The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitroge...The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.展开更多
This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinic...This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.展开更多
Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution...Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution methods,to solve and track the quasi-periodic solutions with multiple base frequencies until now.In this work,a multi-steps variable-coefficient formulation is proposed,which provides a unified framework to enable either harmonic balance method or collocation method or finite difference method to solve quasi-periodic solutions with multiple base frequencies.For this purpose,a method of alternating U and S domain is also developed to efficiently evaluate the nonlinear force terms.Furthermore,a new robust phase condition is presented for all of the three methods to make them track the quasi-periodic solutions with prior unknown multiple base frequencies,while the stability of the quasi-periodic solutions is assessed by mean of Lyapunov exponents.The feasibility of the constructed methods under the above framework is verified by application to three nonlinear systems.展开更多
In the face of constantly changing environments,the central nervous system(CNS)rapidly and accurately calculates the body's needs,regulates feeding behavior,and maintains energy homeostasis.The arcuate nucleus of ...In the face of constantly changing environments,the central nervous system(CNS)rapidly and accurately calculates the body's needs,regulates feeding behavior,and maintains energy homeostasis.The arcuate nucleus of the hypothalamus(ARC)plays a key role in this process,serv-ing as a critical brain region for detecting nutrition-related hormones and regulating appetite and energy homeostasis.Agouti-related protein(AgRP)/neuropeptide Y(NPY)neu-rons in the ARC are core elements that interact with other brain regions through a complex appetite-regulating network to comprehensively control energy homeostasis.In this review,we explore the discovery and research progress of AgRP neurons in regulating feeding and energy metabolism.In addition,recent advances in terms of feeding behavior and energy homeostasis,along with the redundant neural mecha-nisms involved in energy metabolism,are discussed.Finally,the challenges and opportunities in the field of neural regula-tion of feeding and energy metabolism are briefly discussed.展开更多
BACKGROUND Congenital intestinal atresia(CIA)is a common intestinal malformation in the neonatal period,and surgery is currently the main treatment method.The choice of postoperative feeding is crucial for the recover...BACKGROUND Congenital intestinal atresia(CIA)is a common intestinal malformation in the neonatal period,and surgery is currently the main treatment method.The choice of postoperative feeding is crucial for the recovery of gastrointestinal function in children.AIM To compare and analyze the effects of different postoperative feeding methods on gastrointestinal function reconstruction in newborns with CIA.METHODS Twenty-six children diagnosed with neonatal CIA,treated with minimally invasive surgery at Shijiazhuang Maternal and Child Health Hospital between January 2021 and May 2024,were selected for this single-center prospective randomized controlled study.They were divided into two groups using envelope randomization:Enteral nutrition(EN)group(n=13)and parenteral nutrition(PN)group(n=13).Baseline and clinical characteristics were collected,and recovery time of bowel sounds and time to first defecation were used as evaluation indices for gastrointestinal functional reconstruction.Differences between the groups were analyzed using t-test,χ2 test,and Fisher’s exact test.Spearman’s correlation tests and linear regression models were employed to analyze factors influencing time to first defecation.RESULTS The time to bowel sound recovery(51.54 vs 65.85,P=0.013)and first defecation(58.15 vs 76.62,P<0.001)was shorter in the EN group compared to the PN group.Clinical improvements in the EN group,including discharge weight(P=0.044),hospital stay(P=0.027),white blood cell count(P=0.023),albumin content(P=0.013),and direct bilirubin content(P=0.018),were also better than those in the PN group.No substantial differences in postoperative complications were found between the groups.Correlation analysis indicated that abdominal infection and operation time may relate to time to first defecation.Linear regression analysis demonstrated a considerable association between EN feeding and shorter time to first defecation.Abdominal infection and an operation time>2 hours may be risk factors for prolonged time to first defecation.CONCLUSION EN substantially promotes the recovery of gastrointestinal function after CIA in neonates and can improve clinical outcomes in children.Future research should explore optimal EN practices to enhance clinical application and child health.展开更多
Background Post-weaning diarrhea(PWD)in piglets,often caused by F4^(+)enterotoxigenic Escherichia coli(ETEC),poses significant challenges in pig production.Traditional solutions like antibiotics and zinc oxide face in...Background Post-weaning diarrhea(PWD)in piglets,often caused by F4^(+)enterotoxigenic Escherichia coli(ETEC),poses significant challenges in pig production.Traditional solutions like antibiotics and zinc oxide face increasing restrictions due to growing concerns over antibiotic resistance and environmental sustainability.This study investigates the application of bivalent heavy chain variable domain(V_(H)H)constructs(BL1.2 and BL2.2)targeting ETEC virulence factors,administered in feed to mitigate ETEC-induced PWD in weaned piglets.Results The supplementation of BL1.2 and BL2.2 in both mash and pelleted feed significantly reduced the diarrhea incidence and fecal shedding of F4^(+)ETEC in challenged piglets.Pelleted feed containing V_(H)H constructs helped to preserve gut barrier integrity by maintaining levels of the tight junction protein occludin in the small intestine.Additionally,the constructs maintained blood granulocyte counts at a similar level to the non-challenged control group,including neutrophils,and ameliorated the acute phase protein response after challenge.Notably,even at low feed intake immediately after weaning,V_(H)H constructs helped maintain piglet health by mitigating ETEC-induced inflammation and the resulting diarrhea.Conclusions Our findings demonstrated that using V_(H)H constructs as feed additives could serve as an effective strategy to help manage ETEC-associated PWD,by reducing F4^(+)ETEC gut colonization and supporting gut barrier function of weaned piglets.The high stability of these V_(H)H constructs supports their incorporation into industrial feed manufacturing processes,offering a more sustainable preventive strategy compared to traditional antimicrobial interventions,which could contribute to sustainable farming practices.展开更多
