Gentamicin,an aminoglycoside antibiotic,is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases...Gentamicin,an aminoglycoside antibiotic,is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases.Comprising a complex array of closely related aminoglycoside compounds,the gentamicin B and C complexes emerge as particularly pertinent in clinical contexts.This review outlines the latest advancements in the biosynthesis and production of gentamicin,commencing with a comprehensive overview of its biosynthetic pathway.Subsequently,the article encapsulates a spectrum of strategies currently deployed to augment genta-micin yields.These strategies include mutation screening,molecular biological techniques,and optimization of the fermentation process.Moreover,numerous methods have been documented for detecting gentamicin across a range of matrices,underscoring the significance of precise quantitative analysis.Finally,the review furnishes an exhaustive market analysis and future outlook,elucidating prevailing trends and challenges within the genta-micin industry.Overall,this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research,furnishing a meticulous introduction to efficient synthesis technologies and diverse ap-plications,alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production.展开更多
基金supported by the National Key Research and Development Program of China(2022YFC2105403)the Taishan Scholars Program+2 种基金the Shanghai Pilot Program for Basic Research(22TQ1400100-14)the Natural Science Foundation of Shanghai(23ZR1416500)the Frontiers Science Center for Materiobiology and Dynamic Chemistry(JKVJ1231036)。
文摘Gentamicin,an aminoglycoside antibiotic,is generated by a few species within the genus Micromonospora and has garnered significant attention due to its broad-spectrum efficacy in combating numerous infectious diseases.Comprising a complex array of closely related aminoglycoside compounds,the gentamicin B and C complexes emerge as particularly pertinent in clinical contexts.This review outlines the latest advancements in the biosynthesis and production of gentamicin,commencing with a comprehensive overview of its biosynthetic pathway.Subsequently,the article encapsulates a spectrum of strategies currently deployed to augment genta-micin yields.These strategies include mutation screening,molecular biological techniques,and optimization of the fermentation process.Moreover,numerous methods have been documented for detecting gentamicin across a range of matrices,underscoring the significance of precise quantitative analysis.Finally,the review furnishes an exhaustive market analysis and future outlook,elucidating prevailing trends and challenges within the genta-micin industry.Overall,this article serves as a pivotal resource for researchers and professionals engaged in gentamicin research,furnishing a meticulous introduction to efficient synthesis technologies and diverse ap-plications,alongside presenting innovative concepts and methodologies aimed at increasing gentamicin production.
