This work aimed at revealing the mechanism of strong ground pressure behaviour(SGPB)induced by high-position hard roof(HHR).Based on the supporting structures model of HHR,a modified voussoir beam mechanical model for...This work aimed at revealing the mechanism of strong ground pressure behaviour(SGPB)induced by high-position hard roof(HHR).Based on the supporting structures model of HHR,a modified voussoir beam mechanical model for HHR was established by considering the gangue support coefficient,through which the modified expressions of limit breaking span and breaking energy of HHR were deduced.Combined with the relationship between the dynamic-static loading stress of supporting body(hydraulic support and coal wall)and its comprehensive supporting strength,the criteria of ground pressure behaviour(GPB)induced by HHR were discussed.The types of Ⅰ_(1),Ⅰ_(2),Ⅱ_(1),andⅡ_(2) of GPB were interpreted.Results showed that types Ⅰ_(1) and Ⅰ_(2) were the main forms of SGPB in extra-thick coal seam mining.The main manifestation of SGPB was static stress,which was mainly derived from the instability of HHR rather than fracture.Accordingly,an innovative control technology was proposed,which can weaken static load by vertical-well separated fracturing HHR.The research results have been successfully applied to the 8101 working face in Tashan coal mine,Shanxi Province,China.The results of a digital borehole camera observation and stress monitoring proved the rationality of the GPB criteria.The control technology was successful,paving the way for new possibilities to HHR control for safety mining.展开更多
This paper analyzes the gas source of the horizontally sectioned fully mechanized caving face in the steeply inclined and extra-thick seam of Adaohai Coal Mine, and numerically simulates the stress distribution and pr...This paper analyzes the gas source of the horizontally sectioned fully mechanized caving face in the steeply inclined and extra-thick seam of Adaohai Coal Mine, and numerically simulates the stress distribution and pressure relief of the lower section coal after the upper section working face is mined. It theoretically analyzed the reasonable layout of the drainage boreholes, and designed the drainage borehole layout accordingly. In the upper and lower section of the working face, the actual drainage effect of the boreholes was inspected, and the air exhaust gas volume in the working face was statistically analyzed. It was confirmed that the layout of boreholes was reasonable, the gas control effect of working face was greatly improved and fully met the needs of safe mining. The control effect was greatly improved and the need for safe mining was fully met, and thus a gas drainage technology suitable for the coal seam storage conditions and mining technology of the Adaohai Coal Mine was found. That is to say: the gas emission from the working face of the section mining mainly comes from its lower coal body. Pre-draining the lower coal body of the section and depressurizing gas interception and drainage are the key to effectively solve the problem of gas emission from the working face. Drainage boreholes in the working face of the section should be arranged at high and low positions. The high-level boreholes are located about 2 m from the top of the working face, and the high-level boreholes are about 9 m away from the top of the working face. Through the pre drainage of high and low-level boreholes in advance and the interception and pressure relief drainage, the gas control in the horizontal sublevel fully mechanized caving mining face in steep and extra thick coal seam can realize a virtuous cycle.展开更多
In this paper,a physical model of coal roadway which is clamped by upper and lower softrock with extra thickness was built according to the characteristics of soft rock strata in china's western mining area.Then,a...In this paper,a physical model of coal roadway which is clamped by upper and lower softrock with extra thickness was built according to the characteristics of soft rock strata in china's western mining area.Then,a series of orthogonal numerical experiments were carried out by selecting the strength and stiffness parameters of soft rock and coal seam as well as the in situ stress of soft rock strata as experimental factors and roadway displacements(convergence displacements of sides,displacement of roof to floor)as experimental indexes.By constructing the F statistics with different inspection levels,evaluation method for influence of the experimental factors on stability indexes were defined.Thus,influence degrees of specified parameters on the stability of roadway were divided into five classes as follows:highly significant influence,significant influence,relatively significant influence,little significant influence,and no influence respectively which realize the quantitative analysis of the influence degrees of experimental factors.The finite element calculation results showed that main failure mode of coal roadway that usually showed as tension failure of coal seam in roof and deformation factors of coal seam had the most remarkable effect on roadway displacements.The conclusions provide theoretical basis for further analysis of the mechanism of"roof burst"in roadway maintenance.展开更多
