F.Scott.Fitzgerald was a well known American writer in the 1920s.He worte some works which represented the characteristics of the 1920s America and he was considered as the spokesman for that time period,the Jazz Age....F.Scott.Fitzgerald was a well known American writer in the 1920s.He worte some works which represented the characteristics of the 1920s America and he was considered as the spokesman for that time period,the Jazz Age..His masterpiece was The Great Gatsby.The novel fully reveals the life and people of the Jazz age,showing the epicurean,indulging,and immoral ethos of the whole American society and people's fasicination about wealth and enjoyment,looking down upon and deserting the traditional faiths and values.This article discusses F.Scott.Fitzgerald and his protagists' fascination about rich girls in his two novels The Great Gatsby and "Winter Dreams" from the life and love stories of the author and his protagonists,men's love ideal under the influence of American dream and the Jzaa Age,several characteristivs of love itself.Through this article,we may see the influence of the social faith and social ethos on individual's love ideal,and the beautiful and wordly aspects about love.展开更多
Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcom...Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.展开更多
We present a very different cause of search engine user behaviors ——fascination. It is generally identified as the initial effect of a product attribute on users' interest and purchase intentions. Considering th...We present a very different cause of search engine user behaviors ——fascination. It is generally identified as the initial effect of a product attribute on users' interest and purchase intentions. Considering the fact that in most cases the cursor is driven directly by a hand to move via a mouse (or touchpad), we use the cursor movement as the critical feature to analyze the personal reaction against the fascinating search results. This paper provides a deep insight into the goal-directed cursor movement that occurs within a remarkably short period of time (<30 milliseconds), which is the interval between a user's click-through and decision-making behaviors. Instead of the fundamentals, we focus on revealing the characteristics of the split-second cursor movement. Our empirical findings showed that a user may push or pull the mouse with a slightly greater strength when fascinated by a search result. As a result, the cursor slides toward the search result with an increased momentum. We model the momentum through a combination of translational and angular kinetic energy calculations. Based on Fitts' law, we implement goal-directed cursor movement identification. Supported by the momentum, together with other physical features, we built different fascination-based search result reranking systems. Our experiments showed that goal-directed cursor momentum is an effective feature in detecting fascination. In particular, they show feasibility in both the personalized and cross-media cases. In addition, we detail the advantages and disadvantages of both click-through rate and cursor momentum for re-ranking search results.展开更多
Objectives:Deletion of Fscn2 gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells.Cisplatin,an antitumor drug,can cause various side effects,including ototoxicity.The aim of this...Objectives:Deletion of Fscn2 gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells.Cisplatin,an antitumor drug,can cause various side effects,including ototoxicity.The aim of this study was to investigate the effects of Fscn2 on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.Methods:Two-week-old Fscn2^(+/+)mice and Fscn2^(−/−)mice were treated with two doses of cisplatin,with a 3-day recovery period in between.ABR(auditory evoked brain stem response)thresholds were measured and cochlear pathology was observed at 3 weeks of age.Results:Both Fscn2^(+/+)and Fscn2^(−/−)mice showed hearing loss under the effect of cisplatin,but the impairment was more severe in Fscn2^(−/−)mice.Further experiments showed that the percentages of outer hair cell(OHC)and spiral ganglion neuron(SGN)loss were significantly higher in cisplatin-treated Fscn2^(−/−)mice compared to Fscn2^(+/+)mice.Additionally,knockdown of Fscn2 in HEI-OC1 cells worsened cisplatin-induced cell apoptosis.Conclusion:FSCN2 mediates reduction of CDDP induced ototoxicity by inhibiting cell apoptosis.展开更多
Background:The Fascin(FSCN)family,comprising actin-bundling proteins,plays vital roles in cytoskeletal reorganization and cell migration.FSCN1,FSCN2,and FSCN3 are implicated in cancer progression through cell motility...Background:The Fascin(FSCN)family,comprising actin-bundling proteins,plays vital roles in cytoskeletal reorganization and cell migration.FSCN1,FSCN2,and FSCN3 are implicated in cancer progression through cell motility,invasion,and metastasis.However,their specific contributions across different cancer types remain unclear.Methods:We conducted a pan-cancer bioinformatics analysis of FSCN genes using data from The Cancer Genome Atlas.This included differential expression patterns,copy number variations(CNVs),mutations,methylation status,and correlations with tumor mutational burden,microsatellite instability,and immune checkpoint molecule expression.Differential expression was analyzed using DESeq2,while CNV and mutation analyses utilized GISTIC2.0 and MuTect2.Methylation data were assessed using the Illumina Human Methylation 450K BeadChip.Results:FSCN1 and FSCN2 showed significant differential expression in multiple cancers,often correlating with poor prognosis.FSCN3 exhibited less variability but a protective role in certain contexts.CNV analysis indicated frequent gene gains in FSCN genes,correlating with increased expression.FSCN3 had a higher mutation rate,suggesting genetic instability.Methylation analysis showed hypomethylation of FSCN1 and FSCN2 in tumors compared to normal tissues,whereas FSCN3 had minor changes.Significant associations were found between FSCN gene expression and tumor mutational burden,microsatellite instability,and immune checkpoint molecules,suggesting their involvement in tumor immunogenicity and the immune microenvironment.Conclusions:This pan-cancer analysis highlights the multifaceted roles of FSCN genes in cancer biology,emphasizing their potential as biomarkers and therapeutic targets.FSCN1 and FSCN2 are associated with poor prognosis and aggressive phenotypes,while FSCN3 shows protective roles in specific contexts.These findings offer new avenues for cancer diagnosis and treatment,particularly in personalized medicine.Future studies should validate these findings and explore the underlying mechanisms to fully harness the clinical potential of FSCN family proteins in oncology.展开更多
文摘F.Scott.Fitzgerald was a well known American writer in the 1920s.He worte some works which represented the characteristics of the 1920s America and he was considered as the spokesman for that time period,the Jazz Age..His masterpiece was The Great Gatsby.The novel fully reveals the life and people of the Jazz age,showing the epicurean,indulging,and immoral ethos of the whole American society and people's fasicination about wealth and enjoyment,looking down upon and deserting the traditional faiths and values.This article discusses F.Scott.Fitzgerald and his protagists' fascination about rich girls in his two novels The Great Gatsby and "Winter Dreams" from the life and love stories of the author and his protagonists,men's love ideal under the influence of American dream and the Jzaa Age,several characteristivs of love itself.Through this article,we may see the influence of the social faith and social ethos on individual's love ideal,and the beautiful and wordly aspects about love.
