The classical hypercube structure is a popular topological architecture in parallel computing environments and a large number of variations based on the hypercube were posed in the past three decades. Reliability eval...The classical hypercube structure is a popular topological architecture in parallel computing environments and a large number of variations based on the hypercube were posed in the past three decades. Reliability evaluation of systems is important to the design and maintenance of multiprocessor systems. The h-extra edge-connectivity of graph G（V, E） is a kind of measure for the reliability of interconnection systems, which is defined as the minimum cardinality of a subset of edge set, if any, whose deletion disconnects G and such that every re- maining component has at least h vertices. This paper shows that the h-extra edge-connectivity 2n-1 2n-1 of the hypercube Qn is a constant 2n-1 for 2n-1/3≤ h2n-1, and n ≥ 4, which extends the result of [Bounding the size of the subgraph induced by m vertices and extra edge-connectivity of hypercubes, Discrete Applied Mathematics, 2013, 161（16）： 2753-2757].展开更多
Deformation prediction for extra-high arch dams is highly important for ensuring their safe operation.To address the challenges of complex monitoring data,the uneven spatial distribution of deformation,and the constru...Deformation prediction for extra-high arch dams is highly important for ensuring their safe operation.To address the challenges of complex monitoring data,the uneven spatial distribution of deformation,and the construction and optimization of a prediction model for deformation prediction,a multipoint ultrahigh arch dam deformation prediction model,namely,the CEEMDAN-KPCA-GSWOA-KELM,which is based on a clustering partition,is pro-posed.First,the monitoring data are preprocessed via variational mode decomposition(VMD)and wavelet denoising(WT),which effectively filters out noise and improves the signal-to-noise ratio of the data,providing high-quality input data for subsequent prediction models.Second,scientific cluster partitioning is performed via the K-means++algorithm to precisely capture the spatial distribution characteristics of extra-high arch dams and ensure the consistency of deformation trends at measurement points within each partition.Finally,CEEMDAN is used to separate monitoring data,predict and analyze each component,combine the KPCA(Kernel Principal Component Analysis)and the KELM(Kernel Extreme Learning Machine)optimized by the GSWOA(Global Search Whale Optimization Algorithm),integrate the predictions of each component via reconstruction methods,and precisely predict the overall trend of ultrahigh arch dam deformation.An extra high arch dam project is taken as an example and validated via a comparative analysis of multiple models.The results show that the multipoint deformation prediction model in this paper can combine data from different measurement points,achieve a comprehensive,precise prediction of the deformation situation of extra high arch dams,and provide strong technical support for safe operation.展开更多
BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging e...BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients.展开更多
Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studie...Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studied because it is related to an alteration of the normal metabolism of glucose and lipids,ultimately leading to triglyceride accumulation within hepatocytes.This lipid overload triggers an inflammatory status,also influenced by gut-liver axis dysfunction,with gut dysbiosis,which alters intestinal permeability,causing inflammation and IR in a vicious circle.Several approaches have been attempted to treat this condition and stop its poss-ible evolution towards increasingly serious stages,but the first step is always lifestyle modification.The Mediterranean diet seems to be the most reliable for affecting liver steatosis,probably thanks to extra virgin olive oil,a healthy food with a high content of monounsaturated fatty acids and variable concentrations of phenols(oleocanthal)and phenolic alcohols,such as hydroxytyrosol and tyrosol.This review investigates the mechanisms underlying the bidirectional and synergistic relationships among metabolic dysfunction-associated steatotic liver disease,IR,and the gut-liver axis,specifically focusing on the role of extra virgin olive oil as one of the main antioxidant components of the Mediterranean diet.展开更多
