of NAFL patients may progress to NASH,and 35%to 50%of NASH patients further develop into liver cirrhosis or even liver cancer.Additionally,NAFLD is closely associated with various chronic diseases and tumors,such as obesity,hyperlipidemia,diabetes,breast cancer,and colorectal cancer.Despite the high and rising incidence of NAFLD,there are currently no clinically proven safe and effective drugs specifically targeting each stage of NAFLD.展开更多
BACKGROUND Pneumoparotid is a rare disease associated with retrograde airflow into the ductal system.There is no established treatment for this disease,which has no known complications.Mouth puffing and playing wind i...BACKGROUND Pneumoparotid is a rare disease associated with retrograde airflow into the ductal system.There is no established treatment for this disease,which has no known complications.Mouth puffing and playing wind instruments are known to be the causes of this disease.CASE SUMMARY We managed a case,in which pneumoparotid suddenly recurred 4 months after surgery for purulent parotiditis.The patient did not report any obvious etiological factors,such as mouth puffing or playing a wind instrument.We reviewed 128 articles(from 1941 to 2023)that reported on a total of 166 patients with pneumoparotid,including the patient from the present case report,with imaging findings.This is the first reported case of pneumoparotid following surgery for purulent parotitis.The etiology in our case was classified as idiopathic.CONCLUSION Imaging findings could be sufficient for accurate pneumoparotid diagnoses and the exclusion of complications;computed tomography could be useful.展开更多
For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in ...For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in suppressing impulse noise and achieving superior direction finding performance using the maximum likelihood(ML)estimation method.A quantum equilibrium optimizer algorithm(QEOA)is devised to resolve the corresponding objective function for efficient and accurate direc-tion finding.The results of simulation reveal the capability of the presented method in success rate and root mean square error over existing direction-finding methods in different application situations,e.g.,locating coherent signal sources with very few snapshots in strong impulse noise.Other than that,the Cramér-Rao bound(CRB)under impulse noise environment has been drawn to test the capability of the presented method.展开更多
文摘According to the measurement principle of the traditional interferometer,a narrowband signal model is established and used,however,for wideband signals or multiple signals,this model is invalid.For the problems of direction finding with interferometer for wideband signals and multiple signals scene,a frequency domain phase interferometer is proposed and the concrete implementation scheme is given.The proposed method computes the phase difference in frequency domain,and finds multi-target results with judging the spectrum amplitude changing,and uses the frequency phase difference to compute the arrival angle.Theoretical analysis and simulation results show that the proposed method effectively solves the problem of the angle estimation with phase interferometer for wideband signals,and has good performance in multiple signals scene with nonoverlapping spectrum or partially overlapping.In addition,the wider the signal bandwidth,the better direction finding performance of this algorithm.
文摘To describe and analyze the current status of benefit-finding research in patients with chronic diseases and to provide a reference for clinical practice and future research in this field.Using Arksey and O’Malley’s scoping review methodology as a framework,we searched PubMed,Web of Science,Science Direct,and CINAHL(4 English databases);and China National Knowledge Infrastructure,the VIP Database for Chinese Technical Periodicals,the Wan Fang Database and China Biomedical Database(4 Chinese databases)for literature on benefit finding in patients with chronic diseases,with a search time frame of construction to April 20,2024,and the literature was screened,extracted,and summarized.A total of 44 papers were included,comprising 18 in Chinese and 26 in English.Among them,a total of 19 assessment tools were used,and the influential factors investigated were categorized into socio-demographic characteristics,disease-related characteristics,psychological and behavioral characteristics,coping styles,and social support.Benefit finding is found to be a positive psychological experience and important for patients with chronic diseases,and the influencing factors are complex and diverse,with a wide range of assessment tools.However,domestic tools lack autonomy and specificity.Clinical caregivers and staff should develop relevant assessment tools and formulate a personalized research plan based on the characteristics of patients with chronic diseases in China to promote the adoption of healthy lifestyles by patients with chronic diseases,improve their self-management ability,and provide a practical basis for improving the quality of life of patients with chronic diseases.
