Respiratory rate monitoring is of great significance in pig healthy breeding for the early detection and timely prevention of respiratory diseases.Humidity sensing is an important noncontact method to monitor pig resp...Respiratory rate monitoring is of great significance in pig healthy breeding for the early detection and timely prevention of respiratory diseases.Humidity sensing is an important noncontact method to monitor pig respiration,which does not cause direct harm to pigs and meets the requirements of animal welfare.This paper proposes a humidity sensor based on graphene oxide wrapped-silica microspheres(GO@SiO_(2)).First,the sensor shows fast response/recovery performances of 0.24/0.73 s.Experiments demonstrate that the wrapped microsphere structure can inhibit water aggregation.It is speculated that the wrapped microsphere structure can inhibit the stacking of GO,and its curved surface can promote the evaporation of water molecules.Second,the sensor shows a high sensitivity of 1.2%/%RH-4.2%/%RH in 11%-95%RH range.This can be attributed to different sensing mechanisms,from hopping transport to increasing ion transport,leading to a significant change in the sensor’s resistance.Third,the sensor shows selectivity to water molecules due to the hydrophilic characteristic of GO and the significant increase in conductivity by ion transport.Finally,the sensor is applied to realize the respiratory rate monitoring of adult pigs and piglets.展开更多
BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing...BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress responses.Moreover,stress responses are more severe in older adult patients.Therefore,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal surgery.and demonstrate nursing benefits through clinical practice.METHODS This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress response.Next,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,respectively.Intraoperative physiological parameters during surgery and postoperative recovery indicators were compared between the groups.RESULTS Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and swelling.The appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation training.Compared with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of postoperative infection,obstruction,poor wound healing,and gastrointestinal reactions were lower in the study group(all P<0.05).CONCLUSION The evidence-based nursing measures targeting stress responses based on the conventional ERAS nursing model resulted in stable intraoperative physiological parameters during surgery,promoted postoperative recovery,and reduced the incidence of complications.展开更多
Flexible piezoresistive pressure sensors have attracted much attention for applications in health monitoring and human-machine interfaces due to their simple device structures and easy-to-read signals.For practical ap...Flexible piezoresistive pressure sensors have attracted much attention for applications in health monitoring and human-machine interfaces due to their simple device structures and easy-to-read signals.For practical applications,the deployment of flexible pressure sensors characterized by high sensitivity and fast response time is imperative for the rapid and accurate detection and monitoring of tiny signals.Such capabilities are essential for facilitating immediate feedback and informed decision-making across a spectrum of contexts.Drawing lessons from the hypersensitive and fast-responding pressure sensing structures in the dragonfly’s neck(for stable imaging during its highly maneuverable flight),a Biomimetic Piezoresistive Pressure Sensor(BPPS)with exquisite mechanically interlocking sensing microstructures is developed.Each interlocking perceptual structure pair consists of an ox-horn-shaped and a mushroom-shaped structural unit.Through the characteristic configuration of the perceptual structure pair,the BPPS realizes a fast gradient accumulation of the contact area,thus synergistically enhancing the sensitivity and fast response capability.Remarkably,the sensitivity of the BPPS reaches 0.35 kPa^(−1),which increased by 75%compared to the 0.2 kPa^(−1) of the pressure sensors without biomimetic structures.Moreover,the BPPS also achieves rapid response/recovery times(<90/15 ms).Our BPPS finds utility in tasks such as identifying objects of different weights,monitoring human respiratory status,and tracking motion,demonstrating its potential in wearable healthcare devices,assistive technology,and intelligent soft robotics.Moreover,it possesses the advantages of high sensitivity and fast response time in practical applications.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is a common and frequently encountered malignancy in clinical practice.Patients who lack understanding of the disease and surgical treatment are prone to fear,depression,and oth...BACKGROUND Hepatocellular carcinoma(HCC)is a common and frequently encountered malignancy in clinical practice.Patients who lack understanding of the disease and surgical treatment are prone to fear,depression,and other negative emotions,which further aggravate psychological stress.As such,less stimulating and minimally invasive surgical modalities,such as ultrasound-guided interventions,should be adopted to alleviate or eliminate negative perioperative psychological states,which can be evaluated using validated tools such as the Hamilton Anxiety Scale(HAM-A)and Hamilton Depression Scale(HAM-D).AIM To investigate the impact of ultrasound-guided surgery on stress,complications,and recovery in patients with HCC and comorbid anxiety/depression.METHODS Ninety patients with primary small HCC and comorbid anxiety/depression were randomly divided into 2 groups according to treatment(n=45 each):Experimental(ultrasound-guided intervention);and control(conventional laparoscopic hepatectomy).The HAM-A and HAM-D were used to assess psychological states before and 1 week after surgery.C-reactive protein(CRP),vascular endothelial growth factor(VEGF),and superoxide dismutase(SOD)levels,in addition to specific liver-function indicators,complication rates,and postoperative metrics were measured.Recurrence rates were monitored for 6 months.RESULTS There were no significant differences in preoperative HAM-A and HAM-D scores between the 2 groups(P>0.05);however,scores in the study group were significantly lower postoperatively(P<0.05).On postoperative day 1,there were no significant differences in serum levels of CRP,VEGF,or SOD between the groups(P>0.05),whereas the levels in the intervention group were significantly lower than those in the control group on days 3 and 7(P<0.05).The incidence of postoperative complications in the study group(6.66%)was significantly lower than that in the control group[17.78%(P<0.05)].The study group also had a significantly shorter time to first flatus,oral intake,and postoperative hospital stay(P<0.05).Postoperative serum alanine aminotransferase,aspartate aminotransferase,and total bilirubin levels decreased in both groups compared with preoperative levels,although with significantly lower values in the study group(P<0.05)but no differences preoperatively(P>0.05).There was no statistical difference in tumor recurrence rates between the 2 groups during the six-month follow-up(P>0.05).CONCLUSION Ultrasound-guided intervention for patients with primary small HCC and anxiety/depression effectively improves negative emotional states,reduce stress responses,decreases postoperative complications,promotes recovery,and enhances quality of life.展开更多
