Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize ...Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.展开更多
As a deposition technology, gas metal arc welding （GMAW） has shown new promise for rapid prototyping of metallic parts. During the process of metal forming using the arc of GMA W, low heat input and stable droplet t...As a deposition technology, gas metal arc welding （GMAW） has shown new promise for rapid prototyping of metallic parts. During the process of metal forming using the arc of GMA W, low heat input and stable droplet transition are critical to high quality figuration. The effects of various processing parameters on figuration quality were studied in the experiment of GMA W rapid prototyping using the wire of ERSO-6 , including welding voltage, wire feeding rate, welding speed and so on. The optimal parameters for ERSO-6 are obtained. Simultaneously, it is verified that the rapid prototyping parts with favorable structures and quality can be achieved under the conditions of low heat input and stable droplet transition.展开更多
The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly...The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly have at least one resource, or referred to as suppliers. Because each manufac turing unit might be carried out in different geographical places that implies t his probably gives rise to transportation cost, the selection of resources for e ach manufacturing unit must considers not only the manufacturing price of each r esource but also the transfer cost between any two potential resources. This pap er discusses the resource reconfiguration problem with two hypotheses: 1. Permit s one or more resources to attend the same manufacturing unit as long as the tot al cost can reach its least; 2. The freight contains the initial part, that is t he freight concave. Indeed, these hypotheses are much meaningful in the real wor ld. Furthermore, to simplify the solution for this problem, we propose two conce pts: assembly tree (AT) and combinatorial mode base (CMB). Formally an AT is a c omplete production line, which can ensure the parts equilibrium, and its capacit y is subjected to the least capacity of every resources and every path in it. In the end, we propose an implicit enumeration algorithm (IEA) by the use of CMB, including it is a heuristic algorithm for integer programming (HAIP) by the use of AT. The IEA can be outlined that for a determined combinatorial mode, if it h as not enumerated, we use the HAIP to get an near optima and corresponding CMB, marking every combinatorial mode extended from the CMB as enumerated, other cont inue a new iteration. The HAIP can be outlined that for a determined combinatori al mode, there are some determined number of AT, we select an AT with the le ast slope, and select the volume of this AT to its ultimate within its capacity, iterates this doing until the needed volume reached. In the end, we conclude th is paper and prospect the deep research based on GA thought.展开更多
A multi-electrode array is commonly applied in a plasma sparker to generate stable acoustic pulses.In this paper, the effects of the electrode configuration on the performance of a plasma sparker have been investigate...A multi-electrode array is commonly applied in a plasma sparker to generate stable acoustic pulses.In this paper, the effects of the electrode configuration on the performance of a plasma sparker have been investigated. In terms of the load electrical characteristics, the electrode radius and distance have negligible influence on the electric characteristics, whereas a larger electrode number results in a smaller voltage and a larger current but has little effect on the load energy. Regarding the acoustic characteristics, both the expansion and collapse pulses can be increased by decreasing the electrode tip radius. the influence of the electrode number and electrode gap distance on the amplitude of the expansion pulse was found to be negligible. And the amplitude of the collapse pulse decreases significantly with increasing electrode number. Increasing the electrode number decreases the energy efficiency for intense bubble interactions, thus, a small electrode tip radius and a small electrode number are preferred for the design of a plasma sparker if the total discharge energy is given.展开更多
A comprehensive behavioral investigation of gain and noise figure （NF） at different erbium doped fiber amplifier （EDFA） configurations is proposed. Configurations such as single pass （SP）, single pass with filt...A comprehensive behavioral investigation of gain and noise figure （NF） at different erbium doped fiber amplifier （EDFA） configurations is proposed. Configurations such as single pass （SP）, single pass with filter （SPF）, double pass （DP） and double pass with filter （DPF） are designed, investigated and compared. A continuous increasing of gain value is recorded by changing the configuration from SP to SPF to DP then to DPF. The NF value shows different behaviors at different configurations.展开更多
