AIM:To investigate the effect of interferon-a (IFN-α) on preventing or reversing hepatic fibrosis in rat experimental model induced by CCI4. METHODS: One hundred and ten Sprague-Dawley rats were divided into five gro...AIM:To investigate the effect of interferon-a (IFN-α) on preventing or reversing hepatic fibrosis in rat experimental model induced by CCI4. METHODS: One hundred and ten Sprague-Dawley rats were divided into five groups: group A (normal controls, n = 18), group B (fibrotic model controls, n = 22), group C (IFN-α prevention, n = 22) initially treated with intramuscular injection of IFN-a in saline daily at the doses of 1× 105 U for 6 wk, group D (IFN-a treatment, n = 24) treated with intra-muscular injection of IFN-a in saline daily at the doses of 1×105 U for 6 wk after the first 6 wk, group E (0.9% sodium chloride treatment control, n = 24) treated with intra-muscular injection of 0.01 mL/kg daily for 6 wk after the first 6 wk. At the end of the experiment, all rats of each group were killed. Samples of the liver obtained by biopsy were subjected to histological, immunohistochemical and electron microscopic studies for the expressions of transforming growth factor-pi (TGF- μ41) and α-smooth muscle actin (α-SMA). RESULTS: The expressions of TGF-pl, the number of activated hepatic stellate cells and a-SMA in hepatic tissue of group C were significantly less than those of group B (P<0.01). The degree of fibrosis score in group B was also significantly less than that of group C under light microscope (P<0.01). CONCLUSION: IFN-a can inhibit the production of TGF-pl, decrease HSC activation and stimulate its apoptosis.展开更多
【目的】针对超临界机组燃水比(firing rate to feed water ratio,FR/FW)控制过程中存在强耦合性、负荷量大和抗扰动能力弱等问题,根据自耦PID控制理论提出了自耦PI(auto-coupling PI,ACPI)新型控制方法。【方法】将多变量FR/FW系统等...【目的】针对超临界机组燃水比(firing rate to feed water ratio,FR/FW)控制过程中存在强耦合性、负荷量大和抗扰动能力弱等问题,根据自耦PID控制理论提出了自耦PI(auto-coupling PI,ACPI)新型控制方法。【方法】将多变量FR/FW系统等效为多个单变量闭合回路系统,并将FR/FW系统的耦合性、已知或未知内部动态、外界扰动等一切复杂因素定义为总扰动,进而将FR/FW控制系统等价映射为线性扰动系统,构建了在总扰动激励下的受控误差系统。在此基础上,对每个单变量系统设计了基于速度因子的自耦PI控制器,并在复频域理论分析了控制系统的鲁棒稳定性和抗扰动鲁棒性。【结果】与PI、自抗扰控制方法相比,ACPI控制方法具有响应速度快、无超调的动态品质与抗扰动能力强的稳态性能。【结论】研究成果对提升超临界机组FR/FW系统的控制精度与鲁棒性具有重要意义。展开更多
文摘AIM:To investigate the effect of interferon-a (IFN-α) on preventing or reversing hepatic fibrosis in rat experimental model induced by CCI4. METHODS: One hundred and ten Sprague-Dawley rats were divided into five groups: group A (normal controls, n = 18), group B (fibrotic model controls, n = 22), group C (IFN-α prevention, n = 22) initially treated with intramuscular injection of IFN-a in saline daily at the doses of 1× 105 U for 6 wk, group D (IFN-a treatment, n = 24) treated with intra-muscular injection of IFN-a in saline daily at the doses of 1×105 U for 6 wk after the first 6 wk, group E (0.9% sodium chloride treatment control, n = 24) treated with intra-muscular injection of 0.01 mL/kg daily for 6 wk after the first 6 wk. At the end of the experiment, all rats of each group were killed. Samples of the liver obtained by biopsy were subjected to histological, immunohistochemical and electron microscopic studies for the expressions of transforming growth factor-pi (TGF- μ41) and α-smooth muscle actin (α-SMA). RESULTS: The expressions of TGF-pl, the number of activated hepatic stellate cells and a-SMA in hepatic tissue of group C were significantly less than those of group B (P<0.01). The degree of fibrosis score in group B was also significantly less than that of group C under light microscope (P<0.01). CONCLUSION: IFN-a can inhibit the production of TGF-pl, decrease HSC activation and stimulate its apoptosis.
文摘【目的】针对超临界机组燃水比(firing rate to feed water ratio,FR/FW)控制过程中存在强耦合性、负荷量大和抗扰动能力弱等问题,根据自耦PID控制理论提出了自耦PI(auto-coupling PI,ACPI)新型控制方法。【方法】将多变量FR/FW系统等效为多个单变量闭合回路系统,并将FR/FW系统的耦合性、已知或未知内部动态、外界扰动等一切复杂因素定义为总扰动,进而将FR/FW控制系统等价映射为线性扰动系统,构建了在总扰动激励下的受控误差系统。在此基础上,对每个单变量系统设计了基于速度因子的自耦PI控制器,并在复频域理论分析了控制系统的鲁棒稳定性和抗扰动鲁棒性。【结果】与PI、自抗扰控制方法相比,ACPI控制方法具有响应速度快、无超调的动态品质与抗扰动能力强的稳态性能。【结论】研究成果对提升超临界机组FR/FW系统的控制精度与鲁棒性具有重要意义。