基金supported by the National Natural Science Foundation of China(Nos.12375194,12341504,12375197,12025502)。
文摘Reconstructing the trajectories of charged particles in high-energy physics experiments is a complex task,particularly for long-lived particles.At the future Super Tau-Charm Facility(STCF),such particles are expected to appear in several key benchmark physics processes.A Common Tracking Software was used to reconstruct the trajectories of long-lived particles,revealing that the track-finding performance of the widely used combinatorial Kalman filter is limited by its seeding algorithm.This limitation can be mitigated by guiding the combinatorial Kalman filter using initial tracks provided by the Hough transform.The track-finding performance of the combined Hough transform and combinatorial Kalman filter was evaluated using the process J∕ψ→Λ(→pπ−)Λ(→pπ+)at STCF.
文摘AIM:To analyze the ocular findings of patients who received lifelong leptin therapy due to congenital leptin deficiency(CLD),an extremely rare condition.METHODS:A prospective,cross-sectional comparative study was performed on six patients with CLD and 13 healthy age-and sex-matched controls.The central corneal thickness(CCT),anterior chamber depth(ACD),axial length(AL),keratometry(K1,K2),optical coherence tomography(OCT),and OCT angiography parameters were compared between the leptin and control groups at the baseline visit.The change in these measurements in leptin patients over a two-year period was analyzed.RESULTS:CLD patients had lower mean AL,ACD,and CCT(P≤0.012 for all).Mean K1,K2(P≤0.047 for both),choroidal thickness(P≤0.001),and central ganglion cell layer(GCL)thickness(P=0.029)were higher in the leptin group.Perifoveal superficial capillary plexus(SCP)density was decreased in all quadrants except the temporal region(P<0.05),and parafoveal deep capillary plexus(DCP)density was decreased in the superior hemisphere,temporal quadrant(P≤0.036 for both)and nasal quadrant(P=0.048)in the leptin group.During the two-year follow-up,no changes in anterior and posterior segment measurements were observed in the leptin patients,except for subfoveal choroidal thickness(P<0.001).CONCLUSION:CLD patients exhibit structural alterations in both the anterior and posterior segments of the eye,including notable changes in retinal and choroidal vasculature.However,there is limited evidence concerning the influence of leptin therapy on the eye.
基金Supported by the National Natural Science Foundation of China,No.82160330the Science and Technology Program of the Health Commission of Jiangxi Province,No.2025110045+1 种基金the Ganzhou Science and Technology Planning Project,No.GZ2024YLJ016,No.GZ2024YLJ026,and No.GZ2024ZSF064the Ganzhou Health Commission Scientific Research Planning Project,No.GZWJW202402108.
文摘BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is an uncom-mon and highly aggressive form of lymphoma that represents less than 1%of all non-Hodgkin’s lymphomas.At present,few reports have focused on the imaging findings of MEITL,which poses significant challenges for clinical diagnosis.A 78-year-old female with recurrent vomiting and abdominal distension was admitted to our hospital.Magnetic resonance and^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)examinations revealed multiple segmental malignant tumors in the small intestine with me-senteric lymph node metastasis.An endoscopic biopsy revealed MEITL.After three cycles of reduced-dose cyclophosphamide,vinorelbine,and prednisone che-motherapy,follow-up^(18)F-FDG PET/CT demonstrated a partial response to treatment.The patient was still alive after 6 months of follow-up.CONCLUSION Magnetic resonance imaging serves as a valuable tool in detecting malignant tumor lesions of MEITL,whereas^(18)F-FDG PET/CT offers additional assistance in tumor staging and assessing treatment efficacy.
基金supported by National Natural Science Foundation of China(No.62073212)Shanghai Science and Technology Commission(No.23ZR1426600).
