The concept of Fiedler matrices was introduced in [1] by L. Stuart and R.Weaver.In[1], they investigated the factorization of Fiedler matrix into Fiedler matrices and pre-sented some open questions i. e. When is a Fie...The concept of Fiedler matrices was introduced in [1] by L. Stuart and R.Weaver.In[1], they investigated the factorization of Fiedler matrix into Fiedler matrices and pre-sented some open questions i. e. When is a Fiedler matrix factorizable as a product ofFiedler matrices? Are there useful sufficient conditions? If a Fiedler matrix is factorizable,are the factors unique? If not, are the dimensions of the factors unique? In this paper,展开更多
This part II-C of our work completes the factorizational theory of asymptotic expansions in the real domain. Here we present two algorithms for constructing canonical factorizations of a disconjugate operator starting...This part II-C of our work completes the factorizational theory of asymptotic expansions in the real domain. Here we present two algorithms for constructing canonical factorizations of a disconjugate operator starting from a basis of its kernel which forms a Chebyshev asymptotic scale at an endpoint. These algorithms arise quite naturally in our asymptotic context and prove very simple in special cases and/or for scales with a small numbers of terms. All the results in the three Parts of this work are well illustrated by a class of asymptotic scales featuring interesting properties. Examples and counterexamples complete the exposition.展开更多
Let G be a graph and f an integer-valued function defined on V(G). It is proved that every (0,mf - m+1)-graph G has a (0,f)-factorization orthogonal to any given subgraph with m edges.
A condition number is an amplification coefficient due to errors in computing. Thus the theory of condition numbers plays an important role in error analysis. In this paper, following the approach of Rice, condition n...A condition number is an amplification coefficient due to errors in computing. Thus the theory of condition numbers plays an important role in error analysis. In this paper, following the approach of Rice, condition numbers are defined for factors of some matrix factorizations such as the Cholesky factorization of a symmetric positive definite matrix and QR factorization of a general matrix. The condition numbers are derived by a technique of analytic expansion of the factor dependent on one parameter and matrix-vector equation. Condition numbers of the Cholesky and QR factors are different from the ones previously introduced by other authors, but similar to Chang's results. In Cholesky factorization, corresponding with the condition number of the factor matrix L , K _L is a low bound of Stewart's condition number K .展开更多
Let G be a graph and g, f be two nonnegative integer-valued functions defined on the vertices set V(G) of G and g less than or equal to f. A (g, f)-factor of a graph G is a spanning subgraph F of G such that g(x)less ...Let G be a graph and g, f be two nonnegative integer-valued functions defined on the vertices set V(G) of G and g less than or equal to f. A (g, f)-factor of a graph G is a spanning subgraph F of G such that g(x)less than or equal to d(F)(x)less than or equal to f(x) for all x is an element of V(G). If G itself is a (g, f)-factor, then it is said that G is a (g, f)-graph. If the edges of G can be decomposed into some edge disjoint (g, f)-factors, then it is called that G is (g, f)-factorable. In this paper, one sufficient condition for a graph to be (g, f)-factorable is given.展开更多
Let G be a graph, k(1), ... , k(m) be positive integers. If the edges of graph G can be decomposed into some edge disjoint [0, k(1)]-factor F-1, ..., [0, k(m)]-factor F-m, then we can say (F) over bar = {F-1, ..., F-m...Let G be a graph, k(1), ... , k(m) be positive integers. If the edges of graph G can be decomposed into some edge disjoint [0, k(1)]-factor F-1, ..., [0, k(m)]-factor F-m, then we can say (F) over bar = {F-1, ..., F-m}, is a [0, k(i)](1)(m) -factorization of G. If H is a subgraph with m edges in graph G and / E (H) boolean AND E(F-i) / = 1 for all 1 less than or equal to i less than or equal to m, then we can call that (F) over bar is orthogonal to H. It is proved that if G is a [0, k(1) + ... + k(m) - m + 1]-graph, H is a subgraph with m edges in G, then graph G has a [0, k(i)](1)(m)-factorization orthogonal to H.展开更多
This paper considers the updating problem of the hyperbolic matrix factorizations. The sufficient conditions for the existence of the updated hyperbolic matrix factorizations are first provided. Then, some differentia...This paper considers the updating problem of the hyperbolic matrix factorizations. The sufficient conditions for the existence of the updated hyperbolic matrix factorizations are first provided. Then, some differential inequalities and first order perturbation expansions for the updated hyperbolic factors are derived. These results generalize the corresponding ones for the updating problem of the classical QR factorization obtained by Jiguang SUN.展开更多
