BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in iden...BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.AIM To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental health.METHODS A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants.The neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity index.Pearson's correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health indicators.RESULTS A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)respondents.The rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were mild.Among the mental health indicators,there were significant differences by age and between those with siblings and those who were only children.Neuroticism and cognitive failures were significantly positively correlated with mental health indicators.Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.CONCLUSION Cognitive failures and neuroticism play important roles in mental health.Therefore,enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.展开更多
The insertion and extraction of lithium ions in active materials lead to significant volumetric deformation,resulting in stresses that drive the mechanical degradation of these materials.This accumulation of mechanica...The insertion and extraction of lithium ions in active materials lead to significant volumetric deformation,resulting in stresses that drive the mechanical degradation of these materials.This accumulation of mechanical degradation ultimately leads to mechanical failure in lithium-ion batteries(LIB).This paper summarizes the experimental characterization techniques used to observe the mechanical degradation of lithium battery cells,electrodes,and particles across macro,micro,and nano scales.Additionally,the mechanical failure model for LIB that spans from the microscopic to the macroscopic scale has been outlined.Finally,we analyze the current challenges and opportunities,including the standardization of battery measurements,the quantification of mechanical failures,and the correlation between mechanical failures and electrochemical performance.展开更多
Compared to single-layer networks,multilayer networks exhibit a more complex node degree composition,comprising both intra-layer and inter-layer degrees.However,the distinct impacts of these degree types on cascading ...Compared to single-layer networks,multilayer networks exhibit a more complex node degree composition,comprising both intra-layer and inter-layer degrees.However,the distinct impacts of these degree types on cascading failures remain underexplored.Distinguishing their effects is crucial for a deeper understanding of network structure,information propagation,and behavior prediction.This paper proposes a capacity-load model to influence and compare the influence of different degree types on cascading failures in multilayer networks.By designing three node removal strategies based on total degree,intra-layer degree,and inter-layer degree,simulation experiments are conducted on four types of networks.Network robustness is evaluated using the maximum number of removable nodes before collapse.The relationships between network robustness and the coupling coefficient,as well as load and capacity adjustment parameters,are also analyzed.The results indicate that the node removal strategy with the least impact on cascading failures varies across different types of networks,revealing the significance of different node degrees in failure propagation.Compared to other models,the proposed model enables networks to maintain a higher maximum number of removable nodes during cascading failures,demonstrating superior robustness.展开更多
In wind and solar renewable-dominant hybrid alternating current/direct current(AC/DC)power systems,the active power of high-voltage direct current(HVDC)system is significantly limited by the security and stability eve...In wind and solar renewable-dominant hybrid alternating current/direct current(AC/DC)power systems,the active power of high-voltage direct current(HVDC)system is significantly limited by the security and stability events caused by cascading failures.To identify critical lines in cascading failures,a rapid risk assessment method is proposed based on the gradient boosting decision tree(GBDT)and frequent pat-tern growth(FP-Growth)algorithms.First,security and stability events triggered by cascading failures are analyzed to explain the impact of cascading failures on the maximum DC power.Then,a cascading failure risk index is defined,focusing on the DC power being limited.To handle the strong nonlinear relationship between the maximum DC power and cascading failures,a GBDT with an update strategy is utilized to rapidly predict the maximum DC power under uncertain operating conditions.Finally,the FP-Growth algorithm is improved to mine frequent patterns in cascading failures.The importance index for each fault in a frequent pattern is defined by evaluating its impact on cascading failures,enabling the identification of critical lines.Simulation results of a modified Ningxia–Shandong hybrid AC/DC system in China demonstrate that the proposed method can rapidly assess the risk of cascading failures and effectively identify critical lines.展开更多
This study explores ethical violations and audit failures in various large-scale corporate fraud cases.Using a qualitative descriptive method and based on secondary data from documented fraud cases and published audit...This study explores ethical violations and audit failures in various large-scale corporate fraud cases.Using a qualitative descriptive method and based on secondary data from documented fraud cases and published audit reports,the study applies the Fraud Triangle framework,focusing on how weak integrity,objectivity,and professional competence have undermined public trust in the auditing profession.Using a qualitative descriptive method and the Fraud Triangle framework,which includes pressure,opportunity,and rationalization,the study analyzes cases from Indonesia(SNP Finance,Jiwasraya),China(Evergrande),and Germany(Wirecard).The analysis reveals that many audit failures observed in this study appear to stem more from ethical challenges than from technical incapability,driven by client pressure,weak internal controls,and compromised auditor independence.These cases demonstrate a recurring global pattern in which auditors neglect their responsibility to act in the public interest.展开更多
This study explores ethical violations and audit failures in various large-scale corporate fraud cases.Using a qualitative descriptive method and based on secondary data from documented fraud cases and published audit...This study explores ethical violations and audit failures in various large-scale corporate fraud cases.Using a qualitative descriptive method and based on secondary data from documented fraud cases and published audit reports,the study applies the Fraud Triangle framework,focusing on how weak integrity,objectivity,and professional competence have undermined public trust in the auditing profession.Using a qualitative descriptive method and the Fraud Triangle framework,which includes pressure,opportunity,and rationalization,the study analyzes cases from Indonesia(SNP Finance,Jiwasraya),China(Evergrande),and Germany(Wirecard).The analysis reveals that many audit failures observed in this study appear to stem more from ethical challenges than from technical incapability,driven by client pressure,weak internal controls,and compromised auditor independence.These cases demonstrate a recurring global pattern in which auditors neglect their responsibility to act in the public interest.展开更多
