Sequential Quadratic Programming(SQP) is the most efficient algorithm for nonlinear optimization.But a penalty function is usually used for linear search,causing some problems.Filter-SQP developed by Roger Fletcher an...Sequential Quadratic Programming(SQP) is the most efficient algorithm for nonlinear optimization.But a penalty function is usually used for linear search,causing some problems.Filter-SQP developed by Roger Fletcher and Sven Leyffer avoids using penalty function.In the view of filter-SQP,NLP problem has two objectives,one is minimizing objective function,the other is satisfying the constraints.The concept of filter is proposed on the basis of these two objectives.In this paper flowsheet optimization using filter-SQP in modular simulator environment was studied.Infeasible path strategy was used and the constraint function was composed of tear stream equation,specific design and unsatisfied inequality constraint.When filter could not find a step as the starting point of the next iteration,in order to avoid algorithm failure three strategies were used.They were restarting strategy,converging recycle strategy and feasible path strategy.A successive scaling strategy was proposed for filter-SQP to improve the efficiency of optimization.A case study of process optimization with filter-SQP was very encouraging.展开更多
Flattening filter-free(FFF) beams generated by medical linear particle accelerators(linacs) have recently been used in radiotherapy clinical practice.FFF beams have fundamental physical parameter differences with resp...Flattening filter-free(FFF) beams generated by medical linear particle accelerators(linacs) have recently been used in radiotherapy clinical practice.FFF beams have fundamental physical parameter differences with respect to standard flattening filter(FF) beams,such that the generally used dosimetric parameters and definitions are not always viable.This study investigates dosimetric parameters for use in the quality assurance of FFF beams generated by medical linacs in radiotherapy.The main characteristics of the photon beams are analyzed using specific data generated by a Varian True Beam linac having both FFF and FF beams of 6 and 10 MV(megavolt) energy,respectively.Definitions for dose profile parameters are suggested,starting from the renormalization of the FFF with respect to the corresponding FF beam.From this point,the flatness concept is translated into one of "un-flatness",and other definitions are proposed,maintaining a strict parallelism between FFF and FF parameter concepts.The quality controls used in establishing a quality assurance program when introducing FFF beams into the clinical environment are given,maintaining similarity to those used for standard FF beams,and recommendations for the introduction of FFF beams into clinical radiotherapy application for breast cancer patients are provided as an example for comparison between FFF and FF for dose distribution and coverage for a target volume.Although there are many advantages of using a FFF beam,especially for advanced radiotherapy techniques,there are a few limitations(e.g.,using a relatively higher energy photon beam for stereotactic radiotherapy(SRT),limited speed of current multileaf collimators(MLCs),and off-axis distance-dependent modulation in intensitymodulated radiation therapy(IMRT)) as well as challenges(e.g.,criteria for beam quality evaluation and penumbra,establishment of dosimetry methods,and consequences of photon target burn-up) that need to be addressed for establishing the FFF beam as a viable alternative to the FF beam.展开更多
Algebraic attack was applied to attack Filter-Combintr model keystreamgenerators. We proposed the technique of function composition to improve the model, and the improvedmodel can resist the algebraic attack. A new cr...Algebraic attack was applied to attack Filter-Combintr model keystreamgenerators. We proposed the technique of function composition to improve the model, and the improvedmodel can resist the algebraic attack. A new criterion for designing Filter-Combiner model was alsoproposed: the total length I. of Linear Finite State Machines used in the model should be largeenough and the degree d of Filter-Combiner function should be approximate [L/2].展开更多