文摘As the number of automated guided vehicles(AGVs)within automated container terminals(ACT)continues to rise,conflicts have becomemore frequent.Addressing point and edge conflicts ofAGVs,amulti-AGVconflict-free path planning model has been formulated to minimize the total path length of AGVs between shore bridges and yards.For larger terminalmaps and complex environments,the grid method is employed to model AGVs’road networks.An improved bounded conflict-based search(IBCBS)algorithmtailored to ACT is proposed,leveraging the binary tree principle to resolve conflicts and employing focal search to expand the search range.Comparative experiments involving 60 AGVs indicate a reduction in computing time by 37.397%to 64.06%while maintaining the over cost within 1.019%.Numerical experiments validate the proposed algorithm’s efficacy in enhancing efficiency and ensuring solution quality.
基金supported by Dravet Syndrome Foundation,NIH/NINDS R01-NS112500.
文摘Developmental and epileptic encephalopathies(DEEs)are neurological disorders generally involving medically intractable seizures and a diverse array of comorbid neuropsychiatric delays and deficits that may severely affect cognition,mood,sleep,social behavior,movement control,learning,and/or memory.Dravet syndrome(DS),also known as Severe Myoclonic Epilepsy of Infancy.
基金supported by the National SKA Program of China(Grant Nos.2020SKA0120104 and 2020SKA0120200)the National Key R&D Program of China(Grant No.2022YFA1603104)the National Natural Science Foundation of China(Grant No.12041301)。
文摘The importance of Very Long Baseline Interferometry(VLBI)for pulsar research is becoming increasingly prominent and receiving more and more attention.We present the pathfinding pulsar observation results with the Chinese VLBI Network(CVN)incorporating the Five-hundred-meter Aperture Spherical radio Telescope(FAST).On MJD 60045(11th April 2023),PSRs B0919+06 and B1133+16 were observed with the phase-referencing mode in the L-band using four radio telescopes(FAST,TianMa,Haoping,and Nanshan)and correlated with the pulsar binning mode of the distributed FX-style software correlator in Shanghai.After further data processing with the NRAO Astronomical Image Processing System(AIPS),we detected these two pulsars and fitted their current positions with accuracy at the milliarcsecond level.By comparison,our results show significantly better agreement with predicted values based on historical VLBI observations than those with previous timing observations,as pulsar astrometry with the VLBI provides a more direct and model-independent method for accurately obtaining related parameters.
基金The CCC-ACS project is a collaborative project of the American Heart Association and the Chinese Society of Cardiology.The American Heart Association received funding from Pfizer through an independent grant for learning and change and AstraZeneca as a quality improvement initiative.The author(s)disclosed receipt of the following financial support for the research,authorship,and/or publication of this article:81973841,81573744 from the China National Natural Scientific Foundation.
文摘BACKGROUND Stress hyperglycemia ratio(SHR)could provide accurate information on the acute status of hyperglycemia.The relationship between SHR and acute coronary syndrome(ACS)prognosis remains unclear.This study was conducted to identity the association between SHR and in-hospital outcomes in patients with ACS.METHODS A total of 12,010 patients were eventually enrolled in the study.The relationship between SHR and in-hospital major adverse cardiovascular events(MACEs)was then modeled by restricted cubic spline(RCS)curves,and all patients were divided into three groups according to the results.The multivariate logistic regression analysis was used to determine the associations between the SHR and in-hospital outcomes,described as odds ratios(ORs)and 95%confidence intervals(CIs).Subgroup analyses were also performed on different diseases.RESULTS The median age of this cohort was 63(54,71)years old,and 8942(74.5%)were male.Group 1 was defined as SHR<0.6(n=426),Group 2 was defined as SHR between 0.6 and 1(n=5821),and Group 3 was defined as SHR>1(n=5763).Compared with Group 2,Group 1(OR=1.891,95%CI:1.028-3.479,P<0.001)and Group 3(OR=1.868,95%CI:1.434-2.434,P<0.001)had higher risks of suffering from in-hospital MACEs.SHR was associated with higher risks of in-hospital MACEs in the subgroups of DM[OR=2.282,95%CI:1.477-3.524).CONCLUSIONS Both low and high SHR levels were independently associated with in-hospital MACEs.Young males with DM,hypertension,and decreased renal function had much higher risks of suffering from SHR-correlated MACEs.
基金supported by the Canadian Institutes of Health Research(CIHR),Grant No.AAM 108751.