Response prediction is a fundamental yet challenging task in aeronautical engineering,requiring an accurate selection of sensor positions correlated with the target responses to achieve precise predictions. Unfortunat...Response prediction is a fundamental yet challenging task in aeronautical engineering,requiring an accurate selection of sensor positions correlated with the target responses to achieve precise predictions. Unfortunately, in large-scale structures, the rigorous selection of reliable sensor candidates for multi-target responses remains largely unexplored. In this paper, we propose a flexible and generalized framework for selecting the most relevant sensors to the multi-target response and predicting the target response, referred to as the Fast-aware Multi-Target Response Prediction(FMTRP) approach in the spirit of divide-and-conquer. Specifically, first, a multi-task learning module is designed to predict multi-point response tasks at the same time. Simultaneously, we meticulously devise adaptive mechanisms to facilitate loss-term reweighting and encourage prioritization of challenging tasks in multiple prediction tasks. Second, to ensure ease of interpretation,we introduce a hybrid penalty to select sensors at the group-sparsity, individual-sparsity and element-sparsity levels. Finally, due to the substantial number of candidate sensors posing a significant computational burden, we develop a more efficient search strategy and support computation to make the proposed approach applicable in practice, leading to substantial runtime improvements. Extensive experiments on aircraft standard model response datasets and large airliner test flight datasets validate the effectiveness of the proposed approach in identifying sensor locations and simultaneously predicting responses at multiple points. Compared to state-of-the-art methods,the proposed approach achieves an accuracy of over 99% in sinusoidal excitation and exhibits the shortest runtime(3.514 s).展开更多
Two novel decyloxyphenylquinoxaline-based donor-acceptor （D-A） electroactive monomers bearing dialkoxythiophene as the donor unit are synthesized using Stille coupling reaction. The corresponding polymers, poly[2,3-...Two novel decyloxyphenylquinoxaline-based donor-acceptor （D-A） electroactive monomers bearing dialkoxythiophene as the donor unit are synthesized using Stille coupling reaction. The corresponding polymers, poly[2,3- bis（4-decyloxyphenyl）-5,8-bis（3,4-dimethoxylthiophen-2-yl）quinoxaline] （P1） and poly[2,3-bis（4-decyloxyphenyl）-5,8- bis（2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl）quinoxaline] （P2）, are directly deposited onto the working electrode surface by electropolymerization. All materials were characterized by nuclear magnetic resonance （NMR）, mass spectrometry （MS）, scanning electron microscopy （SEM）, cyclic voltammetry （CV）, ultraviolet-visible absorption spectrometry （UV-Vis） and spectro-electrochemical measurements. Electrochemical studies demonstrate that both polymers are capable of showing both reasonable n- and p-doping processes, and advanced long-term switching stabilities. 3,4-Ethylenedioxythiophene substituted for 3,4-dimethoxythiophene as a donor unit, which enhances the conjugated double-bond character of the conducting polymer, thus leading to a lower electronic band-gap. Likewise, the neutral state color of the synthesized polymer tuned from blue to blue-green corresponding to the red shift of the maximum absorption wavelengths in the visible region. In addition, kinetics study of P1 revealed 42% （595 nm）, 30% （839 nm） and 69% （1500 nm） transmittance changes （A7%）, while P2 exhibited 32% （740 nm）, 71% （2000 nm） at the dominant wavelengths. It was also observed that both films could switch quickly between the neutral state and oxidation state, with the response time less than 1 s both in visible and near infrared regions.展开更多
Six coupled general circulation models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) are em-ployed for examining the full evolution of the North Pacific mode water and Subtropical Countercurrent (STCC...Six coupled general circulation models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) are em-ployed for examining the full evolution of the North Pacific mode water and Subtropical Countercurrent (STCC) under global warming over 400 years following the Representative Concentration Pathways (RCP) 4.5. The mode water and STCC first show a sharp weakening trend when the radiative forcing increases, but then reverse to a slow strengthening trend of smaller magnitude after the radiative forcing is stablized. As the radiative forcing increases during the 21st century, the ocean warming is surface-intensified and decreases with depth, strengthening the upper ocean's stratification and becoming unfavorable for the mode water formation. Moving southward in the subtropical gyre, the shrinking mode water decelerates the STCC to the south. After the radiative forcing is stabilized in the 2070s, the subsequent warming is greater at the subsurface than at the sea surface, destabilizing the upper ocean and becoming favorable for the mode water formation. As a result, the mode water and STCC recover gradually after the radiative forc-ing is stabilized.展开更多
MoS2,acting as a promising gas sensing material,has shown huge potential in monitoring of toxic and harmful gases at room temperature.However,MoS2-based gas sensors still suffer from poor gas sensing performance such ...MoS2,acting as a promising gas sensing material,has shown huge potential in monitoring of toxic and harmful gases at room temperature.However,MoS2-based gas sensors still suffer from poor gas sensing performance such as poor sensitivity,long response time.Constructing the hete ro structure is an effective approach to improve gas-sensing performance of MoS2.Herein,PbS@MoS2 composites synthesized by mechanical exfoliation combining with wet-chemical precipitation are used to investigate its performance in detecting NO2 at room temperature.The response value of PbS@MoS2 gas sensor against NO2 is significantly improved compared with the pure MoS2 gas sensor.At the same time,the modification with PbS also accelerates the response speed of MoS2,and the response time is almost reduced by two orders of magnitude,from hundreds of seconds to less than ten seconds.The enhanced response value and fast response time are mainly benefited from the modulation effect of NO2 to PbS@MoS2 heterostructure and the mechanically exfoliated MoS2 surface with few defects.This work can be expected to provide useful guidance for designing composite materials with excellent gas sensing properties.展开更多
Red mud, the waste generated during alumina production, contains iron and other valuable metals. To recover the iron efficiently from red mud, a three-factor five-level central composite design in response surface met...Red mud, the waste generated during alumina production, contains iron and other valuable metals. To recover the iron efficiently from red mud, a three-factor five-level central composite design in response surface methodology was used to study the effects of process parameters, such as FC/O （the molar ratio of fixed carbon in coal to reducible oxygen of iron oxide in red mud）, reduction temperature, reduction time, and their interaction on the iron recovery rate and total iron content in magnetic product obtained from the process of direct reduction-magnetic separation. The relevant assessment model was established. The model could predict the changing rules of iron recovery rate and total iron content in the magnetic product affected by the process parameters. The results show that the iron recovery rate is significantly influenced by three factors and reduction temperature plays the most important role. The iron recovery rate and total iron content in magnetic product could be up to 98.37 and 82.52%, respectively, under the numerically optimal process parameters condition of reduction temperature of 1400 ℃, FC/O of 0.80 and reduction time of 100 min obtained by the assessment model. The predicted values are in good agreement with the experimental values.展开更多