It is widely known that the equation 2xx= has and only has two roots 0 and 1. Jiglevich A.B. and Petrov N. N. discovered that equation has two other roots, i.e. infinite place’s numbers (called super numbers): 821289...It is widely known that the equation 2xx= has and only has two roots 0 and 1. Jiglevich A.B. and Petrov N. N. discovered that equation has two other roots, i.e. infinite place’s numbers (called super numbers): 8212890625X=L and 1787109376Y=L, and obtained 4 (super number) roots of the equation2xx=. For progressing to wider conditions, with the way of exactly divisible and mutually orthogonal Latin squares, three attractive results are obtained: 1) A kind of polynomial 1()()niiPxxa==P-, ,1,2,,iain?KZ has and only has different n2 super number roots; 2) When n>2 and n 6, those n2 roots of the polynomial ()Px can be arranged in an n-order square matrix, of which n roots of every row and every column satisfy Vieta Formula of roots and coefficients; 3) In *Z ring of super number, the polynomial1()()niiPxxa==P-, ,1,2,,iain?KZ has n! different factorizations.展开更多
Let G be an (mg, mf)-graph, where g and f are integer-valued functions defined on V(G) and such that 0≤g(x)≤f(x) for each x ∈ V(G). It is proved that(1) If Z ≠ , both g and f may be not even, G has a (g, f)-factor...Let G be an (mg, mf)-graph, where g and f are integer-valued functions defined on V(G) and such that 0≤g(x)≤f(x) for each x ∈ V(G). It is proved that(1) If Z ≠ , both g and f may be not even, G has a (g, f)-factorization, where Z = {x ∈ V(G):mf(x)-dG(x)≤t(x) or dG(x)-mg(x)≤ t(x), t(x)=f(x)-g(x)>0}.(2) Let G be an m-regular graph with 2n vertices, m ≥ n. If (P1, P2,..., Pr) is a partition of m, P1 ≡m (mod 2), Pi≡0 (mod 2), i=2,..., r, then the edge set E(G) of G can be parted into r parts E1,E2,..., Er of E(G) such that G[Ei] is a Pi-factor of G.展开更多
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.展开更多
In this paper,rank factorizations and factor left prime factorizations are studied.The authors prove that any polynomial matrix with full row rank has factor left prime factorizations.And for a class of polynomial mat...In this paper,rank factorizations and factor left prime factorizations are studied.The authors prove that any polynomial matrix with full row rank has factor left prime factorizations.And for a class of polynomial matrices,the authors give an algorithm to decide whether they have rank factorizations or factor left prime factorizations and compute these factorizations if they exist.展开更多
This is a survey of some recent progress in the theory of groups with factorizations. Some of the methods can be used to obtain information about finite groups in general, nilpotent algebras and nearrings.
Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macro...Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.展开更多
Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is cha...Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is characterized by bleeding within the brain.Stroke is a lifethreatening cerebrovascular condition characterized by intricate pathophysiological mechanisms,including oxidative stress,inflammation,mitochondrial dysfunction,and neuronal injury.Critical transcription factors,such as nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B,play central roles in the progression of stroke.Nuclear factor erythroid 2-related factor 2 is sensitive to changes in the cellular redox status and is crucial in protecting cells against oxidative damage,inflammatory responses,and cytotoxic agents.It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function,endoplasmic reticulum stress,and lysosomal activity and regulating metabolic pathways and cytokine expression.Conversely,nuclear factor-kappa B is closely associated with mitochondrial dysfunction,the generation of reactive oxygen species,oxidative stress exacerbation,and inflammation.Nuclear factor-kappa B contributes to neuronal injury,apoptosis,and immune responses following stroke by modulating cell adhesion molecules and inflammatory mediators.The interplay between these pathways,potentially involving crosstalk among various organelles,significantly influences stroke pathophysiology.Advancements in single-cell sequencing and spatial transcriptomics have greatly improved our understanding of stroke pathogenesis and offer new opportunities for the development of targeted,individualized,cell typespecific treatments.In this review,we discuss the mechanisms underlying the involvement of nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in both ischemic and hemorrhagic stroke,with an emphasis on their roles in oxidative stress,inflammation,and neuroprotection.展开更多