Accidents such as support failure and excessive deformation of roadways due to drastic changes in strata behaviors are frequently reported when mining the extra-thick coal seams Nos.3e5 in Datong coal mine with top-co...Accidents such as support failure and excessive deformation of roadways due to drastic changes in strata behaviors are frequently reported when mining the extra-thick coal seams Nos.3e5 in Datong coal mine with top-coal caving method,which significantly hampers the mine's normal production.To understand the mechanism of strata failure,this paper presented a structure evolution model with respect to strata behaviors.Then the behaviors of strata overlying the extra-thick coal seams were studied with the combined method of theoretical analysis,physical simulation,and field measurement.The results show that the key strata,which are usually thick-hard strata,play an important role in overlying movement and may influence the mining-induced strata behaviors in the working face using top-coal caving method.The structural model of far-field key strata presents a 'masonry beam' type structure when'horizontal O-X' breakage type happens.The rotational motion of the block imposed radial compressive stress on the surrounding rock mass of the roadway.This can induce excessive deformation of roadway near the goaf.Besides,this paper proposed a pre-control technology for the hard roof based on fracture holes and underground roof pre-splitting.It could effectively reduce stress concentration and release the accumulated energy of the strata,when mining underground coal resources with top-coal caving method.展开更多
The EGAT Mae Moh Mine is the largest open pit lignite mine in Thailand and it produces lignite about 16 million tons annually. In the near future, the pit limit of the mine will be reached and underground mine will th...The EGAT Mae Moh Mine is the largest open pit lignite mine in Thailand and it produces lignite about 16 million tons annually. In the near future, the pit limit of the mine will be reached and underground mine will then be developed through the open pit in the depth of 400 - 600 m from the surface. However, due to the challenges for underground mining such as poor geological conditions, extra thickness (20 - 30 m) of coal seams, and weak mechanical properties of coal seams and the surrounding rock, the success possibility of underground mining and an applicable underground mining method is being investigated at the present. The paper discusses the applicability of multi-slice bord-and-pillar method for the soft extra thick coal seams in the Mae Moh mine by means of numerical analyses using the 3D finite difference code “FLAC3D”.展开更多
In order to clarify the danger of water breakout in the bottom plate of extra-thick coal seam mining, 2202 working face of a mine in the west is taken as the research object, and it is proposed to use the on-site moni...In order to clarify the danger of water breakout in the bottom plate of extra-thick coal seam mining, 2202 working face of a mine in the west is taken as the research object, and it is proposed to use the on-site monitoring means combining borehole peeping and microseismic monitoring, combined with the theoretical analysis to analyze the danger of water breakout in the bottom plate. The results show that: 1) the theoretically calculated maximum damage depth of the bottom plate is 27.5 m, and its layer is located above the Austrian ash aquifer, which has the danger of water breakout;2) the drill hole peeping at the bottom plate of the working face shows that the depth of the bottom plate fissure development reaches 26 m, and the integrity of the water barrier layer has been damaged, so there is the risk of water breakout;3) for the microseismic monitoring of the anomalous area, the bottom plate of the return air downstream channel occurs in the field with a one-week lag, which shows that microseismic monitoring events may reflect the water breakout of the underground. This shows that the microseismic monitoring events can reflect the changes of the underground flow field, which can provide a reference basis for the early warning of water breakout. The research results can provide reference for the prediction of sudden water hazard.展开更多
BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging e...BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients.展开更多
Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studie...Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studied because it is related to an alteration of the normal metabolism of glucose and lipids,ultimately leading to triglyceride accumulation within hepatocytes.This lipid overload triggers an inflammatory status,also influenced by gut-liver axis dysfunction,with gut dysbiosis,which alters intestinal permeability,causing inflammation and IR in a vicious circle.Several approaches have been attempted to treat this condition and stop its poss-ible evolution towards increasingly serious stages,but the first step is always lifestyle modification.The Mediterranean diet seems to be the most reliable for affecting liver steatosis,probably thanks to extra virgin olive oil,a healthy food with a high content of monounsaturated fatty acids and variable concentrations of phenols(oleocanthal)and phenolic alcohols,such as hydroxytyrosol and tyrosol.This review investigates the mechanisms underlying the bidirectional and synergistic relationships among metabolic dysfunction-associated steatotic liver disease,IR,and the gut-liver axis,specifically focusing on the role of extra virgin olive oil as one of the main antioxidant components of the Mediterranean diet.展开更多
Zeolites are crystalline microporous materials widely used in catalysis,adsorption,and ion exchange owing to their tunable pore structures and acid centers[1].Traditional zeolites,however,often suffer from limitations...Zeolites are crystalline microporous materials widely used in catalysis,adsorption,and ion exchange owing to their tunable pore structures and acid centers[1].Traditional zeolites,however,often suffer from limitations such as restricted molecular diffusion and rapid coking,which hinder their efficiency in processing large molecules.展开更多
Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. M...Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan （Extra） acupoint were adopted. In the control group, Jiáj （夹脊 EX-B 2） at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale （VAS） was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group （all P0.05）. The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group （both P0.05）. Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan （Extra） achieves the significant analgesic effect on herpes zoster.展开更多
Based on the characteristics of the top coal thickness of the fully mechanized caving in special thick coal seam,the long distance of coal gangue caving,as well as the different sizes of the coal gangue broken fragmen...Based on the characteristics of the top coal thickness of the fully mechanized caving in special thick coal seam,the long distance of coal gangue caving,as well as the different sizes of the coal gangue broken fragment dimension and spatial variation of drop flow,this paper uses laboratory dispersion simulation experiment and theoretical analysis to study the arch structure effect and its influence rule on the top coal loss in the process of coal gangue flow.Research shows that in the process of coal gangue flow,arch structure can be formed in three types:the lower arch structure,middle arch structure,and upper arch structure.Moreover,the arch structure has the characteristics of dynamic random arch,the formation probability of dynamic random arch with different layers is not the same,dynamic random arch caused the reduction of the top coal fluency;analyzing the dynamic random arch formation mechanism,influencing factors,and the conditions of instability;the formation probability of the lower arch structure is the highest,the whole coal arch and the coal gangue arch structure has the greatest impact on top coal loss.Therefore,to prevent or reduce the formation of lower whole coal arch structure,the lower coal gangue arch structure and the middle whole coal arch structure is the key to reduce the top coal loss.The research conclusion provides theoretical basis for the further improvement of the top coal recovery rate of the fully mechanized caving in extra thick coal seam.展开更多
This paper defines the following advantages of ELS （Extra Long Staple） also known as Pima cotton planted in the United States： first, the only variety which is concentrated in the planting area with good soil moist...This paper defines the following advantages of ELS （Extra Long Staple） also known as Pima cotton planted in the United States： first, the only variety which is concentrated in the planting area with good soil moisture and fertilizer retention performances and abundant light and heat resources; second; advanced and practi- cal material equipment and technology; third; high yield and good quality, significant planting scale benefit; fourth, feasible and reliable modernized intensive farm man- agement mode with large-scale agricultural machinery operation; fifth, high-efficient social services and policy support system, as well as reasonable planting layout, good brand influence, synchronization of high yield and good quality with large-scale benefits. Although the production capability of Pima cotton in the United States is considered to be the largest and most powerful country in the world, compared with the ELS production in China, both have their own advantages and characteristics. Therefore, it is suggested that by using the ELS production experience ol the Unit- ed Stages for reference, China should make use of the modern breeding technJques to accelerate the modification of synthetic genetic features of ELS variety, try its best to breed the ELS variety which is suitable for mechanical plucking as soon as possible, actively develop new technology to simplify the whole cost saving cultiva- tion, reform ELS production organization, vigorously develop the social service sys- tem, and adjust and optimize the ELS industry support policies, so as to fundamen- tally improve the competitiveness of China＇s ELS in international market.展开更多
