目的基于LASSO-Logistic回归分析影响慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)术后嗅觉功能恢复的危险因素,构建预测模型。方法收集2022年9月至2024年12月于本院行鼻内镜手术的CRSwNP患者270例,依据术后...目的基于LASSO-Logistic回归分析影响慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)术后嗅觉功能恢复的危险因素,构建预测模型。方法收集2022年9月至2024年12月于本院行鼻内镜手术的CRSwNP患者270例,依据术后嗅觉功能恢复情况分为良好组(n=207)和不良组(n=63),分析影响CRSwNP术后嗅觉功能恢复的危险因素,并构建预测模型。结果270例患者术后嗅觉功能恢复不良发生率为23.33%(63/270)。LASSO回归结合多因素Logistic回归分析显示,嗅觉功能障碍持续时间、合并变应性鼻炎、病变类型、疾病分型以及分期、Lund-Kennedy评分、复诊次数是独立影响因素(P均<0.001)。基于此构建的列线图预测模型内部验证一致性指数为0.731,校准良好;ROC曲线下面积(AUC)为0.783(95%CI:0.677~0.889),敏感度和特异性分别为81.25%与67.50%。结论影响CRSwNP患者术后嗅觉功能恢复的危险因素包括嗅觉功能障碍持续时间≥2年、合并变应性鼻炎、嗅裂区息肉、疾病分型及分期≥Ⅱ型2期、Lund-Kennedy评分≥2分以及复诊次数>3次,基于上述因素所构建的预测模型,可为临床医生提供术后嗅觉功能恢复的预测依据。展开更多
Functional redundancy in soil microbial communities seems to contradict the notion that individual species have distinct metabolic niches in multi-species communities.All soil microbiota have the metabolic capacity fo...Functional redundancy in soil microbial communities seems to contradict the notion that individual species have distinct metabolic niches in multi-species communities.All soil microbiota have the metabolic capacity for"basic"functions(e.g.,respiration and nitrogen and phosphorus cycling),but only a few soil microbiota participate in"rare"functions(e.g.,methanogenesis and mineralization of recalcitrant organic pollutants).The objective of this perspective paper is to use the phylogenetic niche conservatism theory as an explanation for the functional redundancy of soil microbiota.Phylogenetic niche conservatism is defined as the tendency for lineages to retain ancestral functional characteristics through evolutionary time-scales.The present-day soil microbiota is the result of a community assembly process that started when prokaryotes first appeared on Earth.For billions of years,microbiota have retained a highly conserved set of core genes that control the essential redox and biogeochemical reactions for life on Earth.These genes are passed from microbe to microbe,which contributes to functional redundancy in soil microbiota at the planetary scale.The assembly of microbial communities during soil formation is consistent with phylogenetic niche conservatism.Within a specific soil,the heterogeneous matrix provides an infinite number of sets of diverse environmental conditions,i.e.,niches that lead to the divergence of microbial species.The phylogenetic niche conservatism theory predicts that two or more microbial species diverging from the same clade will have an overlap in their niches,implying that they are functionally redundant in some of their metabolic processes.The endogenous genetic factors that constrain the adaptation of individuals and,thus,populations to changing environmental conditions constitute the core process of phylogenetic niche conservatism.Furthermore,the degree of functional redundancy in a particular soil is proportional to the complexity of the considered function.We conclude with a conceptual model that identifies six patterns of functional redundancy in soil microbial communities,consistent with the phylogenetic niche conservatism theory.展开更多
The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues,...The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia.展开更多
The study endeavors to provide statistical inference for a (1 + 1) cascade system for exponential distribution under joint effect of stress-strength attenuation factors. Estimators of reliability function are obtained...The study endeavors to provide statistical inference for a (1 + 1) cascade system for exponential distribution under joint effect of stress-strength attenuation factors. Estimators of reliability function are obtained using Maximum Likelihood Estimator (MLE) and Uniformly Minimum Variance Unbiased Estimator (UMVUE) of the parameters. Asymptotic distribution of the parameters is also obtained. Comparison between estimators is made using data obtained through simulation experiment.展开更多
In this paper, a finite crack with constant length （Yoffe type crack） propagating in a functionally graded coating with spatially varying elastic properties bonded to a homogeneous substrate of finite thickness unde...In this paper, a finite crack with constant length （Yoffe type crack） propagating in a functionally graded coating with spatially varying elastic properties bonded to a homogeneous substrate of finite thickness under anti-plane loading was studied. A multi-layered model is employed to model arbitrary variations of material properties based on two linearly-distributed material compliance parameters. The mixed boundary problem is reduced to a system of singular integral equations that are solved numerically. Some numerical examples are given to demonstrate the accuracy, efficiency and versatility of the model. The numerical results show that the graded parameters, the thicknesses of the interfacial layer and the two homogeneous layers, the crack size and speed have significant effects on the dynamic fracture behavior.展开更多