According to some observed dama ge phenomena in the smart structure systems, the issues related to the damage and failures of smart structures are addressed in this paper. A few possible damage patterns and the def...According to some observed dama ge phenomena in the smart structure systems, the issues related to the damage and failures of smart structures are addressed in this paper. A few possible damage patterns and the definition of the failure of the smart structures are given. It is pointed out that more attentions should be paid to the functional failures o f smart structures. The effects on the control the static deformation due to par tial debonding of PZT actuators are analyzed by the finite element method. Preli minary numerical results show that partial debonding of PZT actuators may have a p preciate reduction on their actuating ability thus reducing the control ability and accuracy of the smart structures.展开更多
BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM ...BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.展开更多
BACKGROUND Congenital hypothyroidism(CH)is a common condition in both preterm and term infants characterized by either thyroid gland absence or hypofunctionality.The clinical association of refractory lactic acidosis ...BACKGROUND Congenital hypothyroidism(CH)is a common condition in both preterm and term infants characterized by either thyroid gland absence or hypofunctionality.The clinical association of refractory lactic acidosis and heart failure has rarely been observed in cases of pediatric patients with CH pathology.Here,we explored the etiological relationship between CH,heart failure,and refractory lactic acidosis to reflect the importance of thyroid function screening in neonates with heart disease.CASE SUMMARY A 33-day-old extremely premature female infant presented with tachypnea,respiratory distress,recurrent infections,and abdominal distension postnatal.On admission to our facility,she had cardiomegaly,hepatomegaly,and lactic acidosis(revealed on blood gas analysis),with lactate progressively rising to 25 mmol/L.Chest radiographs showed pulmonary congestion,while echocardiography revealed cardiac enlargement,left ventricular wall thickening,and pericardial effusion.Initial management aimed at correcting acidosis and treating heart failure proved ineffective.After reassessment,thyroid function tests showed significantly decreased triiodothyronine,free triiodothyronine,thyroxine,and free thyroxine levels,with a significantly increased thyroidstimulating hormone level,confirming a CH diagnosis.Levothyroxine was administered,resulting in rapid correction of lactic acidosis and gradual improvement of thyroid function and systemic symptoms,culminating in full recovery and discharge.We also reviewed the relevant literature on thyroid and cardiac dysfunctions in order to explore their deeper association.CONCLUSION This case links CH-induced heart failure with refractory lactic acidosis,urging prompt thyroid screening in affected neonates to reduce mortality.展开更多
Background:“Qi deficiency”(a pathological state where the body’s vital energy(Qi)is insufficient or weakened,impairing physiological functions and diminishing the body’s ability to perform daily activities,defend ...Background:“Qi deficiency”(a pathological state where the body’s vital energy(Qi)is insufficient or weakened,impairing physiological functions and diminishing the body’s ability to perform daily activities,defend against illness,and maintain homeostasis)syndrome is considered a critical syndrome in traditional Chinese medicine(TCM)and is associated with poor prognosis in heart failure(HF).This study investigates the clinical,metabolic,and transcriptomic differences between heart failure patients with and without Qi deficiency syndrome.Methods:56 heart failure patients were evaluated using a Qi deficiency syndrome scale and divided into Qi deficiency syndrome(QD)and non-Qi deficiency(non-QD)groups based on the median score.Clinical characteristics,including baseline N-terminal pro-B-type natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),total diuretic use during hospitalization,and 90-day rehospitalization rates,were compared between the groups.Differentially expressed genes(DEGs)and differential metabolites were identified,followed by enrichment analyses and validation using qPCR and Western blot in AC16 cardiomyocytes.Results:QD patients exhibited significantly higher NT-proBNP levels,lower LVEF,and increased 90-day rehospitalization rates.Metabolomic profiling revealed lipid metabolism disruptions,notably in linoleic acid and phospholipid pathways.Transcriptomic analysis highlighted 17 DEGs,including CISD2,a critical mitochondrial regulator,which was downregulated in QD patients.Correlation analysis identified significant associations between DEGs(e.g.,CISD2,BPGM)and lipid metabolites such as PC(16:0/P-16:0).Functional knockdown of CISD2 in AC16 cells led to upregulation of lipid oxidation enzymes ALOX15 and CYP1A2,linking CISD2 dysfunction to lipid metabolic dysregulation.Conclusion:Qi deficiency is associated with more severe heart failure symptoms,worse prognosis,and distinct metabolic and transcriptomic profiles,particularly in lipid metabolism.CISD2 emerges as a potential therapeutic target,offering new avenues for integrating molecular insights with TCM approaches to optimize HF management.展开更多
The local-world (LW) evolving network model shows a transition for the degree distribution between the exponential and power-law distributions, depending on the LW size. Cascading failures under intentional attacks in...The local-world (LW) evolving network model shows a transition for the degree distribution between the exponential and power-law distributions, depending on the LW size. Cascading failures under intentional attacks in LW network models with different LW sizes were investigated using the cascading failures load model. We found that the LW size has a significant impact on the network's robustness against deliberate attacks. It is much easier to trigger cascading failures in LW evolving networks with a larger LW size. Therefore, to avoid cascading failures in real networks with local preferential attachment such as the Internet, the World Trade Web and the multi-agent system, the LW size should be as small as possible.展开更多