While silicon carbide(SiC)metal-oxide-semiconductor field-effect transistors(MOSFETs)have entered commercial markets,they still rely on specialized device structural approaches tailored to meet specific application de...While silicon carbide(SiC)metal-oxide-semiconductor field-effect transistors(MOSFETs)have entered commercial markets,they still rely on specialized device structural approaches tailored to meet specific application demands.The intricate and interdependent relationships among diverse physical parameters of SiC MOSFETs have not been fully elucidated to address the trade-offs that influence each other.This study aims to clarify these complex relationships and propose a well-balanced trade-off strategy.The proposed buried-MOS configuration ensures a harmonious balance among lower Ron,sp,reduced CGD,and milder EOX without compromising breakdown voltage(BV),thereby optimizing the interconnected physical parameters of SiC devices and significantly enhancing their highvoltage,high-frequency performance and reliability.The experimental results quantitatively demonstrate the advantages of the buried-MOS structure:high-frequency figure of merit high-frequency figure of merit(HF-FOM)(RDS,on3CGD)by 2.53,HF-FOM(RDS,on 3 QGD)by 2.23 and Baliga figure of merit(BFOM[4BV^(2)/Ron,sp)by 1.73 compared with the conventional BOX-MOS.Importantly,this approach embodies both theoretical significance and practical applicability,which is compatible with the existing large-scalemanufacturing processes and requires no additional steps.展开更多
Intelligent robots play a crucial role in space exploration,representing a significant trend in space automation technology.Modular robots,which can regenerate configurations and functions through self-reconfiguration...Intelligent robots play a crucial role in space exploration,representing a significant trend in space automation technology.Modular robots,which can regenerate configurations and functions through self-reconfiguration[1],offer distinct adaptability and versatility[2,3]over traditional robots with fixed structures and single-purpose functions.Therefore,self-reconfiguration is regarded as a highly promising capability for space exploration and remains a primary motivation for research in this field[4].展开更多
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).展开更多
The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ ...The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).展开更多
Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,...Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).展开更多
At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a...At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.展开更多
The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation...The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).展开更多
By the aid of the double sphere coordination point charge field model （DSCPCF） we have investigated the variation of the d-orbital level of the complex ion MX4n- with that of the bond angle and predicted its equilib...By the aid of the double sphere coordination point charge field model （DSCPCF） we have investigated the variation of the d-orbital level of the complex ion MX4n- with that of the bond angle and predicted its equilibrium configuration and the d-d transition bands.展开更多
This letter proposes a new method of determining equivalent configuration. The method is called 'the method of dividing the total spin groups'. The rules are as follows: （1） Find L to determine the spectrum ...This letter proposes a new method of determining equivalent configuration. The method is called 'the method of dividing the total spin groups'. The rules are as follows: （1） Find L to determine the spectrum terms for a given total spin quantum number S（S =N/2, N/2 -1,…, 0 or 112）, which are grouped from large to small, for S determines Nα and Nβ for each group. Next find MLmaxα and MLmaxβ according to rule （2） to find Lα and Lβ.展开更多
Following the publication of Xu et al.(2022),an error was identified in Figure 1D.Specifically,the top left panel was inadvertently duplicated during figure preparation.To ensure the accuracy and integrity of our publ...Following the publication of Xu et al.(2022),an error was identified in Figure 1D.Specifically,the top left panel was inadvertently duplicated during figure preparation.To ensure the accuracy and integrity of our published work,we request the publication of a corrigendum with the corrected image.We apologize for this oversight and any confusion it may have caused.The amended figure is provided in the updated Supplementary Materials.展开更多
Following the publication of Liu et al.(2024),an error was identified in Figure 4B,in which the image representing the lung from the E529G group was inadvertently duplicated with the image of the lung from the WT grou...Following the publication of Liu et al.(2024),an error was identified in Figure 4B,in which the image representing the lung from the E529G group was inadvertently duplicated with the image of the lung from the WT group during figure preparation.展开更多
The authors(Cai et al.,2022)claim that their proposed machine learning(ML)models,which are based on three typical ML algorithms and are trained to predict the burst capacity of pitting corroded pipelines,perform bette...The authors(Cai et al.,2022)claim that their proposed machine learning(ML)models,which are based on three typical ML algorithms and are trained to predict the burst capacity of pitting corroded pipelines,perform better than the existing semi-empirical formulas recommended by the international engineering code developers,DNV and ASME.The authors’assessments of the semi-empiri‐cal burst capacity formulas in Figure 10(a)and Table 8(Cai et al.,2022)incorrectly indicate that DNVGL-RP F101,ASME B31G,and modified ASME B31G are dan‐gerously unsafe due to significantly overestimating burst pressures in several cases.In contrast to the results and conclusions in Cai et al.展开更多
During the final proofing stage of the paper,the wrong version of Fig.2 was accidently used when replacing it with a high-resolution version.The star and circle marks were missing in the published version.
