Grain size traits, including grain length, grain width and grain thickness, are controlled by quantitative trait loci （QTLs）. Many QTLs relating to rice grain size traits had been reported, but their control mechani...Grain size traits, including grain length, grain width and grain thickness, are controlled by quantitative trait loci （QTLs）. Many QTLs relating to rice grain size traits had been reported, but their control mechanisms have not yet been elucidated. A recombinant inbred line （RIL） population of 240 lines, deriving from a cross between TD70, an extra-large grain size japonica line with 80 g of 1000-grain weight, and Kasalath, a small grain size indica variety, were constructed and used to map grain size QTLs to a linkage map by using 141 SSR markers in 2010 and 2011. Five QTLs for grain length, six for grain width and seven for grain thickness were detected distributing over chromosomes 2, 3, 5, 7, 9 and 12. Seven QTLs, namely qGL3.1, qGW2, qGW2.2, qGW5.1, qGW5.2, qGT2.3 and qGT3.1, were detected in either of the two years and explained for 56.19%, 4.42%, 29.41%, 10.37%, 7.61%, 21.19% and 17.06% of the observed phenotypic variances on average, respectively. The marker interval RM1347-RM5699 on chromosome 2 was found common for grain length, grain width and grain thickness; qGL3.1 and qGT3.1 were mapped to the same interval RM6080-RM6832 on chromosome 3. All 18 QTL alleles were derived from the large grain parent TD70. Most of the QTLs mapped in the present study were found the same as the genes previously cloned （GW2, GS3 or qGL3, GW5 and GS5）, and several were the same as the QTLs （GS7 and qGL-7） previously mapped. Three QTLs, qGL2.2 on chromosome 2, qGW9 and qGT9 on chromosome 9, were first detected. These results laid a foundation for further fine mapping or cloning of these QTLs.展开更多
In solid backfill mining without gangue removal, the gangue is separated directly underground and backfilled into goaf. This necessitates the underground construction of an extra-large section chamber for separation e...In solid backfill mining without gangue removal, the gangue is separated directly underground and backfilled into goaf. This necessitates the underground construction of an extra-large section chamber for separation equipments. For the construction of an extra-large section chamber in the Tangshan mine, we proposed an active support through a combination of bolting, anchor cables, lining, and a reinforced chamber floor by inverted arch pouring. ABAQUS software was used to analyze the surrounding rock deformation and the plastic zone development of the chamber under different excavation schemes.The best excavation scheme was determined, and the effectiveness of the combined supports was verified. In practice, the engineering installation showed good overall control of the movement of the surrounding rock, with roof-to-floor and side-to-side convergences of 154.6 and 77.5 mm, respectively,which meets the requirements for underground coal gangue separation.展开更多
1Project objective Extra-large shield tunnels have become the best choice for urban transportation tunnels due to the advantage of taking the best use of underground space.Hengqin Island in Zhuhai is a demonstration a...1Project objective Extra-large shield tunnels have become the best choice for urban transportation tunnels due to the advantage of taking the best use of underground space.Hengqin Island in Zhuhai is a demonstration area to explore a new cooperation mode among Guangzhou,Hong Kong and Macao,which is also an important pivot of the 21st Century Maritime Silk Road.Thus,it takes an important role in serving Hong Kong and Macao and driving the economic development of the Pearl River Delta.However,as typhoons are frequent in Zhuhai,Hengqin Island will be isolated to the mainland when bridges are obstructed in typhoon seasons.Therefore,the bridges cannot satisfy the traffic demand to the island.The inconvenient transportation has a neglect influence on production and live of people on the island,which also affects the long term development of Hengqin Island.Apart from the two existed bridges,Maliuzhou Traffic Tunnel in Zhuhai is the third major link of Hengqin Island to the mainland,which will put an end to the"losing connectionM problem due to obstructing the bridges in typhoon seasons.This linkage is able to promote Zhuhai tourism exploitation and the long term development of the city,and also increase the security of peopled lives.Meanwhile,the construction of the Maliuzhou Traffic Tunnel has conquered the challenges in designing and building of the extra-large shield tunnel in composite ground and undersea circumstances.The designing methods and constructing approaches used in this project will provide theoretical supports and technical guarantees to similar projects.展开更多
