In 2025,the 22nd China-ASEAN Expo(CAEXPO)is bringing the spotlight to artificial intelligence(AI),placing enterprises at the center of engagement,and supporting development of a closer China-ASEAN community with a sha...In 2025,the 22nd China-ASEAN Expo(CAEXPO)is bringing the spotlight to artificial intelligence(AI),placing enterprises at the center of engagement,and supporting development of a closer China-ASEAN community with a shared future.展开更多
BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts betwee...BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts between work and family roles,significantly impacting their professional involvement.The concept of work-family facilitation,highlighting mutual facilitation between work and family domains,has considerable theoretical and practical significance but remains underexplored in this context.This study integrates ecosystem theory,spillover theory,social exchange theory,and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement.Specifically,it investigates the roles of psychological resilience and job satisfaction in this relationship,providing a novel theoretical perspective and empirical evidence.AIM To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.METHODS A cross-sectional questionnaire survey was conducted among 436 PE teachers.Structural equation modeling was used to examine relationships among variables and assess mediating effects.RESULTS Work-family facilitation positively correlated with psychological resilience,job satisfaction,and work engagement(r=0.323-0.705,P<0.001).Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement,demonstrating a significant chain mediation effect.CONCLUSION This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction,thereby significantly boosting work engagement among PE teachers.These findings underline the importance of targeted interventions to enhance work-family resources,psychological resilience,and job satisfaction,contributing to theoretical advancements and practical implications for educational management.展开更多
Neuropathic pain,often featuring allodynia,imposes significant physical and psychological burdens on patients,with limited treatments due to unclear central mechanisms.Addressing this challenge remains a crucial unsol...Neuropathic pain,often featuring allodynia,imposes significant physical and psychological burdens on patients,with limited treatments due to unclear central mechanisms.Addressing this challenge remains a crucial unsolved issue in pain medicine.Our previous study,using protein kinase C gamma(PKCγ)-tdTomato mice,highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia.However,the regulatory mechanisms governing this circuit necessitate further elucidation.We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin(5-HT)facilitation system on spinal PKCγ neurons.Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT_(2C) receptors,disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia.Inhibiting spinal 5-HT_(2C) receptors restored the feedforward inhibitory circuit,effectively preventing neuropathic allodynia.These insights offer promising therapeutic targets for neuropathic allodynia management,emphasizing the potential of spinal 5-HT_(2C) receptors as a novel avenue for intervention.展开更多
目的观察温针疗法结合本体感觉训练治疗膝骨关节炎的临床效果。方法研究纳入2022年1月—2023年12月收治膝骨关节炎患者共计110例,以随机数字表法分为治疗组与对照组,对照组患者(56例)均采取西乐葆(塞来昔布胶囊)治疗,治疗组患者(54例)...目的观察温针疗法结合本体感觉训练治疗膝骨关节炎的临床效果。方法研究纳入2022年1月—2023年12月收治膝骨关节炎患者共计110例,以随机数字表法分为治疗组与对照组,对照组患者(56例)均采取西乐葆(塞来昔布胶囊)治疗,治疗组患者(54例)采取西乐葆+温针疗法结合本体感觉训练治疗,对比两组患者治疗前后各项观察指标变化情况:治疗总有效率、治疗前后中医证候积分、疼痛视觉模拟(visual analog scale,VAS)评分及西安大略和麦克马斯特大学(Western Ontario and McMaster Universities,WOMAC)评分、外周血中白细胞介素-1β(interleukin-1β,IL-1β)及肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、Ⅱ型胶原羧基端端肽(C-telopeptide of typeⅡcollagen,CTX-Ⅱ)及软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP),并观测不良反应。结果治疗组患者总有效率为91.07%(51/56),比对照组患者总有效率72.22%(39/54)更高(P<0.05);治疗前两组患者中医证候积分(膝关节疼痛、关节肿胀、关节畏寒、倦怠乏力)、VAS评分及WOMAC评分、外周血中IL-1β及TNF-α、CTX-II及COMP水平比较差异无统计学意义(P>0.05),治疗后两组患者以上指标均优于对照组(P<0.05)。结论温针疗法结合本体感觉促进训练治疗膝骨关节炎临床效果显著,可较好改善患者临床症状及膝关节功能,可较好控制机体炎症反应,促进患者病情好转,治疗不良反应少,较为安全可靠。展开更多