This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized ...This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized via the esterification of phytosterol and oleic acid,whose structure was characterized using Fourier-transform infrared spectroscopy(FTIR)and mass spectrometry(MS).Its liquid crystalline behavior was confirmed via the polarized optical microscopy(POM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),wide-angle X-ray scattering(WAXS),and small-angle X-ray scattering(SAXS).UV absorption tests were conducted to assess the UV-blocking performance of the oleic acid sterol ester liquid crystals.To improve the stability of its liquid crystalline structure,the oleic acid sterol ester was encapsulated into microcapsules through the emulsion polymerization.SPF measurements were performed on the sunscreen formulations containing liquid crystal microcapsules.The oleic acid sterol ester displayed cholesteric liquid crystalline behavior and strong UVA absorption,which indicates its suitability as a natural UV absorber.Microencapsulation further enhanced its stability and UV-blocking properties.SPF testing showed that the formulations with microcapsules achieved an SPF value of 7.01,which surpasses the nano titanium dioxide(SPF=6.23)and significantly outperform the unencapsulated liquid crystal formulations(SPF=2.65).This study highlights the potential of microencapsulated oleic acid sterol ester as a novel UV absorber in the sunscreen formulations,offers the enhanced stability and effective UV protection,and showcases its application potential in the innovative cosmetic products.展开更多
Cashew processing in Côte d’Ivoire focuses only on the cashew nut, to the detriment of the apple. Only a very small proportion of the apple is processed into juice. The aim of this work is to enhance the value o...Cashew processing in Côte d’Ivoire focuses only on the cashew nut, to the detriment of the apple. Only a very small proportion of the apple is processed into juice. The aim of this work is to enhance the value of cashew apples by transforming them into jam. Specifically, the aim was first to characterize the sensory properties of cashew apple jam formulations using baobab powder as a source of pectin and then to optimise the formulations. A Box-Behken design with pH, Sugar, and Baobab as factors was used to model and characterize the jam sensory descriptors, and a multivariate analysis with SensomineR was used to characterize the jam formulations. The desirability function was used to optimise the formulations. The results show globally significant regressions at the 0.05 threshold for the sensory descriptors Gelling, Brilliance, Smell, Sweetness, and (-)Astringency, with the exception of (-)Salinity. The R2 coefficients are greater than 80%. The factors studied could have effects on the sensory descriptors of cashew jam formulations. The Baobab had the main effect on the gelling, smell, and astringency of the jams. Brilliance depended on the added sugar. A product effect (p < 0.001) was observed for the descriptors Smell, Gelling, Brilliance, and Sweetness, as these allowed the panelists to find differences between the formulations. Optimum jam formulation can be achieved with 51.56% sugar and 2.12% Baobab at a pH of 3.15. Cashew apple jam using Baobab offers opportunities to add value to apples that have long been abandoned in the field. It would be important to find conditions for prolonged storage of this jam.展开更多
In aquaculture, feed represents the main component of production costs, and the development of this sector depends on the development of an economical feed formulation that meets the qualitative and quantitative requi...In aquaculture, feed represents the main component of production costs, and the development of this sector depends on the development of an economical feed formulation that meets the qualitative and quantitative requirements of fish. The aim of this study was to determine the nutritive and microbiological quality of fish feed formulated from local flours enriched with Hermetia illucens larvae. The raw materials used for formulation were fishmeal, corn meal, low-grade rice, soybean meal and Hermetia illucens larvae meal. Different iso-protein feed compositions were prepared with 0%, 10%, 25%, 35%, 50%, 65%, 75% and 100% incorporation of Hermetia illucens larvae meal as a substitute for fish meal. Biochemical and microbiological analyses of these flours were determined using standard methods. The results showed that incorporation of larvae meal had an influence on the biochemical characteristics ash (8.15 to 20.27%), lipid (11.55 to 24.94%), fiber (13.93 to 20.41%) and dry matter (89.65 to 91.19%) of various formulated feed. Loads of fecal Streptococci, Staphylococci, Aeromonas, yeasts and molds ranged from 2.4 to 4.9 log 10 CFU/g;3.6 to 3.9 log 10 CFU/g;2.2 to 2.7 log 10 CFU/g;2.1 to 2.3 log 10 CFU/g, respectively. The level of contamination of these flours was below the microbiological criteria applicable to animal feed. Feed formulated with 0% and 10% Hermetia illucens larvae showed the best nutritive and microbiological characteristics. These results suggest that flours enriched with Hermetia illucens larvae could be used in fish feed.展开更多
Microplastic(MP)pollution has spread from the mainland to the ocean.However,Haizhou Bay,which is one of the important land-ocean transition zones,has been reported relatively little about the enrichment of MPs.To prov...Microplastic(MP)pollution has spread from the mainland to the ocean.However,Haizhou Bay,which is one of the important land-ocean transition zones,has been reported relatively little about the enrichment of MPs.To provide fundamental data for MP pollution in Haizhou Bay,we studied the occurrence of microplastics in the intestines of 8 species of fish with different habits and feeding modes.The fish intestines were digested with a 10%KOH solution,and MPs are separated with a glass fiber filter.Then,the size,shape,color,and composition of the MPs were analyzed using a stereomicroscope and Fourier transform infrared spectrometer.The results showed the abundance of MP intake ranged from 0.02 items g^(-1) to 0.16 items g^(-1) and the detection rate of MPs ranged from 53.33% to 80% across different fish species.The MP intake in benthic fish and omnivorous fish was significantly higher than that of pelagic fish and predatory fish.Smaller MPs(<0.25 mm)were the dominant types and accounted for 62.50% of the total.The fiber was the prevailing shape of MPs,and the black MPs were the most common,followed by red and yellow ones.Polyethylene terephthalate(PET),polyamide(PA),and polystyrene(PS)were the main components of MPs,accounting for 34.9%,29.9%,and 16.4%,respectively.According to the composition analysis of MPs,the main sources of MPs in fish of Haizhou Bay were attributed to marine aquaculture and port construction.The results are helpful for our better understanding of the status of MP pollution in this area,and further aid in the development of the pointed measures to mitigate and prevent the MP pollution in this ecologically important area.展开更多
