As a deposition technology, gas metal arc welding （GMAW） has shown new promise for rapid prototyping of metallic parts. During the process of metal forming using the arc of GMA W, low heat input and stable droplet t...As a deposition technology, gas metal arc welding （GMAW） has shown new promise for rapid prototyping of metallic parts. During the process of metal forming using the arc of GMA W, low heat input and stable droplet transition are critical to high quality figuration. The effects of various processing parameters on figuration quality were studied in the experiment of GMA W rapid prototyping using the wire of ERSO-6 , including welding voltage, wire feeding rate, welding speed and so on. The optimal parameters for ERSO-6 are obtained. Simultaneously, it is verified that the rapid prototyping parts with favorable structures and quality can be achieved under the conditions of low heat input and stable droplet transition.展开更多
The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly...The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly have at least one resource, or referred to as suppliers. Because each manufac turing unit might be carried out in different geographical places that implies t his probably gives rise to transportation cost, the selection of resources for e ach manufacturing unit must considers not only the manufacturing price of each r esource but also the transfer cost between any two potential resources. This pap er discusses the resource reconfiguration problem with two hypotheses: 1. Permit s one or more resources to attend the same manufacturing unit as long as the tot al cost can reach its least; 2. The freight contains the initial part, that is t he freight concave. Indeed, these hypotheses are much meaningful in the real wor ld. Furthermore, to simplify the solution for this problem, we propose two conce pts: assembly tree (AT) and combinatorial mode base (CMB). Formally an AT is a c omplete production line, which can ensure the parts equilibrium, and its capacit y is subjected to the least capacity of every resources and every path in it. In the end, we propose an implicit enumeration algorithm (IEA) by the use of CMB, including it is a heuristic algorithm for integer programming (HAIP) by the use of AT. The IEA can be outlined that for a determined combinatorial mode, if it h as not enumerated, we use the HAIP to get an near optima and corresponding CMB, marking every combinatorial mode extended from the CMB as enumerated, other cont inue a new iteration. The HAIP can be outlined that for a determined combinatori al mode, there are some determined number of AT, we select an AT with the le ast slope, and select the volume of this AT to its ultimate within its capacity, iterates this doing until the needed volume reached. In the end, we conclude th is paper and prospect the deep research based on GA thought.展开更多
Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize ...Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.展开更多
A multi-electrode array is commonly applied in a plasma sparker to generate stable acoustic pulses.In this paper, the effects of the electrode configuration on the performance of a plasma sparker have been investigate...A multi-electrode array is commonly applied in a plasma sparker to generate stable acoustic pulses.In this paper, the effects of the electrode configuration on the performance of a plasma sparker have been investigated. In terms of the load electrical characteristics, the electrode radius and distance have negligible influence on the electric characteristics, whereas a larger electrode number results in a smaller voltage and a larger current but has little effect on the load energy. Regarding the acoustic characteristics, both the expansion and collapse pulses can be increased by decreasing the electrode tip radius. the influence of the electrode number and electrode gap distance on the amplitude of the expansion pulse was found to be negligible. And the amplitude of the collapse pulse decreases significantly with increasing electrode number. Increasing the electrode number decreases the energy efficiency for intense bubble interactions, thus, a small electrode tip radius and a small electrode number are preferred for the design of a plasma sparker if the total discharge energy is given.展开更多
A comprehensive behavioral investigation of gain and noise figure （NF） at different erbium doped fiber amplifier （EDFA） configurations is proposed. Configurations such as single pass （SP）, single pass with filt...A comprehensive behavioral investigation of gain and noise figure （NF） at different erbium doped fiber amplifier （EDFA） configurations is proposed. Configurations such as single pass （SP）, single pass with filter （SPF）, double pass （DP） and double pass with filter （DPF） are designed, investigated and compared. A continuous increasing of gain value is recorded by changing the configuration from SP to SPF to DP then to DPF. The NF value shows different behaviors at different configurations.展开更多