Unit commitment (UC) is to determine the optimal unit status and generation level during each time interval of the scheduled period. The purpose of UC is to minimize the total generation cost while satisfying system d...Unit commitment (UC) is to determine the optimal unit status and generation level during each time interval of the scheduled period. The purpose of UC is to minimize the total generation cost while satisfying system demand, reserve requirements, and unit constraints. Among the UC constraints, an adequate provision of reserve is important to ensure the security of power system and the fast-response reserve is essential to bring system frequency back to acceptable level following the loss of an online unit within a few seconds. In this paper, the authors present and solve a UC problem including the frequency-based reserve constraints to determine the optimal FRR requirements and unit MW schedules. The UC problem is solved by using Lagrangian Relaxation-based approach and compared with the actual system schedules. It is observed that favorable reserve and unit MW schedules are obtained by the proposed method while the system security is maintained.展开更多
The inertia response and primary frequency regulation capability of synchronous grids are declining owing to the increasing penetration of inverter-based resources. The fast frequency response(FFR) of inverter-based r...The inertia response and primary frequency regulation capability of synchronous grids are declining owing to the increasing penetration of inverter-based resources. The fast frequency response(FFR) of inverter-based resources is an important mitigation option for maintaining grid security under the conditions of low inertia and insufficient primary frequency response capability. However, the understanding and technical characteristics of the FFR of inverter-based resources are still unclear. Aiming at solving the aforementioned problems, this paper proposes a definition for FFR based on the impact mechanism of FFR on system frequency. The performance requirements of FFR are clarified. Then, the effects of FFR on system frequency characteristics are further analyzed based on steady-state frequency deviation, the initial rate of change of frequency, and the maximum transient frequency deviation. Finally, the system requirements for FFR and its application effects are verified by simulating an actual bulk power grid, providing technical support for subsequent engineering application.展开更多
In 26 patients with confirmed primary verified gonarthrosis(PGA),a clinical and instrumental examination was conducted to evaluate the response energy osteopathy followed by statistical processing of the data.Three ty...In 26 patients with confirmed primary verified gonarthrosis(PGA),a clinical and instrumental examination was conducted to evaluate the response energy osteopathy followed by statistical processing of the data.Three types of the body’s response to treatment were identified:immediate,fast,and delayed,which,despite the different informative value of the data of the polyparametric study,allowed judging the effectiveness of the method used.展开更多
In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain sta...In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.展开更多
Six kinds of Sn(OH)_4 precipitates were prepared by the chemical precipitation method (liquid-phase),of which the pH values are 3.0 (sample 1),4.5 (sample 2),6.0 (sample 3),7.5 (sample 4),9.0 (sample 5) and 10.5 (samp...Six kinds of Sn(OH)_4 precipitates were prepared by the chemical precipitation method (liquid-phase),of which the pH values are 3.0 (sample 1),4.5 (sample 2),6.0 (sample 3),7.5 (sample 4),9.0 (sample 5) and 10.5 (sample 6),respectively. After washed and dried,the Sn(OH)_4 precipitates were first calcined into tin oxide powder.Six kinds of gas sensors were made from the obtained SnO_2 powders.The XRD patterns of all the samples were recorded.The sensing properties of all samples to C_2H_5OH and H_2 gases were measured in different gas concentrations and temperatures,including the sensitivities of all samples,their response and recovery properties.The recovery properties of all samples to C_2H_5OH exhibit the sinusoidal oscillation character.展开更多
In this study,the decomposed fast and slow responses of clouds to an abruptly quadrupled CO_(2)concentration(approximately 1139 ppmv)in East Asia(EA)are obtained quantitatively by using a general circulation model,BCC...In this study,the decomposed fast and slow responses of clouds to an abruptly quadrupled CO_(2)concentration(approximately 1139 ppmv)in East Asia(EA)are obtained quantitatively by using a general circulation model,BCC–AGCM2.0.Our results show that in the total response,the total cloud cover(TCC),low cloud cover(LCC),and high cloud cover(HCC)all increased north of 40°N and decreased south of 40°N except in the Tibetan Plateau(TP).The mean changes of the TCC,LCC,and HCC in EA were–0.74%,0.38%,and–0.38%in the total response,respectively;1.05%,–0.03%,and 1.63%in the fast response,respectively;and–1.79%,0.41%,and–2.01%in the slow response,respectively.By comparison,we found that changes in cloud cover were dominated by the slow response in most areas in EA due to the changes in atmospheric temperature,circulation,and water vapor supply together.Overall,the changes in the cloud forcing over EA related to the fast and slow responses were opposite to each other,and the final cloud forcing was dominated by the slow response.The mean net cloud forcing(NCF)in the total response over EA was–1.80 W m^(–2),indicating a cooling effect which partially offset the warming effect caused by the quadrupled CO_(2).The total responses of NCF in the TP,south China(SC),and northeast China(NE)were–6.74 W m^(–2),6.11 W m^(–2),and–7.49 W m^(–2),respectively.Thus,the local effects of offsetting or amplifying warming were particularly obvious.展开更多
In this article,an effective technique is developed to efficiently obtain the output responses of parameterized structural dynamic problems.This technique is based on the conception of reduced basis method and the usa...In this article,an effective technique is developed to efficiently obtain the output responses of parameterized structural dynamic problems.This technique is based on the conception of reduced basis method and the usage of linear interpolation principle.The original problem is projected onto the reduced basis space by linear interpolation projection,and subsequently an associated interpolation matrix is generated.To ensure the largest nonsingularity,the interpolation matrix needs to go through a timenode choosing process,which is developed by applying the angle of vector spaces.As a part of this technique,error estimation is recommended for achieving the computational error bound.To ensure the successful performance of this technique,the offline-online computational procedures are conducted in practical engineering.Two numerical examples demonstrate the accuracy and efficiency of the presented method.展开更多
The modeling methodologies and calculation of dynamic response of underground structure under Rayleigh waves is investigated in this paper. First the free field responses under Rayleigh waves are analyzed and the nume...The modeling methodologies and calculation of dynamic response of underground structure under Rayleigh waves is investigated in this paper. First the free field responses under Rayleigh waves are analyzed and the numerical results agree well with the theoretical results. Then, the approximate Rayleigh waves are put forward based on the preliminary re- search, and Rayleigh wave field is obtained through fast Fourier transform technique. Taking a utility tunnel as an example, its dynamic responses under Rayleigh waves is calculated by ABAQUS. The results demonstrate that bending deformation is the main component of structural deformation and the deformation at the top of the structure is about twice as much as that at bottom of the structure. The effect of soil-structure interface and the buried depth of underground structure are also investi- gated via parameter analysis. For the shallow buffed underground structures, Rayleigh waves can be the key factor to control the responses and damage of the structure.展开更多