文摘Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.
文摘As a deposition technology, gas metal arc welding （GMAW） has shown new promise for rapid prototyping of metallic parts. During the process of metal forming using the arc of GMA W, low heat input and stable droplet transition are critical to high quality figuration. The effects of various processing parameters on figuration quality were studied in the experiment of GMA W rapid prototyping using the wire of ERSO-6 , including welding voltage, wire feeding rate, welding speed and so on. The optimal parameters for ERSO-6 are obtained. Simultaneously, it is verified that the rapid prototyping parts with favorable structures and quality can be achieved under the conditions of low heat input and stable droplet transition.
文摘The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly have at least one resource, or referred to as suppliers. Because each manufac turing unit might be carried out in different geographical places that implies t his probably gives rise to transportation cost, the selection of resources for e ach manufacturing unit must considers not only the manufacturing price of each r esource but also the transfer cost between any two potential resources. This pap er discusses the resource reconfiguration problem with two hypotheses: 1. Permit s one or more resources to attend the same manufacturing unit as long as the tot al cost can reach its least; 2. The freight contains the initial part, that is t he freight concave. Indeed, these hypotheses are much meaningful in the real wor ld. Furthermore, to simplify the solution for this problem, we propose two conce pts: assembly tree (AT) and combinatorial mode base (CMB). Formally an AT is a c omplete production line, which can ensure the parts equilibrium, and its capacit y is subjected to the least capacity of every resources and every path in it. In the end, we propose an implicit enumeration algorithm (IEA) by the use of CMB, including it is a heuristic algorithm for integer programming (HAIP) by the use of AT. The IEA can be outlined that for a determined combinatorial mode, if it h as not enumerated, we use the HAIP to get an near optima and corresponding CMB, marking every combinatorial mode extended from the CMB as enumerated, other cont inue a new iteration. The HAIP can be outlined that for a determined combinatori al mode, there are some determined number of AT, we select an AT with the le ast slope, and select the volume of this AT to its ultimate within its capacity, iterates this doing until the needed volume reached. In the end, we conclude th is paper and prospect the deep research based on GA thought.
基金supported by the National Key R&D Program of China under Grant 2016YFC0303901NSFC with grant numbers:U1606401,41476080,21276232 and 51377145+3 种基金Public Science and Technology Research Funds Projects of Ocean with grant number:201405036-2NSF of Zhejiang Province with grant number:LQ14D060004,LY13E070002 and 2014C33022Program for Zhejiang Leading Team of S&T Innovation with grant number:2013TD07Research Fund for the Taishan Scholar Project of Shandong Province with grant number:TSPD20161007
文摘A multi-electrode array is commonly applied in a plasma sparker to generate stable acoustic pulses.In this paper, the effects of the electrode configuration on the performance of a plasma sparker have been investigated. In terms of the load electrical characteristics, the electrode radius and distance have negligible influence on the electric characteristics, whereas a larger electrode number results in a smaller voltage and a larger current but has little effect on the load energy. Regarding the acoustic characteristics, both the expansion and collapse pulses can be increased by decreasing the electrode tip radius. the influence of the electrode number and electrode gap distance on the amplitude of the expansion pulse was found to be negligible. And the amplitude of the collapse pulse decreases significantly with increasing electrode number. Increasing the electrode number decreases the energy efficiency for intense bubble interactions, thus, a small electrode tip radius and a small electrode number are preferred for the design of a plasma sparker if the total discharge energy is given.
基金MMU and KFUPM/HBCC for their support in providing the various facilities utilized in the presentation of this paper
文摘A comprehensive behavioral investigation of gain and noise figure （NF） at different erbium doped fiber amplifier （EDFA） configurations is proposed. Configurations such as single pass （SP）, single pass with filter （SPF）, double pass （DP） and double pass with filter （DPF） are designed, investigated and compared. A continuous increasing of gain value is recorded by changing the configuration from SP to SPF to DP then to DPF. The NF value shows different behaviors at different configurations.