Zeolites are crystalline microporous materials widely used in catalysis,adsorption,and ion exchange owing to their tunable pore structures and acid centers[1].Traditional zeolites,however,often suffer from limitations...Zeolites are crystalline microporous materials widely used in catalysis,adsorption,and ion exchange owing to their tunable pore structures and acid centers[1].Traditional zeolites,however,often suffer from limitations such as restricted molecular diffusion and rapid coking,which hinder their efficiency in processing large molecules.展开更多
Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. M...Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan （Extra） acupoint were adopted. In the control group, Jiáj （夹脊 EX-B 2） at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale （VAS） was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group （all P0.05）. The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group （both P0.05）. Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan （Extra） achieves the significant analgesic effect on herpes zoster.展开更多
This paper defines the following advantages of ELS （Extra Long Staple） also known as Pima cotton planted in the United States： first, the only variety which is concentrated in the planting area with good soil moist...This paper defines the following advantages of ELS （Extra Long Staple） also known as Pima cotton planted in the United States： first, the only variety which is concentrated in the planting area with good soil moisture and fertilizer retention performances and abundant light and heat resources; second; advanced and practi- cal material equipment and technology; third; high yield and good quality, significant planting scale benefit; fourth, feasible and reliable modernized intensive farm man- agement mode with large-scale agricultural machinery operation; fifth, high-efficient social services and policy support system, as well as reasonable planting layout, good brand influence, synchronization of high yield and good quality with large-scale benefits. Although the production capability of Pima cotton in the United States is considered to be the largest and most powerful country in the world, compared with the ELS production in China, both have their own advantages and characteristics. Therefore, it is suggested that by using the ELS production experience ol the Unit- ed Stages for reference, China should make use of the modern breeding technJques to accelerate the modification of synthetic genetic features of ELS variety, try its best to breed the ELS variety which is suitable for mechanical plucking as soon as possible, actively develop new technology to simplify the whole cost saving cultiva- tion, reform ELS production organization, vigorously develop the social service sys- tem, and adjust and optimize the ELS industry support policies, so as to fundamen- tally improve the competitiveness of China＇s ELS in international market.展开更多
基金Supported by the National Natural Science Foundation of China(11171283,11471273,11461038,11301440)Natural Sciences Foundation of Shanxi Province(2014021010-2)
文摘The classical hypercube structure is a popular topological architecture in parallel computing environments and a large number of variations based on the hypercube were posed in the past three decades. Reliability evaluation of systems is important to the design and maintenance of multiprocessor systems. The h-extra edge-connectivity of graph G（V, E） is a kind of measure for the reliability of interconnection systems, which is defined as the minimum cardinality of a subset of edge set, if any, whose deletion disconnects G and such that every re- maining component has at least h vertices. This paper shows that the h-extra edge-connectivity 2n-1 2n-1 of the hypercube Qn is a constant 2n-1 for 2n-1/3≤ h2n-1, and n ≥ 4, which extends the result of [Bounding the size of the subgraph induced by m vertices and extra edge-connectivity of hypercubes, Discrete Applied Mathematics, 2013, 161（16）： 2753-2757].
基金supported by the National Natural Science Foundation of China(Grant Nos.52069029,52369026)the Belt and Road Special Foundation of National Key Laboratory of Water Disaster Preven-tion(Grant No.2023490411)+2 种基金the Yunnan Agricultural Basic Research Joint Special General Project(Grant Nos.202501BD070001-060,202401BD070001-071)Construction Project of the Yunnan Key Laboratory of Water Security(No.20254916CE340051)the Youth Talent Project of“Xingdian Talent Support Plan”in Yunnan Province(Grant No.XDYC-QNRC-2023-0412).
