目的 分析HIV/AIDS患者衰弱的研究热点,为该领域的研究提供临床参考和理论基础。方法 检索Web of Science(WOS)核心合集数据库2015年1月至2025年1月发表的HIV/AIDS患者衰弱相关的文献,采用CiteSpace软件对文献进行可视化分析。结果 共纳...目的 分析HIV/AIDS患者衰弱的研究热点,为该领域的研究提供临床参考和理论基础。方法 检索Web of Science(WOS)核心合集数据库2015年1月至2025年1月发表的HIV/AIDS患者衰弱相关的文献,采用CiteSpace软件对文献进行可视化分析。结果 共纳入251篇文献,在国家层面,发文量居首位的为美国(135篇),中国的发文量相对较少(10篇)。中介中心性最高的为南非(0.82)。在机构层面,发文量最高的为约翰斯·霍普金斯大学(51篇),中介中心性(0.10)仅次于伦敦大学(0.12)。关键词共现分析频次最高的前三个为older adults(老年人)、infection(感染)、phenotype(表型);关键词聚类共有13个标签;关键词突现结果显示近几年研究的关键词为depression(抑郁)、challenges(挑战)、index(指数)、people with HIV(HIV感染者)、people(人群)、predictor(预测因子)。结论 老年人是HIV/AIDS衰弱研究领域的核心人群,该领域的研究热点围绕优化老年HIV/AIDS患者的共病管理、提升cART效果、开发HIV/AIDS患者衰弱针对性评估工具展开。未来研究需加强HIV/AIDS患者社会心理因素的关注力度,贯彻落实以患者为中心的护理,提高预测因子识别HIV/AIDS患者衰弱的准确性,开展多学科合作。展开更多
The visual navigation marks are established purposely,which transfer information to the trained observer in order to navigate.The visual aids to navigation in freshwater could give aid to navigation.In addition,throug...The visual navigation marks are established purposely,which transfer information to the trained observer in order to navigate.The visual aids to navigation in freshwater could give aid to navigation.In addition,through its basic shape,appearance forms and colors,the landscape of navigation waterway is also displayed.The aids to navigation together with channel revetment and other surrounding landscape elements determine the landscape effect of the navigation waterway.Through analyzing the design of aids to navigation features,the design impact factors,the landscape design principles and methods of treatment are proposed in this research,in order to provide some references for the design of future visual aids to navigation.展开更多
To assess functional outcomes of optical low vision aids(LVAs) for pediatric visual impairment due to central nervous system(CNS) tumors. A prospective case study was conducted on 15 children with history of CNS tumor...To assess functional outcomes of optical low vision aids(LVAs) for pediatric visual impairment due to central nervous system(CNS) tumors. A prospective case study was conducted on 15 children with history of CNS tumors with mean age of 10.47±1.85 y. Lighthouse distance, near visual acuity tests, cycloplegic refraction, reading speed measurement and visual field examination were done. Prescription of far and near LVAs followed by training sessions. LVPrasad-functional vision questionnaire was done to evaluate performance. Visual impairment was moderate(13.3%), severe(73.3%), profound(6.7%) and near blindness in 6.7%. Telescopes prescribed in 33.4%, video magnifier in 46.7%. Questionnaire scores were significantly improved for distant rather than near tasks(P≤0.05) after training. LVAs rehabilitation is an effective method of improving vision in pediatric visual defects secondary to CNS tumors.展开更多
The introduction of the ICTs （Information and Communication Technologies） in education has set a new paradigm in knowledge acquisition. The Internet, overhead projectors and interactive boards, presentation and anim...The introduction of the ICTs （Information and Communication Technologies） in education has set a new paradigm in knowledge acquisition. The Internet, overhead projectors and interactive boards, presentation and animation software, and online databases are only some resources that teachers use in order to present information in a more dynamic, immediate, and stunning way, transforming and revitalizing the teaching-learning process. The ICTs have been established in the university classroom and nowadays, they have become an essential part in this teaching-learning process. Lecturers make use of them in the same proportion as they make of traditional materials. At the same time, students have to be