Fibroblast activation protein(FAP)is overexpressed in cancer-associated fibroblasts across various cancer types.Numerous radiolabeled FAP inhibitors(FAPIs)(Fig.S1A)currently under clinical investigation have shown rem...Fibroblast activation protein(FAP)is overexpressed in cancer-associated fibroblasts across various cancer types.Numerous radiolabeled FAP inhibitors(FAPIs)(Fig.S1A)currently under clinical investigation have shown remarkable potential in cancer theranostics.展开更多
目的:探讨^(68)Ga标记的成纤维细胞激活蛋白抑制剂(fibroblast activation protein inhibitor,FAPI)-04正电子发射断层显像/X线计算机体层成像(positron emission tomography and computed tomography,PET/CT)对初诊胰腺癌的诊断价值及...目的:探讨^(68)Ga标记的成纤维细胞激活蛋白抑制剂(fibroblast activation protein inhibitor,FAPI)-04正电子发射断层显像/X线计算机体层成像(positron emission tomography and computed tomography,PET/CT)对初诊胰腺癌的诊断价值及对肿瘤分期的影响。方法:回顾性收集2021年8月至2023年8月于重庆大学附属肿瘤医院就诊的134例因怀疑胰腺占位的患者临床及影像资料。分析^(68)Ga-FAPI-04 PET/CT对胰腺癌原发灶及转移灶的诊断价值;并与传统CT比较,分析^(68)Ga-FAPI-04 PET/CT对胰腺癌肿瘤分期的影响。结果:共计纳入134例患者,其中胰腺癌127例,良性病变7例。^(68)Ga-FAPI-04 PET/CT对胰腺癌原发灶、区域淋巴结及远处转移灶检出率分别为100%(127/127)、68.63%(35/51),95.35%(41/43)。胰腺癌中位最大标准化摄取值(standard uptake value maxium,SUVmax)为14.92,高于胰腺良性病变中位SUVmax(6.1)(Z=−2.921,P=0.003)。与传统CT比较,^(68)Ga-FAPI PET/CT检查后共有32.28%(41/127)胰腺癌患者TNM分期发生改变。3.94%(5/127)患者改变了治疗方案。结论:^(68)Ga-FAPI-04 PET/CT对胰腺癌原发灶诊断具有较高的敏感性,较传统CT可发现更多远处转移病灶,改善患者M分期,有助于全面评估全身肿瘤负荷、制定治疗计划。展开更多
基金supported by the grants provided by Zhuhai People's Hospital,China(Grant No.:2021KYQD-03)the National Natural Science Foundation of China(Grant No.:22176016).
文摘Fibroblast activation protein(FAP)is overexpressed in cancer-associated fibroblasts across various cancer types.Numerous radiolabeled FAP inhibitors(FAPIs)(Fig.S1A)currently under clinical investigation have shown remarkable potential in cancer theranostics.
文摘目的探讨^(68)Ga-FAPI PET/CT对初诊食管癌患者原发病灶及转移病灶的检出能力,并与^(18)F-FDG PET/CT进行比较。方法回顾分析厦门大学附属第一医院2019-12-01-2022-12-30行^(18)F-FDG和^(68)Ga-FAPI PET/CT检查的32例食管癌患者,其中男26例,女6例,年龄43~85岁,平均年龄(62.16±10.11)岁。采用配对t检验或Wilcoxon符号秩检验比较^(68)Ga-FAPI与^(18)F-FDG在病灶中的最大标准摄取值(SUV_(max))及2种显像检出的病变数量,采用Pearson相关性分析确定显像剂摄取值高低与原发病灶大小之间的关系,采用方差分析或Kruskal-Wallis秩和检验比较3种不同病理分化类型病灶间SUV_(max)的差异。结果32例初诊食管癌患者中有30例鳞状细胞癌与2例腺癌。在食管癌原发病灶中,^(68)Ga-FAPI的SUV_(max)比^(18)F-FDG更高(17.43±5.74 vs 12.94±4.67,t=-4.128,P<0.001)。^(68)Ga-FAPI的SUV_(max)与原发病灶的纵向直径不相关(r=0.111,P=0.545),但^(18)F-FDG的SUV_(max)与其相关(r=0.368,P=0.038)。在两者共检测出的130个可疑淋巴结转移病灶中,^(68)Ga-FAPI的SUV_(max)较^(18)F-FDG更高[8.72(5.30,12.68)vs 5.88(3.78,13.50),Z=-6.150,P<0.001];且在同一患者中,^(68)Ga-FAPI能检测出更多可疑的淋巴结转移病灶[3.0(1.0,5.0)vs 3.0(2.0,5.0),Z=-2.254,P=0.024]。在两者共同检测出的21个远处转移病灶中,^(68)Ga-FAPI的SUV_(max)比^(18)F-FDG更高(12.11±4.42 vs 6.37±1.73,t=-6.263,P<0.001)。结论^(68)Ga-FAPI较^(18)F-FDG在食管癌原发和转移病灶中有更高的放射性摄取,在视觉分析中能发现更多的转移病灶,有利于初诊食管癌患者个体化治疗方式选择。