BACKGROUND: Fast track strategy in the management of patients undergoing intra-abdominal surgery of various types has emerged as a landmark approach to reduce surgical stress and accelerate recovery. This study was to...BACKGROUND: Fast track strategy in the management of patients undergoing intra-abdominal surgery of various types has emerged as a landmark approach to reduce surgical stress and accelerate recovery. This study was to evaluate the effect of fast track strategy on patients subjected to pancreaticoduo-denectomy (PD) from an individual unit during transit from low to a high volume center. METHODS: A total of 142 PD patients who had been subjected to fast track strategy between June 2008 and September 2012 were compared with 46 patients who had received convention-al surgery between January 2006 and May 2008. Comparative analysis was made of postoperative complications, postopera-tive recovery, length of hospital stay and patient readmission requirement. RESULTS: The patients subjected to fast track strategy had a faster recovery and a shorter hospital stay than those who were treated conventionally (7.8 vs 12.1 days). The intraoperative events like operative blood loss (417.9±83.8 vs 997.4 ±151.8 mL, P<0.001), blood transfused (a median of 0 vs 1 unit,P<0.001) and operative time taken (125 vs 245 minutes,P<0.001) were signiifcantly lower in the fast track group. The frequency of pancreatic ifstula (4.9% vs 13.0%) and delayed gastric empty-ing (7.0% vs 17.4%) was also signiifcantly reduced with fast track treatment. Nevertheless, the readmission rate (11.3% vs 6.5%) was found relatively higher within the fast track group. However, increased readmission rates in this study seem to be independent of fast track protocol. CONCLUSIONS: This preliminary analysis suggests that the fast track approach might be beneifcial to the well-being of the patients after PD, for it accelerates the immediate clinical recovery of patients and signiifcantly shortens their length of hospital stay.展开更多
Fourier transform （FF） is a commonly used method in spectral analysis of ocean wave and offshore structure responses, but it is not suitable for records of short length. In this paper another method, wavelet transfo...Fourier transform （FF） is a commonly used method in spectral analysis of ocean wave and offshore structure responses, but it is not suitable for records of short length. In this paper another method, wavelet transform （WT）, is applied to ＇analyze the data of short length. The Morlet wavelet is employed to calculate the spectra density functions for wave records and simulated Floating Production Storage and Offloading （FPSO） vessels＇ responses. Computed wave data include simulated wave data based on JONSWAP spectrum and the recorded data of Storm 149 from North Alwyn. Wavelet method is validated by comparing the statistical characteristics by WF method and those by fast Fourier transform （FFT） method with those of target spectra. The spectral density fnnctions＇ shapes calculated by WT are less malformed and have less error of statistical characteristics compared with those by FT especially when the record lengths decrease.展开更多
Spinal cord injury(SCI)is a serious traumatic event to the central nervous system.Studies show that long non-coding RNAs(lncRNAs)play an important role in regulating the inflammatory response in the acute stage of SCI...Spinal cord injury(SCI)is a serious traumatic event to the central nervous system.Studies show that long non-coding RNAs(lncRNAs)play an important role in regulating the inflammatory response in the acute stage of SCI.Here,we investigated a new lncRNA related to spinal cord injury and acute inflammation.We analyzed the expression profile of lncRNAs after SCI,and explored the role of lncRNA Airsci(acute inflammatory response in SCI)on recovery following acute SCI.The rats were divided into the control group,SCI group,and SCI+lncRNA Airsci-siRNA group.The expression of inflammatory factors,including nuclear factor kappa B[NF-κB(p65)],NF-κB inhibitor IκBαand phosphorylated IκBα(p-IκBα),and the p-IκBα/IκBαratio were examined 1–28 days after SCI in rats by western blot assay.The differential lncRNA expression profile after SCI was assessed by RNA sequencing.The differentially expressed lncRNAs were analyzed by bioinformatics technology.The differentially expressed lncRNA Airsci,which is involved in NF-κB signaling and associated with the acute inflammatory response,was verified by quantitative real-time PCR.Interleukin(IL-1β),IL-6 and tumor necrosis factor(TNF-α)at 3 days after SCI were measured by western blot assay and quantitative real-time PCR.The histopathology of the spinal cord was evaluated by hematoxylin-eosin and Nissl staining.Motor function was assessed with the Basso,Beattie and Bresnahan Locomotor Rating Scale.Numerous differentially expressed lncRNAs were detected after SCI,including 151 that were upregulated and 186 that were downregulated in the SCI 3 d group compared with the control group.LncRNA Airsci was the most significantly expressed among the five lncRNAs involved in the NF-κB signaling pathway.LncRNA Airsci-siRNA reduced the inflammatory response by inhibiting the NF-κB signaling pathway,alleviated spinal cord tissue injury,and promoted the recovery of motor function in SCI rats.These findings show that numerous lncRNAs are differentially expressed following SCI,and that inhibiting lncRNA Airsci reduces the inflammatory response through the NF-κB signaling pathway,thereby promoting functional recovery.All experimental procedures and protocols were approved by the approved by the Animal Ethics Committee of Jining Medical University(approval No.JNMC-2020-DW-RM-003)on January 18,2020.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12302127)the Talents Introduction Project of Xihua University(Grant No.Z241008)the Key Project of Sichuan Province Modern Agricultural Equipment Engineering Technology Research Center(Grant No.XDNY2024-002).
文摘Respiratory rate monitoring is of great significance in pig healthy breeding for the early detection and timely prevention of respiratory diseases.Humidity sensing is an important noncontact method to monitor pig respiration,which does not cause direct harm to pigs and meets the requirements of animal welfare.This paper proposes a humidity sensor based on graphene oxide wrapped-silica microspheres(GO@SiO_(2)).First,the sensor shows fast response/recovery performances of 0.24/0.73 s.Experiments demonstrate that the wrapped microsphere structure can inhibit water aggregation.It is speculated that the wrapped microsphere structure can inhibit the stacking of GO,and its curved surface can promote the evaporation of water molecules.Second,the sensor shows a high sensitivity of 1.2%/%RH-4.2%/%RH in 11%-95%RH range.This can be attributed to different sensing mechanisms,from hopping transport to increasing ion transport,leading to a significant change in the sensor’s resistance.Third,the sensor shows selectivity to water molecules due to the hydrophilic characteristic of GO and the significant increase in conductivity by ion transport.Finally,the sensor is applied to realize the respiratory rate monitoring of adult pigs and piglets.