The fast solution of linear equations has always been one of the hot spots in scientific computing.A kind of the diagonal matrix splitting iteration methods are provided,which is different from the classical matrix sp...The fast solution of linear equations has always been one of the hot spots in scientific computing.A kind of the diagonal matrix splitting iteration methods are provided,which is different from the classical matrix splitting methods.Taking the decomposition of the diagonal elements for coefficient matrix as the key point,some new preconditioners are constructed.Taking the tri-diagonal coefficient matrix as an example,the convergence domains and optimal relaxation factor of the new method are analyzed theoretically.The presented new iteration methods are applied to solve linear algebraic equations,even 2D and 3D diffusion problems with the fully implicit discretization.The results of numerical experiments are matched with the theoretical analysis,and show that the iteration numbers are reduced greatly.The superiorities of presented iteration methods exceed some classical iteration methods dramatically.展开更多
This is a survey on the recent progress in the theory of finite groups with factorizations and around it,done by the author and his coauthors,and this has no pretensions to cover all topics in this wide area of resear...This is a survey on the recent progress in the theory of finite groups with factorizations and around it,done by the author and his coauthors,and this has no pretensions to cover all topics in this wide area of research.In particular,we only touch the great consequences of the fundamental paper of Liebeck,Praeger and Saxl on maximal factorizations of almost simple finite groups for the theory of groups with factorizations.In each case the reader can find additional references at the end of Section 1.Some of the methods of investigation can be used to obtain information about finite groups in general,nilpotent algebras and related nearrings.展开更多
The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this ...The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this study,we investigated the role of Oryza sativa AUXIN RESPONSE FACTOR 13(OsARF13),a transcription factor involved in callus-related processes.We observed that OsARF13 expression is significantly higher in japonica rice callus than in indica rice callus.This differential expression might be associated with an allelic variation in the promoter region of OsARF13,where a deletion commonly found in indica rice corresponds to the loss of a conserved auxin-responsive element(AuxRE)motif.To functionally characterize OsARF13,we generated CRISPR/Cas9-mediated knockout mutants.These mutants exhibited a substantial reduction in callus fresh weight,demonstrating that OsARF13 is required for efficient callus induction.Transcriptome analysis of the osarf13 mutant further showed that OsARF13 influences the expression of genes involved in hormone signal transduction and stress responses.Our findings suggest that OsARF13 is a key component of the regulatory network governing callus induction and that natural variation in its promoter might provide a potential explanation for the differential regenerative capacity between japonica and indica rice subspecies.展开更多
Biological aging is a complex physiological process characterized by a decline in tissue function and the loss of cellular capabilities,which increase an individual's risk of various diseases[1].While genetic fact...Biological aging is a complex physiological process characterized by a decline in tissue function and the loss of cellular capabilities,which increase an individual's risk of various diseases[1].While genetic factors and lifestyle are key influences on biological aging,environmental factors also play a significant role.Given the rapid aging of the global population,elucidating the factors that influence biological aging is crucial for promoting healthy aging.展开更多
This systematic review synthesizes empirical research on external risk factors for adolescent smartphone addiction.Scopus and Web of Science were searched for English peer-reviewed empirical articles from 2008 onward;...This systematic review synthesizes empirical research on external risk factors for adolescent smartphone addiction.Scopus and Web of Science were searched for English peer-reviewed empirical articles from 2008 onward;28 met inclusion criteria(excluding non-adolescents,generic internet addiction,non-empirical work,or non-English).Thematic synthesis organized findings into three external risk domains—family,school,and peers—considering cultural/contextual mechanisms.Family dynamics(parental phubbing,harsh parenting,dysfunction),school stressors,and adverse peer relationships were identified as accumulating,direct and indirect contributors to smartphone addiction.These operate within a techno-ecological framework,where digital technologies amplify vulnerabilities and create new pathways for maladaptive use.Evidence favors an ecological,multi-level perspective.Future research should use longitudinal designs,standardize measures across cultures,and examine understudied regions—especially Africa—to guide culturally sensitive interventions.展开更多