This minireview synthesizes literature on the use of feeding jejunostomy tubes(FJTs)in the postoperative management of gastroesophageal cancer patients.Gastrectomy and esophagectomy remain the primary curative treatme...This minireview synthesizes literature on the use of feeding jejunostomy tubes(FJTs)in the postoperative management of gastroesophageal cancer patients.Gastrectomy and esophagectomy remain the primary curative treatments for gastric and esophageal cancers,respectively,but are frequently accompanied by significant postoperative malnutrition,which adversely impacts surgical and oncological outcomes as well as patients’quality of life.To address this,the European Society for Clinical Nutrition and Surgery and the National Comprehensive Cancer Network recommend early enteral feeding through FJT placement following major surgery.While previous studies have demonstrated that FJT is an effective and reliable route for nutritional support,its placement is invasive and carries associated risks.Consequently,many clinicians opt for less invasive alternatives such as total parenteral nutrition or nasogastric tube feeding,although these approaches yield variable results.This review explores the benefits and potential complications of FJT placement,identifies variability in clinical adoption and the absence of standardized protocols,and highlights areas for future research to optimize patient care in this challenging context.展开更多
The widespread ban on in-feed antibiotics in many regions has driven the search for natural alternatives to maintain health and production efficiency in swine and poultry.Phytogenic feed additives(PFAs)derived from he...The widespread ban on in-feed antibiotics in many regions has driven the search for natural alternatives to maintain health and production efficiency in swine and poultry.Phytogenic feed additives(PFAs)derived from herbs and plant extracts have emerged as promising candidates owing to their antioxidant,anti-inflammatory,and antimicrobial properties.Among these,silymarin—a flavonolignan complex extracted from milk thistle(Silybum marianum)—has attracted particular attention due to its hepatoprotective and growth-promoting activities.This review summarizes the chemical characteristics and mechanisms of action of silymarin/silybin.Also,evidence from both experimental and field studies shows that silymarin improves growth performance,nutrient digestibility,gut health,and reproductive outcomes.Advances in formulation technologies,such as micellization,have been addressed for improved bioavailability of silymarin.Despite these promising results,further long-term field studies and economic evaluations are needed to fully integrate silymarin into commercial animal production systems.展开更多
Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the und...Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the underlying genetic mechanisms that underlie FE-related traits in sheep are not fully understood.Herein,we measured the FE-related traits of 1,280 Hu sheep and conducted the phenotype statistics and correlation analysis,the result showcase that there was a large variation for FE-related traits,and RFI was significant positive correlation with average daily feed intake(ADFI)and FCR.Moreover,a genome-wide association study(GWAS)was conducted using whole-genome resequencing data to investigate the genetic associations of ADFI,FCR and RFI.For ADFI and FCR traits,2 and one single nucleotide polymorphisms(SNPs)exceeded the genome-wide significance threshold,whereas ten and 5 SNPs exceeded the suggestive significance threshold.For RFI traits,only 4 SNPs exceeded the suggestive significance threshold.Finally,a total of 8 genes(LOC101121953,LOC101110202,CTNNA3,IZUMO3,PPM1E,YIPF7,ZSCAN12and LOC105603808)were identified as potential candidate genes for FE-related traits.Simultaneously,we further analyzed the effects of 2 candidate SNPs associated with RFI on growth and FE traits in enlarged experimental population,the results demonstrated that these 2 SNPs was not significantly associated with growth traits(P>0.05),but significantly related to RFI traits(P<0.05).These findings will provide valuable reference data and key genetic variants that can be used to effectively select feed-efficient individual in sheep breeding programs.展开更多
Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and poten...Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and potential mechanisms of FHF for treating vaginitis,and reveal its pharmacological activities against vaginitis.Results:A total of 12 anti-inflammatory components in FHF and 584 pharmacological targets were identified.Furthermore,1427 vaginitis-associated targets were identified,and 184 intersection targets between FHF and vaginitis were constructed for network analysis.Gene Ontology and pathway analysis revealed that the therapeutical targets of FHF against vaginitis are involved in modulating inflammatory stress,enhancing immunoregulation,reconstructing the microenvironment,and suppressing cell damage.Molecular docking analysis further suggested the possible direct binding of the bioactive compounds of FHF(fumarine)to the core targets,including AKT Serine/Threonine Kinase 1(AKT1),Signal Transducer and Activator of Transcription 3(STAT3),and nuclear factor-kappaB(NF-κB).Experimental validation found that FHF-treated vaginitis rats exhibited reduced intracellular AKT1,STAT3,and NF-κB protein expressions.Conclusion:Overall,we identified the bioactive compounds and pharmacological mechanisms of FHF against vaginitis,thus offering a theoretical fundament for exploring FHF for treating vaginitis in the future.展开更多
This work focuses on the formulation of a dietary cold sauce,mayonnaise,which combines the therapeutic properties of two basic ingredients:PSO(Pumpkin Seed Oil)and quail egg,both of which are renowned for their high f...This work focuses on the formulation of a dietary cold sauce,mayonnaise,which combines the therapeutic properties of two basic ingredients:PSO(Pumpkin Seed Oil)and quail egg,both of which are renowned for their high functional properties.PSO is essentially made up of unsaturated fatty acids(50%to 65%)including linoleic acid,from the omega 6 family,oleic acid(20%to 50%),a monounsaturated fatty acid(omega 9),cucurbitin,phytosterols,tri-terpenes and vitamin E(3.5 mg%).The nutritional,fatty acid,vitamin and mineral compositions of the mayonnaise compared with the ingredients,the physico-chemical characteristics of the quail egg,the PSO and the tasting of the mayonnaise were determined and gave results in terms of variable contents which are recorded in Tables 2-8.The results obtained were satisfactory.Mayonnaise,a semi-solid emulsion of oil in water with viscoelastic properties due to the network formed by lipoproteins adsorbed around neighbouring drops of oil,was prepared using the ratio of quail egg and PSO 1/4.This study may offer an alternative way of making dietary sauces.展开更多
