心血管疾病(cardiovascular disease, CVD)是全球发病率和死亡率的主要原因,严重威胁着全球人类的健康。CVD包含疾病有多种其中急性心肌梗死(AMI)是最常见严重危害中老年人群健康的心血管疾病之一,血清甘油三酯葡萄糖指数(triglyceride-...心血管疾病(cardiovascular disease, CVD)是全球发病率和死亡率的主要原因,严重威胁着全球人类的健康。CVD包含疾病有多种其中急性心肌梗死(AMI)是最常见严重危害中老年人群健康的心血管疾病之一,血清甘油三酯葡萄糖指数(triglyceride-glucose index, TyG指数)是胰岛素抵抗(insulin resistance, IR)的一种新型替代指标,为条件受限地区临床决策提供有力依据。有研究指出TyG指数不仅可预测CVD、2型糖尿病的发生发展,还可评估代谢性疾病发生。SII对冠心病患者介入治疗后发生不良心血管事件的预测价值优于传统危险。FAR在预测主要心血管不良事件尤其是合并DM方面比单独用FIB和Alb有更高敏感性和特异性。本文旨在阐述TyG指数与FIB/Alb比值(FAR)、SII在AMI患者中冠脉病变严重程度的发生发展关系,以便更好地了解TyG指数、FIB/Alb比值(FAR)、SII在AMI中的应用价值。Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and poses a serious threat to human health worldwide. CVD includes a variety of diseases, among which acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that seriously harm the health of middle-aged and elderly people. Serum triglyceride-glucose index (TyG index) is a novel proxy for insulin resistance (IR), which provides a strong basis for clinical decision-making in restricted areas. Some studies have pointed out that TyG index can not only predict the occurrence and development of CVD and type 2 diabetes, but also evaluate the occurrence of metabolic diseases. The predictive value of SII for adverse cardiovascular events in patients with coronary heart disease after interventional therapy is better than that of traditional risk. FAR has higher sensitivity and specificity than FIB and Alb alone in predicting major cardiovascular adverse events, especially with DM. This paper aims to describe the relationship between TyG index, FIB/Alb ratio (FAR) and SII in the severity of coronary lesions in patients with AMI, so as to better understand the application value of TyG index, FIB/Alb ratio (FAR) and SII in AMI.展开更多
The history of human being is a result of various activities to live.Humanity has lived with the nature which has enabled to sustain the lives.Humanity has gained great benefits by the use of nature and its alternatio...The history of human being is a result of various activities to live.Humanity has lived with the nature which has enabled to sustain the lives.Humanity has gained great benefits by the use of nature and its alternation.The comfortable environment development made the increase of population and the alternation of nature has extended.The past few hundred years can be said the era of fossil fuels.Surprisingly,it has caused the global warming.The construction sector is the industry in which the foundation for social and economic activities is created.It has been believed that a comfortable and safety life,production and use of environments will lead to happiness for humanity.However,we could not put a break on the development.Of course it is,the construction-related sectors that consume the most large natural resources and energy,and therefore emit the largest quantity of CO_(2).Fortunately,a concept in which we can deal with this situation was developed.It is sustainability concept.In this paper,firstly the concept“sustainability”which was born at the end of 20th century is reconfirmed.As the performance-based design has played a significant role in sustainability design,secondly the concept is explained based on the author’s paper and book.Thirdly the development of sustainability in fib is comprehensively discussed including sustainability-resilience dispute and ethics.展开更多
目的:多参数磁共振成像(multiparametric magnetic resonance imaging, mpMRI)联合血清碱性磷酸酶(alkaline phosphatase, ALP)、D-二聚体(D-dimer, DD2)、纤维蛋白原(fibrinogen, FIB)诊断前列腺癌骨转移的效能分析。方法:对169例前列...目的:多参数磁共振成像(multiparametric magnetic resonance imaging, mpMRI)联合血清碱性磷酸酶(alkaline phosphatase, ALP)、D-二聚体(D-dimer, DD2)、纤维蛋白原(fibrinogen, FIB)诊断前列腺癌骨转移的效能分析。方法:对169例前列腺癌患者的临床资料进行回顾性收集和分析,根据骨扫描的检查结果辅以核磁共振,将盆腔有无骨转移的病人分为前列腺癌骨转移组80例和非骨转移组89例。所有患者在手术前都接受了MRI检查,对血清PSA、ALP、D-二聚体、FIB水平进行定量检测。对不同影像指标与前列腺癌骨转移结果之间的一致性采用Kappa一致性检验;利用单因素和多因素Logistic回归分析,评估mpMRI、ALP、D-二聚体、FIB及其他临床指标在前列腺癌骨转移诊断中的价值。利用受试者工作特征(receiver operating characteristic, ROC)曲线对前列腺癌骨转移中纳入的mpMRI、ALP、D-二聚体、FIB及其联合指标的临床应用价值进行评价。