文摘BACKGROUND Although the 2021 Chinese Clinical Practice Guidelines for Enhanced Recovery after Surgery(ERAS)provide recommendations for ERAS in gastrointestinal surgery,the clinical application of standard ERAS nursing models is challenging due to the variety of diseases involved in gastrointestinal surgery and the com-plex factors contributing to patient stress responses.Moreover,stress responses are more severe in older adult patients.Therefore,precision medicine is required to improve the quality of nursing care and promote postoperative recovery in gastrointestinal surgery.and demonstrate nursing benefits through clinical practice.METHODS This randomized clinical trial first established an evidence-based nursing ERAS protocol in older adult patients based on literature related to perioperative nursing measures for gastrointestinal surgery stress response.Next,392 older adult patients who underwent gastrointestinal surgery and were admitted to our hospital between December 2021 and June 2023 were categorized into two groups to receive evidence-based(study group)or conventional(control group)ERAS nursing models,respectively.Intraoperative physiological parameters during surgery and postoperative recovery indicators were compared between the groups.RESULTS Among 64 domestic and international studies,the stress responses of older adult patients mainly included emotional anxiety,sleep disorders,gastrointestinal discomfort,physical weakness,pain,and swelling.The appropriate nursing interventions included comprehensive psychological counseling,pre-and postoperative nutritional support,temperature control,pain management,and rehabilitation training.Compared with the control group,the study group showed lower heart rate,mean arterial pressure,blood glucose level,and adrenaline level;shorter duration of drainage tube placement,time to first flatus,time to first ambulation,and postoperative hospital stay;lower anxiety scores on postoperative day 3;and lower incidences of postoperative infection,obstruction,poor wound healing,and gastrointestinal reactions were lower in the study group(all P<0.05).CONCLUSION The evidence-based nursing measures targeting stress responses based on the conventional ERAS nursing model resulted in stable intraoperative physiological parameters during surgery,promoted postoperative recovery,and reduced the incidence of complications.
基金supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.52021003)National Natural Science Foundation of China(Nos.52222509,52105301)+1 种基金the Natural Science Foundation of Jilin Province(Grant No.20220101220JC)supported by“Fundamental Research Funds for the Central Universities”.
文摘Flexible piezoresistive pressure sensors have attracted much attention for applications in health monitoring and human-machine interfaces due to their simple device structures and easy-to-read signals.For practical applications,the deployment of flexible pressure sensors characterized by high sensitivity and fast response time is imperative for the rapid and accurate detection and monitoring of tiny signals.Such capabilities are essential for facilitating immediate feedback and informed decision-making across a spectrum of contexts.Drawing lessons from the hypersensitive and fast-responding pressure sensing structures in the dragonfly’s neck(for stable imaging during its highly maneuverable flight),a Biomimetic Piezoresistive Pressure Sensor(BPPS)with exquisite mechanically interlocking sensing microstructures is developed.Each interlocking perceptual structure pair consists of an ox-horn-shaped and a mushroom-shaped structural unit.Through the characteristic configuration of the perceptual structure pair,the BPPS realizes a fast gradient accumulation of the contact area,thus synergistically enhancing the sensitivity and fast response capability.Remarkably,the sensitivity of the BPPS reaches 0.35 kPa^(−1),which increased by 75%compared to the 0.2 kPa^(−1) of the pressure sensors without biomimetic structures.Moreover,the BPPS also achieves rapid response/recovery times(<90/15 ms).Our BPPS finds utility in tasks such as identifying objects of different weights,monitoring human respiratory status,and tracking motion,demonstrating its potential in wearable healthcare devices,assistive technology,and intelligent soft robotics.Moreover,it possesses the advantages of high sensitivity and fast response time in practical applications.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is a common and frequently encountered malignancy in clinical practice.Patients who lack understanding of the disease and surgical treatment are prone to fear,depression,and other negative emotions,which further aggravate psychological stress.As such,less stimulating and minimally invasive surgical modalities,such as ultrasound-guided interventions,should be adopted to alleviate or eliminate negative perioperative psychological states,which can be evaluated using validated tools such as the Hamilton Anxiety Scale(HAM-A)and Hamilton Depression Scale(HAM-D).AIM To investigate the impact of ultrasound-guided surgery on stress,complications,and recovery in patients with HCC and comorbid anxiety/depression.METHODS Ninety patients with primary small HCC and comorbid anxiety/depression were randomly divided into 2 groups according to treatment(n=45 each):Experimental(ultrasound-guided intervention);and control(conventional laparoscopic hepatectomy).The HAM-A and HAM-D were used to assess psychological states before and 1 week after surgery.C-reactive protein(CRP),vascular endothelial growth factor(VEGF),and superoxide dismutase(SOD)levels,in addition to specific liver-function indicators,complication rates,and postoperative metrics were measured.Recurrence rates were monitored for 6 months.RESULTS There were no significant differences in preoperative HAM-A and HAM-D scores between the 2 groups(P>0.05);however,scores in the study group were significantly lower postoperatively(P<0.05).On postoperative day 1,there were no significant differences in serum levels of CRP,VEGF,or SOD between the groups(P>0.05),whereas the levels in the intervention group were significantly lower than those in the control group on days 3 and 7(P<0.05).The incidence of postoperative complications in the study group(6.66%)was significantly lower than that in the control group[17.78%(P<0.05)].The study group also had a significantly shorter time to first flatus,oral intake,and postoperative hospital stay(P<0.05).Postoperative serum alanine aminotransferase,aspartate aminotransferase,and total bilirubin levels decreased in both groups compared with preoperative levels,although with significantly lower values in the study group(P<0.05)but no differences preoperatively(P>0.05).There was no statistical difference in tumor recurrence rates between the 2 groups during the six-month follow-up(P>0.05).CONCLUSION Ultrasound-guided intervention for patients with primary small HCC and anxiety/depression effectively improves negative emotional states,reduce stress responses,decreases postoperative complications,promotes recovery,and enhances quality of life.