The extra-large scale multiple-input multiple-output(XL-MIMO)for the beyond fifth/sixth generation mobile communications is a promising technology to provide Tbps data transmission and stable access service.However,th...The extra-large scale multiple-input multiple-output(XL-MIMO)for the beyond fifth/sixth generation mobile communications is a promising technology to provide Tbps data transmission and stable access service.However,the extremely large antenna array aperture arouses the channel near-field effect,resulting in the deteriorated data rate and other challenges in the practice communication systems.Meanwhile,multi-panel MIMO technology has attracted extensive attention due to its flexible configuration,low hardware cost,and wider coverage.By combining the XL-MIMO and multi-panel array structure,we construct multi-panel XL-MIMO and apply it to massive Internet of Things(IoT)access.First,we model the multi-panel XL-MIMO-based near-field channels for massive IoT access scenarios,where the electromagnetic waves corresponding to different panels have different angles of arrival/departure(AoAs/AoDs).Then,by exploiting the sparsity of the near-field massive IoT access channels,we formulate a compressed sensing based joint active user detection(AUD)and channel estimation(CE)problem which is solved by AMP-EM-MMV algorithm.The simulation results exhibit the superiority of the AMP-EM-MMV based joint AUD and CE scheme over the baseline algorithms.展开更多
The current High-Speed Railway(HSR)communications increasingly fail to satisfy the massive access services of numerous user equipment brought by the increasing number of people traveling by HSRs.To this end,this paper...The current High-Speed Railway(HSR)communications increasingly fail to satisfy the massive access services of numerous user equipment brought by the increasing number of people traveling by HSRs.To this end,this paper investigates millimeter-Wave(mmWave)extra-large scale(XL)-MIMO-based massive Internet-of-Things(loT)access in near-field HSR communications,and proposes a block simultaneous orthogonal matching pursuit(B-SOMP)-based Active User Detection(AUD)and Channel Estimation(CE)scheme by exploiting the spatial block sparsity of the XLMIMO-based massive access channels.Specifically,we first model the uplink mmWave XL-MIMO channels,which exhibit the near-field propagation characteristics of electromagnetic signals and the spatial non-stationarity of mmWave XL-MIMO arrays.By exploiting the spatial block sparsity and common frequency-domain sparsity pattern of massive access channels,the joint AUD and CE problem can be then formulated as a Multiple Measurement Vectors Compressive Sensing(MIMV-CS)problem.Based on the designed sensing matrix,a B-SOMP algorithm is proposed to achieve joint AUD and CE.Finally,simulation results show that the proposed solution can obtain a better AUD and CE performance than the conventional CS-based scheme for massive IoT access in near-field HSR communications.展开更多
An extra-large landslide occurred on June 19,2021,on the footwall slope of the Nanfen Open-pit Iron Mine in Liaoning Province,China,with a volume of approximately 1.2×107 m3.To elucidate the causative factors,dev...An extra-large landslide occurred on June 19,2021,on the footwall slope of the Nanfen Open-pit Iron Mine in Liaoning Province,China,with a volume of approximately 1.2×107 m3.To elucidate the causative factors,development process,and destructive mechanisms of this catastrophic landslide,comprehensive field tests,investigations,and laboratory experiments were conducted.Initially,the heavily weathered rock mass of the slope was intersected by faults and joint fissures,facilitating rainwater infiltration.Moreover,the landslide contained a substantial clay mineral with highly developed micro-cracks and micro-pores,exhibiting strong water-absorption properties.As moisture content increased,the rock mass underwent softening,resulting in reduced strength.Ultimately,continuous heavy rainfall infiltration amplified the slope's weight,diminishing the weak structural plane's strength,leading to fracture propagation,slip plane penetration,and extensive tensile-shear and uplift failure of the slope.The study highlights poor geological conditions as the decisive factor for this landslide,with continuous heavy rainfall as the triggering factor.Presently,adverse environmental factors persistently affect the landslide,and deformation and failure continue to escalate.Hence,it is imperative to urgently implement integrated measures encompassing slope reinforcement,monitoring,and early-warning to real-time monitor the landslide's deformation and deep mechanical evolution trends.展开更多