结果:T1WI、T2WI压脂、DWI及mpMRI与前列腺癌骨转移结果比较的Kappa值分别为0.536、0.470、0.629、0.691 (P Objective: To analyze the efficacy of multiparametric MRI (mpMRI) combined with serum ALP, D-dimer, and FIB in the diagnosis of bone metastasis in prostate cancer. Methods: A retrospective collection and analysis of clinical data from 169 prostate cancer patients were conducted. Based on the results of bone scans supplemented by MRI, patients with or without pelvic bone metastasis were divided into the prostate cancer bone metastasis group (80 cases) and the non-bone metastasis group (89 cases). All patients underwent MRI examination prior to surgery, and serum levels of PSA, ALP, D-dimer, and FIB were quantitatively measured. Kappa consistency tests were used to analyze the agreement between different imaging indicators and the results of prostate cancer bone metastasis. Uni- and multivariable logistic regression analyses were performed to evaluate the value of mpMRI, ALP, D-dimer, FIB, and other clinical indicators in the diagnosis of prostate cancer bone metastasis. The clinical application value of mpMRI, ALP, D-dimer, FIB, and their combined indicators in diagnosing prostate cancer bone metastasis was assessed using receiver operating characteristic (ROC) curves. Results: The Kappa values comparing T1WI, T2WI fat suppression, DWI, and mpMRI with the results of prostate cancer bone metastasis were 0.536, 0.470, 0.629, and 0.691, respectively (P < 0.001). Compared to the non-bone metastasis group, the serum levels of ALP, D-dimer, and FIB in the bone metastasis group were significantly higher (P < 0.001). Multivariable logistic regression analysis indicated that mpMRI, ALP, D-dimer, and FIB are independent risk factors for prostate cancer bone metastasis (P < 0.05). The combined indicators showed the best performance, followed by the individual indicators of D-dimer, mpMRI, ALP, and FIB, all of which demonstrated good diagnostic value (P < 0.05). Conclusion: mpMRI, ALP, D-dimer, and FIB all demonstrate certain diagnostic efficacy for prostate cancer bone metastasis. The combined use of these indicators can further enhance diagnostic value, suggesting that they should be considered for broader application in clinical practice.展开更多
目的探讨炎症反应与慢性阻塞性肺疾病(COPD)相关肺动脉高压及其高凝状态的关系。方法收集COPD患者80例,根据心脏超声估测肺动脉收缩压(PASP),以PASP 40 mm Hg为界将患者分为COPD伴肺动脉高压组和COPD无肺动脉高压组两组(每组40例),检测...目的探讨炎症反应与慢性阻塞性肺疾病(COPD)相关肺动脉高压及其高凝状态的关系。方法收集COPD患者80例,根据心脏超声估测肺动脉收缩压(PASP),以PASP 40 mm Hg为界将患者分为COPD伴肺动脉高压组和COPD无肺动脉高压组两组(每组40例),检测两组血清C反应蛋白(CRP)、白介素6(IL-6)、白介素8(IL-8)、肿瘤坏死因子-α(TNF-α)、脑钠肽(BNP)、D-二聚体(D-D)、纤维蛋白原(FIB)、红细胞压积(HCT),比较两组各项检测的差异,分析炎性因子与肺动脉压、D-D的相关性以及肺动脉高压、高凝状态的影响因素。结果肺动脉高压组血清CRP、IL-6、IL-8、TNF-α、D-D、FIB、BNP水平高于无肺动脉高压组(P均<0.05)。偏相关性分析显示,CRP、IL-6、IL-8水平与PASP呈正相关,Pa O2与PASP呈负相关(r分别为0.387、0.611、0.412、-0.576,P均<0.05),CRP水平与D-D呈正相关(r=0.379,P<0.05)。二元Logistic回归分析示,CRP、IL-8、TNF-α为肺动脉高压的危险因素;Pa O2为其保护因素;CRP、IL-6为血液高凝状态的危险因素。结论炎症反应及其炎症因子对COPD相关肺动脉高压及其血液高凝状态形成有重要作用。展开更多
文摘心血管疾病(cardiovascular disease, CVD)是全球发病率和死亡率的主要原因,严重威胁着全球人类的健康。CVD包含疾病有多种其中急性心肌梗死(AMI)是最常见严重危害中老年人群健康的心血管疾病之一,血清甘油三酯葡萄糖指数(triglyceride-glucose index, TyG指数)是胰岛素抵抗(insulin resistance, IR)的一种新型替代指标,为条件受限地区临床决策提供有力依据。有研究指出TyG指数不仅可预测CVD、2型糖尿病的发生发展,还可评估代谢性疾病发生。SII对冠心病患者介入治疗后发生不良心血管事件的预测价值优于传统危险。FAR在预测主要心血管不良事件尤其是合并DM方面比单独用FIB和Alb有更高敏感性和特异性。本文旨在阐述TyG指数与FIB/Alb比值(FAR)、SII在AMI患者中冠脉病变严重程度的发生发展关系,以便更好地了解TyG指数、FIB/Alb比值(FAR)、SII在AMI中的应用价值。Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and poses a serious threat to human health worldwide. CVD includes a variety of diseases, among which acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that seriously harm the health of middle-aged and elderly people. Serum triglyceride-glucose index (TyG index) is a novel proxy for insulin resistance (IR), which provides a strong basis for clinical decision-making in restricted areas. Some studies have pointed out that TyG index can not only predict the occurrence and development of CVD and type 2 diabetes, but also evaluate the occurrence of metabolic diseases. The predictive value of SII for adverse cardiovascular events in patients with coronary heart disease after interventional therapy is better than that of traditional risk. FAR has higher sensitivity and specificity than FIB and Alb alone in predicting major cardiovascular adverse events, especially with DM. This paper aims to describe the relationship between TyG index, FIB/Alb ratio (FAR) and SII in the severity of coronary lesions in patients with AMI, so as to better understand the application value of TyG index, FIB/Alb ratio (FAR) and SII in AMI.