Self-piercing riveting(SPR)is a cold forming technique used to fasten together two or more sheets of materials with a rivet without the need to predrill a hole.The application of SPR in the automotive sector has becom...Self-piercing riveting(SPR)is a cold forming technique used to fasten together two or more sheets of materials with a rivet without the need to predrill a hole.The application of SPR in the automotive sector has become increasingly popular mainly due to the growing use of lightweight materials in transportation applications.However,SPR joining of these advanced light materials remains a challenge as these materials often lack a good combination of high strength and ductility to resist the large plastic deformation induced by the SPR process.In this paper,SPR joints of advanced materials and their corresponding failure mechanisms are discussed,aiming to provide the foundation for future improvement of SPR joint quality.This paper is divided into three major sections:1)joint failures focusing on joint defects originated from the SPR process and joint failure modes under different mechanical loading conditions,2)joint corrosion issues,and 3)joint optimisation via process parameters and advanced techniques.展开更多
A fault tolerant control （FTC） design technique against actuator stuck faults is investigated using integral-type sliding mode control （ISMC） with application to spacecraft attitude maneuvering control system. The...A fault tolerant control （FTC） design technique against actuator stuck faults is investigated using integral-type sliding mode control （ISMC） with application to spacecraft attitude maneuvering control system. The principle of the proposed FTC scheme is to design an integral-type sliding mode attitude controller using on-line parameter adaptive updating law to compensate for the effects of stuck actuators. This adaptive law also provides both the estimates of the system parameters and external disturbances such that a prior knowledge of the spacecraft inertia or boundedness of disturbances is not required. Moreover, by including the integral feedback term, the designed controller can not only tolerate actuator stuck faults, but also compensate the disturbances with constant components. For the synthesis of controller, the fault time, patterns and values are unknown in advance, as motivated from a practical spacecraft control application. Complete stability and performance analysis are presented and illustrative simulation results of application to a spacecraft show that high precise attitude control with zero steady-error is successfully achieved using various scenarios of stuck failures in actuators.展开更多
Many experimental results have demonstrated the apparent discrepancy of a rock material between its flexural tensile strength measured using various bending methods and its tensile strength measured using direct tensi...Many experimental results have demonstrated the apparent discrepancy of a rock material between its flexural tensile strength measured using various bending methods and its tensile strength measured using direct tension method or Brazil disc(BD)method.To understand the physical mechanism for such discrepancy,numerical simulation using the realistic failure process analysis(RFPA)is carried out in this work to simulate the tensile failure of heterogeneous rocks.Direct tension and semi-circular bend(SCB)tests are simulated using RFPA for rock materials with different levels of inhomogeneity,which is characterized by the homogeneity index of the Weibull distribution used in RFPA.The numerical results show that the discrepancy in the tensile strength values is caused by the inhomogeneity of the rock material.Furthermore,non-local failure criterion is adopted to calculate the characteristic length of the rock materials used in the simulation.It is shown that below a certain value of the homogeneity index,both the characteristic length and discrepancy between two types of tensile strengths of rock decrease with increase of the homogeneity index up to a critical value,at which the discrepancy disappears and the rock material is essentially homogeneous.展开更多
AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed...AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures.展开更多
The paper attempts to represent a case of repeated failures on a high cut slope due to multi-excavation. The characteristics of each failure induced by excavation are analyzed through geological investigation, and the...The paper attempts to represent a case of repeated failures on a high cut slope due to multi-excavation. The characteristics of each failure induced by excavation are analyzed through geological investigation, and then a geological model at different failure stages is proposed. The geological analysis shows that the excavation-induced repeated failures are related to the exposure of the weak bedding plane and the toe unloading of the cut slope, Numerical modeling is conducted based on a sequential method, taking into account the main failure stages of cut slope. The simulation results fairly coincide with the practical phenomena observed in field. It is shown that the decrease in normal stress of displaced mass on cut slope will induce the increase in shear stress in bedding planes and that at the toe of the cut slope. The released stress leads to repeated gravitational instabilities of cut slope due to the decrease in normal stress and the increase in shear stress along the bedding planes of mudstone.展开更多
In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control （FTC） design problem of actuator fault and perturbation compensations for linear time-invariant...In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control （FTC） design problem of actuator fault and perturbation compensations for linear time-invariant systems.A more general and practical model of actuator faults is presented.While both eventual faults on actuators and perturbations are unknown,the adaptive schemes are addressed to estimate the lower and upper bounds of actuator-stuck faults and perturbations online,as well as to estimate control effectiveness on actuators.Thus,on the basis of the information from adaptive schemes,an adaptive robust state feed-back controller is designed to compensate the effects of faults and perturbations automatically.According to Lyapunov stability theory,it is shown that the robust adaptive closed-loop systems can be ensured to be asymptotically stable under the influence of actuator faults and bounded perturbations.An example is provided to further illustrate the fault compensation effectiveness.展开更多
Evaluation of blocky or layered rock slopes against toppling failures has remained of great concern for engineers in various rock mechanics projects.Several step-by-step analytical solutions have been developed for an...Evaluation of blocky or layered rock slopes against toppling failures has remained of great concern for engineers in various rock mechanics projects.Several step-by-step analytical solutions have been developed for analyzing these types of slope failures.However,manual application of these analytical solutions for real case studies can be time-consuming,complicated,and in certain cases even impossible.This study will first examine existing methods for toppling failure analyses that are reviewed,modified and generalized to consider the effects of a wide range of external and dead loads on slope stability.Next,based on the generalized presented formulae,a Windows form computer code is programmed using Visual C#for analysis of common types of toppling failures.Input parameters,including slope geometry,joint sets parameters,rock and soil properties,ground water level,dynamic loads,support anchor loads as well as magnitudes and forms of external forces,are first loaded into the code.The input data are then saved and used to graphically draw the slope model.This is followed by automatic identification of the toppling failure mode and a deterministic analysis of the slope stability against this failure mode.The results are presented using a graphical approach.The developed code allows probabilistic introduction of the input parameters via probability distribution functions(PDFs)and thus a probabilistic analysis of the toppling failure modes using Monte-Carlo simulation technique.This allows calculation of the probability of slope failure.Finally,several published case studies and typical examples are analyzed with the developed code.The outcomes are compared with those of the main references to assess the performance and robustness of the developed computer code.The comparisons demonstrate good agreement between the results.展开更多