While silicon carbide(SiC)metal-oxide-semiconductor field-effect transistors(MOSFETs)have entered commercial markets,they still rely on specialized device structural approaches tailored to meet specific application de...While silicon carbide(SiC)metal-oxide-semiconductor field-effect transistors(MOSFETs)have entered commercial markets,they still rely on specialized device structural approaches tailored to meet specific application demands.The intricate and interdependent relationships among diverse physical parameters of SiC MOSFETs have not been fully elucidated to address the trade-offs that influence each other.This study aims to clarify these complex relationships and propose a well-balanced trade-off strategy.The proposed buried-MOS configuration ensures a harmonious balance among lower Ron,sp,reduced CGD,and milder EOX without compromising breakdown voltage(BV),thereby optimizing the interconnected physical parameters of SiC devices and significantly enhancing their highvoltage,high-frequency performance and reliability.The experimental results quantitatively demonstrate the advantages of the buried-MOS structure:high-frequency figure of merit high-frequency figure of merit(HF-FOM)(RDS,on3CGD)by 2.53,HF-FOM(RDS,on 3 QGD)by 2.23 and Baliga figure of merit(BFOM[4BV^(2)/Ron,sp)by 1.73 compared with the conventional BOX-MOS.Importantly,this approach embodies both theoretical significance and practical applicability,which is compatible with the existing large-scalemanufacturing processes and requires no additional steps.展开更多
By the aid of the double sphere coordination point charge field model （DSCPCF） we have investigated the variation of the d-orbital level of the complex ion MX4n- with that of the bond angle and predicted its equilib...By the aid of the double sphere coordination point charge field model （DSCPCF） we have investigated the variation of the d-orbital level of the complex ion MX4n- with that of the bond angle and predicted its equilibrium configuration and the d-d transition bands.展开更多
This letter proposes a new method of determining equivalent configuration. The method is called 'the method of dividing the total spin groups'. The rules are as follows: （1） Find L to determine the spectrum ...This letter proposes a new method of determining equivalent configuration. The method is called 'the method of dividing the total spin groups'. The rules are as follows: （1） Find L to determine the spectrum terms for a given total spin quantum number S（S =N/2, N/2 -1,…, 0 or 112）, which are grouped from large to small, for S determines Nα and Nβ for each group. Next find MLmaxα and MLmaxβ according to rule （2） to find Lα and Lβ.展开更多
Background:A significant challenge regarding notable historical figures is determining the accuracy of the words and actions attributed to them with the limited available evidence,when their biographers have presented...Background:A significant challenge regarding notable historical figures is determining the accuracy of the words and actions attributed to them with the limited available evidence,when their biographers have presented a biased life assessment.Lauded as a founding suffragette,the first female school principal,and the first white female practicing physician in Canada,Dr.Emily Stowe did not help historians.She destroyed her records,leaving her life story to be told by her daughter,who portrayed her as a heroine–a view that has persisted since the start of the 20th century.To improve the accuracy of assessing the life of Emily Stowe,as much information as possible about Stowe must be collected and interpreted.Methods:Presented is a narrative research method for analyzing historical figures that examines 22 life-changing events in the life of Stowe by answering six types of questions about each event:when,where,who,what,how,and why.Results:This narrative research,representing a psychoanalytic research process,finds that much of the repeated story of Stowe is either exaggerated or likely false.Conclusion:Following the example of Emily Stowe,this unique method is applicable for improving the historical accuracy in assessing the lives of other notable figures.It represents a method extendable to those currently alive,outside the public eye,searching to develop their own narrative.展开更多
The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3...The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.展开更多
With the brisk winter season just around the corner,my now 5-year-old's birthday was approaching,and I had a big celebration planned full of presents,cake and a fun day out.However,this year,she had a request of h...With the brisk winter season just around the corner,my now 5-year-old's birthday was approaching,and I had a big celebration planned full of presents,cake and a fun day out.However,this year,she had a request of her own.One frosty evening,she glided up to me and said,"Dad,this year for my birthday,I want to learn how to be a figure skater."展开更多
Intelligent robots play a crucial role in space exploration,representing a significant trend in space automation technology.Modular robots,which can regenerate configurations and functions through self-reconfiguration...Intelligent robots play a crucial role in space exploration,representing a significant trend in space automation technology.Modular robots,which can regenerate configurations and functions through self-reconfiguration[1],offer distinct adaptability and versatility[2,3]over traditional robots with fixed structures and single-purpose functions.Therefore,self-reconfiguration is regarded as a highly promising capability for space exploration and remains a primary motivation for research in this field[4].展开更多