文摘BACKGROUND The association of cardiovascular risk burden with disability is unclear.We examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCRS)with the trajectories of limitations of physical function in older adults.METHODS A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCRS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were included.FGCRS at baseline was assessed and categorized into tertiles.Physical function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects models.RESULTS At baseline,FGCRS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,respectively.In the trajectories of limitations of physical function,the lowest FGCRS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCRS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(P<0.05).Alternatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(P<0.05).CONCLUSIONS Higher cardiovascular risk burden is associated with decreased physical performance,especially in gait.Results suggest SPPB may provide a measure of cardiovascular health in older adults.
基金supported by the National Natural Science Foundation of China(No.81960074)the Natural Science Foundation-Outstanding Youth Fund Project of Jiangxi Province(No.20232ACB216006)。
文摘BACKGROUND Oxidative stress is closely associated with hypertensive outcomes.The oxidative balance score(OBS)measures oxidative stress exposure from dietary and lifestyle elements.The objective of this study was to investigate the association between OBS and mortality in hypertensive patients.METHODS This study included 7823 hypertensive patients from the National Health and Nutrition Examination Survey(NHA-NES)1999-2014.Several models,including Cox regression,restricted cubic splines(RCS),Kaplan-Meier survival analysis,subgroup,and sensitivity analyses,were exploited to investigate the relationship between OBS and the risk of mortality.RESULTS Controlling for all potential confounders,a significantly inverse association was observed between elevated OBS and all-cause[hazard ratio(HR)=0.90,95%CI:0.85-0.95]and cardiovascular mortality(HR=0.85,95%CI:0.75-0.95).With adjustment for covariates,significant associations between lifestyle OBS and mortality risks diminished,whereas associations between dietary OBS and these mortality risks remained robust(all-cause mortality:HR=0.91,95%CI:0.86-0.96;cardiovascular mortality:HR=0.85,95%CI:0.76-0.96).RCS demonstrated a linear relationship between OBS and all-cause and cardiovascular mortality risk(P_(nonlinear)=0.088 and P_(nonlinear)=0.447,respectively).Kaplan-Meier curves demonstrated that the mortality rate was lower with a high OBS(P<0.001).The consistency of the association was demonstrated in subgroup and sensitivity analyses.RCS after stratification showed that among current drinkers,those with higher OBS had a lower risk of mortality compared with former or never drinkers.CONCLUSIONS In hypertensive individuals,there was a negative association between OBS and all-cause and cardiovascular mortality.Encouraging hypertensive individuals,especially those currently drinking,to maintain high levels of OBS may be beneficial in improving their prognosis.
文摘Background: The community tuberculosis care program was started to reduce the impact of TB and increase successful treatment outcomes, thus contributing to meeting WHO targets on TB. According to the Botswana Ministry of Health, community tuberculosis care was introduced with the main goal of reducing tuberculosis-related morbidity and mortality among communities through the expansion of direct observed therapy and community involvement to community settings. The community caregivers were to support tuberculosis patients throughout their treatment period until they were cured or had completed their treatment. Settings: Two major cities of Botswana, Francistown and Gaborone, with more than twenty-two health clinics offering tuberculosis care. Objective: To investigate community caregivers’ experiences and identify programmatic strategies to improve active TB case findings under the community TB care (CTBC) program in Botswana during 2016-2021. Methods: We adopted a descriptive qualitative research design, followed by convenience purposive sampling. We obtained consent and interviewed 40 participants who met the inclusion criteria, 16 out of 73 in Gaborone and 24 out of 38 from Francistown. Results: We interviewed 40 caregivers with a mean age of 43.4 years. Accepting the caregiving role was identified as the main experience by more than two thirds of the caregivers. While at least more than two-fifth felt obligated to care for the patient at home due to personal relations. More than half of the respondents found caregiving difficult or frustrating due to some challenges encountered during the caregiving role. Behavioral modifications were suggested under different subthemes as strategies to improve active case finding. [-rId13-]Conclusion: Acceptance was the major experience in CTBC. Intensification of known programmatic strategies was suggested by caregivers to improve tuberculosis active case finding in CTBC.