Globally,gastric cancer ranks as the fifth most common malignancy and the third leading cause of cancer-related mortality.Gastrectomy combined with periop-erative chemotherapy is currently the standard of care in loca...Globally,gastric cancer ranks as the fifth most common malignancy and the third leading cause of cancer-related mortality.Gastrectomy combined with periop-erative chemotherapy is currently the standard of care in locally advanced stages,but the completion rate of multimodal approach is influenced also by patient related factors.Malnutrition is a well-known risk factor associated with poor oncological outcomes.Its perioperative supplementation could lead to an im-provement of the nutritional status.This article reviews and comments the retro-spective study conducted by Jaquet et al,which evaluates the impact of enteral nutrition by jejunostomy feeding in patients undergoing gastrectomy for cancer.The authors included 172 patients,35%of whom received jejunostomy.Patients with optimized biological nutritional parameters(body mass index,albumin,prealbumin)showed reduced major complications(>III),according to the Dindo-Clavien classification,0(0%)vs 8(4.7%)(P=0.05).In the era of multimodal treatment,optimization of nutritional and performance status is integral part of the therapeutic strategy.展开更多
Objectives Breastfeeding plays a critical role in the healthy development of infants,yet exclusive breastfeeding(EBF)rates remain low,particularly among low-income mothers.This study aimed to develop and validate an A...Objectives Breastfeeding plays a critical role in the healthy development of infants,yet exclusive breastfeeding(EBF)rates remain low,particularly among low-income mothers.This study aimed to develop and validate an AI-based educational innovative solution to increase breastfeeding literacy across caregivers and mothers.Methods The BabyChat(AI-based)was developed through two phases.In phase I,the content was created using the Canvas application,with the idea tree structured through MindMeister,and delivered via the ManyChat tool on Facebook.The focus was on the benefits of EBF during the initial 6 months of life,as recommended by the WHO,and continued breastfeeding until 1,000 days of life.In Phase II,functionality tests were performed using UserTesting and subsequently validated by the Content Validity Index(CVI).Healthcare professionals reviewed the clarity and relevance of the information on a four-point scale.Intra-examiner concordance was assessed by percentage of agreement and the median for each CVI-I point.Results The contents of BabyChat included 8 topics and 18 subtopics(based on relevant contents including nutritional and anatomical aspects,weaning strategies among others)aimed to educate mothers and caregivers.Five mothers participated in evaluation of the BabyChat.Overall,most participants found the chatbot’s question-and-answer functionality clear and helpful,with accurate command execution and timely response speeds,etc.However,two participants noted occasional issues such as misinterpreted questions,delayed command responses,and unclear or hard-to-find interface buttons.A total of four experts in psychology,dentistry,and medicine validated the framework.The agreement rate between experts ranged from 25%to 100%,with median values between 3 and 4,indicating excellent content relevance.Conclusion The BabyChat was developed and validated for use in increasing breastfeeding literacy among caregivers and mothers.Future studies should be considered to expand the BabyChat validation to other healthcare professionals,including nursing staff,to comprehensively capture the impact of BabyChat on mothers,as well as to incorporate population-specific topics that depend on cultural and geographical aspects.展开更多
Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These f...Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These factors initiate inflammation,collagen breakdown,and visible signs of aging.Polyherbal formulation with multiple plant extracts with synergistic bioactive compounds offers a sustainable and scientifically proven way of modulating the interrelated pathways that contribute to skin aging.This comprehensive review features 7 key anti-aging plants,including Curcuma longa,Curcuma aromatica,Glycyrrhiza glabra,Calendula officinalis,Boehavia diffusa,Withania somnifera,and Matricaria chamomilla,and discusses their active phytoconstituents such as curcumin,glabridin,withanolides,and apigenin.These agents improve the hydration of skin,increase collagen synthesis,inhibit matrix metalloproteinases(MMPs),and modulate oxidative stress.This review emphasizes the opportunity to combine some of the most sophisticated dermal delivery methods(e.g.,liposome,ethosome,and emulgel technologies)with traditional ethnobotanical knowledge to increase bioavailability and efficacy of herbal actives.All research indicates that polyherbal formulations offer a multi-targeted,sustainable,and therapeutically viable alternative to synthetic anti-aging pharmaceuticals,bridging traditional knowledge and contemporary cosmeceutical techniques.展开更多
The efficiency and mechanism of hydrous iron oxide(HFO)and HFO/calcite mixture to inactivate the phosphorus in the overlying water(OW)/sediment system under the feed adding condition were explored,and the effect of HF...The efficiency and mechanism of hydrous iron oxide(HFO)and HFO/calcite mixture to inactivate the phosphorus in the overlying water(OW)/sediment system under the feed adding condition were explored,and the effect of HFO and HFO/calcite mixture addition on the diversity,composition and function of bacterial communities in the sediment was examined.HFO and HFO/calcite mixture direct addition can effectively lower the concentration of soluble reactive phosphorus(RSP)and diffusion gradient in thin film-unstable phosphorus(PD GT)in OW and inactivate the P DGTin the upper sediment.The elimination efficiencies of RSP by the direct HFO and HFO/calcite mixture addition were 48.9%-97.0%and 42.4%-95.4%,respectively.The alteration in the addition mode from the one-time to multiple direct addition was beneficial to the immobilization of RSP and PD GTin OW and P DGTin the upper sediment by HFO and HFO/calcite mixture under the feed input condition in the long run.Permeable fabric wrapping reduced the inactivation efficiency of RSP in OW by HFO and HFO/calcite mixture,but it made the recycling of these materials possible.Most of P immobilized by HFO and HFO/calcite mixture was relatively or very stable.After the HFO and HFO/calcite mixture addition,the composition of bacterial communities in the surface sediment changed.However,the bacterial communities in the amended sediments still can perform good ecological function.Our findings suggest that HFO and HFO/calcite mixture are promising phosphorus-immobilization materials for the inactivation of RSP and PD GTin OW and PD GTin the upper sediment under the feed inputting condition.展开更多
基金financially supported by the Key Research and Development Program of Shandong,China(No.2021SFGC0701)。
文摘The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.