基金sponsored by the Innovation Foundation for National Natural Science Foundation of China(No.11872312)。
文摘Response prediction is a fundamental yet challenging task in aeronautical engineering,requiring an accurate selection of sensor positions correlated with the target responses to achieve precise predictions. Unfortunately, in large-scale structures, the rigorous selection of reliable sensor candidates for multi-target responses remains largely unexplored. In this paper, we propose a flexible and generalized framework for selecting the most relevant sensors to the multi-target response and predicting the target response, referred to as the Fast-aware Multi-Target Response Prediction(FMTRP) approach in the spirit of divide-and-conquer. Specifically, first, a multi-task learning module is designed to predict multi-point response tasks at the same time. Simultaneously, we meticulously devise adaptive mechanisms to facilitate loss-term reweighting and encourage prioritization of challenging tasks in multiple prediction tasks. Second, to ensure ease of interpretation,we introduce a hybrid penalty to select sensors at the group-sparsity, individual-sparsity and element-sparsity levels. Finally, due to the substantial number of candidate sensors posing a significant computational burden, we develop a more efficient search strategy and support computation to make the proposed approach applicable in practice, leading to substantial runtime improvements. Extensive experiments on aircraft standard model response datasets and large airliner test flight datasets validate the effectiveness of the proposed approach in identifying sensor locations and simultaneously predicting responses at multiple points. Compared to state-of-the-art methods,the proposed approach achieves an accuracy of over 99% in sinusoidal excitation and exhibits the shortest runtime(3.514 s).
基金financially supported by the National Natural Science Foundation of China(Nos.51473074 and 31400044)the General and Special Program of the Postdoctoral Science Foundation China(Nos.2013M530397 and 2014T70861)+1 种基金the Postgraduate Innovation Project of China University of Petroleum(East China)(No.YCX2015022)the Fundamental Research Funds for the Central Universities(No.15CX06049A)
文摘Two novel decyloxyphenylquinoxaline-based donor-acceptor （D-A） electroactive monomers bearing dialkoxythiophene as the donor unit are synthesized using Stille coupling reaction. The corresponding polymers, poly[2,3- bis（4-decyloxyphenyl）-5,8-bis（3,4-dimethoxylthiophen-2-yl）quinoxaline] （P1） and poly[2,3-bis（4-decyloxyphenyl）-5,8- bis（2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl）quinoxaline] （P2）, are directly deposited onto the working electrode surface by electropolymerization. All materials were characterized by nuclear magnetic resonance （NMR）, mass spectrometry （MS）, scanning electron microscopy （SEM）, cyclic voltammetry （CV）, ultraviolet-visible absorption spectrometry （UV-Vis） and spectro-electrochemical measurements. Electrochemical studies demonstrate that both polymers are capable of showing both reasonable n- and p-doping processes, and advanced long-term switching stabilities. 3,4-Ethylenedioxythiophene substituted for 3,4-dimethoxythiophene as a donor unit, which enhances the conjugated double-bond character of the conducting polymer, thus leading to a lower electronic band-gap. Likewise, the neutral state color of the synthesized polymer tuned from blue to blue-green corresponding to the red shift of the maximum absorption wavelengths in the visible region. In addition, kinetics study of P1 revealed 42% （595 nm）, 30% （839 nm） and 69% （1500 nm） transmittance changes （A7%）, while P2 exhibited 32% （740 nm）, 71% （2000 nm） at the dominant wavelengths. It was also observed that both films could switch quickly between the neutral state and oxidation state, with the response time less than 1 s both in visible and near infrared regions.
基金supported by the National Basic Research Program of China(2012CB955602)National Key Program for Developing Basic Science(2010CB428904)Natural Science Foundation of China(41176006 and 40921004)
文摘Six coupled general circulation models from the Coupled Model Intercomparison Project Phase 5 (CMIP5) are em-ployed for examining the full evolution of the North Pacific mode water and Subtropical Countercurrent (STCC) under global warming over 400 years following the Representative Concentration Pathways (RCP) 4.5. The mode water and STCC first show a sharp weakening trend when the radiative forcing increases, but then reverse to a slow strengthening trend of smaller magnitude after the radiative forcing is stablized. As the radiative forcing increases during the 21st century, the ocean warming is surface-intensified and decreases with depth, strengthening the upper ocean's stratification and becoming unfavorable for the mode water formation. Moving southward in the subtropical gyre, the shrinking mode water decelerates the STCC to the south. After the radiative forcing is stabilized in the 2070s, the subsequent warming is greater at the subsurface than at the sea surface, destabilizing the upper ocean and becoming favorable for the mode water formation. As a result, the mode water and STCC recover gradually after the radiative forc-ing is stabilized.
基金supported by Hunan Provincial Natural Science Foundation of China(No.2018JJ2404)Scientific Research Foundation of Hunan Provincial Education Department(Nos.19A475,19C1739)Hunan Science and Technology Plan Program(No.2019RS1056)。
文摘MoS2,acting as a promising gas sensing material,has shown huge potential in monitoring of toxic and harmful gases at room temperature.However,MoS2-based gas sensors still suffer from poor gas sensing performance such as poor sensitivity,long response time.Constructing the hete ro structure is an effective approach to improve gas-sensing performance of MoS2.Herein,PbS@MoS2 composites synthesized by mechanical exfoliation combining with wet-chemical precipitation are used to investigate its performance in detecting NO2 at room temperature.The response value of PbS@MoS2 gas sensor against NO2 is significantly improved compared with the pure MoS2 gas sensor.At the same time,the modification with PbS also accelerates the response speed of MoS2,and the response time is almost reduced by two orders of magnitude,from hundreds of seconds to less than ten seconds.The enhanced response value and fast response time are mainly benefited from the modulation effect of NO2 to PbS@MoS2 heterostructure and the mechanically exfoliated MoS2 surface with few defects.This work can be expected to provide useful guidance for designing composite materials with excellent gas sensing properties.
基金The authors are especially thankful to the National Natural Science Foundation of China （51374058 and 51704061 ）, China Postdoctoral Science Foundation （2016M601321 ） and Fundamental Research Funds of the Central Universities of China （N162503003）.
文摘Red mud, the waste generated during alumina production, contains iron and other valuable metals. To recover the iron efficiently from red mud, a three-factor five-level central composite design in response surface methodology was used to study the effects of process parameters, such as FC/O （the molar ratio of fixed carbon in coal to reducible oxygen of iron oxide in red mud）, reduction temperature, reduction time, and their interaction on the iron recovery rate and total iron content in magnetic product obtained from the process of direct reduction-magnetic separation. The relevant assessment model was established. The model could predict the changing rules of iron recovery rate and total iron content in the magnetic product affected by the process parameters. The results show that the iron recovery rate is significantly influenced by three factors and reduction temperature plays the most important role. The iron recovery rate and total iron content in magnetic product could be up to 98.37 and 82.52%, respectively, under the numerically optimal process parameters condition of reduction temperature of 1400 ℃, FC/O of 0.80 and reduction time of 100 min obtained by the assessment model. The predicted values are in good agreement with the experimental values.