Programmable droplet manipulation based on external stimulation is in high demand in various modern technologies.Despite notable progress,current manipulation strategies still suffer from a common drawback such as sin...Programmable droplet manipulation based on external stimulation is in high demand in various modern technologies.Despite notable progress,current manipulation strategies still suffer from a common drawback such as single control means of modulating the external stimulation input,which leads to huge challenges in sophisticated and large scale-up droplet handling.Herein,a unique patternreconfiguration-driven droplet manipulation method is developed on conductive/nonconductive pattern surfaces under charge deposition.Contactless charge deposition induces the“edge barrier”phenomenon at the boundaries of conductive/nonconductive patterns,analogous to an invisible and tunable wall guiding droplet behaviors.The edge barrier effect can be flexibly tuned by the nonconductive surface pattern.Thus,with charge deposition,surfaces are endowed with protean control functionality.The design of conductive/nonconductive patterns can effectively enable multifunction droplet manipulations,including track-guided sliding,sorting,merging,and mixing.Moreover,dynamical pattern reconfiguration drives programmable fluidics with sophisticated and large scale-up droplet handling capabilities in a low-cost and simple approach.展开更多
A pulsed laser system is realized with graphene employed as a Q-switch.The graphene is exfoliated from its solution using an optical deposition and the optical tweezer effect.A fiber ferrule that already has the graph...A pulsed laser system is realized with graphene employed as a Q-switch.The graphene is exfoliated from its solution using an optical deposition and the optical tweezer effect.A fiber ferrule that already has the graphene deposited on it is inserted into an erbium-ytterbium laser（EYL）system with linear cavity configuration.We successfully demonstrate a pulsed EYL with a pulse duration of approximately 5.9μs and a repetition rate of 20.0 kHz.展开更多
Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,...Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).展开更多
The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ ...The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).展开更多
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).展开更多
At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a...At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.展开更多
The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation...The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).展开更多
文摘As a deposition technology, gas metal arc welding （GMAW） has shown new promise for rapid prototyping of metallic parts. During the process of metal forming using the arc of GMA W, low heat input and stable droplet transition are critical to high quality figuration. The effects of various processing parameters on figuration quality were studied in the experiment of GMA W rapid prototyping using the wire of ERSO-6 , including welding voltage, wire feeding rate, welding speed and so on. The optimal parameters for ERSO-6 are obtained. Simultaneously, it is verified that the rapid prototyping parts with favorable structures and quality can be achieved under the conditions of low heat input and stable droplet transition.
文摘The agile manufacturing is a new conception for rap id reaction to the consumers. One of its implements is establishing a virtual ente rprise (VE) around the task, where each manufacturing unit, or sub-task, probab ly have at least one resource, or referred to as suppliers. Because each manufac turing unit might be carried out in different geographical places that implies t his probably gives rise to transportation cost, the selection of resources for e ach manufacturing unit must considers not only the manufacturing price of each r esource but also the transfer cost between any two potential resources. This pap er discusses the resource reconfiguration problem with two hypotheses: 1. Permit s one or more resources to attend the same manufacturing unit as long as the tot al cost can reach its least; 2. The freight contains the initial part, that is t he freight concave. Indeed, these hypotheses are much meaningful in the real wor ld. Furthermore, to simplify the solution for this problem, we propose two conce pts: assembly tree (AT) and combinatorial mode base (CMB). Formally an AT is a c omplete production line, which can ensure the parts equilibrium, and its capacit y is subjected to the least capacity of every resources and every path in it. In the end, we propose an implicit enumeration algorithm (IEA) by the use of CMB, including it is a heuristic algorithm for integer programming (HAIP) by the use of AT. The IEA can be outlined that for a determined combinatorial mode, if it h as not enumerated, we use the HAIP to get an near optima and corresponding CMB, marking every combinatorial mode extended from the CMB as enumerated, other cont inue a new iteration. The HAIP can be outlined that for a determined combinatori al mode, there are some determined number of AT, we select an AT with the le ast slope, and select the volume of this AT to its ultimate within its capacity, iterates this doing until the needed volume reached. In the end, we conclude th is paper and prospect the deep research based on GA thought.