Cascading failures are common phenomena in many of real-world networks,such as power grids,Internet,transportation networks and social networks.It's worth noting that once one or a few users on a social network ar...Cascading failures are common phenomena in many of real-world networks,such as power grids,Internet,transportation networks and social networks.It's worth noting that once one or a few users on a social network are unavailable for some reasons,they are more likely to influence a large portion of social network.Therefore,an effective mitigation strategy is very critical for avoiding or reducing the impact of cascading failures.In this paper,we firstly quantify the user loads and construct the processes of cascading dynamics,then elaborate the more reasonable mechanism of sharing the extra user loads with considering the features of social networks,and further propose a novel mitigation strategy on social networks against cascading failures.Based on the realworld social network datasets,we evaluate the effectiveness and efficiency of the novel mitigation strategy.The experimental results show that this mitigation strategy can reduce the impact of cascading failures effectively and maintain the network connectivity better with lower cost.These findings are very useful for rationally advertising and may be helpful for avoiding various disasters of cascading failures on many real-world networks.展开更多
With society＇s increasing dependence on critical infrastructure such as power grids and communications systems, the robustness of these systems has attracted significant attention.Failure of some nodes can trigger a ...With society＇s increasing dependence on critical infrastructure such as power grids and communications systems, the robustness of these systems has attracted significant attention.Failure of some nodes can trigger a cascading failure, which completely fragments the network, necessitating recovery efforts to improve robustness of complex systems. Inspired by real-world scenarios, this paper proposes repair models after two kinds of network failures, namely complete and incomplete collapse. In both models, three kinds of repair strategies are possible, including random selection（RS）, node selection based on single network node degree（SD）, and node selection based on double network node degree（DD）. We find that the node correlation in each of the two coupled networks affects repair efficiency. Numerical simulation and analysis results suggest that the repair node ratio and repair strategies may have a significant impact on the economics of the repair process. The results of this study thus provide insight into ways to improve the robustness of coupled networks after cascading failures.展开更多
基金Supported by National Natural Science Foundation of China,No.82271546 and No.82301744The Shanxi Province Science and Technology Innovation Think Tank Construction Research Project,No.KXKT202317+1 种基金Fundamental Research Program of Shanxi Province,No.202303021222346 and No.202103021223224The Research Foundation of The First Hospital of Shanxi Medical University,No.YQ2208.
文摘BACKGROUND The coronavirus disease 2019 pandemic has had an ongoing impact on the public’s mental health that requires long-term attention.Exploring the relationship between mental health indicators would aid in identifying solutions to improve public mental health.AIM To investigate the prevalence of anxiety,depression,and insomnia and explore the relationship among neuroticism,cognitive failures,and mental health.METHODS A cross-sectional survey was conducted in December 2023 using an online platform to recruit adult participants.The neuroticism,subjective cognitive function,and mental health of the participants were assessed using the neuroticism subscale of the Chinese Big Five Personality Inventory Brief Version,cognitive failures questionnaire,generalized anxiety disorder-7,patient health questionnaire-9,and insomnia severity index.Pearson's correlation analysis,independent samples t-tests,one-way analysis of variance,and structural equation model were used to examine the relationship between mental health indicators.RESULTS A total of 1011 valid questionnaires were collected,of which 343 were completed by male(33.93%)respondents and 668 were completed by female(66.07%)respondents.The rates of anxiety,depression,and insomnia were 41.3%,44.6%,and 36.3%,respectively,most cases of which were mild.Among the mental health indicators,there were significant differences by age and between those with siblings and those who were only children.Neuroticism and cognitive failures were significantly positively correlated with mental health indicators.Further moderated mediation analysis showed that cognitive failures mediated the relationship between insomnia and anxiety and between insomnia and depression,with neuroticism moderating the first half of this pathway and the effect being greater in the low-neuroticism group.CONCLUSION Cognitive failures and neuroticism play important roles in mental health.Therefore,enhancing subjective cognitive function and regulating emotional stability may contribute to the improvement of mental health.
基金funded by the Key Research and Development Project of Guangdong Province(No.2023B0909050004)the National Natural Science Foundation of China(No.12402214).
文摘The insertion and extraction of lithium ions in active materials lead to significant volumetric deformation,resulting in stresses that drive the mechanical degradation of these materials.This accumulation of mechanical degradation ultimately leads to mechanical failure in lithium-ion batteries(LIB).This paper summarizes the experimental characterization techniques used to observe the mechanical degradation of lithium battery cells,electrodes,and particles across macro,micro,and nano scales.Additionally,the mechanical failure model for LIB that spans from the microscopic to the macroscopic scale has been outlined.Finally,we analyze the current challenges and opportunities,including the standardization of battery measurements,the quantification of mechanical failures,and the correlation between mechanical failures and electrochemical performance.