文摘Unit commitment (UC) is to determine the optimal unit status and generation level during each time interval of the scheduled period. The purpose of UC is to minimize the total generation cost while satisfying system demand, reserve requirements, and unit constraints. Among the UC constraints, an adequate provision of reserve is important to ensure the security of power system and the fast-response reserve is essential to bring system frequency back to acceptable level following the loss of an online unit within a few seconds. In this paper, the authors present and solve a UC problem including the frequency-based reserve constraints to determine the optimal FRR requirements and unit MW schedules. The UC problem is solved by using Lagrangian Relaxation-based approach and compared with the actual system schedules. It is observed that favorable reserve and unit MW schedules are obtained by the proposed method while the system security is maintained.
基金supported by National Science Foundation of China(51477091)。
文摘The inertia response and primary frequency regulation capability of synchronous grids are declining owing to the increasing penetration of inverter-based resources. The fast frequency response(FFR) of inverter-based resources is an important mitigation option for maintaining grid security under the conditions of low inertia and insufficient primary frequency response capability. However, the understanding and technical characteristics of the FFR of inverter-based resources are still unclear. Aiming at solving the aforementioned problems, this paper proposes a definition for FFR based on the impact mechanism of FFR on system frequency. The performance requirements of FFR are clarified. Then, the effects of FFR on system frequency characteristics are further analyzed based on steady-state frequency deviation, the initial rate of change of frequency, and the maximum transient frequency deviation. Finally, the system requirements for FFR and its application effects are verified by simulating an actual bulk power grid, providing technical support for subsequent engineering application.
文摘In 26 patients with confirmed primary verified gonarthrosis(PGA),a clinical and instrumental examination was conducted to evaluate the response energy osteopathy followed by statistical processing of the data.Three types of the body’s response to treatment were identified:immediate,fast,and delayed,which,despite the different informative value of the data of the polyparametric study,allowed judging the effectiveness of the method used.
基金supported by the General Program of the National Natural Science Foundation of China(52074335)the National Key Research and Development Program of China(2022YFE0129900 and 2019YFA0708700)+1 种基金the Fundamental Research Funds for the Central Universities(23CX07003A)the Special Funding Program for the Operational Expenses of National Research Institutions(SKLDOG2024-ZYRC-01).
文摘In deep oil reservoir development,enhanced oil recovery(EOR)techniques encounter significant challenges under high-temperature and high-salinity conditions.Traditional profile-control agents often fail to maintain stable blocking under extreme conditions and exhibit poor resistance to high temperature and high salinity.This study develops a functionalized nanographite system(the MEGO system)with superior high-temperature dispersibility and thermosalinity-responsive capability through polyether amine(PEA)grafting and noncovalent interactions with disodium naphthalene sulfonate(DNS)molecules.The grafted PEA and DNS provide steric hindrance and electrostatic repulsion,enhancing thermal and salinity resistance.After ten days of aggregation,the MEGO system forms stable particle aggregates(55.51-61.80 lm)that are suitable for deep reservoir migration and profile control.Both experiments and simulations reveal that particle size variations are synergistically controlled by temperature and salt ions(Na^(+),Ca^(2+),and Mg^(2+)).Compared with monovalent ions,divalent ions promote nanographite aggregation more strongly through double-layer compression and bridging effects.In core displacement experiments,the MEGO system demonstrated superior performance in reservoirs with permeabilities ranging from 21.6 to 103 mD.The aggregates formed within the pore throats significantly enhanced flow resistance,expanded the sweep volume,and increased the overall oil recovery to 56.01%.This research indicates that the MEGO system holds excellent potential for EOR in deep oil reservoirs.
文摘Six kinds of Sn(OH)_4 precipitates were prepared by the chemical precipitation method (liquid-phase),of which the pH values are 3.0 (sample 1),4.5 (sample 2),6.0 (sample 3),7.5 (sample 4),9.0 (sample 5) and 10.5 (sample 6),respectively. After washed and dried,the Sn(OH)_4 precipitates were first calcined into tin oxide powder.Six kinds of gas sensors were made from the obtained SnO_2 powders.The XRD patterns of all the samples were recorded.The sensing properties of all samples to C_2H_5OH and H_2 gases were measured in different gas concentrations and temperatures,including the sensitivities of all samples,their response and recovery properties.The recovery properties of all samples to C_2H_5OH exhibit the sinusoidal oscillation character.
基金supported by the National Key R&D Program of China(2017YFA0603502)the National Natural Science Foundation of China(Grant No.41905081)S&T Development Fund of CAMS(2021KJ004&2022KJ019).
文摘In this study,the decomposed fast and slow responses of clouds to an abruptly quadrupled CO_(2)concentration(approximately 1139 ppmv)in East Asia(EA)are obtained quantitatively by using a general circulation model,BCC–AGCM2.0.Our results show that in the total response,the total cloud cover(TCC),low cloud cover(LCC),and high cloud cover(HCC)all increased north of 40°N and decreased south of 40°N except in the Tibetan Plateau(TP).The mean changes of the TCC,LCC,and HCC in EA were–0.74%,0.38%,and–0.38%in the total response,respectively;1.05%,–0.03%,and 1.63%in the fast response,respectively;and–1.79%,0.41%,and–2.01%in the slow response,respectively.By comparison,we found that changes in cloud cover were dominated by the slow response in most areas in EA due to the changes in atmospheric temperature,circulation,and water vapor supply together.Overall,the changes in the cloud forcing over EA related to the fast and slow responses were opposite to each other,and the final cloud forcing was dominated by the slow response.The mean net cloud forcing(NCF)in the total response over EA was–1.80 W m^(–2),indicating a cooling effect which partially offset the warming effect caused by the quadrupled CO_(2).The total responses of NCF in the TP,south China(SC),and northeast China(NE)were–6.74 W m^(–2),6.11 W m^(–2),and–7.49 W m^(–2),respectively.Thus,the local effects of offsetting or amplifying warming were particularly obvious.