The design of roof frame is one of the most important parts of LNG tank design.In China,however,the calculation of roof frame system of extra-large LNG tanks is currently faced with a series of problems.For example,th...The design of roof frame is one of the most important parts of LNG tank design.In China,however,the calculation of roof frame system of extra-large LNG tanks is currently faced with a series of problems.For example,there is no united yardstick on buckling characteristic value,the calculation is based on many assumptions,and the calculation is inconsistent with domestic specifications and stipulations.In view of these problems,the material non-linearity and structural non-linearity were introduced and the initial defect was taken into consideration.Then,the large non-linear finite element calculation software ABAQUS was adopted to carry out modeling on the roof frame and liner system of extra-large LNG tanks and calculate and analyze the force applied on them and their stability.Finally,a complete set of design algorithm for the roof frame and liner system of extra-large LNG tanks was established and applied to the design of a certain LNG tank(20×10^(4)m^(3))in China.It is indicated that this design algorithm can simulate the actual situations accurately.This design algorithm is structurally composed of shell units and beam units,and it is connected in the pattern of common node.Besides,force calculation is conducted in 10 operational modes and the buckling calculation in 7 operational modes,including all operational modes in the construction process of roof frame and liner system of LNG tanks.It is also revealed that the maximum stress on the roof frame is 125.7 MPa,that on the liner is 101.4 MPa and the minimum safety coefficient used for buckling calculation is 2.57.Under this system,the force and stability of the roof frame of LNG tanks are satisfactory.The research results can be used as reference for relevant design and calculation.展开更多
In this paper,a class of semilinear parabolic equations with cross coupling of power and exponential functions and large initial values are studied.By constructing and solving ordinary differential equations,the upper...In this paper,a class of semilinear parabolic equations with cross coupling of power and exponential functions and large initial values are studied.By constructing and solving ordinary differential equations,the upper and lower bounds on the solution life span of the equations areobtained.展开更多
Significant two-way shape memory effect(TWSME)was achieved in single crystals of single-phase multielement Ni42-x Cu8 Cox Mn37 Ga13(8≤x≤12)alloys by performing thermomechanical training.However,anomalous dependence ...Significant two-way shape memory effect(TWSME)was achieved in single crystals of single-phase multielement Ni42-x Cu8 Cox Mn37 Ga13(8≤x≤12)alloys by performing thermomechanical training.However,anomalous dependence of the martensitic transformation temperature span on Co content was observed.Before training,quite a narrow temperature span of the martensitic transformation,nearly independent of the Co content,was observed in all single crystals.After training the temperature span was still narrow for 8≤x≤10.9 but was obviously expanded for 10.9<x≤12.High-resolution transmission electron microscopy revealed that at the atomic scale,there exists incommensurate modulated structure in the single phase single crystals,as evidenced by nonperiodic satellite spots in the selected area electronic diffraction patterns.Moreover,the modulated wave vector of the satellite spots was increased by higher Co contents.Combining first principal calculations it was considered that the incommensurate modulated structure originates from the formation of Co-Co pairs.After training arrays of ordered dislocations with the same Burgers vector were introduced for 8≤x≤10.9 but the network of dislocations was formed for 10.9<x≤12.Based on analysis of transmission electron microscopy,geometric phase,thermodynamics,and Landau theory,it was considered that the austenite/martensite phase interface was pinned by the network of dislocations,expanding the temperature span of the martensitic transformation.This work supplies new insights for understanding the microstructure and martensitic transformation of Ni-Mn-Ga-based alloys.展开更多
Background:In 2021,the American College of Medical Genetics and Genomics(ACMG)recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available....Background:In 2021,the American College of Medical Genetics and Genomics(ACMG)recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available.Evaluations of the association of actionable genotypes in these genes with life span are currently lacking.Methods:We assessed the prevalence of coding and splice variants in genes on the ACMG Secondary Findings,version 3.0(ACMG SF v3.0),list in the genomes of 57,933 Icelanders.We assigned pathogenicity to all reviewed variants using reported evidence in the ClinVar database,the frequency of variants,and their associations with disease to create a manually curated set of actionable genotypes(variants).We assessed the relationship between these genotypes and life span and further examined the specific causes of death among carriers.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 31271678)the Jiangsu Agricultural Scientific Self-Innovation Fund (Grant No. CX[11]4023)the Super Rice Breeding and Demonstration Program of the Ministry of Agriculture in China
