Hydrogen peroxide and polarity are closely related to many physiological activities and pathological processes.However,near-infrared fluorescent probes that are sensitive to both H_(2)O_(2)and polarity are still scarc...Hydrogen peroxide and polarity are closely related to many physiological activities and pathological processes.However,near-infrared fluorescent probes that are sensitive to both H_(2)O_(2)and polarity are still scarce.Herein,we developed the first dual-channel near-infrared fluorescent probe NBO,with an AIE effect,enabling simultaneous monitoring of H_(2)O_(2)and polarity.The probe presented high sensitivity,high selectivity,and low detection limit for H_(2)O_(2).It also had high sensitivity to polarity,independent of pH and viscosity,with large Stokes shifts,good photostability,and low cytotoxicity.Moreover,NBO was able to detect both endogenous and exogenous H_(2)O_(2)as well as polarity fluctuations in vivo as a method to effectively differentiate between cancer cells and normal cells.Importantly,it also could monitor the therapeutic effects of drugs in inflammation and iron-dead cells and mice.Based on NIR emission,NBO could be used as an imaging tool and a way to evaluate the therapeutic effect of drugs for inflammation and ferroptosis.展开更多
基金support from Scientific and Technological Key Project in Henan Province(22170015)National Natural Science Foundation of China(U1704161,22106061)+1 种基金Zhengzhou University(32211807)Henan Provincial Science and Technology Research Project(JC21253010)。
文摘Hydrogen peroxide and polarity are closely related to many physiological activities and pathological processes.However,near-infrared fluorescent probes that are sensitive to both H_(2)O_(2)and polarity are still scarce.Herein,we developed the first dual-channel near-infrared fluorescent probe NBO,with an AIE effect,enabling simultaneous monitoring of H_(2)O_(2)and polarity.The probe presented high sensitivity,high selectivity,and low detection limit for H_(2)O_(2).It also had high sensitivity to polarity,independent of pH and viscosity,with large Stokes shifts,good photostability,and low cytotoxicity.Moreover,NBO was able to detect both endogenous and exogenous H_(2)O_(2)as well as polarity fluctuations in vivo as a method to effectively differentiate between cancer cells and normal cells.Importantly,it also could monitor the therapeutic effects of drugs in inflammation and iron-dead cells and mice.Based on NIR emission,NBO could be used as an imaging tool and a way to evaluate the therapeutic effect of drugs for inflammation and ferroptosis.