基金supported by the National Natural Science Foundation of China (10802028)the Major State Basic Research Development Program of China (2010CB832705)the National Science Fund for Distinguished Young Scholars (10725208)
文摘In this article,an effective technique is developed to efficiently obtain the output responses of parameterized structural dynamic problems.This technique is based on the conception of reduced basis method and the usage of linear interpolation principle.The original problem is projected onto the reduced basis space by linear interpolation projection,and subsequently an associated interpolation matrix is generated.To ensure the largest nonsingularity,the interpolation matrix needs to go through a timenode choosing process,which is developed by applying the angle of vector spaces.As a part of this technique,error estimation is recommended for achieving the computational error bound.To ensure the successful performance of this technique,the offline-online computational procedures are conducted in practical engineering.Two numerical examples demonstrate the accuracy and efficiency of the presented method.
基金supported by key project of the National Science and Technology Pillar Program (Grant No. 2006BAJ03B03)Research Fund from State Key Laboratory for Disaster Reduction in Civil Engineering (Grand No. SLDRCE08-C-03)
文摘The modeling methodologies and calculation of dynamic response of underground structure under Rayleigh waves is investigated in this paper. First the free field responses under Rayleigh waves are analyzed and the numerical results agree well with the theoretical results. Then, the approximate Rayleigh waves are put forward based on the preliminary re- search, and Rayleigh wave field is obtained through fast Fourier transform technique. Taking a utility tunnel as an example, its dynamic responses under Rayleigh waves is calculated by ABAQUS. The results demonstrate that bending deformation is the main component of structural deformation and the deformation at the top of the structure is about twice as much as that at bottom of the structure. The effect of soil-structure interface and the buried depth of underground structure are also investi- gated via parameter analysis. For the shallow buffed underground structures, Rayleigh waves can be the key factor to control the responses and damage of the structure.
文摘BACKGROUND: Fast track strategy in the management of patients undergoing intra-abdominal surgery of various types has emerged as a landmark approach to reduce surgical stress and accelerate recovery. This study was to evaluate the effect of fast track strategy on patients subjected to pancreaticoduo-denectomy (PD) from an individual unit during transit from low to a high volume center. METHODS: A total of 142 PD patients who had been subjected to fast track strategy between June 2008 and September 2012 were compared with 46 patients who had received convention-al surgery between January 2006 and May 2008. Comparative analysis was made of postoperative complications, postopera-tive recovery, length of hospital stay and patient readmission requirement. RESULTS: The patients subjected to fast track strategy had a faster recovery and a shorter hospital stay than those who were treated conventionally (7.8 vs 12.1 days). The intraoperative events like operative blood loss (417.9±83.8 vs 997.4 ±151.8 mL, P<0.001), blood transfused (a median of 0 vs 1 unit,P<0.001) and operative time taken (125 vs 245 minutes,P<0.001) were signiifcantly lower in the fast track group. The frequency of pancreatic ifstula (4.9% vs 13.0%) and delayed gastric empty-ing (7.0% vs 17.4%) was also signiifcantly reduced with fast track treatment. Nevertheless, the readmission rate (11.3% vs 6.5%) was found relatively higher within the fast track group. However, increased readmission rates in this study seem to be independent of fast track protocol. CONCLUSIONS: This preliminary analysis suggests that the fast track approach might be beneifcial to the well-being of the patients after PD, for it accelerates the immediate clinical recovery of patients and signiifcantly shortens their length of hospital stay.
文摘Fourier transform （FF） is a commonly used method in spectral analysis of ocean wave and offshore structure responses, but it is not suitable for records of short length. In this paper another method, wavelet transform （WT）, is applied to ＇analyze the data of short length. The Morlet wavelet is employed to calculate the spectra density functions for wave records and simulated Floating Production Storage and Offloading （FPSO） vessels＇ responses. Computed wave data include simulated wave data based on JONSWAP spectrum and the recorded data of Storm 149 from North Alwyn. Wavelet method is validated by comparing the statistical characteristics by WF method and those by fast Fourier transform （FFT） method with those of target spectra. The spectral density fnnctions＇ shapes calculated by WT are less malformed and have less error of statistical characteristics compared with those by FT especially when the record lengths decrease.
基金This work was supported by the National Natural Science Foundation of China(No.81801906,to KG)the Natural Science Foundation of Shandong Province of China(No.ZR2018PH024,to KG).
文摘Spinal cord injury(SCI)is a serious traumatic event to the central nervous system.Studies show that long non-coding RNAs(lncRNAs)play an important role in regulating the inflammatory response in the acute stage of SCI.Here,we investigated a new lncRNA related to spinal cord injury and acute inflammation.We analyzed the expression profile of lncRNAs after SCI,and explored the role of lncRNA Airsci(acute inflammatory response in SCI)on recovery following acute SCI.The rats were divided into the control group,SCI group,and SCI+lncRNA Airsci-siRNA group.The expression of inflammatory factors,including nuclear factor kappa B[NF-κB(p65)],NF-κB inhibitor IκBαand phosphorylated IκBα(p-IκBα),and the p-IκBα/IκBαratio were examined 1–28 days after SCI in rats by western blot assay.The differential lncRNA expression profile after SCI was assessed by RNA sequencing.The differentially expressed lncRNAs were analyzed by bioinformatics technology.The differentially expressed lncRNA Airsci,which is involved in NF-κB signaling and associated with the acute inflammatory response,was verified by quantitative real-time PCR.Interleukin(IL-1β),IL-6 and tumor necrosis factor(TNF-α)at 3 days after SCI were measured by western blot assay and quantitative real-time PCR.The histopathology of the spinal cord was evaluated by hematoxylin-eosin and Nissl staining.Motor function was assessed with the Basso,Beattie and Bresnahan Locomotor Rating Scale.Numerous differentially expressed lncRNAs were detected after SCI,including 151 that were upregulated and 186 that were downregulated in the SCI 3 d group compared with the control group.LncRNA Airsci was the most significantly expressed among the five lncRNAs involved in the NF-κB signaling pathway.LncRNA Airsci-siRNA reduced the inflammatory response by inhibiting the NF-κB signaling pathway,alleviated spinal cord tissue injury,and promoted the recovery of motor function in SCI rats.These findings show that numerous lncRNAs are differentially expressed following SCI,and that inhibiting lncRNA Airsci reduces the inflammatory response through the NF-κB signaling pathway,thereby promoting functional recovery.All experimental procedures and protocols were approved by the approved by the Animal Ethics Committee of Jining Medical University(approval No.JNMC-2020-DW-RM-003)on January 18,2020.