文摘Deformation prediction for extra-high arch dams is highly important for ensuring their safe operation.To address the challenges of complex monitoring data,the uneven spatial distribution of deformation,and the construction and optimization of a prediction model for deformation prediction,a multipoint ultrahigh arch dam deformation prediction model,namely,the CEEMDAN-KPCA-GSWOA-KELM,which is based on a clustering partition,is pro-posed.First,the monitoring data are preprocessed via variational mode decomposition(VMD)and wavelet denoising(WT),which effectively filters out noise and improves the signal-to-noise ratio of the data,providing high-quality input data for subsequent prediction models.Second,scientific cluster partitioning is performed via the K-means++algorithm to precisely capture the spatial distribution characteristics of extra-high arch dams and ensure the consistency of deformation trends at measurement points within each partition.Finally,CEEMDAN is used to separate monitoring data,predict and analyze each component,combine the KPCA(Kernel Principal Component Analysis)and the KELM(Kernel Extreme Learning Machine)optimized by the GSWOA(Global Search Whale Optimization Algorithm),integrate the predictions of each component via reconstruction methods,and precisely predict the overall trend of ultrahigh arch dam deformation.An extra high arch dam project is taken as an example and validated via a comparative analysis of multiple models.The results show that the multipoint deformation prediction model in this paper can combine data from different measurement points,achieve a comprehensive,precise prediction of the deformation situation of extra high arch dams,and provide strong technical support for safe operation.
基金Supported by National Natural Science Foundation of China,No.81960115,No.82160123 and No.82260124Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,No.GKEZZ202107+1 种基金Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor,No.GKE-ZZ202218Guangxi Science and Technology Program,No.AD25069077.
文摘BACKGROUND Hepatitis B virus(HBV)infection is a leading cause of global hepatocellular carcinoma(HCC).Conventional biomarkers such as alpha-fetoprotein(AFP)demonstrate suboptimal sensitivity and specificity.Emerging evidence suggests that serum extra spindle pole bodies like 1(ESPL1)protein and p53 antibody may improve diagnostic accuracy.AIM To assess and compare the diagnostic performance of serum ESPL1 protein and p53 antibody in HBV-related HCC(HBV-HCC).METHODS This case-control study from the First Affiliated Hospital of Guangxi Medical University enrolled 30 patients with chronic hepatitis B(CHB),30 with HBV-related liver cirrhosis(HBV-LC),55 with HBV-HCC,and 30 healthy controls.Serum ESPL1 protein and p53 antibody levels were quantified via ELISA.Diagnostic performance was evaluated using receiver operating characteristic(ROC)curve analysis,including sensitivity,specificity,and correlation with AFP.RESULTS Serum ESPL1 protein levels progressively increased across disease stages(CHB:89.9 ng/L;HBV-LC:188.83 ng/L;HBV-HCC:317.63 ng/L),with a significantly higher area under the ROC curve(AUC=0.917)than either p53 antibody(AUC=0.725)or AFP(AUC=0.678).p53 antibody levels were significantly elevated only in the HBVHCC group.ESPL1 demonstrated superior sensitivity and concordance with histopathological findings.A significant correlation between ESPL1 and p53 antibody levels was observed exclusively in the HBV-HCC group(r=0.320,P=0.017),suggesting potential interplay in malignant transformation.CONCLUSION Serum ESPL1 protein,a promising biomarker for early HBV-HCC detection,outperforms p53 antibody in diagnostic reliability.Higher ESPL1 levels correlate with increased HCC risk in chronic HBV patients.
文摘Metabolic dysfunction-associated steatotic liver disease is a multifaceted disease associated with obesity,insulin resistance(IR),type 2 diabetes mellitus-in a word,metabolic syndrome-which has been extensively studied because it is related to an alteration of the normal metabolism of glucose and lipids,ultimately leading to triglyceride accumulation within hepatocytes.This lipid overload triggers an inflammatory status,also influenced by gut-liver axis dysfunction,with gut dysbiosis,which alters intestinal permeability,causing inflammation and IR in a vicious circle.Several approaches have been attempted to treat this condition and stop its poss-ible evolution towards increasingly serious stages,but the first step is always lifestyle modification.The Mediterranean diet seems to be the most reliable for affecting liver steatosis,probably thanks to extra virgin olive oil,a healthy food with a high content of monounsaturated fatty acids and variable concentrations of phenols(oleocanthal)and phenolic alcohols,such as hydroxytyrosol and tyrosol.This review investigates the mechanisms underlying the bidirectional and synergistic relationships among metabolic dysfunction-associated steatotic liver disease,IR,and the gut-liver axis,specifically focusing on the role of extra virgin olive oil as one of the main antioxidant components of the Mediterranean diet.