Given a graph G and a non-negative integer h, the h-restricted connectivity κh（G） of G is the minimum cardinality of a set of vertices of G, in which at least h neighbors of any vertex is not included, if any, whos...Given a graph G and a non-negative integer h, the h-restricted connectivity κh（G） of G is the minimum cardinality of a set of vertices of G, in which at least h neighbors of any vertex is not included, if any, whose deletion disconnects G and every remaining component has the minimum degree of vertex at least h; and the h-extra connectivity κh（G） of G is the minimum cardinality of a set of vertices of G, if any, whose deletion disconnects G and every remaining component has order more than h. This paper shows that for the hypercube Qn and the folded hypercube FQn, κ1（Qn）=κ（1）（Qn）=2n-2 for n≥3, κ2（Qn）=3n-5 for n≥4, κ1（FQn）=κ（1）（FQn）=2n for n≥4 and κ（2）（FQn）=4n-4 for n≥8.展开更多
The formation and distribution of fractures are controlled by paleotectonic stress field, and their preservative status and effects on development are dominated by the modern stress field. Since Triassic, it has exper...The formation and distribution of fractures are controlled by paleotectonic stress field, and their preservative status and effects on development are dominated by the modern stress field. Since Triassic, it has experienced four tectonic movements and developed four sets of tectonic fractures in the extra low-permeability sandstone reservoir at the south of western Sichuan depression. The strikes of fractures are in the S-N, NE-SW, E-W, and NW-SE directions respectively. At the end of Triassic, under the horizontal compression tectonic stress field, for which the maximum principal stress direction was NW.SE, the fractures were well developed near the S-N faults and at the end of NE-SW faults, because of their stress concentration. At the end of Cretaceous, in the horizontal compression stress fields of the NE-SW direction, the stress was obviously lower near the NE-SW faults, thus, fractures mainly developed near the S-N faults. At the end of Neogene-Early Pleistocene, under the horizontal compression tectonic stress fields of E-W direction, stress concentrated near the NE-SW faults and fractures developed at these places, especially at the end of the NE-SE faults, the cross positions of NE-SW, and S-N faults. Therefore, fractures developed mostly near S-N faults and NE-SW faults. At the cross positions of the above two sets of faults, the degree of development of the fractures was the highest. Under the modern stress field of the NW-SE direction, the NW-SE fractures were mainly the seepage ones with tensional state, the best connectivity, the widest aperture, the highest permeability, and the minimum opening pressure.展开更多
基金This work was jointly supported by the National Natural Science Foundation of China(No.51974042)the Shanxi Province Science and Technology Plan Exposed Bidding Project(No.20191101015)+3 种基金the Open Project Program of Key Laboratory of Mine Disaster Prevention and Control(No.JMDPC202102)the Scientific Research Project of Introducing Talents in Guizhou University(No.202045)the Open Project Program of National Engineering Technology Research Center of Development and Utilization for Phosphorus Resources(NECP202210)the Growth Project of Young Scientific and Technological Talents in Universities of Guizhou Province(KY2022139).
文摘This work aimed at revealing the mechanism of strong ground pressure behaviour(SGPB)induced by high-position hard roof(HHR).Based on the supporting structures model of HHR,a modified voussoir beam mechanical model for HHR was established by considering the gangue support coefficient,through which the modified expressions of limit breaking span and breaking energy of HHR were deduced.Combined with the relationship between the dynamic-static loading stress of supporting body(hydraulic support and coal wall)and its comprehensive supporting strength,the criteria of ground pressure behaviour(GPB)induced by HHR were discussed.The types of Ⅰ_(1),Ⅰ_(2),Ⅱ_(1),andⅡ_(2) of GPB were interpreted.Results showed that types Ⅰ_(1) and Ⅰ_(2) were the main forms of SGPB in extra-thick coal seam mining.The main manifestation of SGPB was static stress,which was mainly derived from the instability of HHR rather than fracture.Accordingly,an innovative control technology was proposed,which can weaken static load by vertical-well separated fracturing HHR.The research results have been successfully applied to the 8101 working face in Tashan coal mine,Shanxi Province,China.The results of a digital borehole camera observation and stress monitoring proved the rationality of the GPB criteria.The control technology was successful,paving the way for new possibilities to HHR control for safety mining.