文摘Grain size traits, including grain length, grain width and grain thickness, are controlled by quantitative trait loci （QTLs）. Many QTLs relating to rice grain size traits had been reported, but their control mechanisms have not yet been elucidated. A recombinant inbred line （RIL） population of 240 lines, deriving from a cross between TD70, an extra-large grain size japonica line with 80 g of 1000-grain weight, and Kasalath, a small grain size indica variety, were constructed and used to map grain size QTLs to a linkage map by using 141 SSR markers in 2010 and 2011. Five QTLs for grain length, six for grain width and seven for grain thickness were detected distributing over chromosomes 2, 3, 5, 7, 9 and 12. Seven QTLs, namely qGL3.1, qGW2, qGW2.2, qGW5.1, qGW5.2, qGT2.3 and qGT3.1, were detected in either of the two years and explained for 56.19%, 4.42%, 29.41%, 10.37%, 7.61%, 21.19% and 17.06% of the observed phenotypic variances on average, respectively. The marker interval RM1347-RM5699 on chromosome 2 was found common for grain length, grain width and grain thickness; qGL3.1 and qGT3.1 were mapped to the same interval RM6080-RM6832 on chromosome 3. All 18 QTL alleles were derived from the large grain parent TD70. Most of the QTLs mapped in the present study were found the same as the genes previously cloned （GW2, GS3 or qGL3, GW5 and GS5）, and several were the same as the QTLs （GS7 and qGL-7） previously mapped. Three QTLs, qGL2.2 on chromosome 2, qGW9 and qGT9 on chromosome 9, were first detected. These results laid a foundation for further fine mapping or cloning of these QTLs.
基金supported by the National Natural Science Foundation of China (No. 51304206)the Project of National Scientific and Technical Supporting Programs Foundation of China (No. 2012BAB13B03)the Program for New Century Excellent Talents in University of Ministry of Education of China (No. NCET-11-0728)
文摘In solid backfill mining without gangue removal, the gangue is separated directly underground and backfilled into goaf. This necessitates the underground construction of an extra-large section chamber for separation equipments. For the construction of an extra-large section chamber in the Tangshan mine, we proposed an active support through a combination of bolting, anchor cables, lining, and a reinforced chamber floor by inverted arch pouring. ABAQUS software was used to analyze the surrounding rock deformation and the plastic zone development of the chamber under different excavation schemes.The best excavation scheme was determined, and the effectiveness of the combined supports was verified. In practice, the engineering installation showed good overall control of the movement of the surrounding rock, with roof-to-floor and side-to-side convergences of 154.6 and 77.5 mm, respectively,which meets the requirements for underground coal gangue separation.
文摘1Project objective Extra-large shield tunnels have become the best choice for urban transportation tunnels due to the advantage of taking the best use of underground space.Hengqin Island in Zhuhai is a demonstration area to explore a new cooperation mode among Guangzhou,Hong Kong and Macao,which is also an important pivot of the 21st Century Maritime Silk Road.Thus,it takes an important role in serving Hong Kong and Macao and driving the economic development of the Pearl River Delta.However,as typhoons are frequent in Zhuhai,Hengqin Island will be isolated to the mainland when bridges are obstructed in typhoon seasons.Therefore,the bridges cannot satisfy the traffic demand to the island.The inconvenient transportation has a neglect influence on production and live of people on the island,which also affects the long term development of Hengqin Island.Apart from the two existed bridges,Maliuzhou Traffic Tunnel in Zhuhai is the third major link of Hengqin Island to the mainland,which will put an end to the"losing connectionM problem due to obstructing the bridges in typhoon seasons.This linkage is able to promote Zhuhai tourism exploitation and the long term development of the city,and also increase the security of peopled lives.Meanwhile,the construction of the Maliuzhou Traffic Tunnel has conquered the challenges in designing and building of the extra-large shield tunnel in composite ground and undersea circumstances.The designing methods and constructing approaches used in this project will provide theoretical supports and technical guarantees to similar projects.
基金supported by National Key Research and Development Program of China under Grants 2021YFB1600500,2021YFB3201502,and 2022YFB3207704Natural Science Foundation of China(NSFC)under Grants U2233216,62071044,61827901,62088101 and 62201056+1 种基金supported by Shandong Province Natural Science Foundation under Grant ZR2022YQ62supported by Beijing Nova Program,Beijing Institute of Technology Research Fund Program for Young Scholars under grant XSQD-202121009.