文摘The history of human being is a result of various activities to live.Humanity has lived with the nature which has enabled to sustain the lives.Humanity has gained great benefits by the use of nature and its alternation.The comfortable environment development made the increase of population and the alternation of nature has extended.The past few hundred years can be said the era of fossil fuels.Surprisingly,it has caused the global warming.The construction sector is the industry in which the foundation for social and economic activities is created.It has been believed that a comfortable and safety life,production and use of environments will lead to happiness for humanity.However,we could not put a break on the development.Of course it is,the construction-related sectors that consume the most large natural resources and energy,and therefore emit the largest quantity of CO_(2).Fortunately,a concept in which we can deal with this situation was developed.It is sustainability concept.In this paper,firstly the concept“sustainability”which was born at the end of 20th century is reconfirmed.As the performance-based design has played a significant role in sustainability design,secondly the concept is explained based on the author’s paper and book.Thirdly the development of sustainability in fib is comprehensively discussed including sustainability-resilience dispute and ethics.
文摘目的:多参数磁共振成像(multiparametric magnetic resonance imaging, mpMRI)联合血清碱性磷酸酶(alkaline phosphatase, ALP)、D-二聚体(D-dimer, DD2)、纤维蛋白原(fibrinogen, FIB)诊断前列腺癌骨转移的效能分析。方法:对169例前列腺癌患者的临床资料进行回顾性收集和分析,根据骨扫描的检查结果辅以核磁共振,将盆腔有无骨转移的病人分为前列腺癌骨转移组80例和非骨转移组89例。所有患者在手术前都接受了MRI检查,对血清PSA、ALP、D-二聚体、FIB水平进行定量检测。对不同影像指标与前列腺癌骨转移结果之间的一致性采用Kappa一致性检验;利用单因素和多因素Logistic回归分析,评估mpMRI、ALP、D-二聚体、FIB及其他临床指标在前列腺癌骨转移诊断中的价值。利用受试者工作特征(receiver operating characteristic, ROC)曲线对前列腺癌骨转移中纳入的mpMRI、ALP、D-二聚体、FIB及其联合指标的临床应用价值进行评价。结果:T1WI、T2WI压脂、DWI及mpMRI与前列腺癌骨转移结果比较的Kappa值分别为0.536、0.470、0.629、0.691 (P Objective: To analyze the efficacy of multiparametric MRI (mpMRI) combined with serum ALP, D-dimer, and FIB in the diagnosis of bone metastasis in prostate cancer. Methods: A retrospective collection and analysis of clinical data from 169 prostate cancer patients were conducted. Based on the results of bone scans supplemented by MRI, patients with or without pelvic bone metastasis were divided into the prostate cancer bone metastasis group (80 cases) and the non-bone metastasis group (89 cases). All patients underwent MRI examination prior to surgery, and serum levels of PSA, ALP, D-dimer, and FIB were quantitatively measured. Kappa consistency tests were used to analyze the agreement between different imaging indicators and the results of prostate cancer bone metastasis. Uni- and multivariable logistic regression analyses were performed to evaluate the value of mpMRI, ALP, D-dimer, FIB, and other clinical indicators in the diagnosis of prostate cancer bone metastasis. The clinical application value of mpMRI, ALP, D-dimer, FIB, and their combined indicators in diagnosing prostate cancer bone metastasis was assessed using receiver operating characteristic (ROC) curves. Results: The Kappa values comparing T1WI, T2WI fat suppression, DWI, and mpMRI with the results of prostate cancer bone metastasis were 0.536, 0.470, 0.629, and 0.691, respectively (P < 0.001). Compared to the non-bone metastasis group, the serum levels of ALP, D-dimer, and FIB in the bone metastasis group were significantly higher (P < 0.001). Multivariable logistic regression analysis indicated that mpMRI, ALP, D-dimer, and FIB are independent risk factors for prostate cancer bone metastasis (P < 0.05). The combined indicators showed the best performance, followed by the individual indicators of D-dimer, mpMRI, ALP, and FIB, all of which demonstrated good diagnostic value (P < 0.05). Conclusion: mpMRI, ALP, D-dimer, and FIB all demonstrate certain diagnostic efficacy for prostate cancer bone metastasis. The combined use of these indicators can further enhance diagnostic value, suggesting that they should be considered for broader application in clinical practice.