Varicocele(VC)is widely recognized as a prevalent and clinically significant cause of male infertility.However,the comprehensive pathogenic mechanisms underlying VC development and progression remain incompletely unde...Varicocele(VC)is widely recognized as a prevalent and clinically significant cause of male infertility.However,the comprehensive pathogenic mechanisms underlying VC development and progression remain incompletely understood,creating an important knowledge gap in the field of andrology.This review establishes that VC pathogenesis centers on abnormal vascular remodeling and integrates multiple contributing elements,including anatomical abnormalities,biochemical disturbances,genetic factors,low body mass index(BMI),age,and specific sports habits,while secondary varicoceles are primarily induced by compressive pathologies.Through a systematic synthesis of current evidence and recent advances,this review aims to elucidate the complex pathogenic network of VC and provide valuable insights to guide future research directions and inform the development of targeted clinical applications.展开更多
基金This work is supported by the Natural Scientific Research Foundation of Yunnan Province(200A0001--1M)the Scientific Research Foundation of Education Commission of Yunnan Province(9911126)
文摘The concept of Fiedler matrices was introduced in [1] by L. Stuart and R.Weaver.In[1], they investigated the factorization of Fiedler matrix into Fiedler matrices and pre-sented some open questions i. e. When is a Fiedler matrix factorizable as a product ofFiedler matrices? Are there useful sufficient conditions? If a Fiedler matrix is factorizable,are the factors unique? If not, are the dimensions of the factors unique? In this paper,
文摘This part II-C of our work completes the factorizational theory of asymptotic expansions in the real domain. Here we present two algorithms for constructing canonical factorizations of a disconjugate operator starting from a basis of its kernel which forms a Chebyshev asymptotic scale at an endpoint. These algorithms arise quite naturally in our asymptotic context and prove very simple in special cases and/or for scales with a small numbers of terms. All the results in the three Parts of this work are well illustrated by a class of asymptotic scales featuring interesting properties. Examples and counterexamples complete the exposition.
文摘Let G be a graph and f an integer-valued function defined on V(G). It is proved that every (0,mf - m+1)-graph G has a (0,f)-factorization orthogonal to any given subgraph with m edges.
文摘A condition number is an amplification coefficient due to errors in computing. Thus the theory of condition numbers plays an important role in error analysis. In this paper, following the approach of Rice, condition numbers are defined for factors of some matrix factorizations such as the Cholesky factorization of a symmetric positive definite matrix and QR factorization of a general matrix. The condition numbers are derived by a technique of analytic expansion of the factor dependent on one parameter and matrix-vector equation. Condition numbers of the Cholesky and QR factors are different from the ones previously introduced by other authors, but similar to Chang's results. In Cholesky factorization, corresponding with the condition number of the factor matrix L , K _L is a low bound of Stewart's condition number K .
文摘Let G be a graph and g, f be two nonnegative integer-valued functions defined on the vertices set V(G) of G and g less than or equal to f. A (g, f)-factor of a graph G is a spanning subgraph F of G such that g(x)less than or equal to d(F)(x)less than or equal to f(x) for all x is an element of V(G). If G itself is a (g, f)-factor, then it is said that G is a (g, f)-graph. If the edges of G can be decomposed into some edge disjoint (g, f)-factors, then it is called that G is (g, f)-factorable. In this paper, one sufficient condition for a graph to be (g, f)-factorable is given.
文摘Let G be a graph, k(1), ... , k(m) be positive integers. If the edges of graph G can be decomposed into some edge disjoint [0, k(1)]-factor F-1, ..., [0, k(m)]-factor F-m, then we can say (F) over bar = {F-1, ..., F-m}, is a [0, k(i)](1)(m) -factorization of G. If H is a subgraph with m edges in graph G and / E (H) boolean AND E(F-i) / = 1 for all 1 less than or equal to i less than or equal to m, then we can call that (F) over bar is orthogonal to H. It is proved that if G is a [0, k(1) + ... + k(m) - m + 1]-graph, H is a subgraph with m edges in G, then graph G has a [0, k(i)](1)(m)-factorization orthogonal to H.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1120150711171361)the Natural Science Foundation Project of CQ CSTC(Grant No.2010BB9215)
文摘This paper considers the updating problem of the hyperbolic matrix factorizations. The sufficient conditions for the existence of the updated hyperbolic matrix factorizations are first provided. Then, some differential inequalities and first order perturbation expansions for the updated hyperbolic factors are derived. These results generalize the corresponding ones for the updating problem of the classical QR factorization obtained by Jiguang SUN.