acquainted with these new technologies and they also have to be able to deal with them. The objective of this paper is twofold： On the one hand, we study and show how our students make use of the technologies when they have to face their oral presentations in the subject Advanced English： Professional Settings （English Studies Degree at Universitat Jaume I in Castellen, Spain）. It is acknowledged that visual aids can be helpful to support a speech, but we want to analyze if the visual aids are successfully applied, how and to which extent. On the other hand, we want to make out the opinions of their classmates about the use of these graphical resources （students fill in a questionnaire about the effectiveness of the visual aids in their classmates＇ presentations and how they would improve them）. Results demonstrate that not only teachers make advantage of the new technological resources, we show, based on the students＇ oral presentations and their peer-reviews, that also our university students are increasingly aware of the advantage and importance of the ICTs in the classroom.展开更多
目的基于CiteSpace对国内外HIV/AIDS合并恶性肿瘤患者的研究现状、热点和趋势进行可视化分析,探索未来研究方向。方法检索建库至2023年12月31日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS合并恶性肿瘤患者的相关文献,借助C...目的基于CiteSpace对国内外HIV/AIDS合并恶性肿瘤患者的研究现状、热点和趋势进行可视化分析,探索未来研究方向。方法检索建库至2023年12月31日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS合并恶性肿瘤患者的相关文献,借助CiteSpace对文献进行可视化分析。结果共纳入文献6064篇(其中CNKI 161篇,WoS 5903篇)。发文量最多的国家为美国(2921篇)。中文文献的关键词、聚类、突现词显示临床特征、肿瘤类型及治疗方案是主要研究方向。英文文献的关键词、聚类、突现词图谱显示其主要围绕恶性肿瘤的流行病学、发病机制、生物标志物和新型治疗策略方面。结论国内外研究方向各有侧重,恶性肿瘤的流行病学、发病机制和治疗是共同的研究热点和趋势。未来研究应结合人工智能、大数据等现代科学技术,深入挖掘HIV/AIDS患者合并恶性肿瘤机制及相关生物标志物,提升HIV/AIDS患者合并恶性肿瘤防治水平。展开更多
West Nile virus(WNV)causes West Nile fever and West Nile encephalitis.Because infection by WNV creates serious public health problems,its simple,rapid,and visual detection is very important in clinical practice,especi...West Nile virus(WNV)causes West Nile fever and West Nile encephalitis.Because infection by WNV creates serious public health problems,its simple,rapid,and visual detection is very important in clinical practice,especially in resource-limited laboratories.We have developed a rapid,specific,and highly sensitive internally controlled reverse transcription recombinase-aided amplification(RTRAA)assay to detect WNV,using both real-timefluoresce nee and the lateral flow dipstick(LFD)at39.0°C for 30 min.The analytical sensitivity of theRT-RAA assay was 10 plasmid copies and 1.6 pfu perreacti on with real-time fluoresce nee,and 1,000plasmid copies per reaction with the LFD.No crossreactionwith other control viruses was observed.Compared with the RT-qPCR assay,the RT-RAA assaydemonstrated 100%sensitivity and 100%specificityfor WNV.展开更多
There are about 253 million people with visual impairment worldwide.Many of them use a white cane and/or a guide dog as the mobility tool for daily travel.Despite decades of efforts,electronic navigation aid that can ...There are about 253 million people with visual impairment worldwide.Many of them use a white cane and/or a guide dog as the mobility tool for daily travel.Despite decades of efforts,electronic navigation aid that can replace white cane is still research in progress.In this paper,we propose an RGB-D camera based visual positioning system(VPS)for real-time localization of a robotic navigation aid(RNA)in an architectural floor plan for assistive navigation.The core of the system is the combination of a new 6-DOF depth-enhanced visual-inertial odometry(DVIO)method and a particle filter localization(PFL)method.DVIO estimates RNA’s pose by using the data from an RGB-D camera and an inertial measurement unit(IMU).It extracts the floor plane from the camera’s depth data and tightly couples the