基金Aeronautical Science Foundation of China(No.20220001057001)。
文摘In recent years,the path planning for multi-agent technology has gradually matured,and has made breakthrough progress.The main difficulties in path planning for multi-agent are large state space,long algorithm running time,multiple optimization objectives,and asynchronous action of multiple agents.To solve the above problems,this paper first introduces the main problem of the research:multi-objective multi-agent path finding with asynchronous action,and proposes the algorithm framework of multi-objective loose synchronous(MO-LS)search.By combining A*and M*,MO-LS-A*and MO-LS-M*algorithms are respectively proposed.The completeness and optimality of the algorithm are proved,and a series of comparative experiments are designed to analyze the factors affecting the performance of the algorithm,verifying that the proposed MO-LS-M*algorithm has certain advantages.
文摘TToo tthhee eeddiittoorr::Autism spectrum disorder(ASD)is believed to have a multifactorial aetiology involving both genetics and environmental factors.Evidence also emphasises that ASD is programmed during the in utero period,with multiple prenatal and postnatal factors influencing the epigenome and contributing to the onset of ASD.
文摘With the improvement of living standards and changes in dietary habits,the non-alcoholic fatty liver disease(NAFLD)has become one of the most common metabolic diseases clinically,with a global prevalence exceeding 25%.NAFLD often presents as a multisystem disease characterized by excessive deposition of triglycerides within hepatocytes,with over 5%of hepatocytes exhibiting steatosis.The clinical progression of NAFLD can mainly be divided into two stages:non-alcoholic fatty liver(NAFL)and non-alcoholic steatohepatitis(NASH).NAFL represents the early stage,primarily characterized by hepatocellular steatosis(which can be reversed with early intervention)and further progression leading to NASH.Besides hepatocellular steatosis,NASH also exhibits hepatocyte inflammation,injury,and fibrosis.Research indicates that 25%of NAFL patients may progress to NASH,and 35%to 50%of NASH patients further develop into liver cirrhosis or even liver cancer.Additionally,NAFLD is closely associated with various chronic diseases and tumors,such as obesity,hyperlipidemia,diabetes,breast cancer,and colorectal cancer.Despite the high and rising incidence of NAFLD,there are currently no clinically proven safe and effective drugs specifically targeting each stage of NAFLD.
文摘BACKGROUND Pneumoparotid is a rare disease associated with retrograde airflow into the ductal system.There is no established treatment for this disease,which has no known complications.Mouth puffing and playing wind instruments are known to be the causes of this disease.CASE SUMMARY We managed a case,in which pneumoparotid suddenly recurred 4 months after surgery for purulent parotiditis.The patient did not report any obvious etiological factors,such as mouth puffing or playing a wind instrument.We reviewed 128 articles(from 1941 to 2023)that reported on a total of 166 patients with pneumoparotid,including the patient from the present case report,with imaging findings.This is the first reported case of pneumoparotid following surgery for purulent parotitis.The etiology in our case was classified as idiopathic.CONCLUSION Imaging findings could be sufficient for accurate pneumoparotid diagnoses and the exclusion of complications;computed tomography could be useful.
基金This work was supported by the National Natural Science Foundation of China(62073093)the Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province(LBH-Q19098)+1 种基金the Heilongjiang Provincial Natural Science Foundation of China(LH2020F017)the Key Laboratory of Advanced Marine Communication and Information Technology,Ministry of Industry and Information Technology.
文摘For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in suppressing impulse noise and achieving superior direction finding performance using the maximum likelihood(ML)estimation method.A quantum equilibrium optimizer algorithm(QEOA)is devised to resolve the corresponding objective function for efficient and accurate direc-tion finding.The results of simulation reveal the capability of the presented method in success rate and root mean square error over existing direction-finding methods in different application situations,e.g.,locating coherent signal sources with very few snapshots in strong impulse noise.Other than that,the Cramér-Rao bound(CRB)under impulse noise environment has been drawn to test the capability of the presented method.