文摘It is widely known that the equation 2xx= has and only has two roots 0 and 1. Jiglevich A.B. and Petrov N. N. discovered that equation has two other roots, i.e. infinite place’s numbers (called super numbers): 8212890625X=L and 1787109376Y=L, and obtained 4 (super number) roots of the equation2xx=. For progressing to wider conditions, with the way of exactly divisible and mutually orthogonal Latin squares, three attractive results are obtained: 1) A kind of polynomial 1()()niiPxxa==P-, ,1,2,,iain?KZ has and only has different n2 super number roots; 2) When n>2 and n 6, those n2 roots of the polynomial ()Px can be arranged in an n-order square matrix, of which n roots of every row and every column satisfy Vieta Formula of roots and coefficients; 3) In *Z ring of super number, the polynomial1()()niiPxxa==P-, ,1,2,,iain?KZ has n! different factorizations.
基金Foundation item:Hunan Provincial Educational Department (03C496)
文摘Let G be an (mg, mf)-graph, where g and f are integer-valued functions defined on V(G) and such that 0≤g(x)≤f(x) for each x ∈ V(G). It is proved that(1) If Z ≠ , both g and f may be not even, G has a (g, f)-factorization, where Z = {x ∈ V(G):mf(x)-dG(x)≤t(x) or dG(x)-mg(x)≤ t(x), t(x)=f(x)-g(x)>0}.(2) Let G be an m-regular graph with 2n vertices, m ≥ n. If (P1, P2,..., Pr) is a partition of m, P1 ≡m (mod 2), Pi≡0 (mod 2), i=2,..., r, then the edge set E(G) of G can be parted into r parts E1,E2,..., Er of E(G) such that G[Ei] is a Pi-factor of G.
基金supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM)the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
文摘Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in spinal cord injury.Previous studies have shown that microglia can promote neuronal survival by phagocytosing dead cells and debris and by releasing neuroprotective and anti-inflammatory factors.However,excessive activation of microglia can lead to persistent inflammation and contribute to the formation of glial scars,which hinder axonal regeneration.Despite this,the precise role and mechanisms of microglia during the acute phase of spinal cord injury remain controversial and poorly understood.To elucidate the role of microglia in spinal cord injury,we employed the colony-stimulating factor 1 receptor inhibitor PLX5622 to deplete microglia.We observed that sustained depletion of microglia resulted in an expansion of the lesion area,downregulation of brain-derived neurotrophic factor,and impaired functional recovery after spinal cord injury.Next,we generated a transgenic mouse line with conditional overexpression of brain-derived neurotrophic factor specifically in microglia.We found that brain-derived neurotrophic factor overexpression in microglia increased angiogenesis and blood flow following spinal cord injury and facilitated the recovery of hindlimb motor function.Additionally,brain-derived neurotrophic factor overexpression in microglia reduced inflammation and neuronal apoptosis during the acute phase of spinal cord injury.Furthermore,through using specific transgenic mouse lines,TMEM119,and the colony-stimulating factor 1 receptor inhibitor PLX73086,we demonstrated that the neuroprotective effects were predominantly due to brain-derived neurotrophic factor overexpression in microglia rather than macrophages.In conclusion,our findings suggest the critical role of microglia in the formation of protective glial scars.Depleting microglia is detrimental to recovery of spinal cord injury,whereas targeting brain-derived neurotrophic factor overexpression in microglia represents a promising and novel therapeutic strategy to enhance motor function recovery in patients with spinal cord injury.
基金supported by the National Science Foundation of China under Grant Nos.11371131 and 11501192
文摘In this paper,rank factorizations and factor left prime factorizations are studied.The authors prove that any polynomial matrix with full row rank has factor left prime factorizations.And for a class of polynomial matrices,the authors give an algorithm to decide whether they have rank factorizations or factor left prime factorizations and compute these factorizations if they exist.
文摘This is a survey of some recent progress in the theory of groups with factorizations. Some of the methods can be used to obtain information about finite groups in general, nilpotent algebras and nearrings.
