Cardiac disorders, including myocardial infarction, heart failure, and arrhythmias, are marked causes of morbidity and mortality worldwide. Early diagnosis and effective management of these conditions are crucial for ...Cardiac disorders, including myocardial infarction, heart failure, and arrhythmias, are marked causes of morbidity and mortality worldwide. Early diagnosis and effective management of these conditions are crucial for improving patient outcomes. Biomarkers, which are measurable biological indicators, have emerged as essential tools in the diagnosis, prognosis, and risk stratification of cardiac diseases. Among the well-established biomarkers, cardiac troponins (cardiac troponin I and cardiac troponin T) exhibit high sensitivity and specificity in the detection of myocardial infarction, and recent advances have improved early diagnosis and risk evaluation. B-type natriuretic peptide and its precursor N-terminal pro-B-type natriuretic peptide play critical roles in the diagnosis and management of heart failure;elevated levels of these factors indicate poor prognosis and can guide therapeutic decision-making. Additionally, C-reactive protein levels have been widely used in cardiovascular risk assessment and show high sensitivity. Emerging biomarkers, such as galectin-3, suppression of tumorigenicity 2, and microRNAs, show promise in enhancing the prediction of heart failure, assessment of myocardial stress, and detection of cardiac conditions in early stages. This review provides a comprehensive evaluation of these biomarkers, highlighting their clinical applications and limitations, as well as the integration of these biomarkers with imaging techniques. This review also explores the potential for future research aimed at developing personalized treatment strategies based on biomarker profiles. Biomarkers are becoming increasingly vital in optimizing cardiac care and improving patient outcomes through more targeted and individualized approaches.展开更多
Objective To analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lungcancer surgery,to identify the risk factors associated with respirator...Objective To analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lungcancer surgery,to identify the risk factors associated with respiratory failureand toinvestigate the clinical significance of independent risk factors for the early prediction of respiratory failure in this patient population.Methods A total of 42 elderly patients who developed respiratory failure following thoracoscopic-assisted radical lung cancer surgery at our hospital between January 1,2021,and December 31,2023,were continuously collected to form the observation group.Concurrently,a control groupp was established by randomly selecting elderly lung cancer patients who did not experience respiratory failure during the same period,in a 1:1 ratio.Clinical data were collected from both groups,and logistic univariate and multivariate analyses were conducted.A receiver operating characteristic(ROC)curve was employed to evaluate the area under the curve(AUC),as well as the sensitivity and specificity of independent risk factors and their combinations.Results The history of diabetes,PCT levels,and surgical day intake had been identified as independent risk factors for respiratory failure.Multivariate analysis revealed that a history of diabetes(OR:1.29,95%CI:0.89-1.69;P=0.012),PCT(0R:1.75,95%CI:1.51-2.38;P=0.005),and surgical day intake(0R:1.42,95%Cl:1.14-1.76;P<0.001)were significantly associated with the occurrence of postoperative respiratory failure.The area under the curve(AUC)values for predicting respiratory failure were 0.679,0.679,and 0.740,respectively.The sensitivity and specificity for a history of diabetes were 41.2%and 87.1%;for PCT,64.7%and 64.5%;and for surgical day intake,70.6%and 74.2%.Notably,a combined model incorporating these three indicators produced an AUC of 0.918,with a sensitivity of 94.1%and a specificity of 80.6%.Conclusion Following thoracoscopic-assisted radical lung cancer surgery,elderly patients with a history of diabetes,elevated PCT levels,and a daily fluid intake exceeding 2000 ml on the day of surgery demonstrate significant clinical value for the early detection of respiratory failure.展开更多
