A recent study published in Nature(Hou et al.,2025)described short peptides of DTLKIVWX that can disassemble tau fibrils and explain the disassembly process by a strain-relief mechanism:since the DTLKIVWX peptides are...A recent study published in Nature(Hou et al.,2025)described short peptides of DTLKIVWX that can disassemble tau fibrils and explain the disassembly process by a strain-relief mechanism:since the DTLKIVWX peptides are right-handed and the tau fibrils are left-handed,by binding of the D-peptide fibrils to the tau fibrils,both fibrils are under strain that is relieved by fragmenting the fibrils(Figure 1).This study offers a novel strain-relief mechanism by applying a peptide-based disaggregator as a therapeutic for amyloid diseases.展开更多
基金supported by the National Natural Science Foundation of China(32525002 and W2411011)Principal Investigator Foundation of Tianfu Jincheng Laboratory(TFJCPI20250022)the Key Research and Development Program of Zhejiang Province(2023C03044).
文摘A recent study published in Nature(Hou et al.,2025)described short peptides of DTLKIVWX that can disassemble tau fibrils and explain the disassembly process by a strain-relief mechanism:since the DTLKIVWX peptides are right-handed and the tau fibrils are left-handed,by binding of the D-peptide fibrils to the tau fibrils,both fibrils are under strain that is relieved by fragmenting the fibrils(Figure 1).This study offers a novel strain-relief mechanism by applying a peptide-based disaggregator as a therapeutic for amyloid diseases.