文摘This paper analyzes the gas source of the horizontally sectioned fully mechanized caving face in the steeply inclined and extra-thick seam of Adaohai Coal Mine, and numerically simulates the stress distribution and pressure relief of the lower section coal after the upper section working face is mined. It theoretically analyzed the reasonable layout of the drainage boreholes, and designed the drainage borehole layout accordingly. In the upper and lower section of the working face, the actual drainage effect of the boreholes was inspected, and the air exhaust gas volume in the working face was statistically analyzed. It was confirmed that the layout of boreholes was reasonable, the gas control effect of working face was greatly improved and fully met the needs of safe mining. The control effect was greatly improved and the need for safe mining was fully met, and thus a gas drainage technology suitable for the coal seam storage conditions and mining technology of the Adaohai Coal Mine was found. That is to say: the gas emission from the working face of the section mining mainly comes from its lower coal body. Pre-draining the lower coal body of the section and depressurizing gas interception and drainage are the key to effectively solve the problem of gas emission from the working face. Drainage boreholes in the working face of the section should be arranged at high and low positions. The high-level boreholes are located about 2 m from the top of the working face, and the high-level boreholes are about 9 m away from the top of the working face. Through the pre drainage of high and low-level boreholes in advance and the interception and pressure relief drainage, the gas control in the horizontal sublevel fully mechanized caving mining face in steep and extra thick coal seam can realize a virtuous cycle.
基金supported by the National Natural Science Foundation of China(Grant No.51174128)the Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20123718110007).
文摘In this paper,a physical model of coal roadway which is clamped by upper and lower softrock with extra thickness was built according to the characteristics of soft rock strata in china's western mining area.Then,a series of orthogonal numerical experiments were carried out by selecting the strength and stiffness parameters of soft rock and coal seam as well as the in situ stress of soft rock strata as experimental factors and roadway displacements(convergence displacements of sides,displacement of roof to floor)as experimental indexes.By constructing the F statistics with different inspection levels,evaluation method for influence of the experimental factors on stability indexes were defined.Thus,influence degrees of specified parameters on the stability of roadway were divided into five classes as follows:highly significant influence,significant influence,relatively significant influence,little significant influence,and no influence respectively which realize the quantitative analysis of the influence degrees of experimental factors.The finite element calculation results showed that main failure mode of coal roadway that usually showed as tension failure of coal seam in roof and deformation factors of coal seam had the most remarkable effect on roadway displacements.The conclusions provide theoretical basis for further analysis of the mechanism of"roof burst"in roadway maintenance.
基金supported by the Special Funding Projects of“Sanjin Scholars”Supporting Plan(Grant No.2050205)
文摘Accidents such as support failure and excessive deformation of roadways due to drastic changes in strata behaviors are frequently reported when mining the extra-thick coal seams Nos.3e5 in Datong coal mine with top-coal caving method,which significantly hampers the mine's normal production.To understand the mechanism of strata failure,this paper presented a structure evolution model with respect to strata behaviors.Then the behaviors of strata overlying the extra-thick coal seams were studied with the combined method of theoretical analysis,physical simulation,and field measurement.The results show that the key strata,which are usually thick-hard strata,play an important role in overlying movement and may influence the mining-induced strata behaviors in the working face using top-coal caving method.The structural model of far-field key strata presents a 'masonry beam' type structure when'horizontal O-X' breakage type happens.The rotational motion of the block imposed radial compressive stress on the surrounding rock mass of the roadway.This can induce excessive deformation of roadway near the goaf.Besides,this paper proposed a pre-control technology for the hard roof based on fracture holes and underground roof pre-splitting.It could effectively reduce stress concentration and release the accumulated energy of the strata,when mining underground coal resources with top-coal caving method.
文摘The EGAT Mae Moh Mine is the largest open pit lignite mine in Thailand and it produces lignite about 16 million tons annually. In the near future, the pit limit of the mine will be reached and underground mine will then be developed through the open pit in the depth of 400 - 600 m from the surface. However, due to the challenges for underground mining such as poor geological conditions, extra thickness (20 - 30 m) of coal seams, and weak mechanical properties of coal seams and the surrounding rock, the success possibility of underground mining and an applicable underground mining method is being investigated at the present. The paper discusses the applicability of multi-slice bord-and-pillar method for the soft extra thick coal seams in the Mae Moh mine by means of numerical analyses using the 3D finite difference code “FLAC3D”.