基金Supported by National Natural Science Foundation of China(82374346)Double Hundred Outstanding Young and Middle-aged Medical and Health Talents of Wuxi City(BJ2023071)Scientific Research Project of Wuxi Municipal Health Commission(Q202358).
文摘This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.
基金supported by the National Natural Science Foundation of China(Grant Nos.12172267 and 12302014).
文摘Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution methods,to solve and track the quasi-periodic solutions with multiple base frequencies until now.In this work,a multi-steps variable-coefficient formulation is proposed,which provides a unified framework to enable either harmonic balance method or collocation method or finite difference method to solve quasi-periodic solutions with multiple base frequencies.For this purpose,a method of alternating U and S domain is also developed to efficiently evaluate the nonlinear force terms.Furthermore,a new robust phase condition is presented for all of the three methods to make them track the quasi-periodic solutions with prior unknown multiple base frequencies,while the stability of the quasi-periodic solutions is assessed by mean of Lyapunov exponents.The feasibility of the constructed methods under the above framework is verified by application to three nonlinear systems.
基金supported by Grants from the Research Funds of the Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYPY20220018)the National Natural Science Foundation of China(31822026,32271063,31500860,and 32100821)the National Science and Technology Innovation 2030 Major Project of China(2021ZD0203900).
文摘In the face of constantly changing environments,the central nervous system(CNS)rapidly and accurately calculates the body's needs,regulates feeding behavior,and maintains energy homeostasis.The arcuate nucleus of the hypothalamus(ARC)plays a key role in this process,serv-ing as a critical brain region for detecting nutrition-related hormones and regulating appetite and energy homeostasis.Agouti-related protein(AgRP)/neuropeptide Y(NPY)neu-rons in the ARC are core elements that interact with other brain regions through a complex appetite-regulating network to comprehensively control energy homeostasis.In this review,we explore the discovery and research progress of AgRP neurons in regulating feeding and energy metabolism.In addition,recent advances in terms of feeding behavior and energy homeostasis,along with the redundant neural mecha-nisms involved in energy metabolism,are discussed.Finally,the challenges and opportunities in the field of neural regula-tion of feeding and energy metabolism are briefly discussed.
文摘BACKGROUND Congenital intestinal atresia(CIA)is a common intestinal malformation in the neonatal period,and surgery is currently the main treatment method.The choice of postoperative feeding is crucial for the recovery of gastrointestinal function in children.AIM To compare and analyze the effects of different postoperative feeding methods on gastrointestinal function reconstruction in newborns with CIA.METHODS Twenty-six children diagnosed with neonatal CIA,treated with minimally invasive surgery at Shijiazhuang Maternal and Child Health Hospital between January 2021 and May 2024,were selected for this single-center prospective randomized controlled study.They were divided into two groups using envelope randomization:Enteral nutrition(EN)group(n=13)and parenteral nutrition(PN)group(n=13).Baseline and clinical characteristics were collected,and recovery time of bowel sounds and time to first defecation were used as evaluation indices for gastrointestinal functional reconstruction.Differences between the groups were analyzed using t-test,χ2 test,and Fisher’s exact test.Spearman’s correlation tests and linear regression models were employed to analyze factors influencing time to first defecation.RESULTS The time to bowel sound recovery(51.54 vs 65.85,P=0.013)and first defecation(58.15 vs 76.62,P<0.001)was shorter in the EN group compared to the PN group.Clinical improvements in the EN group,including discharge weight(P=0.044),hospital stay(P=0.027),white blood cell count(P=0.023),albumin content(P=0.013),and direct bilirubin content(P=0.018),were also better than those in the PN group.No substantial differences in postoperative complications were found between the groups.Correlation analysis indicated that abdominal infection and operation time may relate to time to first defecation.Linear regression analysis demonstrated a considerable association between EN feeding and shorter time to first defecation.Abdominal infection and an operation time>2 hours may be risk factors for prolonged time to first defecation.CONCLUSION EN substantially promotes the recovery of gastrointestinal function after CIA in neonates and can improve clinical outcomes in children.Future research should explore optimal EN practices to enhance clinical application and child health.
基金financially supported by the Green Development and Demonstration Programme(GUDP)(case number 34009-19-1585)。
文摘Background Post-weaning diarrhea(PWD)in piglets,often caused by F4^(+)enterotoxigenic Escherichia coli(ETEC),poses significant challenges in pig production.Traditional solutions like antibiotics and zinc oxide face increasing restrictions due to growing concerns over antibiotic resistance and environmental sustainability.This study investigates the application of bivalent heavy chain variable domain(V_(H)H)constructs(BL1.2 and BL2.2)targeting ETEC virulence factors,administered in feed to mitigate ETEC-induced PWD in weaned piglets.Results The supplementation of BL1.2 and BL2.2 in both mash and pelleted feed significantly reduced the diarrhea incidence and fecal shedding of F4^(+)ETEC in challenged piglets.Pelleted feed containing V_(H)H constructs helped to preserve gut barrier integrity by maintaining levels of the tight junction protein occludin in the small intestine.Additionally,the constructs maintained blood granulocyte counts at a similar level to the non-challenged control group,including neutrophils,and ameliorated the acute phase protein response after challenge.Notably,even at low feed intake immediately after weaning,V_(H)H constructs helped maintain piglet health by mitigating ETEC-induced inflammation and the resulting diarrhea.Conclusions Our findings demonstrated that using V_(H)H constructs as feed additives could serve as an effective strategy to help manage ETEC-associated PWD,by reducing F4^(+)ETEC gut colonization and supporting gut barrier function of weaned piglets.The high stability of these V_(H)H constructs supports their incorporation into industrial feed manufacturing processes,offering a more sustainable preventive strategy compared to traditional antimicrobial interventions,which could contribute to sustainable farming practices.