基金supported by Qingdao Key Medical and Health Discipline ProjectThe Intramural Research Program of the Affiliated Hospital of Qingdao University,No. 4910Qingdao West Coast New Area Science and Technology Project,No. 2020-55 (all to SW)。
文摘Border-associated macrophages are located at the interface between the brain and the periphery, including the perivascular spaces, choroid plexus, and meninges. Until recently, the functions of border-associated macrophages have been poorly understood and largely overlooked. However, a recent study reported that border-associated macrophages participate in stroke-induced inflammation, although many details and the underlying mechanisms remain unclear. In this study, we performed a comprehensive single-cell analysis of mouse border-associated macrophages using sequencing data obtained from the Gene Expression Omnibus(GEO) database(GSE174574 and GSE225948). Differentially expressed genes were identified, and enrichment analysis was performed to identify the transcription profile of border-associated macrophages. CellChat analysis was conducted to determine the cell communication network of border-associated macrophages. Transcription factors were predicted using the ‘pySCENIC' tool. We found that, in response to hypoxia, borderassociated macrophages underwent dynamic transcriptional changes and participated in the regulation of inflammatory-related pathways. Notably, the tumor necrosis factor pathway was activated by border-associated macrophages following ischemic stroke. The pySCENIC analysis indicated that the activity of signal transducer and activator of transcription 3(Stat3) was obviously upregulated in stroke, suggesting that Stat3 inhibition may be a promising strategy for treating border-associated macrophages-induced neuroinflammation. Finally, we constructed an animal model to investigate the effects of border-associated macrophages depletion following a stroke. Treatment with liposomes containing clodronate significantly reduced infarct volume in the animals and improved neurological scores compared with untreated animals. Taken together, our results demonstrate comprehensive changes in border-associated macrophages following a stroke, providing a theoretical basis for targeting border-associated macrophages-induced neuroinflammation in stroke treatment.
基金supported by grants from the Zhejiang Provincial TCM Science and Technology Plan Project,No.2023ZL156(to YH)Ningbo Top Medical and Health Research Program,No.2022020304(to XG)+1 种基金the Natural Science Foundation of Ningbo,No.2023J019(to YH)Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province,No.2022E10026(to YH)。
文摘Strokes include both ischemic stroke,which is mediated by a blockade or reduction in the blood supply to the brain,and hemorrhagic stroke,which comprises intracerebral hemorrhage and subarachnoid hemorrhage and is characterized by bleeding within the brain.Stroke is a lifethreatening cerebrovascular condition characterized by intricate pathophysiological mechanisms,including oxidative stress,inflammation,mitochondrial dysfunction,and neuronal injury.Critical transcription factors,such as nuclear factor erythroid 2-related factor 2 and nuclear factor kappa B,play central roles in the progression of stroke.Nuclear factor erythroid 2-related factor 2 is sensitive to changes in the cellular redox status and is crucial in protecting cells against oxidative damage,inflammatory responses,and cytotoxic agents.It plays a significant role in post-stroke neuroprotection and repair by influencing mitochondrial function,endoplasmic reticulum stress,and lysosomal activity and regulating metabolic pathways and cytokine expression.Conversely,nuclear factor-kappa B is closely associated with mitochondrial dysfunction,the generation of reactive oxygen species,oxidative stress exacerbation,and inflammation.Nuclear factor-kappa B contributes to neuronal injury,apoptosis,and immune responses following stroke by modulating cell adhesion molecules and inflammatory mediators.The interplay between these pathways,potentially involving crosstalk among various organelles,significantly influences stroke pathophysiology.Advancements in single-cell sequencing and spatial transcriptomics have greatly improved our understanding of stroke pathogenesis and offer new opportunities for the development of targeted,individualized,cell typespecific treatments.In this review,we discuss the mechanisms underlying the involvement of nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B in both ischemic and hemorrhagic stroke,with an emphasis on their roles in oxidative stress,inflammation,and neuroprotection.
基金The National Natural Science Foundations of China (12202219)the Natural Science Foundations of Ningxia (2024AAC02009, 2023AAC05001)the Ningxia Youth Top Talents Training Project。
文摘The fast solution of linear equations has always been one of the hot spots in scientific computing.A kind of the diagonal matrix splitting iteration methods are provided,which is different from the classical matrix splitting methods.Taking the decomposition of the diagonal elements for coefficient matrix as the key point,some new preconditioners are constructed.Taking the tri-diagonal coefficient matrix as an example,the convergence domains and optimal relaxation factor of the new method are analyzed theoretically.The presented new iteration methods are applied to solve linear algebraic equations,even 2D and 3D diffusion problems with the fully implicit discretization.The results of numerical experiments are matched with the theoretical analysis,and show that the iteration numbers are reduced greatly.The superiorities of presented iteration methods exceed some classical iteration methods dramatically.
