Background:Outbreaks of coronavirus disease 2019(COVID-19)have been recorded in different countries across the globe.The virus is highly contagious,hence early detection,isolation,and quarantine of infected patients w...Background:Outbreaks of coronavirus disease 2019(COVID-19)have been recorded in different countries across the globe.The virus is highly contagious,hence early detection,isolation,and quarantine of infected patients will play an important role in containing the viral spread.Diagnosis in a mobile lab can aid to find infected patients in time.Methods:Here,we develop a field-deployable diagnostic workflow that can reliably detect COVID-19.Instruments used in this workflow can easily fit in a mobile cabin hospital and also be installed in the community.Different steps from sample inactivation to detection were optimized to find the fastest steps and portable instruments in the detection of COVID-19.Each step was compared to that of the normal laboratory diagnosis setup.Results:From the results,our proposed workflow(80 min)was two times faster compared to that of the normal laboratory workflow(183 min)and a maximum of 32 samples could be detected at each run.Additionally,we showed that using 1%Rewocid WK-30 could inactivate the novel coronavirus directly without affecting the overall detection results.Comparison of our workflow using an in-house assay to that of a commercially acquired assay produced highly reliable results.From the 250 hospital samples tested,there was a high concordance 247/250(98.8%)between the two assays.The in-house assay sensitivity and specificity were 116/116(100%)and 131/134(97.8%)compared to that of the commercial assay.Conclusion:Based on these results,we believe that our workflow is fast,reliable,adaptable and most importantly,field-deployable.展开更多
Working memory plays an important role in human cognition. This study investigated how working memory was encoded by the power of multichannel local field potentials （LFPs） based on sparse non negative matrix factor...Working memory plays an important role in human cognition. This study investigated how working memory was encoded by the power of multichannel local field potentials （LFPs） based on sparse non negative matrix factorization （SNMF）. SNMF was used to extract features from LFPs recorded from the prefrontal cortex of four SpragueDawley rats during a memory task in a Y maze, with 10 trials for each rat. Then the powerincreased LFP components were selected as working memoryrelated features and the other components were removed. After that, the inverse operation of SNMF was used to study the encoding of working memory in the time frequency domain. We demonstrated that theta and gamma power increased significantly during the working memory task. The results suggested that postsynaptic activity was simulated well by the sparse activity model. The theta and gamma bands were meaningful for encoding working memory.展开更多
Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, ...Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, effect of propofol on LFPs in rat’s prefrontal cortex during working memory task was evaluated. Young (approximately 3 month) male Sprague-Dawley rats were divided into two group: propofol rats and control rats. Propofol rats received propofol at 0.9 mg/Kg·min intravenously for 2 h. After 12 h, LFPs of all rats were measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Y-maze. LFPs instantaneous phase were obtained by applying Hilbert transform, and cross-correlation coherence of LFPs was calculated. The results indicate that propofol decreased the correct rate and crosscorrelation coherence of LFPs on the first two days (p 0.05). Our results suggest that propofol can impair cross-correlation coherence of LFPs in the first two days, but not long time.展开更多
It is discovered that the product of the current and the electric field in a PN junction should be regarded as the rate of work(power)done by the electric field force on moving charges(hole current and electron curren...It is discovered that the product of the current and the electric field in a PN junction should be regarded as the rate of work(power)done by the electric field force on moving charges(hole current and electron current),which was previously misinterpreted as solely a Joule heating effect.We clarify that it is exactly the work done by the electric field force on the moving charges to stimulate the emergence of non-equilibrium carriers,which triggers the novel physical phenomena.As regards to Joule heat,we point out that it should be calculated from Ohm’s law,rather than simply from the product of the current and the electric field.Based on this understanding,we conduct thorough discussion on the role of the electric field force in the process of carrier recombination and carrier generation.The thermal effects of carrier recombination and carrier generation followed are incorporated into the thermal equation of energy.The present study shows that the exothermic effect of carrier recombination leads to a temperature rise at the PN interface,while the endothermic effect of carrier generation causes a temperature reduction at the interface.These two opposite effects cause opposite heat flow directions in the PN junction under forward and backward bias voltages,highlighting the significance of managing device heating phenomena in design considerations.Therefore,this study possesses referential significance for the design and tuning on the performance of piezotronic devices.展开更多