Taste acuity of adult patients undergoing cancer treatment has been well investigated;however, studies of taste acuity after completion of cancer treatment are limited, particularly in children. This study aimed to as...Taste acuity of adult patients undergoing cancer treatment has been well investigated;however, studies of taste acuity after completion of cancer treatment are limited, particularly in children. This study aimed to assess taste acuity in pediatric cancer patients after treatment completion. Seventy-three patients who had completed cancer treatment (median age, 13 years;range, 7 - 18 years) and had not received any further treatment for at least 6 months were enrolled. Eighty-one healthy children (median age, 10 years;range, 8 - 19 years) served as controls. We determined the thresholds for four tastes (sweet, salty, sour, and bitter) using the filter-paper disc method. There was no significant difference in the thresholds of taste acuity for the four test solutions between the patient and control groups. The duration since treatment completion (<5 years vs. ≥5 years) had no significant impact on taste acuity for the four test solutions. The threshold for tasting salt was significantly higher in the group that had received chemotherapy + radiation and/or hematopoietic stem cell transplantation than that in the group that had received chemotherapy-only. Our results indicated that taste acuity after treatment completion in pediatric cancer patients was the same as that in healthy children. However, some treatment modalities were correlated with an impaired ability to taste salt. Gustatory test results should be considered while deciding nutritional support modalities after treatment completion in pediatric cancer patients.展开更多
<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> Postoperative irradiation for brain tumor in pregnan...<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> Postoperative irradiation for brain tumor in pregnant women is a matter of concern. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> We aimed to assess the safety of radiotherapy for brain tumors in pregnancy. We here report a successful treatment for anaplastic astrocytoma during pregnancy: surgery + postoperative irradiation. We wish to emphasize how we devised irradiation procedure to achieve both therapeutic effectiveness and safety to the fetus/infant. </span><b><span style="font-family:Verdana;">Case Presentation: </span></b><span style="font-family:Verdana;">A 34-year-old pregnant woman suffered with brain anaplastic astrocytoma. Tumor resection under craniotomy was performed with success. We decided to conduct postoperative radiotherapy at 25 weeks of gestation to reduce the risk of recurrence. We used a flattening filter-free volumetric arc therapy (FFF-VMAT) technique, which can achieve lower out-of-field dose than VMAT with a flattening filter or helical tomotherapy. We prescribed 60 Gy over 30 fractions. During actual beam delivery, surface and rectal dose to the patient (mother) were measured. The total fetal dose was estimated at 0.006 - 0.018 Gy, which is under the threshold set by the ICRP. A male healthy infant was born vaginally at the 37th week of pregnancy. The patient (mother) and the infant are healthy at the time of writing.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">FFF-VMAT is a good choice for brain tumors during pregnancy</span></span></span></span><span style="font-family:Verdana;">.</span>展开更多
There is increasing interest in the clinical use of flattening filter-free(FFF) beams.In this study,we aimed to investigate the dosimetric characteristics of volumetric modulated arc radiotherapy(VMAT) with FFF beams ...There is increasing interest in the clinical use of flattening filter-free(FFF) beams.In this study,we aimed to investigate the dosimetric characteristics of volumetric modulated arc radiotherapy(VMAT) with FFF beams for nasopharyngeal carcinoma(NPC).Ten NPC patients were randomly selected to undergo a RapidArc plan with either FFF beams(RA-FFF) or conventional beams(RA-C).The doses to the planning target volumes(PTVs),organs at risk(OARs),and normal tissues were compared.The technical delivery parameters for RapidArc plans were also assessed to compare the characteristics of FFF and conventional beams.Both techniques delivered adequate doses to PTVs.For PTVs,RA-C delivered lower maximum and mean doses and improved conformity and homogeneity compared with RA-FFF.Both techniques provided similar maximum doses to the optic nerves and lenses.For the brain stem,spinal cord,larynx,parotid glands,oral cavity,and skin,RA-FFF showed significant dose increases compared to RA-C.The dose to normal tissue was lower in RA-FFF.The monitor units(MUs) were(536 ± 46) MU for RA-FFF and(501± 25) MU for RA-C.The treatment duration did not significantly differbetween plans.Although both treatment plans could meet clinical needs,RA-C is dosimetrically superior to RA-FFF for NPC radiotherapy.展开更多
We discuss a filter-based pattern search method for unconstrained optimization in this paper. For the purpose to broaden the search range we use both filter technique and frames, which are fragments of grids, to provi...We discuss a filter-based pattern search method for unconstrained optimization in this paper. For the purpose to broaden the search range we use both filter technique and frames, which are fragments of grids, to provide a new criterion of iterate acceptance. The convergence can be ensured under some conditions. The numerical result shows that this method is practical and efficient.展开更多
