BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients oft...BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.展开更多
Many rock types have naturally occurring inherent anisotropic planes, such as bedding planes, foliation,or flow structures. Such characteristic induces directional features and anisotropy in rocks＇ strength anddeform...Many rock types have naturally occurring inherent anisotropic planes, such as bedding planes, foliation,or flow structures. Such characteristic induces directional features and anisotropy in rocks＇ strength anddeformational properties. The HoekeBrown （HeB） failure criterion is an empirical strength criterionwidely applied to rock mechanics and engineering. A direct modification to HeB failure criterion toaccount for rock anisotropy is considered as the base of the research. Such modification introduced a newdefinition of the anisotropy as direct parameter named the anisotropic parameter （Kb）. However, thecomputation of this parameter takes much experimental work and cannot be calculated in a simple way.The aim of this paper is to study the trend of the relation between the degree of anisotropy （Rc） and theminimum value of anisotropic parameter （Kmin）, and to predict the Kmin directly from the uniaxialcompression tests instead of triaxial tests, and also to decrease the amount of experimental work. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.展开更多
To perform structure buckling and reliability analysis on supercavitating vehicles with high velocity in the submarine,supercavitating vehicles were simplified as variable cross section beam firstly.Then structural bu...To perform structure buckling and reliability analysis on supercavitating vehicles with high velocity in the submarine,supercavitating vehicles were simplified as variable cross section beam firstly.Then structural buckling analysis of supercavitating vehicles with or without engine thrust was conducted,and the structural buckling safety margin equation of supercavitating vehicles was established.The indefinite information was described by interval set and the structure reliability analysis was performed by using non-probabilistic reliability method.Considering interval variables as random variables which satisfy uniform distribution,the Monte-Carlo method was used to calculate the non-probabilistic failure degree.Numerical examples of supercavitating vehicles were presented.Under different ratios of base diameter to cavitator diameter,the change tendency of non-probabilistic failure degree of structural buckling of supercavitating vehicles with or without engine thrust was studied along with the variety of speed.展开更多
文摘BACKGROUND The central link between septic shock and acute skin failure(ASF)is the inflammatory response,which occurs throughout disease progression and can lead to systemic inflammatory response syndrome.Patients often experience bad moods,sleep disorders,and other health issues.Despite recognizing these factors,no studies have examined the correlation between inflammatory factors,lactic acid levels,ASF,mood disturbances,and sleep quality in critically ill patients.We hypothesize that higher levels of inflammatory factors and lactic acid are associated with more severe ASF and poorer mood and sleep quality,which may inform clinical treatment for septic shock and ASF.AIM To explore the relationship between inflammatory factors,lactic acid levels,the severity of ASF,bad mood,and sleep quality.METHODS The retrospective study included 150 patients with septic shock from the Second Hospital of Dalian Medical University,categorized into ASF(n=35)or non-ASF groups(n=115).We compared the peripheral blood inflammatory factors,including tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),lactic acid levels,skin mottling score(SMS),modified early warning score(MEWS),self-rating depression scale(SDS),self-rating anxiety scale(SAS),and Pittsburgh sleep quality index(PSQI)scores.Pearson correlation analysis assessed relationships among these variables.RESULTS The ASF group had significantly higher levels of CRP(19.60±4.10 vs 15.30±2.96 mg/mL),IL-6(298.65±48.65 vs 268.66±33.66 pg/L),procalcitonin,lactic acid(8.42±2.32 vs 5.70±1.27 mmol/L),SMS[0(0,1)vs 3(2,3)],MEWS(9.34±1.92 vs 6.48±1.96),SAS(61.63±12.03 vs 53.71±12.48),SDS(60.17±12.64 vs 52.27±12.64),and PSQI scores(14.23±3.94 vs 8.69±2.46)compared with the non-ASF group(all P<0.001).Pearson correlation analysis revealed that IL-6,CRP,TNF-α,and lactic acid were positively correlated with SMS,MEWS,SAS,SDS,and PSQI scores(P<0.05).CONCLUSION Peripheral blood levels of IL-6,CRP,TNF-α,and lactic acid correlate positively with SMS,MEWS,SAS,SDS,and PSQI in critically ill patients with ASF.
文摘Many rock types have naturally occurring inherent anisotropic planes, such as bedding planes, foliation,or flow structures. Such characteristic induces directional features and anisotropy in rocks＇ strength anddeformational properties. The HoekeBrown （HeB） failure criterion is an empirical strength criterionwidely applied to rock mechanics and engineering. A direct modification to HeB failure criterion toaccount for rock anisotropy is considered as the base of the research. Such modification introduced a newdefinition of the anisotropy as direct parameter named the anisotropic parameter （Kb）. However, thecomputation of this parameter takes much experimental work and cannot be calculated in a simple way.The aim of this paper is to study the trend of the relation between the degree of anisotropy （Rc） and theminimum value of anisotropic parameter （Kmin）, and to predict the Kmin directly from the uniaxialcompression tests instead of triaxial tests, and also to decrease the amount of experimental work. 2014 Institute of Rock and Soil Mechanics, Chinese Academy of Sciences. Production and hosting byElsevier B.V. All rights reserved.
基金Sponsored by the National High-Tech Research and Development Program of China(863 Program)(Grant No. 2006AA04Z410)
文摘To perform structure buckling and reliability analysis on supercavitating vehicles with high velocity in the submarine,supercavitating vehicles were simplified as variable cross section beam firstly.Then structural buckling analysis of supercavitating vehicles with or without engine thrust was conducted,and the structural buckling safety margin equation of supercavitating vehicles was established.The indefinite information was described by interval set and the structure reliability analysis was performed by using non-probabilistic reliability method.Considering interval variables as random variables which satisfy uniform distribution,the Monte-Carlo method was used to calculate the non-probabilistic failure degree.Numerical examples of supercavitating vehicles were presented.Under different ratios of base diameter to cavitator diameter,the change tendency of non-probabilistic failure degree of structural buckling of supercavitating vehicles with or without engine thrust was studied along with the variety of speed.