基金supported by the National Social Science Fund Project(No.23&ZD115)the Graduate Student Research Innovation Project of the School of Mathematics and Statistics,Hubei Minzu University(No.STK2023011)。
文摘Compared to single-layer networks,multilayer networks exhibit a more complex node degree composition,comprising both intra-layer and inter-layer degrees.However,the distinct impacts of these degree types on cascading failures remain underexplored.Distinguishing their effects is crucial for a deeper understanding of network structure,information propagation,and behavior prediction.This paper proposes a capacity-load model to influence and compare the influence of different degree types on cascading failures in multilayer networks.By designing three node removal strategies based on total degree,intra-layer degree,and inter-layer degree,simulation experiments are conducted on four types of networks.Network robustness is evaluated using the maximum number of removable nodes before collapse.The relationships between network robustness and the coupling coefficient,as well as load and capacity adjustment parameters,are also analyzed.The results indicate that the node removal strategy with the least impact on cascading failures varies across different types of networks,revealing the significance of different node degrees in failure propagation.Compared to other models,the proposed model enables networks to maintain a higher maximum number of removable nodes during cascading failures,demonstrating superior robustness.
基金supported by the National Key Research and Development Program of China"Key technologies for system stability and HVDC transmission of large-scale renewable energy generation base without conventional power support(2022YFB2402700)"the project of the State Grid Corporation of China(52272222001J).
文摘In wind and solar renewable-dominant hybrid alternating current/direct current(AC/DC)power systems,the active power of high-voltage direct current(HVDC)system is significantly limited by the security and stability events caused by cascading failures.To identify critical lines in cascading failures,a rapid risk assessment method is proposed based on the gradient boosting decision tree(GBDT)and frequent pat-tern growth(FP-Growth)algorithms.First,security and stability events triggered by cascading failures are analyzed to explain the impact of cascading failures on the maximum DC power.Then,a cascading failure risk index is defined,focusing on the DC power being limited.To handle the strong nonlinear relationship between the maximum DC power and cascading failures,a GBDT with an update strategy is utilized to rapidly predict the maximum DC power under uncertain operating conditions.Finally,the FP-Growth algorithm is improved to mine frequent patterns in cascading failures.The importance index for each fault in a frequent pattern is defined by evaluating its impact on cascading failures,enabling the identification of critical lines.Simulation results of a modified Ningxia–Shandong hybrid AC/DC system in China demonstrate that the proposed method can rapidly assess the risk of cascading failures and effectively identify critical lines.
文摘This study explores ethical violations and audit failures in various large-scale corporate fraud cases.Using a qualitative descriptive method and based on secondary data from documented fraud cases and published audit reports,the study applies the Fraud Triangle framework,focusing on how weak integrity,objectivity,and professional competence have undermined public trust in the auditing profession.Using a qualitative descriptive method and the Fraud Triangle framework,which includes pressure,opportunity,and rationalization,the study analyzes cases from Indonesia(SNP Finance,Jiwasraya),China(Evergrande),and Germany(Wirecard).The analysis reveals that many audit failures observed in this study appear to stem more from ethical challenges than from technical incapability,driven by client pressure,weak internal controls,and compromised auditor independence.These cases demonstrate a recurring global pattern in which auditors neglect their responsibility to act in the public interest.
文摘This study explores ethical violations and audit failures in various large-scale corporate fraud cases.Using a qualitative descriptive method and based on secondary data from documented fraud cases and published audit reports,the study applies the Fraud Triangle framework,focusing on how weak integrity,objectivity,and professional competence have undermined public trust in the auditing profession.Using a qualitative descriptive method and the Fraud Triangle framework,which includes pressure,opportunity,and rationalization,the study analyzes cases from Indonesia(SNP Finance,Jiwasraya),China(Evergrande),and Germany(Wirecard).The analysis reveals that many audit failures observed in this study appear to stem more from ethical challenges than from technical incapability,driven by client pressure,weak internal controls,and compromised auditor independence.These cases demonstrate a recurring global pattern in which auditors neglect their responsibility to act in the public interest.
文摘According to some observed dama ge phenomena in the smart structure systems, the issues related to the damage and failures of smart structures are addressed in this paper. A few possible damage patterns and the definition of the failure of the smart structures are given. It is pointed out that more attentions should be paid to the functional failures o f smart structures. The effects on the control the static deformation due to par tial debonding of PZT actuators are analyzed by the finite element method. Preli minary numerical results show that partial debonding of PZT actuators may have a p preciate reduction on their actuating ability thus reducing the control ability and accuracy of the smart structures.