背景处方精简是一种识别和停用潜在不适当药物的循证实践,已被证实在减少药物不良反应和减轻治疗负担等方面具有重要价值。现有研究揭示了在临床实践中实施处方精简面临的阻碍和促进因素,但缺乏实施科学视角下综合、全面的归纳分析。目...背景处方精简是一种识别和停用潜在不适当药物的循证实践,已被证实在减少药物不良反应和减轻治疗负担等方面具有重要价值。现有研究揭示了在临床实践中实施处方精简面临的阻碍和促进因素,但缺乏实施科学视角下综合、全面的归纳分析。目的本研究采用范围综述的方法,分析实施处方精简的阻碍因素和促进因素,为构建实施策略提供依据。方法系统检索中国知网、万方数据知识服务平台、PubMed和Web of Science 4个文献数据库,检索时限为2000年1月—2024年9月,筛选处方精简实施影响因素的相关研究。由2名研究者独立采用预设的数据提取表格收集研究特征和实施因素等信息,并基于2022年更新版实施性研究综合框架(CFIR)分析实施处方精简的阻碍因素和促进因素。结果共纳入46项研究。促进因素包括:患者与医生对处方精简的积极态度,医疗团队的协作配合,良好的医患沟通,患者对处方精简的认知等。阻碍因素则包括:患者对处方精简的抵触态度,医疗机构之间缺乏有效协作,医患沟通时使用过多专业术语,患者对药物知识的缺乏等。结论处方精简的成功实施涉及多层次因素的综合影响,未来研究应基于特定场景下的促进因素和阻碍因素,精准匹配实施策略,从而为推动处方精简工作提出兼具针对性与可行性的方案。展开更多
Stanbic Bank Zimbabwe is strategically positioning itself as a critical bridge for Zimbabwe’s local businesses,seeking to navigate the vast and complex Chinese market.
Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases....Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).展开更多
BACKGROUND Stroke is a type of cerebrovascular disease with high prevalence,mortality,and onset of disability.As a neurodevelopmental therapy,neuromuscular joint facilitation(NJF)is widely used in the treatment of ort...BACKGROUND Stroke is a type of cerebrovascular disease with high prevalence,mortality,and onset of disability.As a neurodevelopmental therapy,neuromuscular joint facilitation(NJF)is widely used in the treatment of orthopedic and neurological disorders in the clinical practice.It is mainly used for central nervous system diseases or orthopedic diseases,movement disorders,and pain rehabilitation.According to related studies,NJF can also be used as a rehabilitation treatment in patients with hemiplegic shoulder pain(HSP).AIM To investigate the clinical efficacy of acupuncture combined with NJF in patients with HSP.METHODS Forty patients with HSP were randomly divided into a treatment group and a control group.The treatment group was treated with acupuncture combined with NJF and the control group was treated with acupuncture alone.All patients were assessed by using the visual analogue scale(VAS),Fugl-Meyer assessment(FMA),Barthel index(BI),and passive range of motion(PROM)before and after the training.All the clinical data were analyzed using SPSS 20.0 statistical software.RESULTS There was no statistical difference in the general characteristics between the two groups.In the terms of duration of treatment,age,and pre-treatment indicators,the two groups were comparable(P>0.05).After the treatment,VAS,PROM,BI,and FMA scores were significantly improved in the two groups of patients(P<0.05).The VAS,PROM and FMA scores were significantly higher in the treatment group than in the control group(P<0.05).However,there was no significant difference in BI scores between the two groups(P>0.05).CONCLUSION Both acupuncture alone and acupuncture combined with NJF in the treatment of HSP are effective,and can improve the clinical symptoms of patients.Acupuncture combined with NJF can improve the upper limb motor function,relieve pain,and increase joint mobility in patients with HSP.The combination therapy is better than acupuncture alone.However,there is no significant difference in improving the score of patients’self-care ability.展开更多
文摘In 2025,the 22nd China-ASEAN Expo(CAEXPO)is bringing the spotlight to artificial intelligence(AI),placing enterprises at the center of engagement,and supporting development of a closer China-ASEAN community with a shared future.