文摘The extra-large scale multiple-input multiple-output(XL-MIMO)for the beyond fifth/sixth generation mobile communications is a promising technology to provide Tbps data transmission and stable access service.However,the extremely large antenna array aperture arouses the channel near-field effect,resulting in the deteriorated data rate and other challenges in the practice communication systems.Meanwhile,multi-panel MIMO technology has attracted extensive attention due to its flexible configuration,low hardware cost,and wider coverage.By combining the XL-MIMO and multi-panel array structure,we construct multi-panel XL-MIMO and apply it to massive Internet of Things(IoT)access.First,we model the multi-panel XL-MIMO-based near-field channels for massive IoT access scenarios,where the electromagnetic waves corresponding to different panels have different angles of arrival/departure(AoAs/AoDs).Then,by exploiting the sparsity of the near-field massive IoT access channels,we formulate a compressed sensing based joint active user detection(AUD)and channel estimation(CE)problem which is solved by AMP-EM-MMV algorithm.The simulation results exhibit the superiority of the AMP-EM-MMV based joint AUD and CE scheme over the baseline algorithms.
基金supported in part by the Natural Science Foundation of China(NSFC)under Grant 62071044 and Grant 62088101in part by the Shandong Province Natural Science Foundation under Grant ZR2022YQ62in part by the Beijing Nova Program.
文摘The current High-Speed Railway(HSR)communications increasingly fail to satisfy the massive access services of numerous user equipment brought by the increasing number of people traveling by HSRs.To this end,this paper investigates millimeter-Wave(mmWave)extra-large scale(XL)-MIMO-based massive Internet-of-Things(loT)access in near-field HSR communications,and proposes a block simultaneous orthogonal matching pursuit(B-SOMP)-based Active User Detection(AUD)and Channel Estimation(CE)scheme by exploiting the spatial block sparsity of the XLMIMO-based massive access channels.Specifically,we first model the uplink mmWave XL-MIMO channels,which exhibit the near-field propagation characteristics of electromagnetic signals and the spatial non-stationarity of mmWave XL-MIMO arrays.By exploiting the spatial block sparsity and common frequency-domain sparsity pattern of massive access channels,the joint AUD and CE problem can be then formulated as a Multiple Measurement Vectors Compressive Sensing(MIMV-CS)problem.Based on the designed sensing matrix,a B-SOMP algorithm is proposed to achieve joint AUD and CE.Finally,simulation results show that the proposed solution can obtain a better AUD and CE performance than the conventional CS-based scheme for massive IoT access in near-field HSR communications.
基金supported by the National Natural Science Foundation of China(Grant No.52074295)the State Key Laboratory for GeoMechanics and Deep Underground Engineering,China University of Mining&Technology,Beijing(Grant No.SKLGDUEK202217).
文摘An extra-large landslide occurred on June 19,2021,on the footwall slope of the Nanfen Open-pit Iron Mine in Liaoning Province,China,with a volume of approximately 1.2×107 m3.To elucidate the causative factors,development process,and destructive mechanisms of this catastrophic landslide,comprehensive field tests,investigations,and laboratory experiments were conducted.Initially,the heavily weathered rock mass of the slope was intersected by faults and joint fissures,facilitating rainwater infiltration.Moreover,the landslide contained a substantial clay mineral with highly developed micro-cracks and micro-pores,exhibiting strong water-absorption properties.As moisture content increased,the rock mass underwent softening,resulting in reduced strength.Ultimately,continuous heavy rainfall infiltration amplified the slope's weight,diminishing the weak structural plane's strength,leading to fracture propagation,slip plane penetration,and extensive tensile-shear and uplift failure of the slope.The study highlights poor geological conditions as the decisive factor for this landslide,with continuous heavy rainfall as the triggering factor.Presently,adverse environmental factors persistently affect the landslide,and deformation and failure continue to escalate.Hence,it is imperative to urgently implement integrated measures encompassing slope reinforcement,monitoring,and early-warning to real-time monitor the landslide's deformation and deep mechanical evolution trends.
基金Project supported by the Special and Significant Project of China National Offshore Oil Corporation“Study on the design of full-containment large LNG storage tank and engineering applications”(No.:CNOOC-KJ125ZDXM14QD-04QD11).