文摘This is a survey on the recent progress in the theory of finite groups with factorizations and around it,done by the author and his coauthors,and this has no pretensions to cover all topics in this wide area of research.In particular,we only touch the great consequences of the fundamental paper of Liebeck,Praeger and Saxl on maximal factorizations of almost simple finite groups for the theory of groups with factorizations.In each case the reader can find additional references at the end of Section 1.Some of the methods of investigation can be used to obtain information about finite groups in general,nilpotent algebras and related nearrings.
基金supported by the National Natural Science Foundation of China(Grant Nos.32201834 and 32201814)the Hainan Provincial Natural Science Foundation of China(Grant No.324RC530)+1 种基金the Hainan Provincial‘Nanhai NewStar’Science and Technology Innovation Platform Project,China(Grant No.NHXXRCXM-202362)the Research Startup Funding from Hainan Institute of Zhejiang University,China(Grant No.0201-6602-A12202).
文摘The significant variation in plant regeneration efficiency between indica and japonica rice poses a major challenge for crop improvement.However,the molecular basis for this divergence remains largely unclear.In this study,we investigated the role of Oryza sativa AUXIN RESPONSE FACTOR 13(OsARF13),a transcription factor involved in callus-related processes.We observed that OsARF13 expression is significantly higher in japonica rice callus than in indica rice callus.This differential expression might be associated with an allelic variation in the promoter region of OsARF13,where a deletion commonly found in indica rice corresponds to the loss of a conserved auxin-responsive element(AuxRE)motif.To functionally characterize OsARF13,we generated CRISPR/Cas9-mediated knockout mutants.These mutants exhibited a substantial reduction in callus fresh weight,demonstrating that OsARF13 is required for efficient callus induction.Transcriptome analysis of the osarf13 mutant further showed that OsARF13 influences the expression of genes involved in hormone signal transduction and stress responses.Our findings suggest that OsARF13 is a key component of the regulatory network governing callus induction and that natural variation in its promoter might provide a potential explanation for the differential regenerative capacity between japonica and indica rice subspecies.
基金support from the Shenzhen Science and Technology program(grant number 202208183000115)。
文摘Biological aging is a complex physiological process characterized by a decline in tissue function and the loss of cellular capabilities,which increase an individual's risk of various diseases[1].While genetic factors and lifestyle are key influences on biological aging,environmental factors also play a significant role.Given the rapid aging of the global population,elucidating the factors that influence biological aging is crucial for promoting healthy aging.
基金supported by the 2025 Fujian Provincial Social Science Foundation Project(FJ2025C074).
文摘This systematic review synthesizes empirical research on external risk factors for adolescent smartphone addiction.Scopus and Web of Science were searched for English peer-reviewed empirical articles from 2008 onward;28 met inclusion criteria(excluding non-adolescents,generic internet addiction,non-empirical work,or non-English).Thematic synthesis organized findings into three external risk domains—family,school,and peers—considering cultural/contextual mechanisms.Family dynamics(parental phubbing,harsh parenting,dysfunction),school stressors,and adverse peer relationships were identified as accumulating,direct and indirect contributors to smartphone addiction.These operate within a techno-ecological framework,where digital technologies amplify vulnerabilities and create new pathways for maladaptive use.Evidence favors an ecological,multi-level perspective.Future research should use longitudinal designs,standardize measures across cultures,and examine understudied regions—especially Africa—to guide culturally sensitive interventions.
基金funded by China Postdoctoral Science Foundation(Grant Number:2025M773939)NationalNatural Science Foundation of China(Grant Number:82205131)Sichuan Science and Technology Program(Grant Number:2025ZNSFSC1798).
文摘Varicocele(VC)is widely recognized as a prevalent and clinically significant cause of male infertility.However,the comprehensive pathogenic mechanisms underlying VC development and progression remain incompletely understood,creating an important knowledge gap in the field of andrology.This review establishes that VC pathogenesis centers on abnormal vascular remodeling and integrates multiple contributing elements,including anatomical abnormalities,biochemical disturbances,genetic factors,low body mass index(BMI),age,and specific sports habits,while secondary varicoceles are primarily induced by compressive pathologies.Through a systematic synthesis of current evidence and recent advances,this review aims to elucidate the complex pathogenic network of VC and provide valuable insights to guide future research directions and inform the development of targeted clinical applications.