文摘In order to clarify the danger of water breakout in the bottom plate of extra-thick coal seam mining, 2202 working face of a mine in the west is taken as the research object, and it is proposed to use the on-site monitoring means combining borehole peeping and microseismic monitoring, combined with the theoretical analysis to analyze the danger of water breakout in the bottom plate. The results show that: 1) the theoretically calculated maximum damage depth of the bottom plate is 27.5 m, and its layer is located above the Austrian ash aquifer, which has the danger of water breakout;2) the drill hole peeping at the bottom plate of the working face shows that the depth of the bottom plate fissure development reaches 26 m, and the integrity of the water barrier layer has been damaged, so there is the risk of water breakout;3) for the microseismic monitoring of the anomalous area, the bottom plate of the return air downstream channel occurs in the field with a one-week lag, which shows that microseismic monitoring events may reflect the water breakout of the underground. This shows that the microseismic monitoring events can reflect the changes of the underground flow field, which can provide a reference basis for the early warning of water breakout. The research results can provide reference for the prediction of sudden water hazard.
基金Supported by National Natural Science Foundation of China,No.81960115,No.82160123 and No.82260124Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,No.GKEZZ202107+1 种基金Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,No.GKE-ZZ202218Guangxi Science and Technology Program,No.AD25069077.
文摘BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients.
文摘Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studied because it is related to an alteration of the normal metabolism of glucose and lipids,ultimately leading to triglyceride accumulation within hepatocytes.This lipid overload triggers an inflammatory status,also influenced by gut-liver axis dysfunction,with gut dysbiosis,which alters intestinal permeability,causing inflammation and IR in a vicious circle.Several approaches have been attempted to treat this condition and stop its poss-ible evolution towards increasingly serious stages,but the first step is always lifestyle modification.The Mediterranean diet seems to be the most reliable for affecting liver steatosis,probably thanks to extra virgin olive oil,a healthy food with a high content of monounsaturated fatty acids and variable concentrations of phenols(oleocanthal)and phenolic alcohols,such as hydroxytyrosol and tyrosol.This review investigates the mechanisms underlying the bidirectional and synergistic relationships among metabolic dysfunction-associated steatotic liver disease,IR,and the gut-liver axis,specifically focusing on the role of extra virgin olive oil as one of the main antioxidant components of the Mediterranean diet.
基金the support of the National Natural Science Foundation of China(Nos.22205207 and 22378369).
文摘Zeolites are crystalline microporous materials widely used in catalysis,adsorption,and ion exchange owing to their tunable pore structures and acid centers[1].Traditional zeolites,however,often suffer from limitations such as restricted molecular diffusion and rapid coking,which hinder their efficiency in processing large molecules.
文摘Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan （Extra） acupoint were adopted. In the control group, Jiáj （夹脊 EX-B 2） at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale （VAS） was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group （all P0.05）. The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group （both P0.05）. Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan （Extra） achieves the significant analgesic effect on herpes zoster.
基金the Independent Research Subject of State Key Laboratory of Coal Resources and Mine Safety of China University of Mining and Technology (No.SKLCRSM12X03)the Scientific Research and Innovation Project for College Graduates in Jiangsu (No.CXZZ13_0947)+1 种基金Top-Notch Academic Programs of Jiangsu Higher Education Institutionsthe Priority Academic Development Program of Jiangsu Higher Education Institutions
文摘Based on the characteristics of the top coal thickness of the fully mechanized caving in special thick coal seam,the long distance of coal gangue caving,as well as the different sizes of the coal gangue broken fragment dimension and spatial variation of drop flow,this paper uses laboratory dispersion simulation experiment and theoretical analysis to study the arch structure effect and its influence rule on the top coal loss in the process of coal gangue flow.Research shows that in the process of coal gangue flow,arch structure can be formed in three types:the lower arch structure,middle arch structure,and upper arch structure.Moreover,the arch structure has the characteristics of dynamic random arch,the formation probability of dynamic random arch with different layers is not the same,dynamic random arch caused the reduction of the top coal fluency;analyzing the dynamic random arch formation mechanism,influencing factors,and the conditions of instability;the formation probability of the lower arch structure is the highest,the whole coal arch and the coal gangue arch structure has the greatest impact on top coal loss.Therefore,to prevent or reduce the formation of lower whole coal arch structure,the lower coal gangue arch structure and the middle whole coal arch structure is the key to reduce the top coal loss.The research conclusion provides theoretical basis for the further improvement of the top coal recovery rate of the fully mechanized caving in extra thick coal seam.