文摘BACKGROUND Anxiety,depression,and other negative emotions are common among patients with chronic renal failure(CRF).Analyzing the factors related to negative emotions is necessary to provide targeted nursing care.AIM To explore the correlations among life satisfaction,pleasure levels,and negative emotions in patients with CRF.METHODS One hundred patients with CRF who received therapy at the First Affiliated Hospital of Jinzhou Medical University between December 2022 and February 2025 were included.The Depression,Anxiety,and Stress Scale(DASS-21),Satisfaction with Life Scale(SWLS),and Temporal Experience of Pleasure Scale(TEPS)were used to evaluate negative emotions,life satisfaction,and pleasure level,respectively.Pearson’s correlation coefficient analyzed the correlation between life satisfaction,pleasure level,and negative emotions.Linear regression analysis identified the factors affecting negative emotions.RESULTS The average DASS-21 score among patients with CRF was 51.90±2.30,with subscale scores of 17.90±1.50 for depression,18.53±1.18 for anxiety,and 15.47±2.36 for stress,all significantly higher than the domestic norm(P<0.05).The average SWLS score was 22.17±4.90.Correlation analysis revealed a negative correlation between the SWLS and total DASS-21 scores(P<0.05),but not with the individual depression,anxiety,or stress dimensions.The average TEPS score was 67.80±8.34.TEPS scores were negatively correlated with the DASS-21 score and the stress dimension(P<0.05),but not with depression or anxiety.Linear regression analysis showed that TEPS scores significantly influenced DASS-21 scores(P<0.05).CONCLUSION Patients with CRF experience high levels of negative emotions,which are negatively correlated with life satisfaction and pleasure.Furthermore,pleasure level had an impact on negative emotions.
文摘BACKGROUND Congenital hypothyroidism(CH)is a common condition in both preterm and term infants characterized by either thyroid gland absence or hypofunctionality.The clinical association of refractory lactic acidosis and heart failure has rarely been observed in cases of pediatric patients with CH pathology.Here,we explored the etiological relationship between CH,heart failure,and refractory lactic acidosis to reflect the importance of thyroid function screening in neonates with heart disease.CASE SUMMARY A 33-day-old extremely premature female infant presented with tachypnea,respiratory distress,recurrent infections,and abdominal distension postnatal.On admission to our facility,she had cardiomegaly,hepatomegaly,and lactic acidosis(revealed on blood gas analysis),with lactate progressively rising to 25 mmol/L.Chest radiographs showed pulmonary congestion,while echocardiography revealed cardiac enlargement,left ventricular wall thickening,and pericardial effusion.Initial management aimed at correcting acidosis and treating heart failure proved ineffective.After reassessment,thyroid function tests showed significantly decreased triiodothyronine,free triiodothyronine,thyroxine,and free thyroxine levels,with a significantly increased thyroidstimulating hormone level,confirming a CH diagnosis.Levothyroxine was administered,resulting in rapid correction of lactic acidosis and gradual improvement of thyroid function and systemic symptoms,culminating in full recovery and discharge.We also reviewed the relevant literature on thyroid and cardiac dysfunctions in order to explore their deeper association.CONCLUSION This case links CH-induced heart failure with refractory lactic acidosis,urging prompt thyroid screening in affected neonates to reduce mortality.
基金supported by the Sanming Project of Medicine in Shenzhen[SZZYSM202206001]National Natural Science Foundation of China[82004320 and 82374383]+3 种基金Natural Science Foundation of Guangdong Province of China[2022A1515011710 and 2022A1515010679]Shenzhen Science and Technology Innovation Committee[JCYJ20220530141407017 and JCYJ20240813153619026]2024 High-quality Development Research Project of Shenzhen Bao’an Public Hospital[YNXM2024078]and Shenzhen Bao’an Chinese Medicine Hospital Research Program[BAZYY20220702].
文摘Background:“Qi deficiency”(a pathological state where the body’s vital energy(Qi)is insufficient or weakened,impairing physiological functions and diminishing the body’s ability to perform daily activities,defend against illness,and maintain homeostasis)syndrome is considered a critical syndrome in traditional Chinese medicine(TCM)and is associated with poor prognosis in heart failure(HF).This study investigates the clinical,metabolic,and transcriptomic differences between heart failure patients with and without Qi deficiency syndrome.Methods:56 heart failure patients were evaluated using a Qi deficiency syndrome scale and divided into Qi deficiency syndrome(QD)and non-Qi deficiency(non-QD)groups based on the median score.Clinical characteristics,including baseline N-terminal pro-B-type natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF),total diuretic use during hospitalization,and 90-day rehospitalization rates,were compared between the groups.Differentially expressed genes(DEGs)and differential metabolites were identified,followed by enrichment analyses and validation using qPCR and Western blot in AC16 cardiomyocytes.Results:QD patients exhibited significantly higher NT-proBNP levels,lower LVEF,and increased 90-day rehospitalization rates.Metabolomic profiling revealed lipid metabolism disruptions,notably in linoleic acid and phospholipid pathways.Transcriptomic analysis highlighted 17 DEGs,including CISD2,a critical mitochondrial regulator,which was downregulated in QD patients.Correlation analysis identified significant associations between DEGs(e.g.,CISD2,BPGM)and lipid metabolites such as PC(16:0/P-16:0).Functional knockdown of CISD2 in AC16 cells led to upregulation of lipid oxidation enzymes ALOX15 and CYP1A2,linking CISD2 dysfunction to lipid metabolic dysregulation.Conclusion:Qi deficiency is associated with more severe heart failure symptoms,worse prognosis,and distinct metabolic and transcriptomic profiles,particularly in lipid metabolism.CISD2 emerges as a potential therapeutic target,offering new avenues for integrating molecular insights with TCM approaches to optimize HF management.
基金the National Basic Research Program (973) of China (No. 2004CB217902)the National Natural Science Foundation of China (Nos. 60421002 and 60804045)the Postdoctoral Science Foundation of China (No. 20070421163)
文摘The local-world (LW) evolving network model shows a transition for the degree distribution between the exponential and power-law distributions, depending on the LW size. Cascading failures under intentional attacks in LW network models with different LW sizes were investigated using the cascading failures load model. We found that the LW size has a significant impact on the network's robustness against deliberate attacks. It is much easier to trigger cascading failures in LW evolving networks with a larger LW size. Therefore, to avoid cascading failures in real networks with local preferential attachment such as the Internet, the World Trade Web and the multi-agent system, the LW size should be as small as possible.