基金supported by the National Natural Science Foundation of China(Grant No.11705263)the Science and Technology Commission of Shanghai Municipality(Grant No.23511102602)+1 种基金National Key Research and Development Program of China(Grant No.2022YFB3604300,2022YFB3604301,2022YFB3604303)Youth Innovation Promotion Association CAS and Autonomous deployment project of State Key Laboratory of Materials for Integrated Circuits(No.SKLJC-Z2024-C02).
文摘While silicon carbide(SiC)metal-oxide-semiconductor field-effect transistors(MOSFETs)have entered commercial markets,they still rely on specialized device structural approaches tailored to meet specific application demands.The intricate and interdependent relationships among diverse physical parameters of SiC MOSFETs have not been fully elucidated to address the trade-offs that influence each other.This study aims to clarify these complex relationships and propose a well-balanced trade-off strategy.The proposed buried-MOS configuration ensures a harmonious balance among lower Ron,sp,reduced CGD,and milder EOX without compromising breakdown voltage(BV),thereby optimizing the interconnected physical parameters of SiC devices and significantly enhancing their highvoltage,high-frequency performance and reliability.The experimental results quantitatively demonstrate the advantages of the buried-MOS structure:high-frequency figure of merit high-frequency figure of merit(HF-FOM)(RDS,on3CGD)by 2.53,HF-FOM(RDS,on 3 QGD)by 2.23 and Baliga figure of merit(BFOM[4BV^(2)/Ron,sp)by 1.73 compared with the conventional BOX-MOS.Importantly,this approach embodies both theoretical significance and practical applicability,which is compatible with the existing large-scalemanufacturing processes and requires no additional steps.
基金supported by the National Science Fund for Distinguished Young Scholars(Grant No.52025054)。
文摘Intelligent robots play a crucial role in space exploration,representing a significant trend in space automation technology.Modular robots,which can regenerate configurations and functions through self-reconfiguration[1],offer distinct adaptability and versatility[2,3]over traditional robots with fixed structures and single-purpose functions.Therefore,self-reconfiguration is regarded as a highly promising capability for space exploration and remains a primary motivation for research in this field[4].
基金supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
文摘Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).
基金funded by the Japan Society for the Promotion of Science,JSPS,23K07290(to MF).
文摘The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).
基金supported by R01 NS093009 grant from NIH(to VVC).
文摘Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).
文摘At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.
文摘The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).
文摘By the aid of the double sphere coordination point charge field model （DSCPCF） we have investigated the variation of the d-orbital level of the complex ion MX4n- with that of the bond angle and predicted its equilibrium configuration and the d-d transition bands.
文摘This letter proposes a new method of determining equivalent configuration. The method is called 'the method of dividing the total spin groups'. The rules are as follows: （1） Find L to determine the spectrum terms for a given total spin quantum number S（S =N/2, N/2 -1,…, 0 or 112）, which are grouped from large to small, for S determines Nα and Nβ for each group. Next find MLmaxα and MLmaxβ according to rule （2） to find Lα and Lβ.
文摘Following the publication of Xu et al.(2022),an error was identified in Figure 1D.Specifically,the top left panel was inadvertently duplicated during figure preparation.To ensure the accuracy and integrity of our published work,we request the publication of a corrigendum with the corrected image.We apologize for this oversight and any confusion it may have caused.The amended figure is provided in the updated Supplementary Materials.
文摘Following the publication of Liu et al.(2024),an error was identified in Figure 4B,in which the image representing the lung from the E529G group was inadvertently duplicated with the image of the lung from the WT group during figure preparation.
文摘The authors(Cai et al.,2022)claim that their proposed machine learning(ML)models,which are based on three typical ML algorithms and are trained to predict the burst capacity of pitting corroded pipelines,perform better than the existing semi-empirical formulas recommended by the international engineering code developers,DNV and ASME.The authors’assessments of the semi-empiri‐cal burst capacity formulas in Figure 10(a)and Table 8(Cai et al.,2022)incorrectly indicate that DNVGL-RP F101,ASME B31G,and modified ASME B31G are dan‐gerously unsafe due to significantly overestimating burst pressures in several cases.In contrast to the results and conclusions in Cai et al.
文摘During the final proofing stage of the paper,the wrong version of Fig.2 was accidently used when replacing it with a high-resolution version.The star and circle marks were missing in the published version.