After graduating from the physics department of Qinghua University in 1952, I started working in the development of nuclear detectors (including cloud chambers and scintillometers) under the instruction of Profs. Yang...After graduating from the physics department of Qinghua University in 1952, I started working in the development of nuclear detectors (including cloud chambers and scintillometers) under the instruction of Profs. Yang Chengzhong and Dai Chuanzeng at the CAS Institute of Modern Physics.From 1956 to 1958,I studied at Lebedev’s Institute of Physics under the Soviet Academy展开更多
Since 1958. I bave been doing research and teaching work at Harbin Polytechnic on the theories of radar,navigational guidance,and signal processing & information treatment by developing new radar systems. In 1979,...Since 1958. I bave been doing research and teaching work at Harbin Polytechnic on the theories of radar,navigational guidance,and signal processing & information treatment by developing new radar systems. In 1979, I went to England in the status of an honorary research fellow and stayed there for two years.probing into HF radar systems under the guidance of the world-famous British marine telemetrist Professor Shearman at Birmingham University.Here.I briefly展开更多
I graduated from the National Peiyang University (now called Tianjin University) in 1950, majoring in hydraulic engineering. Starting from 1952, my teaching work was basically in mechanics.My first academic probe was ...I graduated from the National Peiyang University (now called Tianjin University) in 1950, majoring in hydraulic engineering. Starting from 1952, my teaching work was basically in mechanics.My first academic probe was in cybernetics, resulting in the publication of the first Chinese paper concerning optimal control. After 1963, I worked on the theory of hydrodynamic stability. My explorative thrust is at the eigenvalues of the Orr Sommerfeld Equation,a non-self adjoint problem in展开更多
Corrected stress field intensity obtained by averaging the superior limit of intrinsic damage dissipation work in critical domain, which considers thoroughly thermodynamic consistency within irreversible thermodynamic...Corrected stress field intensity obtained by averaging the superior limit of intrinsic damage dissipation work in critical domain, which considers thoroughly thermodynamic consistency within irreversible thermodynamic framework, was proposed for predictions of high-cycle fatigue endurance limits. Simultaneously, the effects of mean stress, additional hardening behavior related to non-proportional loading paths and stress gradients on multiaxial high-cycle fatigue are taken into account in the proposed approach. The approach is an extension of the general stress field intensity. For a better comparison, existing multiaxial high-cycle fatigue criteria were employed to predict the endurance limits of different metallic materials subjected to different multiaxial loading paths, and it is shown that present proposal performs better from statistical value of error indexes, which make the proposed approach of corrected stress field intensity and its associated concepts provide a new conception to predict endurance limits of multiaxial high-cycle fatigue with high accuracy.展开更多
International standards state the thermal comfort requirements that office spaces must comply with. These are based on a model developed by Prof. Paul Ole Fanger of the Centre for Indoor Environment and Energy, Denmar...International standards state the thermal comfort requirements that office spaces must comply with. These are based on a model developed by Prof. Paul Ole Fanger of the Centre for Indoor Environment and Energy, Denmark. Today, forty-year research shows an evolution in these experiences. The work presented here is to develop a tool to evaluate the thermal comfort of working environments of office buildings. A methodology is devised on the basis of on-site measurements and questionnaire responses. For measurements, a mobile unit equipped with sensors is used, whereas the questionnaire obtains user responses on thermal quality of the work space. The thermal conditions of thirty office buildings presenting different acclimatization systems have been surveyed. The correlation between objective and subjective data allows developing a formula that shows the thermal comfort level for a given environment as a function of local aspects. For the surveyed buildings, the resulting comfortable temperature was 23.3℃, and the minimum percentage of user individuals experiencing discomfort with such temperature was 7%.展开更多
