IgG4-related disease(IgG4-RD)is a chronic immune-mediated disorder characterized by progressive tissue fibrosis.Current treatments like glucocorticoids and rituximab focus on remission,yet reversing fibrosis remains c...IgG4-related disease(IgG4-RD)is a chronic immune-mediated disorder characterized by progressive tissue fibrosis.Current treatments like glucocorticoids and rituximab focus on remission,yet reversing fibrosis remains challenging[1,2].While interactions between immune cells and fibroblasts are known to drive fibrosis,the role of epithelial cells remains poorly understood[1].展开更多
基金supported by the National Natural Science Foundation of China(82271848,823B2037,and 82471829)the Beijing Natural Science Foundation(7232113)+2 种基金the National High Level Hospital Clinical Research Funding(2022-PUMCH-C-006)the National Key Research and Development Program of China(2022YFC2703104)the Peking Union Medical College Hospital Young Reserve Talent Development Program(UHB12076)。
文摘IgG4-related disease(IgG4-RD)is a chronic immune-mediated disorder characterized by progressive tissue fibrosis.Current treatments like glucocorticoids and rituximab focus on remission,yet reversing fibrosis remains challenging[1,2].While interactions between immune cells and fibroblasts are known to drive fibrosis,the role of epithelial cells remains poorly understood[1].