文摘BACKGROUND Enhancing work engagement among physical education(PE)teachers is crucial for building a strong sports nation and fostering educational advancement.However,PE teachers frequently experience conflicts between work and family roles,significantly impacting their professional involvement.The concept of work-family facilitation,highlighting mutual facilitation between work and family domains,has considerable theoretical and practical significance but remains underexplored in this context.This study integrates ecosystem theory,spillover theory,social exchange theory,and two-factor theory to systematically explore the mechanism through which work-family facilitation influences work engagement.Specifically,it investigates the roles of psychological resilience and job satisfaction in this relationship,providing a novel theoretical perspective and empirical evidence.AIM To systematically explore the mechanism through which work-family facilitation influences work engagement among PE teachers.METHODS A cross-sectional questionnaire survey was conducted among 436 PE teachers.Structural equation modeling was used to examine relationships among variables and assess mediating effects.RESULTS Work-family facilitation positively correlated with psychological resilience,job satisfaction,and work engagement(r=0.323-0.705,P<0.001).Psychological resilience and job satisfaction fully mediated the relationship between work-family facilitation and work engagement,demonstrating a significant chain mediation effect.CONCLUSION This study confirms that promoting work-family facilitation enhances psychological resilience and job satisfaction,thereby significantly boosting work engagement among PE teachers.These findings underline the importance of targeted interventions to enhance work-family resources,psychological resilience,and job satisfaction,contributing to theoretical advancements and practical implications for educational management.
基金supported by the National Natural Science Foundation of China(81971058,82371226,82101295,82301398)the National Funded Postdoctoral Researcher Program(GZC20233585)The Boost Plan of Xijing Hospital(XJZT24QN25,XJZT25CX22).
文摘Neuropathic pain,often featuring allodynia,imposes significant physical and psychological burdens on patients,with limited treatments due to unclear central mechanisms.Addressing this challenge remains a crucial unsolved issue in pain medicine.Our previous study,using protein kinase C gamma(PKCγ)-tdTomato mice,highlights the spinal feedforward inhibitory circuit involving PKCγ neurons in gating neuropathic allodynia.However,the regulatory mechanisms governing this circuit necessitate further elucidation.We used diverse transgenic mice and advanced techniques to uncover the regulatory role of the descending serotonin(5-HT)facilitation system on spinal PKCγ neurons.Our findings revealed that 5-HT neurons from the rostral ventromedial medulla hyperpolarize spinal inhibitory interneurons via 5-HT_(2C) receptors,disinhibiting the feedforward inhibitory circuit involving PKCγ neurons and exacerbating allodynia.Inhibiting spinal 5-HT_(2C) receptors restored the feedforward inhibitory circuit,effectively preventing neuropathic allodynia.These insights offer promising therapeutic targets for neuropathic allodynia management,emphasizing the potential of spinal 5-HT_(2C) receptors as a novel avenue for intervention.
文摘目的观察温针疗法结合本体感觉训练治疗膝骨关节炎的临床效果。方法研究纳入2022年1月—2023年12月收治膝骨关节炎患者共计110例,以随机数字表法分为治疗组与对照组,对照组患者(56例)均采取西乐葆(塞来昔布胶囊)治疗,治疗组患者(54例)采取西乐葆+温针疗法结合本体感觉训练治疗,对比两组患者治疗前后各项观察指标变化情况:治疗总有效率、治疗前后中医证候积分、疼痛视觉模拟(visual analog scale,VAS)评分及西安大略和麦克马斯特大学(Western Ontario and McMaster Universities,WOMAC)评分、外周血中白细胞介素-1β(interleukin-1β,IL-1β)及肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)、Ⅱ型胶原羧基端端肽(C-telopeptide of typeⅡcollagen,CTX-Ⅱ)及软骨寡聚基质蛋白(cartilage oligomeric matrix protein,COMP),并观测不良反应。结果治疗组患者总有效率为91.07%(51/56),比对照组患者总有效率72.22%(39/54)更高(P<0.05);治疗前两组患者中医证候积分(膝关节疼痛、关节肿胀、关节畏寒、倦怠乏力)、VAS评分及WOMAC评分、外周血中IL-1β及TNF-α、CTX-II及COMP水平比较差异无统计学意义(P>0.05),治疗后两组患者以上指标均优于对照组(P<0.05)。结论温针疗法结合本体感觉促进训练治疗膝骨关节炎临床效果显著,可较好改善患者临床症状及膝关节功能,可较好控制机体炎症反应,促进患者病情好转,治疗不良反应少,较为安全可靠。