文摘This study reports the synthesis of oleic acid sterol ester with liquid crystalline properties and its enhanced stability and UV-blocking performance through microencapsulation.Oleic acid sterol ester was synthesized via the esterification of phytosterol and oleic acid,whose structure was characterized using Fourier-transform infrared spectroscopy(FTIR)and mass spectrometry(MS).Its liquid crystalline behavior was confirmed via the polarized optical microscopy(POM),thermogravimetric analysis(TGA),differential scanning calorimetry(DSC),wide-angle X-ray scattering(WAXS),and small-angle X-ray scattering(SAXS).UV absorption tests were conducted to assess the UV-blocking performance of the oleic acid sterol ester liquid crystals.To improve the stability of its liquid crystalline structure,the oleic acid sterol ester was encapsulated into microcapsules through the emulsion polymerization.SPF measurements were performed on the sunscreen formulations containing liquid crystal microcapsules.The oleic acid sterol ester displayed cholesteric liquid crystalline behavior and strong UVA absorption,which indicates its suitability as a natural UV absorber.Microencapsulation further enhanced its stability and UV-blocking properties.SPF testing showed that the formulations with microcapsules achieved an SPF value of 7.01,which surpasses the nano titanium dioxide(SPF=6.23)and significantly outperform the unencapsulated liquid crystal formulations(SPF=2.65).This study highlights the potential of microencapsulated oleic acid sterol ester as a novel UV absorber in the sunscreen formulations,offers the enhanced stability and effective UV protection,and showcases its application potential in the innovative cosmetic products.
文摘Cashew processing in Côte d’Ivoire focuses only on the cashew nut, to the detriment of the apple. Only a very small proportion of the apple is processed into juice. The aim of this work is to enhance the value of cashew apples by transforming them into jam. Specifically, the aim was first to characterize the sensory properties of cashew apple jam formulations using baobab powder as a source of pectin and then to optimise the formulations. A Box-Behken design with pH, Sugar, and Baobab as factors was used to model and characterize the jam sensory descriptors, and a multivariate analysis with SensomineR was used to characterize the jam formulations. The desirability function was used to optimise the formulations. The results show globally significant regressions at the 0.05 threshold for the sensory descriptors Gelling, Brilliance, Smell, Sweetness, and (-)Astringency, with the exception of (-)Salinity. The R2 coefficients are greater than 80%. The factors studied could have effects on the sensory descriptors of cashew jam formulations. The Baobab had the main effect on the gelling, smell, and astringency of the jams. Brilliance depended on the added sugar. A product effect (p < 0.001) was observed for the descriptors Smell, Gelling, Brilliance, and Sweetness, as these allowed the panelists to find differences between the formulations. Optimum jam formulation can be achieved with 51.56% sugar and 2.12% Baobab at a pH of 3.15. Cashew apple jam using Baobab offers opportunities to add value to apples that have long been abandoned in the field. It would be important to find conditions for prolonged storage of this jam.
文摘In aquaculture, feed represents the main component of production costs, and the development of this sector depends on the development of an economical feed formulation that meets the qualitative and quantitative requirements of fish. The aim of this study was to determine the nutritive and microbiological quality of fish feed formulated from local flours enriched with Hermetia illucens larvae. The raw materials used for formulation were fishmeal, corn meal, low-grade rice, soybean meal and Hermetia illucens larvae meal. Different iso-protein feed compositions were prepared with 0%, 10%, 25%, 35%, 50%, 65%, 75% and 100% incorporation of Hermetia illucens larvae meal as a substitute for fish meal. Biochemical and microbiological analyses of these flours were determined using standard methods. The results showed that incorporation of larvae meal had an influence on the biochemical characteristics ash (8.15 to 20.27%), lipid (11.55 to 24.94%), fiber (13.93 to 20.41%) and dry matter (89.65 to 91.19%) of various formulated feed. Loads of fecal Streptococci, Staphylococci, Aeromonas, yeasts and molds ranged from 2.4 to 4.9 log 10 CFU/g;3.6 to 3.9 log 10 CFU/g;2.2 to 2.7 log 10 CFU/g;2.1 to 2.3 log 10 CFU/g, respectively. The level of contamination of these flours was below the microbiological criteria applicable to animal feed. Feed formulated with 0% and 10% Hermetia illucens larvae showed the best nutritive and microbiological characteristics. These results suggest that flours enriched with Hermetia illucens larvae could be used in fish feed.
基金funded by research grants from the National Natural Science Foundation of China(Nos.41706142 and 32071615)the China Agriculture Research System of MOF and MARA(No.CARS-49)the Funding for School-Level Research Projects of Yancheng Institute of Technology(No.XJR2021035)。
文摘Microplastic(MP)pollution has spread from the mainland to the ocean.However,Haizhou Bay,which is one of the important land-ocean transition zones,has been reported relatively little about the enrichment of MPs.To provide fundamental data for MP pollution in Haizhou Bay,we studied the occurrence of microplastics in the intestines of 8 species of fish with different habits and feeding modes.The fish intestines were digested with a 10%KOH solution,and MPs are separated with a glass fiber filter.Then,the size,shape,color,and composition of the MPs were analyzed using a stereomicroscope and Fourier transform infrared spectrometer.The results showed the abundance of MP intake ranged from 0.02 items g^(-1) to 0.16 items g^(-1) and the detection rate of MPs ranged from 53.33% to 80% across different fish species.The MP intake in benthic fish and omnivorous fish was significantly higher than that of pelagic fish and predatory fish.Smaller MPs(<0.25 mm)were the dominant types and accounted for 62.50% of the total.The fiber was the prevailing shape of MPs,and the black MPs were the most common,followed by red and yellow ones.Polyethylene terephthalate(PET),polyamide(PA),and polystyrene(PS)were the main components of MPs,accounting for 34.9%,29.9%,and 16.4%,respectively.According to the composition analysis of MPs,the main sources of MPs in fish of Haizhou Bay were attributed to marine aquaculture and port construction.The results are helpful for our better understanding of the status of MP pollution in this area,and further aid in the development of the pointed measures to mitigate and prevent the MP pollution in this ecologically important area.