文摘Self-piercing riveting(SPR)is a cold forming technique used to fasten together two or more sheets of materials with a rivet without the need to predrill a hole.The application of SPR in the automotive sector has become increasingly popular mainly due to the growing use of lightweight materials in transportation applications.However,SPR joining of these advanced light materials remains a challenge as these materials often lack a good combination of high strength and ductility to resist the large plastic deformation induced by the SPR process.In this paper,SPR joints of advanced materials and their corresponding failure mechanisms are discussed,aiming to provide the foundation for future improvement of SPR joint quality.This paper is divided into three major sections:1)joint failures focusing on joint defects originated from the SPR process and joint failure modes under different mechanical loading conditions,2)joint corrosion issues,and 3)joint optimisation via process parameters and advanced techniques.
基金National Natural Science Foundation of China(61004072)Fundamental Research Funds for the Central Universities(HIT.NSRIF.2009003)+1 种基金Research Fund for the Doctoral Program of Higher Education of China (20070213061, 20102302110031)Scientific Research Foundation for the Returned Overseas Chinese Scholars of Harbin (2010RFLXG001)
文摘A fault tolerant control （FTC） design technique against actuator stuck faults is investigated using integral-type sliding mode control （ISMC） with application to spacecraft attitude maneuvering control system. The principle of the proposed FTC scheme is to design an integral-type sliding mode attitude controller using on-line parameter adaptive updating law to compensate for the effects of stuck actuators. This adaptive law also provides both the estimates of the system parameters and external disturbances such that a prior knowledge of the spacecraft inertia or boundedness of disturbances is not required. Moreover, by including the integral feedback term, the designed controller can not only tolerate actuator stuck faults, but also compensate the disturbances with constant components. For the synthesis of controller, the fault time, patterns and values are unknown in advance, as motivated from a practical spacecraft control application. Complete stability and performance analysis are presented and illustrative simulation results of application to a spacecraft show that high precise attitude control with zero steady-error is successfully achieved using various scenarios of stuck failures in actuators.
基金supported by the Natural Science Foundation of China(Grant Nos.51704211 and 11602165).
文摘Many experimental results have demonstrated the apparent discrepancy of a rock material between its flexural tensile strength measured using various bending methods and its tensile strength measured using direct tension method or Brazil disc(BD)method.To understand the physical mechanism for such discrepancy,numerical simulation using the realistic failure process analysis(RFPA)is carried out in this work to simulate the tensile failure of heterogeneous rocks.Direct tension and semi-circular bend(SCB)tests are simulated using RFPA for rock materials with different levels of inhomogeneity,which is characterized by the homogeneity index of the Weibull distribution used in RFPA.The numerical results show that the discrepancy in the tensile strength values is caused by the inhomogeneity of the rock material.Furthermore,non-local failure criterion is adopted to calculate the characteristic length of the rock materials used in the simulation.It is shown that below a certain value of the homogeneity index,both the characteristic length and discrepancy between two types of tensile strengths of rock decrease with increase of the homogeneity index up to a critical value,at which the discrepancy disappears and the rock material is essentially homogeneous.
文摘AIM:To evaluate the efficacy and safety of tenofovir disoproxil fumarate(TDF) for chronic hepatitis B(CHB) patients after multiple failures.METHODS:A total of 29 CHB patients who had a suboptimal response or developed resistance to two or more previous nucleoside/nucleotide analogue(NA) treatments were included.Study subjects were treated with TDF alone(n = 13) or in combination with lamivudine(LAM,n = 12) or entecavir(ETV,n = 4) for ≥ 6 mo.Complete virologic response(CVR) was defined as an achievement of serum hepatitis B virus(HBV) DNA level ≤ 60 IU/mL by real-time polymerase chain reaction method during treatment.Safety assessment was based on serum creatinine and phosphorus level.Eleven patients had histories of LAM and adefovir dipivoxil(ADV) treatment and 18 patients were exposed to LAM,ADV,and ETV.Twenty-seven patients(93.1%) were hepatitis B e antigen(HBeAg) positive and the mean value of the baseline serum HBV DNA level was 5.5 log IU/mL ± 1.7 log IU/mL.The median treatment duration was 16 mo(range 7 to 29 mo).RESULTS:All the patients had been treated with LAM and developed genotypic and phenotypic resistance to it.Resistance to ADV was present in 7 patients and 10 subjects had a resistance to ETV.One patient had a resistance to both ADV and ETV.The cumulative probabilities of CVR at 12 and 24 mo of TDF containing treatment regimen calculated by the Kaplan Meier method were 86.2% and 96.6%,respectively.Although one patient failed to achieve CVR,serum HBV DNA level decreased by 3.9 log IU/mL from the baseline and the last serum HBV DNA level during treatment was 85 IU/mL,achieving near CVR.No patients in this study showed viral breakthrough or primary non-response during the follow-up period.The cumulative probability of HBeAg clearance in the 27 HBeAg positive patients was 7.4%,12%,and 27% at 6,12,and 18 mo of treatment,respectively.Treatment efficacy of TDF containing regimen was not statistically different according to the presence of specific HBV mutations.History of prior exposure to specific antiviral agents did not make a difference to treatment outcome.Treatment efficacy of TDF was not affected by combination therapy with LAM or ETV.No patient developed renal toxicity and no cases of hypophosphatemia associated with TDF therapy were observed.There were no other adverse events related to TDF therapy observed in the study subjects.CONCLUSION:TDF can be an effective and safe rescue therapy in CHB patients after multiple NA therapy failures.