文摘目的基于LASSO-Logistic回归分析影响慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)术后嗅觉功能恢复的危险因素,构建预测模型。方法收集2022年9月至2024年12月于本院行鼻内镜手术的CRSwNP患者270例,依据术后嗅觉功能恢复情况分为良好组(n=207)和不良组(n=63),分析影响CRSwNP术后嗅觉功能恢复的危险因素,并构建预测模型。结果270例患者术后嗅觉功能恢复不良发生率为23.33%(63/270)。LASSO回归结合多因素Logistic回归分析显示,嗅觉功能障碍持续时间、合并变应性鼻炎、病变类型、疾病分型以及分期、Lund-Kennedy评分、复诊次数是独立影响因素(P均<0.001)。基于此构建的列线图预测模型内部验证一致性指数为0.731,校准良好;ROC曲线下面积(AUC)为0.783(95%CI:0.677~0.889),敏感度和特异性分别为81.25%与67.50%。结论影响CRSwNP患者术后嗅觉功能恢复的危险因素包括嗅觉功能障碍持续时间≥2年、合并变应性鼻炎、嗅裂区息肉、疾病分型及分期≥Ⅱ型2期、Lund-Kennedy评分≥2分以及复诊次数>3次,基于上述因素所构建的预测模型,可为临床医生提供术后嗅觉功能恢复的预测依据。
基金the Natural Sciences and Engineering Research Council of Canada(NSERC)through Discovery Grant(No.RGPIN-2017-05391).
文摘Functional redundancy in soil microbial communities seems to contradict the notion that individual species have distinct metabolic niches in multi-species communities.All soil microbiota have the metabolic capacity for"basic"functions(e.g.,respiration and nitrogen and phosphorus cycling),but only a few soil microbiota participate in"rare"functions(e.g.,methanogenesis and mineralization of recalcitrant organic pollutants).The objective of this perspective paper is to use the phylogenetic niche conservatism theory as an explanation for the functional redundancy of soil microbiota.Phylogenetic niche conservatism is defined as the tendency for lineages to retain ancestral functional characteristics through evolutionary time-scales.The present-day soil microbiota is the result of a community assembly process that started when prokaryotes first appeared on Earth.For billions of years,microbiota have retained a highly conserved set of core genes that control the essential redox and biogeochemical reactions for life on Earth.These genes are passed from microbe to microbe,which contributes to functional redundancy in soil microbiota at the planetary scale.The assembly of microbial communities during soil formation is consistent with phylogenetic niche conservatism.Within a specific soil,the heterogeneous matrix provides an infinite number of sets of diverse environmental conditions,i.e.,niches that lead to the divergence of microbial species.The phylogenetic niche conservatism theory predicts that two or more microbial species diverging from the same clade will have an overlap in their niches,implying that they are functionally redundant in some of their metabolic processes.The endogenous genetic factors that constrain the adaptation of individuals and,thus,populations to changing environmental conditions constitute the core process of phylogenetic niche conservatism.Furthermore,the degree of functional redundancy in a particular soil is proportional to the complexity of the considered function.We conclude with a conceptual model that identifies six patterns of functional redundancy in soil microbial communities,consistent with the phylogenetic niche conservatism theory.
基金supported by the Combined pecific Foundation of Department of Science and Technology of Yunnan Province and Kunming Medical University,No.2008CD037
文摘The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia.
文摘The study endeavors to provide statistical inference for a (1 + 1) cascade system for exponential distribution under joint effect of stress-strength attenuation factors. Estimators of reliability function are obtained using Maximum Likelihood Estimator (MLE) and Uniformly Minimum Variance Unbiased Estimator (UMVUE) of the parameters. Asymptotic distribution of the parameters is also obtained. Comparison between estimators is made using data obtained through simulation experiment.
基金Project supported by the National Natural Science Foundation of China (Nos. 10802078 and 10872150)China Postdoctoral Science Foundation (No. 20100471006)
文摘In this paper, a finite crack with constant length （Yoffe type crack） propagating in a functionally graded coating with spatially varying elastic properties bonded to a homogeneous substrate of finite thickness under anti-plane loading was studied. A multi-layered model is employed to model arbitrary variations of material properties based on two linearly-distributed material compliance parameters. The mixed boundary problem is reduced to a system of singular integral equations that are solved numerically. Some numerical examples are given to demonstrate the accuracy, efficiency and versatility of the model. The numerical results show that the graded parameters, the thicknesses of the interfacial layer and the two homogeneous layers, the crack size and speed have significant effects on the dynamic fracture behavior.