In this paper we propose a Filter-based Uniform Algorithm （FbUA） for optimizing top-κ query in distributed networks, which has been a topic of much recent interest. The basic idea of FhUA is to set a filter at each...In this paper we propose a Filter-based Uniform Algorithm （FbUA） for optimizing top-κ query in distributed networks, which has been a topic of much recent interest. The basic idea of FhUA is to set a filter at each node to pre vent it from sending out the data with little chance to contrib ute to the top-κ result. FbUA can gain exact answers to top-κ query through two phrases of round trip communications between query station and participant nodes. The experiment results show that FbUA reduces network bandwidth consumption dramatically.展开更多
In the field of mobile robotics,human tracking has emerged as an important objective for facilitating human-robot interaction.In this paper,we propose a particle-filter-based walking prediction model that will address...In the field of mobile robotics,human tracking has emerged as an important objective for facilitating human-robot interaction.In this paper,we propose a particle-filter-based walking prediction model that will address an occlusion situation.Since the target being tracked is a human leg,a motion model for a leg is required.The validity of the proposed model is verified experimentally.展开更多
In this paper we present a filter-trust-region algorithm for solving LC1 unconstrained optimization problems which uses the second Dini upper directional derivative. We establish the global convergence of the algorith...In this paper we present a filter-trust-region algorithm for solving LC1 unconstrained optimization problems which uses the second Dini upper directional derivative. We establish the global convergence of the algorithm under reasonable assumptions.展开更多
For the measurement of X-ray energy spectrum with filter-fluorescer method,the high energy tail at the rearward of response function is the main source of background.There are,traditionally,two techniques for measurin...For the measurement of X-ray energy spectrum with filter-fluorescer method,the high energy tail at the rearward of response function is the main source of background.There are,traditionally,two techniques for measuring the background contributions:the same element Z for the fluorescer and filter,or the same element Z?1 for them.Using the formula of fluorescence intensity,and the elemental combinations of cobalt and iron,the backgrounds which the two techniques provide and the real one for measuring black-body radiation at equilibrium temperature of 7×106 K,were calculated.The results show that the Co-Co combination for the filter-fluorescer spectrometer can achieve better effect.A semi-quantitative analysis for the calculation results is discussed.展开更多
In this paper, the Eigenvalue Complementarity Problem (EiCP) with real symmetric matrices is addressed, which appears in the study of contact problem in mechanics. We discuss a quadratic programming formulation to the...In this paper, the Eigenvalue Complementarity Problem (EiCP) with real symmetric matrices is addressed, which appears in the study of contact problem in mechanics. We discuss a quadratic programming formulation to the problem. The resulting problems are nonlinear programs that can be solved by a line search filter-SQP algorithm.展开更多
文摘Sequential Quadratic Programming(SQP) is the most efficient algorithm for nonlinear optimization.But a penalty function is usually used for linear search,causing some problems.Filter-SQP developed by Roger Fletcher and Sven Leyffer avoids using penalty function.In the view of filter-SQP,NLP problem has two objectives,one is minimizing objective function,the other is satisfying the constraints.The concept of filter is proposed on the basis of these two objectives.In this paper flowsheet optimization using filter-SQP in modular simulator environment was studied.Infeasible path strategy was used and the constraint function was composed of tear stream equation,specific design and unsatisfied inequality constraint.When filter could not find a step as the starting point of the next iteration,in order to avoid algorithm failure three strategies were used.They were restarting strategy,converging recycle strategy and feasible path strategy.A successive scaling strategy was proposed for filter-SQP to improve the efficiency of optimization.A case study of process optimization with filter-SQP was very encouraging.