文摘This minireview synthesizes literature on the use of feeding jejunostomy tubes(FJTs)in the postoperative management of gastroesophageal cancer patients.Gastrectomy and esophagectomy remain the primary curative treatments for gastric and esophageal cancers,respectively,but are frequently accompanied by significant postoperative malnutrition,which adversely impacts surgical and oncological outcomes as well as patients’quality of life.To address this,the European Society for Clinical Nutrition and Surgery and the National Comprehensive Cancer Network recommend early enteral feeding through FJT placement following major surgery.While previous studies have demonstrated that FJT is an effective and reliable route for nutritional support,its placement is invasive and carries associated risks.Consequently,many clinicians opt for less invasive alternatives such as total parenteral nutrition or nasogastric tube feeding,although these approaches yield variable results.This review explores the benefits and potential complications of FJT placement,identifies variability in clinical adoption and the absence of standardized protocols,and highlights areas for future research to optimize patient care in this challenging context.
基金supported by the research fund of Dankook University in 2025.
文摘The widespread ban on in-feed antibiotics in many regions has driven the search for natural alternatives to maintain health and production efficiency in swine and poultry.Phytogenic feed additives(PFAs)derived from herbs and plant extracts have emerged as promising candidates owing to their antioxidant,anti-inflammatory,and antimicrobial properties.Among these,silymarin—a flavonolignan complex extracted from milk thistle(Silybum marianum)—has attracted particular attention due to its hepatoprotective and growth-promoting activities.This review summarizes the chemical characteristics and mechanisms of action of silymarin/silybin.Also,evidence from both experimental and field studies shows that silymarin improves growth performance,nutrient digestibility,gut health,and reproductive outcomes.Advances in formulation technologies,such as micellization,have been addressed for improved bioavailability of silymarin.Despite these promising results,further long-term field studies and economic evaluations are needed to fully integrate silymarin into commercial animal production systems.
基金supported by the National Key R&D Program of China(2021YFD1300901)the National Key R&D Young Scientists Project of China(2022YFD1302000)+1 种基金the Education Department of Gansu Province:Outstanding Postgraduate“Innovation Star”,China(2022CXZX-086)the Major Science and Technology Project of Gansu Province,China(22ZD6NC069)。
文摘Feed efficiency(FE)is a crucial economic trait that significantly impacts profitability in intensive sheep production,and can be evaluated by the residual feed intake(RFI)and feed conversion ratio(FCR).However,the underlying genetic mechanisms that underlie FE-related traits in sheep are not fully understood.Herein,we measured the FE-related traits of 1,280 Hu sheep and conducted the phenotype statistics and correlation analysis,the result showcase that there was a large variation for FE-related traits,and RFI was significant positive correlation with average daily feed intake(ADFI)and FCR.Moreover,a genome-wide association study(GWAS)was conducted using whole-genome resequencing data to investigate the genetic associations of ADFI,FCR and RFI.For ADFI and FCR traits,2 and one single nucleotide polymorphisms(SNPs)exceeded the genome-wide significance threshold,whereas ten and 5 SNPs exceeded the suggestive significance threshold.For RFI traits,only 4 SNPs exceeded the suggestive significance threshold.Finally,a total of 8 genes(LOC101121953,LOC101110202,CTNNA3,IZUMO3,PPM1E,YIPF7,ZSCAN12and LOC105603808)were identified as potential candidate genes for FE-related traits.Simultaneously,we further analyzed the effects of 2 candidate SNPs associated with RFI on growth and FE traits in enlarged experimental population,the results demonstrated that these 2 SNPs was not significantly associated with growth traits(P>0.05),but significantly related to RFI traits(P<0.05).These findings will provide valuable reference data and key genetic variants that can be used to effectively select feed-efficient individual in sheep breeding programs.
文摘Background:Fuke Huahuang formulation(FHF)is widely used in the treatment of vaginitis,with clinical evidence indicating its promising anti-inflammatory properties.Methods:We explored the bioactive components and potential mechanisms of FHF for treating vaginitis,and reveal its pharmacological activities against vaginitis.Results:A total of 12 anti-inflammatory components in FHF and 584 pharmacological targets were identified.Furthermore,1427 vaginitis-associated targets were identified,and 184 intersection targets between FHF and vaginitis were constructed for network analysis.Gene Ontology and pathway analysis revealed that the therapeutical targets of FHF against vaginitis are involved in modulating inflammatory stress,enhancing immunoregulation,reconstructing the microenvironment,and suppressing cell damage.Molecular docking analysis further suggested the possible direct binding of the bioactive compounds of FHF(fumarine)to the core targets,including AKT Serine/Threonine Kinase 1(AKT1),Signal Transducer and Activator of Transcription 3(STAT3),and nuclear factor-kappaB(NF-κB).Experimental validation found that FHF-treated vaginitis rats exhibited reduced intracellular AKT1,STAT3,and NF-κB protein expressions.Conclusion:Overall,we identified the bioactive compounds and pharmacological mechanisms of FHF against vaginitis,thus offering a theoretical fundament for exploring FHF for treating vaginitis in the future.
文摘This work focuses on the formulation of a dietary cold sauce,mayonnaise,which combines the therapeutic properties of two basic ingredients:PSO(Pumpkin Seed Oil)and quail egg,both of which are renowned for their high functional properties.PSO is essentially made up of unsaturated fatty acids(50%to 65%)including linoleic acid,from the omega 6 family,oleic acid(20%to 50%),a monounsaturated fatty acid(omega 9),cucurbitin,phytosterols,tri-terpenes and vitamin E(3.5 mg%).The nutritional,fatty acid,vitamin and mineral compositions of the mayonnaise compared with the ingredients,the physico-chemical characteristics of the quail egg,the PSO and the tasting of the mayonnaise were determined and gave results in terms of variable contents which are recorded in Tables 2-8.The results obtained were satisfactory.Mayonnaise,a semi-solid emulsion of oil in water with viscoelastic properties due to the network formed by lipoproteins adsorbed around neighbouring drops of oil,was prepared using the ratio of quail egg and PSO 1/4.This study may offer an alternative way of making dietary sauces.