文摘Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.
基金the National Natural Science Foundation of China (Grant Nos. 61672368, 61373097, and 61672367)the Research Foundation of the Ministry of Education and China Mobile (MCM20150602)the Science and Technology Plan of Jiangsu (BK20151222).
文摘We present a very different cause of search engine user behaviors ——fascination. It is generally identified as the initial effect of a product attribute on users' interest and purchase intentions. Considering the fact that in most cases the cursor is driven directly by a hand to move via a mouse (or touchpad), we use the cursor movement as the critical feature to analyze the personal reaction against the fascinating search results. This paper provides a deep insight into the goal-directed cursor movement that occurs within a remarkably short period of time (<30 milliseconds), which is the interval between a user's click-through and decision-making behaviors. Instead of the fundamentals, we focus on revealing the characteristics of the split-second cursor movement. Our empirical findings showed that a user may push or pull the mouse with a slightly greater strength when fascinated by a search result. As a result, the cursor slides toward the search result with an increased momentum. We model the momentum through a combination of translational and angular kinetic energy calculations. Based on Fitts' law, we implement goal-directed cursor movement identification. Supported by the momentum, together with other physical features, we built different fascination-based search result reranking systems. Our experiments showed that goal-directed cursor momentum is an effective feature in detecting fascination. In particular, they show feasibility in both the personalized and cross-media cases. In addition, we detail the advantages and disadvantages of both click-through rate and cursor momentum for re-ranking search results.
基金supported by the National Natural Science Foundation of China(No.81771020,81570927 and 81271092)Grant for Scientific and Technological Development Plan for Medical and Health in Shandong Province(2019WS341).
文摘Objectives:Deletion of Fscn2 gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells.Cisplatin,an antitumor drug,can cause various side effects,including ototoxicity.The aim of this study was to investigate the effects of Fscn2 on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.Methods:Two-week-old Fscn2^(+/+)mice and Fscn2^(−/−)mice were treated with two doses of cisplatin,with a 3-day recovery period in between.ABR(auditory evoked brain stem response)thresholds were measured and cochlear pathology was observed at 3 weeks of age.Results:Both Fscn2^(+/+)and Fscn2^(−/−)mice showed hearing loss under the effect of cisplatin,but the impairment was more severe in Fscn2^(−/−)mice.Further experiments showed that the percentages of outer hair cell(OHC)and spiral ganglion neuron(SGN)loss were significantly higher in cisplatin-treated Fscn2^(−/−)mice compared to Fscn2^(+/+)mice.Additionally,knockdown of Fscn2 in HEI-OC1 cells worsened cisplatin-induced cell apoptosis.Conclusion:FSCN2 mediates reduction of CDDP induced ototoxicity by inhibiting cell apoptosis.
基金supported by grants from the Tianjin Health Technology Project(Grant no.2022QN106).
文摘Background:The Fascin(FSCN)family,comprising actin-bundling proteins,plays vital roles in cytoskeletal reorganization and cell migration.FSCN1,FSCN2,and FSCN3 are implicated in cancer progression through cell motility,invasion,and metastasis.However,their specific contributions across different cancer types remain unclear.Methods:We conducted a pan-cancer bioinformatics analysis of FSCN genes using data from The Cancer Genome Atlas.This included differential expression patterns,copy number variations(CNVs),mutations,methylation status,and correlations with tumor mutational burden,microsatellite instability,and immune checkpoint molecule expression.Differential expression was analyzed using DESeq2,while CNV and mutation analyses utilized GISTIC2.0 and MuTect2.Methylation data were assessed using the Illumina Human Methylation 450K BeadChip.Results:FSCN1 and FSCN2 showed significant differential expression in multiple cancers,often correlating with poor prognosis.FSCN3 exhibited less variability but a protective role in certain contexts.CNV analysis indicated frequent gene gains in FSCN genes,correlating with increased expression.FSCN3 had a higher mutation rate,suggesting genetic instability.Methylation analysis showed hypomethylation of FSCN1 and FSCN2 in tumors compared to normal tissues,whereas FSCN3 had minor changes.Significant associations were found between FSCN gene expression and tumor mutational burden,microsatellite instability,and immune checkpoint molecules,suggesting their involvement in tumor immunogenicity and the immune microenvironment.Conclusions:This pan-cancer analysis highlights the multifaceted roles of FSCN genes in cancer biology,emphasizing their potential as biomarkers and therapeutic targets.FSCN1 and FSCN2 are associated with poor prognosis and aggressive phenotypes,while FSCN3 shows protective roles in specific contexts.These findings offer new avenues for cancer diagnosis and treatment,particularly in personalized medicine.Future studies should validate these findings and explore the underlying mechanisms to fully harness the clinical potential of FSCN family proteins in oncology.