文摘背景处方精简是一种识别和停用潜在不适当药物的循证实践,已被证实在减少药物不良反应和减轻治疗负担等方面具有重要价值。现有研究揭示了在临床实践中实施处方精简面临的阻碍和促进因素,但缺乏实施科学视角下综合、全面的归纳分析。目的本研究采用范围综述的方法,分析实施处方精简的阻碍因素和促进因素,为构建实施策略提供依据。方法系统检索中国知网、万方数据知识服务平台、PubMed和Web of Science 4个文献数据库,检索时限为2000年1月—2024年9月,筛选处方精简实施影响因素的相关研究。由2名研究者独立采用预设的数据提取表格收集研究特征和实施因素等信息,并基于2022年更新版实施性研究综合框架(CFIR)分析实施处方精简的阻碍因素和促进因素。结果共纳入46项研究。促进因素包括:患者与医生对处方精简的积极态度,医疗团队的协作配合,良好的医患沟通,患者对处方精简的认知等。阻碍因素则包括:患者对处方精简的抵触态度,医疗机构之间缺乏有效协作,医患沟通时使用过多专业术语,患者对药物知识的缺乏等。结论处方精简的成功实施涉及多层次因素的综合影响,未来研究应基于特定场景下的促进因素和阻碍因素,精准匹配实施策略,从而为推动处方精简工作提出兼具针对性与可行性的方案。
文摘Stanbic Bank Zimbabwe is strategically positioning itself as a critical bridge for Zimbabwe’s local businesses,seeking to navigate the vast and complex Chinese market.
基金funded by NIH grants HL154720-03S1, AG057587, AG074283, DK122708-03S1, BrightFocus ADR A20183775Brown Foundation 2020 Healthy Aging Initiative (to WC)
文摘Microglia are the macrophages that populate the brain parenchyma.Research in the past decades has identified them as both essential guardians of the brain and significant contributors to various neurological diseases.A highly versatile cell type,microglia have been shown to fulfill a multitude of critical roles in the central nervous system,including facilitating neurogenesis and myelination,pruning synapses,removing debris and waste,modulating neuronal activity,supporting the blood-brain barrier,repairing tissue damage,and surveilling against microbial invasions under physiological conditions(Prinz et al.,2021;Paolicelli et al.,2022).
文摘BACKGROUND Stroke is a type of cerebrovascular disease with high prevalence,mortality,and onset of disability.As a neurodevelopmental therapy,neuromuscular joint facilitation(NJF)is widely used in the treatment of orthopedic and neurological disorders in the clinical practice.It is mainly used for central nervous system diseases or orthopedic diseases,movement disorders,and pain rehabilitation.According to related studies,NJF can also be used as a rehabilitation treatment in patients with hemiplegic shoulder pain(HSP).AIM To investigate the clinical efficacy of acupuncture combined with NJF in patients with HSP.METHODS Forty patients with HSP were randomly divided into a treatment group and a control group.The treatment group was treated with acupuncture combined with NJF and the control group was treated with acupuncture alone.All patients were assessed by using the visual analogue scale(VAS),Fugl-Meyer assessment(FMA),Barthel index(BI),and passive range of motion(PROM)before and after the training.All the clinical data were analyzed using SPSS 20.0 statistical software.RESULTS There was no statistical difference in the general characteristics between the two groups.In the terms of duration of treatment,age,and pre-treatment indicators,the two groups were comparable(P>0.05).After the treatment,VAS,PROM,BI,and FMA scores were significantly improved in the two groups of patients(P<0.05).The VAS,PROM and FMA scores were significantly higher in the treatment group than in the control group(P<0.05).However,there was no significant difference in BI scores between the two groups(P>0.05).CONCLUSION Both acupuncture alone and acupuncture combined with NJF in the treatment of HSP are effective,and can improve the clinical symptoms of patients.Acupuncture combined with NJF can improve the upper limb motor function,relieve pain,and increase joint mobility in patients with HSP.The combination therapy is better than acupuncture alone.However,there is no significant difference in improving the score of patients’self-care ability.