文摘Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.
基金supported by the National Key R&D Program of China under Grant 2016YFC0303901NSFC with grant numbers:U1606401,41476080,21276232 and 51377145+3 种基金Public Science and Technology Research Funds Projects of Ocean with grant number:201405036-2NSF of Zhejiang Province with grant number:LQ14D060004,LY13E070002 and 2014C33022Program for Zhejiang Leading Team of S&T Innovation with grant number:2013TD07Research Fund for the Taishan Scholar Project of Shandong Province with grant number:TSPD20161007
文摘A multi-electrode array is commonly applied in a plasma sparker to generate stable acoustic pulses.In this paper, the effects of the electrode configuration on the performance of a plasma sparker have been investigated. In terms of the load electrical characteristics, the electrode radius and distance have negligible influence on the electric characteristics, whereas a larger electrode number results in a smaller voltage and a larger current but has little effect on the load energy. Regarding the acoustic characteristics, both the expansion and collapse pulses can be increased by decreasing the electrode tip radius. the influence of the electrode number and electrode gap distance on the amplitude of the expansion pulse was found to be negligible. And the amplitude of the collapse pulse decreases significantly with increasing electrode number. Increasing the electrode number decreases the energy efficiency for intense bubble interactions, thus, a small electrode tip radius and a small electrode number are preferred for the design of a plasma sparker if the total discharge energy is given.
基金MMU and KFUPM/HBCC for their support in providing the various facilities utilized in the presentation of this paper
文摘A comprehensive behavioral investigation of gain and noise figure （NF） at different erbium doped fiber amplifier （EDFA） configurations is proposed. Configurations such as single pass （SP）, single pass with filter （SPF）, double pass （DP） and double pass with filter （DPF） are designed, investigated and compared. A continuous increasing of gain value is recorded by changing the configuration from SP to SPF to DP then to DPF. The NF value shows different behaviors at different configurations.
基金supported by the National Natural Science Foundation of China(Grant No.11705263)the Science and Technology Commission of Shanghai Municipality(Grant No.23511102602)+1 种基金National Key Research and Development Program of China(Grant No.2022YFB3604300,2022YFB3604301,2022YFB3604303)Youth Innovation Promotion Association CAS and Autonomous deployment project of State Key Laboratory of Materials for Integrated Circuits(No.SKLJC-Z2024-C02).
文摘While silicon carbide(SiC)metal-oxide-semiconductor field-effect transistors(MOSFETs)have entered commercial markets,they still rely on specialized device structural approaches tailored to meet specific application demands.The intricate and interdependent relationships among diverse physical parameters of SiC MOSFETs have not been fully elucidated to address the trade-offs that influence each other.This study aims to clarify these complex relationships and propose a well-balanced trade-off strategy.The proposed buried-MOS configuration ensures a harmonious balance among lower Ron,sp,reduced CGD,and milder EOX without compromising breakdown voltage(BV),thereby optimizing the interconnected physical parameters of SiC devices and significantly enhancing their highvoltage,high-frequency performance and reliability.The experimental results quantitatively demonstrate the advantages of the buried-MOS structure:high-frequency figure of merit high-frequency figure of merit(HF-FOM)(RDS,on3CGD)by 2.53,HF-FOM(RDS,on 3 QGD)by 2.23 and Baliga figure of merit(BFOM[4BV^(2)/Ron,sp)by 1.73 compared with the conventional BOX-MOS.Importantly,this approach embodies both theoretical significance and practical applicability,which is compatible with the existing large-scalemanufacturing processes and requires no additional steps.
文摘By the aid of the double sphere coordination point charge field model （DSCPCF） we have investigated the variation of the d-orbital level of the complex ion MX4n- with that of the bond angle and predicted its equilibrium configuration and the d-d transition bands.
文摘This letter proposes a new method of determining equivalent configuration. The method is called 'the method of dividing the total spin groups'. The rules are as follows: （1） Find L to determine the spectrum terms for a given total spin quantum number S（S =N/2, N/2 -1,…, 0 or 112）, which are grouped from large to small, for S determines Nα and Nβ for each group. Next find MLmaxα and MLmaxβ according to rule （2） to find Lα and Lβ.