基金Supported by the Special Project for the Key Research and Development in the Xinjiang Uygur Autonomous Region(2016B01001-2)the Special Fund for Agro-Scientific Research in the Public Interest of the Ministry of Agriculture of China(201503117)+3 种基金the Project for Enriching People and Strengthening County of the Ministry of Science and Technology of Chinathe China Agriculture Research System for Cotton(CARS-18-07)the Special Fund for the Commercialization of Research Findings of the Xinjiang Uygur Autonomous Region(201354103)the Key Laboratory for the Physiological Ecology and Cultivation of Desert Oasis Crops,the Ministry of Agriculture of China~~
文摘This paper defines the following advantages of ELS （Extra Long Staple） also known as Pima cotton planted in the United States： first, the only variety which is concentrated in the planting area with good soil moisture and fertilizer retention performances and abundant light and heat resources; second; advanced and practi- cal material equipment and technology; third; high yield and good quality, significant planting scale benefit; fourth, feasible and reliable modernized intensive farm man- agement mode with large-scale agricultural machinery operation; fifth, high-efficient social services and policy support system, as well as reasonable planting layout, good brand influence, synchronization of high yield and good quality with large-scale benefits. Although the production capability of Pima cotton in the United States is considered to be the largest and most powerful country in the world, compared with the ELS production in China, both have their own advantages and characteristics. Therefore, it is suggested that by using the ELS production experience ol the Unit- ed Stages for reference, China should make use of the modern breeding technJques to accelerate the modification of synthetic genetic features of ELS variety, try its best to breed the ELS variety which is suitable for mechanical plucking as soon as possible, actively develop new technology to simplify the whole cost saving cultiva- tion, reform ELS production organization, vigorously develop the social service sys- tem, and adjust and optimize the ELS industry support policies, so as to fundamen- tally improve the competitiveness of China＇s ELS in international market.
文摘Given a graph G and a non-negative integer h, the h-restricted connectivity κh（G） of G is the minimum cardinality of a set of vertices of G, in which at least h neighbors of any vertex is not included, if any, whose deletion disconnects G and every remaining component has the minimum degree of vertex at least h; and the h-extra connectivity κh（G） of G is the minimum cardinality of a set of vertices of G, if any, whose deletion disconnects G and every remaining component has order more than h. This paper shows that for the hypercube Qn and the folded hypercube FQn, κ1（Qn）=κ（1）（Qn）=2n-2 for n≥3, κ2（Qn）=3n-5 for n≥4, κ1（FQn）=κ（1）（FQn）=2n for n≥4 and κ（2）（FQn）=4n-4 for n≥8.
基金This paper is financially supported by the National Natural Science Foundation of China (No. 40572080)the China National Petroleum Corporation (CNPC) Petroleum Science and Technology Innovation Foundation (No.05E7026)
文摘The formation and distribution of fractures are controlled by paleotectonic stress field, and their preservative status and effects on development are dominated by the modern stress field. Since Triassic, it has experienced four tectonic movements and developed four sets of tectonic fractures in the extra low-permeability sandstone reservoir at the south of western Sichuan depression. The strikes of fractures are in the S-N, NE-SW, E-W, and NW-SE directions respectively. At the end of Triassic, under the horizontal compression tectonic stress field, for which the maximum principal stress direction was NW.SE, the fractures were well developed near the S-N faults and at the end of NE-SW faults, because of their stress concentration. At the end of Cretaceous, in the horizontal compression stress fields of the NE-SW direction, the stress was obviously lower near the NE-SW faults, thus, fractures mainly developed near the S-N faults. At the end of Neogene-Early Pleistocene, under the horizontal compression tectonic stress fields of E-W direction, stress concentrated near the NE-SW faults and fractures developed at these places, especially at the end of the NE-SE faults, the cross positions of NE-SW, and S-N faults. Therefore, fractures developed mostly near S-N faults and NE-SW faults. At the cross positions of the above two sets of faults, the degree of development of the fractures was the highest. Under the modern stress field of the NW-SE direction, the NW-SE fractures were mainly the seepage ones with tensional state, the best connectivity, the widest aperture, the highest permeability, and the minimum opening pressure.