文摘Globally,gastric cancer ranks as the fifth most common malignancy and the third leading cause of cancer-related mortality.Gastrectomy combined with periop-erative chemotherapy is currently the standard of care in locally advanced stages,but the completion rate of multimodal approach is influenced also by patient related factors.Malnutrition is a well-known risk factor associated with poor oncological outcomes.Its perioperative supplementation could lead to an im-provement of the nutritional status.This article reviews and comments the retro-spective study conducted by Jaquet et al,which evaluates the impact of enteral nutrition by jejunostomy feeding in patients undergoing gastrectomy for cancer.The authors included 172 patients,35%of whom received jejunostomy.Patients with optimized biological nutritional parameters(body mass index,albumin,prealbumin)showed reduced major complications(>III),according to the Dindo-Clavien classification,0(0%)vs 8(4.7%)(P=0.05).In the era of multimodal treatment,optimization of nutritional and performance status is integral part of the therapeutic strategy.
基金supported by Hub Mandic(Faculdade Sao Leopoldo Mandic,Campinas,SP,Brazil)。
文摘Objectives Breastfeeding plays a critical role in the healthy development of infants,yet exclusive breastfeeding(EBF)rates remain low,particularly among low-income mothers.This study aimed to develop and validate an AI-based educational innovative solution to increase breastfeeding literacy across caregivers and mothers.Methods The BabyChat(AI-based)was developed through two phases.In phase I,the content was created using the Canvas application,with the idea tree structured through MindMeister,and delivered via the ManyChat tool on Facebook.The focus was on the benefits of EBF during the initial 6 months of life,as recommended by the WHO,and continued breastfeeding until 1,000 days of life.In Phase II,functionality tests were performed using UserTesting and subsequently validated by the Content Validity Index(CVI).Healthcare professionals reviewed the clarity and relevance of the information on a four-point scale.Intra-examiner concordance was assessed by percentage of agreement and the median for each CVI-I point.Results The contents of BabyChat included 8 topics and 18 subtopics(based on relevant contents including nutritional and anatomical aspects,weaning strategies among others)aimed to educate mothers and caregivers.Five mothers participated in evaluation of the BabyChat.Overall,most participants found the chatbot’s question-and-answer functionality clear and helpful,with accurate command execution and timely response speeds,etc.However,two participants noted occasional issues such as misinterpreted questions,delayed command responses,and unclear or hard-to-find interface buttons.A total of four experts in psychology,dentistry,and medicine validated the framework.The agreement rate between experts ranged from 25%to 100%,with median values between 3 and 4,indicating excellent content relevance.Conclusion The BabyChat was developed and validated for use in increasing breastfeeding literacy among caregivers and mothers.Future studies should be considered to expand the BabyChat validation to other healthcare professionals,including nursing staff,to comprehensively capture the impact of BabyChat on mothers,as well as to incorporate population-specific topics that depend on cultural and geographical aspects.
文摘Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These factors initiate inflammation,collagen breakdown,and visible signs of aging.Polyherbal formulation with multiple plant extracts with synergistic bioactive compounds offers a sustainable and scientifically proven way of modulating the interrelated pathways that contribute to skin aging.This comprehensive review features 7 key anti-aging plants,including Curcuma longa,Curcuma aromatica,Glycyrrhiza glabra,Calendula officinalis,Boehavia diffusa,Withania somnifera,and Matricaria chamomilla,and discusses their active phytoconstituents such as curcumin,glabridin,withanolides,and apigenin.These agents improve the hydration of skin,increase collagen synthesis,inhibit matrix metalloproteinases(MMPs),and modulate oxidative stress.This review emphasizes the opportunity to combine some of the most sophisticated dermal delivery methods(e.g.,liposome,ethosome,and emulgel technologies)with traditional ethnobotanical knowledge to increase bioavailability and efficacy of herbal actives.All research indicates that polyherbal formulations offer a multi-targeted,sustainable,and therapeutically viable alternative to synthetic anti-aging pharmaceuticals,bridging traditional knowledge and contemporary cosmeceutical techniques.
基金supported by the Capacity Building Project of Local University of Shanghai Municipal Science and Technology Commission(No.10230502900)the Program for Shanghai Collaborative Innovation Center for Cultivating Elite Breeds and Green-culture of Aquaculture animals(No.2021-KJ-02-12)the Innovation Project for Chongming Agriculture Industry from Chongming District Agriculture Commission of Shanghai(No.2022CNKC-01-05)。
文摘The efficiency and mechanism of hydrous iron oxide(HFO)and HFO/calcite mixture to inactivate the phosphorus in the overlying water(OW)/sediment system under the feed adding condition were explored,and the effect of HFO and HFO/calcite mixture addition on the diversity,composition and function of bacterial communities in the sediment was examined.HFO and HFO/calcite mixture direct addition can effectively lower the concentration of soluble reactive phosphorus(RSP)and diffusion gradient in thin film-unstable phosphorus(PD GT)in OW and inactivate the P DGTin the upper sediment.The elimination efficiencies of RSP by the direct HFO and HFO/calcite mixture addition were 48.9%-97.0%and 42.4%-95.4%,respectively.The alteration in the addition mode from the one-time to multiple direct addition was beneficial to the immobilization of RSP and PD GTin OW and P DGTin the upper sediment by HFO and HFO/calcite mixture under the feed input condition in the long run.Permeable fabric wrapping reduced the inactivation efficiency of RSP in OW by HFO and HFO/calcite mixture,but it made the recycling of these materials possible.Most of P immobilized by HFO and HFO/calcite mixture was relatively or very stable.After the HFO and HFO/calcite mixture addition,the composition of bacterial communities in the surface sediment changed.However,the bacterial communities in the amended sediments still can perform good ecological function.Our findings suggest that HFO and HFO/calcite mixture are promising phosphorus-immobilization materials for the inactivation of RSP and PD GTin OW and PD GTin the upper sediment under the feed inputting condition.