floor plane,the visual features(with and without depth data),and the IMU’s inertial data in a graph optimization framework to estimate the device’s 6-DOF pose.Due to the use of the floor plane and depth data from the RGB-D camera,DVIO has a better pose estimation accuracy than the conventional VIO method.To reduce the accumulated pose error of DVIO for navigation in a large indoor space,we developed the PFL method to locate RNA in the floor plan.PFL leverages geometric information of the architectural CAD drawing of an indoor space to further reduce the error of the DVIO-estimated pose.Based on VPS,an assistive navigation system is developed for the RNA prototype to assist a visually impaired person in navigating a large indoor space.Experimental results demonstrate that:1)DVIO method achieves better pose estimation accuracy than the state-of-the-art VIO method and performs real-time pose estimation(18 Hz pose update rate)on a UP Board computer;2)PFL reduces the DVIO-accrued pose error by 82.5%on average and allows for accurate wayfinding(endpoint position error≤45 cm)in large indoor spaces.展开更多
This paper is mainly concerned with the usage of teaching aids in junior English from three aspects: the visual aids,the audio-visual means, the body language and tone. By this means, it can give the students a compar...This paper is mainly concerned with the usage of teaching aids in junior English from three aspects: the visual aids,the audio-visual means, the body language and tone. By this means, it can give the students a comparatively real circumstances, attract the students’ attention, enhance the students’ interest in English and improve their consciousness of competition.展开更多
目的基于CiteSpace对国内外HIV/AIDS患者血脂异常的研究现状、热点和趋势进行可视化分析,探索未来研究方向。方法检索建库至2023年9月15日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS患者血脂异常的相关文献,借助CiteSpace...目的基于CiteSpace对国内外HIV/AIDS患者血脂异常的研究现状、热点和趋势进行可视化分析,探索未来研究方向。方法检索建库至2023年9月15日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS患者血脂异常的相关文献,借助CiteSpace对文献进行可视化分析。结果共纳入中文文献105篇、英文文献525篇。近年国内发文量持续增长,国外发文量有所回落,但仍高于国内。发文量最多的国家为美国(226篇),中国排名第5(27篇);国外发文量最多的机构为哈佛大学,国内为河南中医药大学;排名前3位的中文高频关键词为血脂异常、艾滋病、高效抗反转录病毒治疗,英文高频关键词为血脂异常、心血管疾病、抗反转录病毒治疗;关键词聚类分析获得8个聚类。结论目前HIV感染合并血脂异常领域的研究热点主要包括影响因素、心血管疾病、患病率、高效抗反转录病毒治疗、蛋白酶抑制剂等。研究方向主要包括:不同抗病毒药物对血脂的影响研究、HIV/AIDS患者血脂异常现状及影响因素研究、抗病毒药物和降血脂药物作用机制及疗效研究等。国内HIV感染合并血脂异常领域还有较大研究空间,后续应开展更多高质量研究。未来可对中医治疗、饮食、运动及其他影响因素干预对血脂的影响做进一步探索。展开更多
文摘目的 分析HIV/AIDS患者衰弱的研究热点,为该领域的研究提供临床参考和理论基础。方法 检索Web of Science(WOS)核心合集数据库2015年1月至2025年1月发表的HIV/AIDS患者衰弱相关的文献,采用CiteSpace软件对文献进行可视化分析。结果 共纳入251篇文献,在国家层面,发文量居首位的为美国(135篇),中国的发文量相对较少(10篇)。中介中心性最高的为南非(0.82)。在机构层面,发文量最高的为约翰斯·霍普金斯大学(51篇),中介中心性(0.10)仅次于伦敦大学(0.12)。关键词共现分析频次最高的前三个为older adults(老年人)、infection(感染)、phenotype(表型);关键词聚类共有13个标签;关键词突现结果显示近几年研究的关键词为depression(抑郁)、challenges(挑战)、index(指数)、people with HIV(HIV感染者)、people(人群)、predictor(预测因子)。结论 老年人是HIV/AIDS衰弱研究领域的核心人群,该领域的研究热点围绕优化老年HIV/AIDS患者的共病管理、提升cART效果、开发HIV/AIDS患者衰弱针对性评估工具展开。未来研究需加强HIV/AIDS患者社会心理因素的关注力度,贯彻落实以患者为中心的护理,提高预测因子识别HIV/AIDS患者衰弱的准确性,开展多学科合作。
文摘The visual navigation marks are established purposely,which transfer information to the trained observer in order to navigate.The visual aids to navigation in freshwater could give aid to navigation.In addition,through its basic shape,appearance forms and colors,the landscape of navigation waterway is also displayed.The aids to navigation together with channel revetment and other surrounding landscape elements determine the landscape effect of the navigation waterway.Through analyzing the design of aids to navigation features,the design impact factors,the landscape design principles and methods of treatment are proposed in this research,in order to provide some references for the design of future visual aids to navigation.