文摘Background:A significant challenge regarding notable historical figures is determining the accuracy of the words and actions attributed to them with the limited available evidence,when their biographers have presented a biased life assessment.Lauded as a founding suffragette,the first female school principal,and the first white female practicing physician in Canada,Dr.Emily Stowe did not help historians.She destroyed her records,leaving her life story to be told by her daughter,who portrayed her as a heroine–a view that has persisted since the start of the 20th century.To improve the accuracy of assessing the life of Emily Stowe,as much information as possible about Stowe must be collected and interpreted.Methods:Presented is a narrative research method for analyzing historical figures that examines 22 life-changing events in the life of Stowe by answering six types of questions about each event:when,where,who,what,how,and why.Results:This narrative research,representing a psychoanalytic research process,finds that much of the repeated story of Stowe is either exaggerated or likely false.Conclusion:Following the example of Emily Stowe,this unique method is applicable for improving the historical accuracy in assessing the lives of other notable figures.It represents a method extendable to those currently alive,outside the public eye,searching to develop their own narrative.
文摘The published article titled“MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase”has been retracted from Oncology Research,Vol.25,No.8,2017,pp.1231–1243.DOI:10.3727/096504017X14850134190255 URL:https://www.techscience.com/or/v25n8/56908 Following the publication,concerns have been raised about a number of figures in this article.An unexpected area of similarity was identified in terms of the cellular data,where the results from differently performed experiments were intended to have been shown,although the areas immediately surrounding this area featured comparatively different distributions of cells.In addition,the western blots in this article were presented with atypical,unusually shaped and possibly anomalous protein bands in many cases.
文摘With the brisk winter season just around the corner,my now 5-year-old's birthday was approaching,and I had a big celebration planned full of presents,cake and a fun day out.However,this year,she had a request of her own.One frosty evening,she glided up to me and said,"Dad,this year for my birthday,I want to learn how to be a figure skater."
基金supported by the National Science Fund for Distinguished Young Scholars(Grant No.52025054)。
文摘Intelligent robots play a crucial role in space exploration,representing a significant trend in space automation technology.Modular robots,which can regenerate configurations and functions through self-reconfiguration[1],offer distinct adaptability and versatility[2,3]over traditional robots with fixed structures and single-purpose functions.Therefore,self-reconfiguration is regarded as a highly promising capability for space exploration and remains a primary motivation for research in this field[4].
基金National Natural Science Foundation of China,Grant/Award Numbers:51975423,U22A20193。
文摘Programmable droplet manipulation based on external stimulation is in high demand in various modern technologies.Despite notable progress,current manipulation strategies still suffer from a common drawback such as single control means of modulating the external stimulation input,which leads to huge challenges in sophisticated and large scale-up droplet handling.Herein,a unique patternreconfiguration-driven droplet manipulation method is developed on conductive/nonconductive pattern surfaces under charge deposition.Contactless charge deposition induces the“edge barrier”phenomenon at the boundaries of conductive/nonconductive patterns,analogous to an invisible and tunable wall guiding droplet behaviors.The edge barrier effect can be flexibly tuned by the nonconductive surface pattern.Thus,with charge deposition,surfaces are endowed with protean control functionality.The design of conductive/nonconductive patterns can effectively enable multifunction droplet manipulations,including track-guided sliding,sorting,merging,and mixing.Moreover,dynamical pattern reconfiguration drives programmable fluidics with sophisticated and large scale-up droplet handling capabilities in a low-cost and simple approach.
文摘A pulsed laser system is realized with graphene employed as a Q-switch.The graphene is exfoliated from its solution using an optical deposition and the optical tweezer effect.A fiber ferrule that already has the graphene deposited on it is inserted into an erbium-ytterbium laser（EYL）system with linear cavity configuration.We successfully demonstrate a pulsed EYL with a pulse duration of approximately 5.9μs and a repetition rate of 20.0 kHz.
基金supported by R01 NS093009 grant from NIH(to VVC).
文摘Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).
基金funded by the Japan Society for the Promotion of Science,JSPS,23K07290(to MF).
文摘The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).
基金supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
文摘Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).
文摘At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.
文摘The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).