文摘The design of roof frame is one of the most important parts of LNG tank design.In China,however,the calculation of roof frame system of extra-large LNG tanks is currently faced with a series of problems.For example,there is no united yardstick on buckling characteristic value,the calculation is based on many assumptions,and the calculation is inconsistent with domestic specifications and stipulations.In view of these problems,the material non-linearity and structural non-linearity were introduced and the initial defect was taken into consideration.Then,the large non-linear finite element calculation software ABAQUS was adopted to carry out modeling on the roof frame and liner system of extra-large LNG tanks and calculate and analyze the force applied on them and their stability.Finally,a complete set of design algorithm for the roof frame and liner system of extra-large LNG tanks was established and applied to the design of a certain LNG tank(20×10^(4)m^(3))in China.It is indicated that this design algorithm can simulate the actual situations accurately.This design algorithm is structurally composed of shell units and beam units,and it is connected in the pattern of common node.Besides,force calculation is conducted in 10 operational modes and the buckling calculation in 7 operational modes,including all operational modes in the construction process of roof frame and liner system of LNG tanks.It is also revealed that the maximum stress on the roof frame is 125.7 MPa,that on the liner is 101.4 MPa and the minimum safety coefficient used for buckling calculation is 2.57.Under this system,the force and stability of the roof frame of LNG tanks are satisfactory.The research results can be used as reference for relevant design and calculation.
基金Supported by Key Project Funding for Shaanxi Higher Education Teaching Reform Research (23BZ078)Shaanxi Provincial Education Science Planning Project (SGH24Y2782)+4 种基金Shaanxi Provincial Social Science Foundation Program(2024D008)Key Projects of the Second Huang Yanpei Vocational Education Thought Research Planning Project (ZJS2024ZN026)Shaanxi Higher Education Society Key Projects(XGHZ2301)2024 Annual Planning Project of the China Association for Non-Government Education (School Development Category)(CANFZG24095)the Youth Innovation Team of Shaanxi Universities。
文摘In this paper,a class of semilinear parabolic equations with cross coupling of power and exponential functions and large initial values are studied.By constructing and solving ordinary differential equations,the upper and lower bounds on the solution life span of the equations areobtained.
基金support from the National Key Research and Development Program of China(Grant No.2021YFB3501402)the National Natural Science Foundation of China(Grant Nos.52250313 and 52121001)Yang Liu and Chen Si acknowledge financial support from the National Natural Science Foundation of China(Grant No.12274013).
文摘Significant two-way shape memory effect(TWSME)was achieved in single crystals of single-phase multielement Ni42-x Cu8 Cox Mn37 Ga13(8≤x≤12)alloys by performing thermomechanical training.However,anomalous dependence of the martensitic transformation temperature span on Co content was observed.Before training,quite a narrow temperature span of the martensitic transformation,nearly independent of the Co content,was observed in all single crystals.After training the temperature span was still narrow for 8≤x≤10.9 but was obviously expanded for 10.9<x≤12.High-resolution transmission electron microscopy revealed that at the atomic scale,there exists incommensurate modulated structure in the single phase single crystals,as evidenced by nonperiodic satellite spots in the selected area electronic diffraction patterns.Moreover,the modulated wave vector of the satellite spots was increased by higher Co contents.Combining first principal calculations it was considered that the incommensurate modulated structure originates from the formation of Co-Co pairs.After training arrays of ordered dislocations with the same Burgers vector were introduced for 8≤x≤10.9 but the network of dislocations was formed for 10.9<x≤12.Based on analysis of transmission electron microscopy,geometric phase,thermodynamics,and Landau theory,it was considered that the austenite/martensite phase interface was pinned by the network of dislocations,expanding the temperature span of the martensitic transformation.This work supplies new insights for understanding the microstructure and martensitic transformation of Ni-Mn-Ga-based alloys.
文摘Background:In 2021,the American College of Medical Genetics and Genomics(ACMG)recommended reporting actionable genotypes in 73 genes associated with diseases for which preventive or therapeutic measures are available.Evaluations of the association of actionable genotypes in these genes with life span are currently lacking.Methods:We assessed the prevalence of coding and splice variants in genes on the ACMG Secondary Findings,version 3.0(ACMG SF v3.0),list in the genomes of 57,933 Icelanders.We assigned pathogenicity to all reviewed variants using reported evidence in the ClinVar database,the frequency of variants,and their associations with disease to create a manually curated set of actionable genotypes(variants).We assessed the relationship between these genotypes and life span and further examined the specific causes of death among carriers.