文摘To assess functional outcomes of optical low vision aids(LVAs) for pediatric visual impairment due to central nervous system(CNS) tumors. A prospective case study was conducted on 15 children with history of CNS tumors with mean age of 10.47±1.85 y. Lighthouse distance, near visual acuity tests, cycloplegic refraction, reading speed measurement and visual field examination were done. Prescription of far and near LVAs followed by training sessions. LVPrasad-functional vision questionnaire was done to evaluate performance. Visual impairment was moderate(13.3%), severe(73.3%), profound(6.7%) and near blindness in 6.7%. Telescopes prescribed in 33.4%, video magnifier in 46.7%. Questionnaire scores were significantly improved for distant rather than near tasks(P≤0.05) after training. LVAs rehabilitation is an effective method of improving vision in pediatric visual defects secondary to CNS tumors.
文摘The introduction of the ICTs （Information and Communication Technologies） in education has set a new paradigm in knowledge acquisition. The Internet, overhead projectors and interactive boards, presentation and animation software, and online databases are only some resources that teachers use in order to present information in a more dynamic, immediate, and stunning way, transforming and revitalizing the teaching-learning process. The ICTs have been established in the university classroom and nowadays, they have become an essential part in this teaching-learning process. Lecturers make use of them in the same proportion as they make of traditional materials. At the same time, students have to be acquainted with these new technologies and they also have to be able to deal with them. The objective of this paper is twofold： On the one hand, we study and show how our students make use of the technologies when they have to face their oral presentations in the subject Advanced English： Professional Settings （English Studies Degree at Universitat Jaume I in Castellen, Spain）. It is acknowledged that visual aids can be helpful to support a speech, but we want to analyze if the visual aids are successfully applied, how and to which extent. On the other hand, we want to make out the opinions of their classmates about the use of these graphical resources （students fill in a questionnaire about the effectiveness of the visual aids in their classmates＇ presentations and how they would improve them）. Results demonstrate that not only teachers make advantage of the new technological resources, we show, based on the students＇ oral presentations and their peer-reviews, that also our university students are increasingly aware of the advantage and importance of the ICTs in the classroom.
文摘目的基于CiteSpace对国内外HIV/AIDS合并恶性肿瘤患者的研究现状、热点和趋势进行可视化分析,探索未来研究方向。方法检索建库至2023年12月31日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS合并恶性肿瘤患者的相关文献,借助CiteSpace对文献进行可视化分析。结果共纳入文献6064篇(其中CNKI 161篇,WoS 5903篇)。发文量最多的国家为美国(2921篇)。中文文献的关键词、聚类、突现词显示临床特征、肿瘤类型及治疗方案是主要研究方向。英文文献的关键词、聚类、突现词图谱显示其主要围绕恶性肿瘤的流行病学、发病机制、生物标志物和新型治疗策略方面。结论国内外研究方向各有侧重,恶性肿瘤的流行病学、发病机制和治疗是共同的研究热点和趋势。未来研究应结合人工智能、大数据等现代科学技术,深入挖掘HIV/AIDS患者合并恶性肿瘤机制及相关生物标志物,提升HIV/AIDS患者合并恶性肿瘤防治水平。
基金supported by grants from the China Mega-Projects for Infectious Disease [2017ZX10302301-004-002,2018ZX10711001,2017ZX10104001,2018ZX10713-002]IVDC [2019HYDQNJJ03]
文摘West Nile virus(WNV)causes West Nile fever and West Nile encephalitis.Because infection by WNV creates serious public health problems,its simple,rapid,and visual detection is very important in clinical practice,especially in resource-limited laboratories.We have developed a rapid,specific,and highly sensitive internally controlled reverse transcription recombinase-aided amplification(RTRAA)assay to detect WNV,using both real-timefluoresce nee and the lateral flow dipstick(LFD)at39.0°C for 30 min.The analytical sensitivity of theRT-RAA assay was 10 plasmid copies and 1.6 pfu perreacti on with real-time fluoresce nee,and 1,000plasmid copies per reaction with the LFD.No crossreactionwith other control viruses was observed.Compared with the RT-qPCR assay,the RT-RAA assaydemonstrated 100%sensitivity and 100%specificityfor WNV.