Dear Editor,Long-term acute care hospitals(LTACHs)are health care facilities designed to address a wide variety of complex patient needs,particularly for individuals requiring mechanical ventilation for prolonged peri...Dear Editor,Long-term acute care hospitals(LTACHs)are health care facilities designed to address a wide variety of complex patient needs,particularly for individuals requiring mechanical ventilation for prolonged periods,weaning from ventilators,specialized wound care,management of multiorgan failure,and postsurgical or organ transplant complications.展开更多
文摘Cardiac disorders, including myocardial infarction, heart failure, and arrhythmias, are marked causes of morbidity and mortality worldwide. Early diagnosis and effective management of these conditions are crucial for improving patient outcomes. Biomarkers, which are measurable biological indicators, have emerged as essential tools in the diagnosis, prognosis, and risk stratification of cardiac diseases. Among the well-established biomarkers, cardiac troponins (cardiac troponin I and cardiac troponin T) exhibit high sensitivity and specificity in the detection of myocardial infarction, and recent advances have improved early diagnosis and risk evaluation. B-type natriuretic peptide and its precursor N-terminal pro-B-type natriuretic peptide play critical roles in the diagnosis and management of heart failure;elevated levels of these factors indicate poor prognosis and can guide therapeutic decision-making. Additionally, C-reactive protein levels have been widely used in cardiovascular risk assessment and show high sensitivity. Emerging biomarkers, such as galectin-3, suppression of tumorigenicity 2, and microRNAs, show promise in enhancing the prediction of heart failure, assessment of myocardial stress, and detection of cardiac conditions in early stages. This review provides a comprehensive evaluation of these biomarkers, highlighting their clinical applications and limitations, as well as the integration of these biomarkers with imaging techniques. This review also explores the potential for future research aimed at developing personalized treatment strategies based on biomarker profiles. Biomarkers are becoming increasingly vital in optimizing cardiac care and improving patient outcomes through more targeted and individualized approaches.
文摘Objective To analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lungcancer surgery,to identify the risk factors associated with respiratory failureand toinvestigate the clinical significance of independent risk factors for the early prediction of respiratory failure in this patient population.Methods A total of 42 elderly patients who developed respiratory failure following thoracoscopic-assisted radical lung cancer surgery at our hospital between January 1,2021,and December 31,2023,were continuously collected to form the observation group.Concurrently,a control groupp was established by randomly selecting elderly lung cancer patients who did not experience respiratory failure during the same period,in a 1:1 ratio.Clinical data were collected from both groups,and logistic univariate and multivariate analyses were conducted.A receiver operating characteristic(ROC)curve was employed to evaluate the area under the curve(AUC),as well as the sensitivity and specificity of independent risk factors and their combinations.Results The history of diabetes,PCT levels,and surgical day intake had been identified as independent risk factors for respiratory failure.Multivariate analysis revealed that a history of diabetes(OR:1.29,95%CI:0.89-1.69;P=0.012),PCT(0R:1.75,95%CI:1.51-2.38;P=0.005),and surgical day intake(0R:1.42,95%Cl:1.14-1.76;P<0.001)were significantly associated with the occurrence of postoperative respiratory failure.The area under the curve(AUC)values for predicting respiratory failure were 0.679,0.679,and 0.740,respectively.The sensitivity and specificity for a history of diabetes were 41.2%and 87.1%;for PCT,64.7%and 64.5%;and for surgical day intake,70.6%and 74.2%.Notably,a combined model incorporating these three indicators produced an AUC of 0.918,with a sensitivity of 94.1%and a specificity of 80.6%.Conclusion Following thoracoscopic-assisted radical lung cancer surgery,elderly patients with a history of diabetes,elevated PCT levels,and a daily fluid intake exceeding 2000 ml on the day of surgery demonstrate significant clinical value for the early detection of respiratory failure.
文摘Dear Editor,Long-term acute care hospitals(LTACHs)are health care facilities designed to address a wide variety of complex patient needs,particularly for individuals requiring mechanical ventilation for prolonged periods,weaning from ventilators,specialized wound care,management of multiorgan failure,and postsurgical or organ transplant complications.