基金Supported by the National Natural Science Foundation of China(41072213 and 40801212)the Opening Fund of Key Laboratory of Mechanics on Disaster and Environment in Western China, Lanzhou University(201207)
文摘The paper attempts to represent a case of repeated failures on a high cut slope due to multi-excavation. The characteristics of each failure induced by excavation are analyzed through geological investigation, and then a geological model at different failure stages is proposed. The geological analysis shows that the excavation-induced repeated failures are related to the exposure of the weak bedding plane and the toe unloading of the cut slope, Numerical modeling is conducted based on a sequential method, taking into account the main failure stages of cut slope. The simulation results fairly coincide with the practical phenomena observed in field. It is shown that the decrease in normal stress of displaced mass on cut slope will induce the increase in shear stress in bedding planes and that at the toe of the cut slope. The released stress leads to repeated gravitational instabilities of cut slope due to the decrease in normal stress and the increase in shear stress along the bedding planes of mudstone.
基金supported by the Funds for Creative Research Groups of China(No.60821063)National 973 Program of China(No.2009CB320604)+2 种基金the Funds of National Science of China(No.60974043)the 111 Project(No.B08015)the Fundamental Research Funds for the Central Universities(No.N090604001,N090604002)
文摘In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control （FTC） design problem of actuator fault and perturbation compensations for linear time-invariant systems.A more general and practical model of actuator faults is presented.While both eventual faults on actuators and perturbations are unknown,the adaptive schemes are addressed to estimate the lower and upper bounds of actuator-stuck faults and perturbations online,as well as to estimate control effectiveness on actuators.Thus,on the basis of the information from adaptive schemes,an adaptive robust state feed-back controller is designed to compensate the effects of faults and perturbations automatically.According to Lyapunov stability theory,it is shown that the robust adaptive closed-loop systems can be ensured to be asymptotically stable under the influence of actuator faults and bounded perturbations.An example is provided to further illustrate the fault compensation effectiveness.
文摘Evaluation of blocky or layered rock slopes against toppling failures has remained of great concern for engineers in various rock mechanics projects.Several step-by-step analytical solutions have been developed for analyzing these types of slope failures.However,manual application of these analytical solutions for real case studies can be time-consuming,complicated,and in certain cases even impossible.This study will first examine existing methods for toppling failure analyses that are reviewed,modified and generalized to consider the effects of a wide range of external and dead loads on slope stability.Next,based on the generalized presented formulae,a Windows form computer code is programmed using Visual C#for analysis of common types of toppling failures.Input parameters,including slope geometry,joint sets parameters,rock and soil properties,ground water level,dynamic loads,support anchor loads as well as magnitudes and forms of external forces,are first loaded into the code.The input data are then saved and used to graphically draw the slope model.This is followed by automatic identification of the toppling failure mode and a deterministic analysis of the slope stability against this failure mode.The results are presented using a graphical approach.The developed code allows probabilistic introduction of the input parameters via probability distribution functions(PDFs)and thus a probabilistic analysis of the toppling failure modes using Monte-Carlo simulation technique.This allows calculation of the probability of slope failure.Finally,several published case studies and typical examples are analyzed with the developed code.The outcomes are compared with those of the main references to assess the performance and robustness of the developed computer code.The comparisons demonstrate good agreement between the results.
基金supported by the National Key Technology R&D Program of China under Grant No.2012BAH46B04
文摘Cascading failures are common phenomena in many of real-world networks,such as power grids,Internet,transportation networks and social networks.It's worth noting that once one or a few users on a social network are unavailable for some reasons,they are more likely to influence a large portion of social network.Therefore,an effective mitigation strategy is very critical for avoiding or reducing the impact of cascading failures.In this paper,we firstly quantify the user loads and construct the processes of cascading dynamics,then elaborate the more reasonable mechanism of sharing the extra user loads with considering the features of social networks,and further propose a novel mitigation strategy on social networks against cascading failures.Based on the realworld social network datasets,we evaluate the effectiveness and efficiency of the novel mitigation strategy.The experimental results show that this mitigation strategy can reduce the impact of cascading failures effectively and maintain the network connectivity better with lower cost.These findings are very useful for rationally advertising and may be helpful for avoiding various disasters of cascading failures on many real-world networks.
基金supported by the National Natural Science Foundation of China(60972145)the National Aerospace Science Foundation of China(20140751008)
文摘With society＇s increasing dependence on critical infrastructure such as power grids and communications systems, the robustness of these systems has attracted significant attention.Failure of some nodes can trigger a cascading failure, which completely fragments the network, necessitating recovery efforts to improve robustness of complex systems. Inspired by real-world scenarios, this paper proposes repair models after two kinds of network failures, namely complete and incomplete collapse. In both models, three kinds of repair strategies are possible, including random selection（RS）, node selection based on single network node degree（SD）, and node selection based on double network node degree（DD）. We find that the node correlation in each of the two coupled networks affects repair efficiency. Numerical simulation and analysis results suggest that the repair node ratio and repair strategies may have a significant impact on the economics of the repair process. The results of this study thus provide insight into ways to improve the robustness of coupled networks after cascading failures.