基金supported by the NIBIB and the NEI of the National Institutes of Health(R01EB018117)。
文摘There are about 253 million people with visual impairment worldwide.Many of them use a white cane and/or a guide dog as the mobility tool for daily travel.Despite decades of efforts,electronic navigation aid that can replace white cane is still research in progress.In this paper,we propose an RGB-D camera based visual positioning system(VPS)for real-time localization of a robotic navigation aid(RNA)in an architectural floor plan for assistive navigation.The core of the system is the combination of a new 6-DOF depth-enhanced visual-inertial odometry(DVIO)method and a particle filter localization(PFL)method.DVIO estimates RNA’s pose by using the data from an RGB-D camera and an inertial measurement unit(IMU).It extracts the floor plane from the camera’s depth data and tightly couples the floor plane,the visual features(with and without depth data),and the IMU’s inertial data in a graph optimization framework to estimate the device’s 6-DOF pose.Due to the use of the floor plane and depth data from the RGB-D camera,DVIO has a better pose estimation accuracy than the conventional VIO method.To reduce the accumulated pose error of DVIO for navigation in a large indoor space,we developed the PFL method to locate RNA in the floor plan.PFL leverages geometric information of the architectural CAD drawing of an indoor space to further reduce the error of the DVIO-estimated pose.Based on VPS,an assistive navigation system is developed for the RNA prototype to assist a visually impaired person in navigating a large indoor space.Experimental results demonstrate that:1)DVIO method achieves better pose estimation accuracy than the state-of-the-art VIO method and performs real-time pose estimation(18 Hz pose update rate)on a UP Board computer;2)PFL reduces the DVIO-accrued pose error by 82.5%on average and allows for accurate wayfinding(endpoint position error≤45 cm)in large indoor spaces.
文摘This paper is mainly concerned with the usage of teaching aids in junior English from three aspects: the visual aids,the audio-visual means, the body language and tone. By this means, it can give the students a comparatively real circumstances, attract the students’ attention, enhance the students’ interest in English and improve their consciousness of competition.
文摘目的基于CiteSpace对国内外HIV/AIDS患者血脂异常的研究现状、热点和趋势进行可视化分析,探索未来研究方向。方法检索建库至2023年9月15日Web of Science核心合集(WOS)和中国知网(CNKI)中HIV/AIDS患者血脂异常的相关文献,借助CiteSpace对文献进行可视化分析。结果共纳入中文文献105篇、英文文献525篇。近年国内发文量持续增长,国外发文量有所回落,但仍高于国内。发文量最多的国家为美国(226篇),中国排名第5(27篇);国外发文量最多的机构为哈佛大学,国内为河南中医药大学;排名前3位的中文高频关键词为血脂异常、艾滋病、高效抗反转录病毒治疗,英文高频关键词为血脂异常、心血管疾病、抗反转录病毒治疗;关键词聚类分析获得8个聚类。结论目前HIV感染合并血脂异常领域的研究热点主要包括影响因素、心血管疾病、患病率、高效抗反转录病毒治疗、蛋白酶抑制剂等。研究方向主要包括:不同抗病毒药物对血脂的影响研究、HIV/AIDS患者血脂异常现状及影响因素研究、抗病毒药物和降血脂药物作用机制及疗效研究等。国内HIV感染合并血脂异常领域还有较大研究空间,后续应开展更多高质量研究。未来可对中医治疗、饮食、运动及其他影响因素干预对血脂的影响做进一步探索。