Considering the effect of work roll shifting on roll temperature field,a finite difference method of PR format for roll temperature field was presented,which can meet the requirements of accuracy and speed of online c...Considering the effect of work roll shifting on roll temperature field,a finite difference method of PR format for roll temperature field was presented,which can meet the requirements of accuracy and speed of online calculation.The step-by-step accumulation method was used to simulate the roll temperature field and thermal crown,and the evolution of roll thermal crown in a rolling campaign was studied.And then,the effects of strip width,rolling rhythm and work roll shifting on roll thermal crown were analyzed.It is found that work roll shifting can disperse the thermal expansion of the roll body especially the edge to make roll thermal contour uniform.The effect of work roll shifting on roll thermal crown is mainly concentrated in regions around twice of roll shifting stroke,and the change range of roll thermal crown is±30μm or so in the same roll body location.展开更多
The Yarlung Suture Zone in Southern Tibet marks the boundary between India and Asia-formerly separated by an ocean basin-and is a critical record of the tectonic processes that created the Tibetan Plateau. The Yarlung...The Yarlung Suture Zone in Southern Tibet marks the boundary between India and Asia-formerly separated by an ocean basin-and is a critical record of the tectonic processes that created the Tibetan Plateau. The Yarlung Suture Zone is also a frontier research area, as difficulty of access has limited research activity, providing ample opportunities for new discoveries. This paper documents field research conducted by the authors along the Yarlung suture zone in eastern Xigaze(Shigatse, Rikaze)County, ~250 km west of the city of Lhasa, in July 2017. The goal of this research was to map the Suture Zone structure in detail, and more specifically to understand the branching relationships between two major fault systems-the Great Counter Thrust and Gangdese Thrust. A summary of early geological exploration is included to provide context for this research.展开更多
Introduction: Cattle are strong animals very often used in agriculture in rural Africa. Unpredictable in their behavior, they regularly inflict injuries to farmers, some of whom are children in rural Africa. Objective...Introduction: Cattle are strong animals very often used in agriculture in rural Africa. Unpredictable in their behavior, they regularly inflict injuries to farmers, some of whom are children in rural Africa. Objective: The purpose of this study was to describe the clinical, therapeutic and evolutionary aspects of abdominal trauma caused by bovidae to children on farms in Burkina Faso. Patients and Method: This is a descriptive study covering the period from January 2014 through December 2016 and was conducted in the General Surgery Unit of the Tenkodogo Regional Hospital in Burkina Faso. It included all patients under the age of 17, victims of abdominal trauma by cattle on farms. Result: A total of 68 patients were identified, which is 3% of all patients under 17 admitted to the service during the same period. The average age of patients was 10.5 years, with a standard variation of 3.6 years. The majority (73.5%) of the patients were boys. The main lesional mechanisms found were horn strokes (88.2%). We noted 35 eviscerations without visceral perforation, 15 intestinal perforations, 6 hepatic wounds and 5 splenic wounds. In 7 cases, there were non-penetrating wounds. All patients underwent surgical intervention under anesthesia. The average length of hospital was 6 days. Two deaths were recorded, making a mortality rate of 3%. Conclusion: Abdominal traumas of the child by attack of cattle are frequent during farm works in rural Burkina Faso. The injuries are sometimes serious. Wearing protective equipment for children should be considered during farm work.展开更多
文摘Background:Outbreaks of coronavirus disease 2019(COVID-19)have been recorded in different countries across the globe.The virus is highly contagious,hence early detection,isolation,and quarantine of infected patients will play an important role in containing the viral spread.Diagnosis in a mobile lab can aid to find infected patients in time.Methods:Here,we develop a field-deployable diagnostic workflow that can reliably detect COVID-19.Instruments used in this workflow can easily fit in a mobile cabin hospital and also be installed in the community.Different steps from sample inactivation to detection were optimized to find the fastest steps and portable instruments in the detection of COVID-19.Each step was compared to that of the normal laboratory diagnosis setup.Results:From the results,our proposed workflow(80 min)was two times faster compared to that of the normal laboratory workflow(183 min)and a maximum of 32 samples could be detected at each run.Additionally,we showed that using 1%Rewocid WK-30 could inactivate the novel coronavirus directly without affecting the overall detection results.Comparison of our workflow using an in-house assay to that of a commercially acquired assay produced highly reliable results.From the 250 hospital samples tested,there was a high concordance 247/250(98.8%)between the two assays.The in-house assay sensitivity and specificity were 116/116(100%)and 131/134(97.8%)compared to that of the commercial assay.Conclusion:Based on these results,we believe that our workflow is fast,reliable,adaptable and most importantly,field-deployable.