文摘Flattening filter-free(FFF) beams generated by medical linear particle accelerators(linacs) have recently been used in radiotherapy clinical practice.FFF beams have fundamental physical parameter differences with respect to standard flattening filter(FF) beams,such that the generally used dosimetric parameters and definitions are not always viable.This study investigates dosimetric parameters for use in the quality assurance of FFF beams generated by medical linacs in radiotherapy.The main characteristics of the photon beams are analyzed using specific data generated by a Varian True Beam linac having both FFF and FF beams of 6 and 10 MV(megavolt) energy,respectively.Definitions for dose profile parameters are suggested,starting from the renormalization of the FFF with respect to the corresponding FF beam.From this point,the flatness concept is translated into one of "un-flatness",and other definitions are proposed,maintaining a strict parallelism between FFF and FF parameter concepts.The quality controls used in establishing a quality assurance program when introducing FFF beams into the clinical environment are given,maintaining similarity to those used for standard FF beams,and recommendations for the introduction of FFF beams into clinical radiotherapy application for breast cancer patients are provided as an example for comparison between FFF and FF for dose distribution and coverage for a target volume.Although there are many advantages of using a FFF beam,especially for advanced radiotherapy techniques,there are a few limitations(e.g.,using a relatively higher energy photon beam for stereotactic radiotherapy(SRT),limited speed of current multileaf collimators(MLCs),and off-axis distance-dependent modulation in intensitymodulated radiation therapy(IMRT)) as well as challenges(e.g.,criteria for beam quality evaluation and penumbra,establishment of dosimetry methods,and consequences of photon target burn-up) that need to be addressed for establishing the FFF beam as a viable alternative to the FF beam.
文摘Algebraic attack was applied to attack Filter-Combintr model keystreamgenerators. We proposed the technique of function composition to improve the model, and the improvedmodel can resist the algebraic attack. A new criterion for designing Filter-Combiner model was alsoproposed: the total length I. of Linear Finite State Machines used in the model should be largeenough and the degree d of Filter-Combiner function should be approximate [L/2].
文摘Taste acuity of adult patients undergoing cancer treatment has been well investigated;however, studies of taste acuity after completion of cancer treatment are limited, particularly in children. This study aimed to assess taste acuity in pediatric cancer patients after treatment completion. Seventy-three patients who had completed cancer treatment (median age, 13 years;range, 7 - 18 years) and had not received any further treatment for at least 6 months were enrolled. Eighty-one healthy children (median age, 10 years;range, 8 - 19 years) served as controls. We determined the thresholds for four tastes (sweet, salty, sour, and bitter) using the filter-paper disc method. There was no significant difference in the thresholds of taste acuity for the four test solutions between the patient and control groups. The duration since treatment completion (<5 years vs. ≥5 years) had no significant impact on taste acuity for the four test solutions. The threshold for tasting salt was significantly higher in the group that had received chemotherapy + radiation and/or hematopoietic stem cell transplantation than that in the group that had received chemotherapy-only. Our results indicated that taste acuity after treatment completion in pediatric cancer patients was the same as that in healthy children. However, some treatment modalities were correlated with an impaired ability to taste salt. Gustatory test results should be considered while deciding nutritional support modalities after treatment completion in pediatric cancer patients.
文摘<strong>Background:</strong><span><span><span style="font-family:""><span style="font-family:Verdana;"> Postoperative irradiation for brain tumor in pregnant women is a matter of concern. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> We aimed to assess the safety of radiotherapy for brain tumors in pregnancy. We here report a successful treatment for anaplastic astrocytoma during pregnancy: surgery + postoperative irradiation. We wish to emphasize how we devised irradiation procedure to achieve both therapeutic effectiveness and safety to the fetus/infant. </span><b><span style="font-family:Verdana;">Case Presentation: </span></b><span style="font-family:Verdana;">A 34-year-old pregnant woman suffered with brain anaplastic astrocytoma. Tumor resection under craniotomy was performed with success. We decided to conduct postoperative radiotherapy at 25 weeks of gestation to reduce the risk of recurrence. We used a flattening filter-free volumetric arc therapy (FFF-VMAT) technique, which can achieve lower out-of-field dose than VMAT with a flattening filter or helical tomotherapy. We prescribed 60 Gy over 30 fractions. During actual beam delivery, surface and rectal dose to the patient (mother) were measured. The total fetal dose was estimated at 0.006 - 0.018 Gy, which is under the threshold set by the ICRP. A male healthy infant was born vaginally at the 37th week of pregnancy. The patient (mother) and the infant are healthy at the time of writing.</span><b><span style="font-family:Verdana;"> Conclusion: </span></b><span style="font-family:Verdana;">FFF-VMAT is a good choice for brain tumors during pregnancy</span></span></span></span><span style="font-family:Verdana;">.</span>
文摘There is increasing interest in the clinical use of flattening filter-free(FFF) beams.In this study,we aimed to investigate the dosimetric characteristics of volumetric modulated arc radiotherapy(VMAT) with FFF beams for nasopharyngeal carcinoma(NPC).Ten NPC patients were randomly selected to undergo a RapidArc plan with either FFF beams(RA-FFF) or conventional beams(RA-C).The doses to the planning target volumes(PTVs),organs at risk(OARs),and normal tissues were compared.The technical delivery parameters for RapidArc plans were also assessed to compare the characteristics of FFF and conventional beams.Both techniques delivered adequate doses to PTVs.For PTVs,RA-C delivered lower maximum and mean doses and improved conformity and homogeneity compared with RA-FFF.Both techniques provided similar maximum doses to the optic nerves and lenses.For the brain stem,spinal cord,larynx,parotid glands,oral cavity,and skin,RA-FFF showed significant dose increases compared to RA-C.The dose to normal tissue was lower in RA-FFF.The monitor units(MUs) were(536 ± 46) MU for RA-FFF and(501± 25) MU for RA-C.The treatment duration did not significantly differbetween plans.Although both treatment plans could meet clinical needs,RA-C is dosimetrically superior to RA-FFF for NPC radiotherapy.