基金the support of the National Natural Science Foundation of China(Nos.22205207 and 22378369).
文摘Zeolites are crystalline microporous materials widely used in catalysis,adsorption,and ion exchange owing to their tunable pore structures and acid centers[1].Traditional zeolites,however,often suffer from limitations such as restricted molecular diffusion and rapid coking,which hinder their efficiency in processing large molecules.
文摘Objective To observe the analgesic effect on herpes zoster treated by the comprehensive therapy of blocking, surrounding needling, pricking and cupping combined with bloodletting at Longyan （龙眼, Extra） acupoint. Methods According to the random mumber table, 104 cases of herpes zoster were randomized into an observation group and a control group, 52 cases in each one. In the observation group, the blocking method was used at the starting site and the ending site of herpetic zone, the surrounding needling method was applied toward the center of the painful zone, with horizontal needling technique; and the local pricking and cupping methods as well as the bloodletting at Longyan （Extra） acupoint were adopted. In the control group, Jiáj （夹脊 EX-B 2） at the corresponding affected nerve segments and the local Ashi points were selected and stimulated with electroacupuncture. The visual analogue scale （VAS） was adopted to determine the analgesic effect 20 min, 1, 6, 12, 24 and 48 h after treatment separately in each group. Results The onset time of analgesic effect in the observation group was shorter than that in the control group and the efficacy time of duration was longer than that in the control group （all P0.05）. The analgesic effect and the result of comprehensive efficacy assessment were superior to those of the control group （both P0.05）. Conclusion The comprehensive therapy of blocking, surrounding needling, pricking and cupping method combined with bloodletting at Longyan （Extra） achieves the significant analgesic effect on herpes zoster.
基金Supported by the Special Project for the Key Research and Development in the Xinjiang Uygur Autonomous Region(2016B01001-2)the Special Fund for Agro-Scientific Research in the Public Interest of the Ministry of Agriculture of China(201503117)+3 种基金the Project for Enriching People and Strengthening County of the Ministry of Science and Technology of Chinathe China Agriculture Research System for Cotton(CARS-18-07)the Special Fund for the Commercialization of Research Findings of the Xinjiang Uygur Autonomous Region(201354103)the Key Laboratory for the Physiological Ecology and Cultivation of Desert Oasis Crops,the Ministry of Agriculture of China~~
文摘This paper defines the following advantages of ELS （Extra Long Staple） also known as Pima cotton planted in the United States： first, the only variety which is concentrated in the planting area with good soil moisture and fertilizer retention performances and abundant light and heat resources; second; advanced and practi- cal material equipment and technology; third; high yield and good quality, significant planting scale benefit; fourth, feasible and reliable modernized intensive farm man- agement mode with large-scale agricultural machinery operation; fifth, high-efficient social services and policy support system, as well as reasonable planting layout, good brand influence, synchronization of high yield and good quality with large-scale benefits. Although the production capability of Pima cotton in the United States is considered to be the largest and most powerful country in the world, compared with the ELS production in China, both have their own advantages and characteristics. Therefore, it is suggested that by using the ELS production experience ol the Unit- ed Stages for reference, China should make use of the modern breeding technJques to accelerate the modification of synthetic genetic features of ELS variety, try its best to breed the ELS variety which is suitable for mechanical plucking as soon as possible, actively develop new technology to simplify the whole cost saving cultiva- tion, reform ELS production organization, vigorously develop the social service sys- tem, and adjust and optimize the ELS industry support policies, so as to fundamen- tally improve the competitiveness of China＇s ELS in international market.