基金supported by the National Natural Science Foundation of China (61074131 and 91132722)the Doctoral Fund of the Ministry of Education of China (21101202110007)
文摘Working memory plays an important role in human cognition. This study investigated how working memory was encoded by the power of multichannel local field potentials （LFPs） based on sparse non negative matrix factorization （SNMF）. SNMF was used to extract features from LFPs recorded from the prefrontal cortex of four SpragueDawley rats during a memory task in a Y maze, with 10 trials for each rat. Then the powerincreased LFP components were selected as working memoryrelated features and the other components were removed. After that, the inverse operation of SNMF was used to study the encoding of working memory in the time frequency domain. We demonstrated that theta and gamma power increased significantly during the working memory task. The results suggested that postsynaptic activity was simulated well by the sparse activity model. The theta and gamma bands were meaningful for encoding working memory.
文摘Propofol may produce memory impairment during anesthesia procedure. Local field potentials (LFPs) are used with increasing frequency in recent years to link neural activity to perception and cognition. In this study, effect of propofol on LFPs in rat’s prefrontal cortex during working memory task was evaluated. Young (approximately 3 month) male Sprague-Dawley rats were divided into two group: propofol rats and control rats. Propofol rats received propofol at 0.9 mg/Kg·min intravenously for 2 h. After 12 h, LFPs of all rats were measured simultaneously from multiple electrodes placed in prefrontal cortex while rats were performing a working memory task in Y-maze. LFPs instantaneous phase were obtained by applying Hilbert transform, and cross-correlation coherence of LFPs was calculated. The results indicate that propofol decreased the correct rate and crosscorrelation coherence of LFPs on the first two days (p 0.05). Our results suggest that propofol can impair cross-correlation coherence of LFPs in the first two days, but not long time.
基金the National Natural Science Foundation of China(Nos.12232007,11972164,and 12102141)。
文摘It is discovered that the product of the current and the electric field in a PN junction should be regarded as the rate of work(power)done by the electric field force on moving charges(hole current and electron current),which was previously misinterpreted as solely a Joule heating effect.We clarify that it is exactly the work done by the electric field force on the moving charges to stimulate the emergence of non-equilibrium carriers,which triggers the novel physical phenomena.As regards to Joule heat,we point out that it should be calculated from Ohm’s law,rather than simply from the product of the current and the electric field.Based on this understanding,we conduct thorough discussion on the role of the electric field force in the process of carrier recombination and carrier generation.The thermal effects of carrier recombination and carrier generation followed are incorporated into the thermal equation of energy.The present study shows that the exothermic effect of carrier recombination leads to a temperature rise at the PN interface,while the endothermic effect of carrier generation causes a temperature reduction at the interface.These two opposite effects cause opposite heat flow directions in the PN junction under forward and backward bias voltages,highlighting the significance of managing device heating phenomena in design considerations.Therefore,this study possesses referential significance for the design and tuning on the performance of piezotronic devices.
文摘After graduating from the physics department of Qinghua University in 1952, I started working in the development of nuclear detectors (including cloud chambers and scintillometers) under the instruction of Profs. Yang Chengzhong and Dai Chuanzeng at the CAS Institute of Modern Physics.From 1956 to 1958,I studied at Lebedev’s Institute of Physics under the Soviet Academy
文摘Since 1958. I bave been doing research and teaching work at Harbin Polytechnic on the theories of radar,navigational guidance,and signal processing & information treatment by developing new radar systems. In 1979, I went to England in the status of an honorary research fellow and stayed there for two years.probing into HF radar systems under the guidance of the world-famous British marine telemetrist Professor Shearman at Birmingham University.Here.I briefly
文摘I graduated from the National Peiyang University (now called Tianjin University) in 1950, majoring in hydraulic engineering. Starting from 1952, my teaching work was basically in mechanics.My first academic probe was in cybernetics, resulting in the publication of the first Chinese paper concerning optimal control. After 1963, I worked on the theory of hydrodynamic stability. My explorative thrust is at the eigenvalues of the Orr Sommerfeld Equation,a non-self adjoint problem in
基金The authors gratefully acknowledge the support provided by Key Natural Science Foundation of Hebei Province of China （E2017203161）.
文摘Corrected stress field intensity obtained by averaging the superior limit of intrinsic damage dissipation work in critical domain, which considers thoroughly thermodynamic consistency within irreversible thermodynamic framework, was proposed for predictions of high-cycle fatigue endurance limits. Simultaneously, the effects of mean stress, additional hardening behavior related to non-proportional loading paths and stress gradients on multiaxial high-cycle fatigue are taken into account in the proposed approach. The approach is an extension of the general stress field intensity. For a better comparison, existing multiaxial high-cycle fatigue criteria were employed to predict the endurance limits of different metallic materials subjected to different multiaxial loading paths, and it is shown that present proposal performs better from statistical value of error indexes, which make the proposed approach of corrected stress field intensity and its associated concepts provide a new conception to predict endurance limits of multiaxial high-cycle fatigue with high accuracy.