文摘We discuss a filter-based pattern search method for unconstrained optimization in this paper. For the purpose to broaden the search range we use both filter technique and frames, which are fragments of grids, to provide a new criterion of iterate acceptance. The convergence can be ensured under some conditions. The numerical result shows that this method is practical and efficient.
基金Supported by the National Natural Science Foun-dation of China (60503036 ,60473073) Fok Ying Tong EducationFoundation (104027)
文摘In this paper we propose a Filter-based Uniform Algorithm （FbUA） for optimizing top-κ query in distributed networks, which has been a topic of much recent interest. The basic idea of FhUA is to set a filter at each node to pre vent it from sending out the data with little chance to contrib ute to the top-κ result. FbUA can gain exact answers to top-κ query through two phrases of round trip communications between query station and participant nodes. The experiment results show that FbUA reduces network bandwidth consumption dramatically.
基金The MKE(Ministry of Knowledge Economy),Korea,under the ITRC(Information Technology Research Center)support program(NIPA-2013-H0301-13-2006)supervised by the NIPA(National IT Industry Promotion Agency)The National Research Foundation of Korea(NRF)grant funded by the Korea government(MEST)(2013-029812)The MKE(Ministry of Knowledge Economy),Korea,under the Human Resources Development Program for Convergence Robot Specialists support program supervised by the NIPA(National IT Industry Promotion Agency)(NIPA-2013-H1502-13-1001)
文摘In the field of mobile robotics,human tracking has emerged as an important objective for facilitating human-robot interaction.In this paper,we propose a particle-filter-based walking prediction model that will address an occlusion situation.Since the target being tracked is a human leg,a motion model for a leg is required.The validity of the proposed model is verified experimentally.
基金Supported by CERG: CityU 101005 of the Government of Hong Kong SAR, Chinathe National Natural ScienceFoundation of China, the Specialized Research Fund of Doctoral Program of Higher Education of China (Grant No.20040319003)the Natural Science Fund of Jiangsu Province of China (Grant No. BK2006214)
文摘In this paper we present a filter-trust-region algorithm for solving LC1 unconstrained optimization problems which uses the second Dini upper directional derivative. We establish the global convergence of the algorithm under reasonable assumptions.
文摘For the measurement of X-ray energy spectrum with filter-fluorescer method,the high energy tail at the rearward of response function is the main source of background.There are,traditionally,two techniques for measuring the background contributions:the same element Z for the fluorescer and filter,or the same element Z?1 for them.Using the formula of fluorescence intensity,and the elemental combinations of cobalt and iron,the backgrounds which the two techniques provide and the real one for measuring black-body radiation at equilibrium temperature of 7×106 K,were calculated.The results show that the Co-Co combination for the filter-fluorescer spectrometer can achieve better effect.A semi-quantitative analysis for the calculation results is discussed.
文摘In this paper, the Eigenvalue Complementarity Problem (EiCP) with real symmetric matrices is addressed, which appears in the study of contact problem in mechanics. We discuss a quadratic programming formulation to the problem. The resulting problems are nonlinear programs that can be solved by a line search filter-SQP algorithm.