文摘International standards state the thermal comfort requirements that office spaces must comply with. These are based on a model developed by Prof. Paul Ole Fanger of the Centre for Indoor Environment and Energy, Denmark. Today, forty-year research shows an evolution in these experiences. The work presented here is to develop a tool to evaluate the thermal comfort of working environments of office buildings. A methodology is devised on the basis of on-site measurements and questionnaire responses. For measurements, a mobile unit equipped with sensors is used, whereas the questionnaire obtains user responses on thermal quality of the work space. The thermal conditions of thirty office buildings presenting different acclimatization systems have been surveyed. The correlation between objective and subjective data allows developing a formula that shows the thermal comfort level for a given environment as a function of local aspects. For the surveyed buildings, the resulting comfortable temperature was 23.3℃, and the minimum percentage of user individuals experiencing discomfort with such temperature was 7%.
基金Sponsored by National Natural Science Foundation of China(51205336)Fujian Natural Science Foundation of China(2013J05086)
文摘Considering the effect of work roll shifting on roll temperature field,a finite difference method of PR format for roll temperature field was presented,which can meet the requirements of accuracy and speed of online calculation.The step-by-step accumulation method was used to simulate the roll temperature field and thermal crown,and the evolution of roll thermal crown in a rolling campaign was studied.And then,the effects of strip width,rolling rhythm and work roll shifting on roll thermal crown were analyzed.It is found that work roll shifting can disperse the thermal expansion of the roll body especially the edge to make roll thermal contour uniform.The effect of work roll shifting on roll thermal crown is mainly concentrated in regions around twice of roll shifting stroke,and the change range of roll thermal crown is±30μm or so in the same roll body location.
基金funded by Montana State Universityincluding National Key Research and Development Plan(Grant No.2016YFC0600303)the National Natural Science Foundation of China(Grant No.41490615)
文摘The Yarlung Suture Zone in Southern Tibet marks the boundary between India and Asia-formerly separated by an ocean basin-and is a critical record of the tectonic processes that created the Tibetan Plateau. The Yarlung Suture Zone is also a frontier research area, as difficulty of access has limited research activity, providing ample opportunities for new discoveries. This paper documents field research conducted by the authors along the Yarlung suture zone in eastern Xigaze(Shigatse, Rikaze)County, ~250 km west of the city of Lhasa, in July 2017. The goal of this research was to map the Suture Zone structure in detail, and more specifically to understand the branching relationships between two major fault systems-the Great Counter Thrust and Gangdese Thrust. A summary of early geological exploration is included to provide context for this research.
文摘Introduction: Cattle are strong animals very often used in agriculture in rural Africa. Unpredictable in their behavior, they regularly inflict injuries to farmers, some of whom are children in rural Africa. Objective: The purpose of this study was to describe the clinical, therapeutic and evolutionary aspects of abdominal trauma caused by bovidae to children on farms in Burkina Faso. Patients and Method: This is a descriptive study covering the period from January 2014 through December 2016 and was conducted in the General Surgery Unit of the Tenkodogo Regional Hospital in Burkina Faso. It included all patients under the age of 17, victims of abdominal trauma by cattle on farms. Result: A total of 68 patients were identified, which is 3% of all patients under 17 admitted to the service during the same period. The average age of patients was 10.5 years, with a standard variation of 3.6 years. The majority (73.5%) of the patients were boys. The main lesional mechanisms found were horn strokes (88.2%). We noted 35 eviscerations without visceral perforation, 15 intestinal perforations, 6 hepatic wounds and 5 splenic wounds. In 7 cases, there were non-penetrating wounds. All patients underwent surgical intervention under anesthesia. The average length of hospital was 6 days. Two deaths were recorded, making a mortality rate of 3%. Conclusion: Abdominal traumas of the child by attack of cattle are frequent during farm works in rural Burkina Faso. The injuries are sometimes serious. Wearing protective equipment for children should be considered during farm work.
