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How Fear Memory is Updated:From Reconsolidation to Extinction?
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作者 Jiahui Chen Zhuowen Fang +2 位作者 Xiaolan Zhang Yanrong Zheng Zhong Chen 《Neuroscience Bulletin》 2025年第6期1054-1084,共31页
Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forget... Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forgetting,suggesting the potential to erase fear memories through timely interventions.Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects.This review explores how fear memory may be erased,particularly focusing on the mnemonic phases of reconsolidation and extinction.Reconsolidation strengthens memory,while extinction weakens it.Interfering with memory reconsolidation could diminish the fear response.Alternatively,the extinction of acquired memory could reduce the fear memory response.This review summarizes experimental animal models of PTSD,examines the nature and epidemiology of reconsolidation to extinction,and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD.In sum,understanding how fear memory updates holds significant promise for PTSD treatment. 展开更多
关键词 Post-traumatic stress disorder Fear memory RECONSOLIDATION extinction Engram
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DNA methylation regulates the extinction of fear memory
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作者 Le Jiang Rui-Xue Ma +11 位作者 Er-Shu He Xiao-Ye Zheng Xin Peng Wen-Hao Ma Ying Li Han-Wei li Xue-Yan Zhang Jie-Yu Ji Yan-Jiao Li Shang-Lan Qu Li-Juan Li Zhi-Ting Gong 《World Journal of Psychiatry》 2025年第7期273-283,共11页
BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge... BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge.Fear conditioning and extinction in animal models offer insights into its mechanisms.Our previous research indi-cates that DNA methyltransferases play a role in fear memory renewal.AIM To investigate the role of DNA methylation in the extinction of fear memory,with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.METHODS This study investigated the role of DNA methylation in fear memory extinction in mice.DNA methylation was manipulated using N-phthalyl-L-tryptophan(RG108)to reduce methylation and L-methionine injections to enhance it.Neuronal activity,and dendritic spine density was measured following extinction training.RESULTS RG108 suppressed extinction,reduced spine density,and inhibited neuronal activity.Methionine injections facilitated extinction.CONCLUSION DNA methylation is crucial for fear memory extinction.Enhancing methylation may improve the efficacy of exposure therapy,offering a potential strategy to treat fear-related disorders. 展开更多
关键词 RG108 DNA methylation Fear memory Exposure therapy extinction
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Extinction and Optimal Control of Stochastic Epidemic Model with Multiple Vaccinations and Time Delay
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作者 YANG Rujie QIU Hong JU Xuewei 《数学理论与应用》 2025年第2期110-121,共12页
In this paper,based on the SVIQR model we develop a stochastic epidemic model with multiple vaccinations and time delay.Firstly,we prove the existence and uniqueness of the global positive solution of the model,and co... In this paper,based on the SVIQR model we develop a stochastic epidemic model with multiple vaccinations and time delay.Firstly,we prove the existence and uniqueness of the global positive solution of the model,and construct suitable functions to obtain sufficient conditions for disease extinction.Secondly,in order to effectively control the spread of the disease,appropriate control strategies are formulated by using optimal control theory.Finally,the results are verified by numerical simulation. 展开更多
关键词 Stochastic epidemic model Multiple vaccinations extinction of disease Isolation delay Optimal control
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Elevated extinction risk of low-elevation populations of two songbirds on the Taiwan island
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作者 Xuntao Ma Yadan Liu +2 位作者 Zhang Zhang Mingwang Zhang Feng Dong 《Avian Research》 2025年第3期467-472,共6页
Prevailing concerns on mountainous biodiversity are concentrated on the impacts of climate change at higher elevations. However, the lower elevations are facing additional human disturbance and are expected to suffer ... Prevailing concerns on mountainous biodiversity are concentrated on the impacts of climate change at higher elevations. However, the lower elevations are facing additional human disturbance and are expected to suffer from higher extinction risk but have attracted less conservation attention. Here, we employed population genomics to compare extinction risk two common songbirds—the Vinous-throated Parrotbill (Sinosuthora webbiana) and the Rufous-capped Babbler (Cyanoderma ruficeps)—at lower and higher elevations on the Taiwan island. As the result, we observed decreased genetic diversity and increased genetic load and thus elevated extinction risk in the low-elevation populations of both birds in the eastern slope of the Central Mountains on the Taiwan island. In contrast, genetic-load patterns of both birds in the western slope might be confused by substantial gene flow across lower and higher elevations. These results, on the one hand, call for conservation efforts to lower elevations in mountains and, on the other hand, highlight the importance of population connection in maintaining population viability under impending global change. 展开更多
关键词 extinction risk Genetic load Human disturbance Mountainous biodiversityi Population genomics
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Selective extinction and habitat nestedness are the main drivers of lizard nestedness in the Zhoushan Archipelago 被引量:2
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作者 Minchu Zhang Chaonan Tang +3 位作者 Qing Zhang Chengxiu Zhan Chuanwu Chen Yanping Wang 《Current Zoology》 SCIE CAS CSCD 2024年第2期244-252,共9页
Nested subset pattern(nestedness)is an important part of the theoretical framework of island biogeography and community ecology.However,most previous studies often used nestedness metrics or randomization algorithms t... Nested subset pattern(nestedness)is an important part of the theoretical framework of island biogeography and community ecology.However,most previous studies often used nestedness metrics or randomization algorithms that are vulnerable to type I error.In this study,we inves-tigated the nestedness of lizard assemblages on 37 islands in the Zhoushan Archipelago,China.We used the line-transect method to survey species occurrence,abundance,and habitat types of lizards on 37 islands during 2 breeding seasons in 2021 and 2022.We applied the nested metric WNODF and the conservative rc null model to control for type I error and quantify the significance of nestedness.Spearman rank cor relations were used to evaluate the role of 4 habitat variables(island area,2 isolation indices,and habitat diversity)and 4 ecological traits(body size,geographic range size,clutch size,and minimum area requirement)in generating nestedness.The results of WNODF analyses showed that lizard assemblages were significantly nested.The habitat-by-site matrix estimated by the program NODF was also significantly nested,support-ing the habitat nestedness hypothesis.The nestedness of lizard assemblages were significantly correlated with island area,habitat diversity.clutch size,and minimum area requirement.Overall,our results suggest that selective extinction and habitat nestedness were the main drivers of lizard nestedness in our system.In contrast,the nestedness of lizard assemblages was not due to passive sampling or selective colonization.To maximize the number of species preserved,our results indicate that we should protect both large islands with diverse habitats and species with largearea requirement and clutch size. 展开更多
关键词 clutch size habitat nestedness LIZARDS minimum area requirement NESTEDNESS selective extinction WNODF Zhoushan Archipelago.
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Foraminiferal Extinction and Size Reduction during the Permian-Triassic Transition in Southern Xizang
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作者 Lirong Yang Xu Dai +6 位作者 Xiaokang Liu Yan Feng Shouyi Jiang Fengyu Wang Huyue Song Li Tian Haijun Song 《Journal of Earth Science》 SCIE CAS CSCD 2024年第6期1799-1809,共11页
The miniaturization of organisms during the Permian-Triassic mass extinction,as an ecological strategy in response to environmental devastation,has been widely recognized in diverse marine invertebrates.Previous studi... The miniaturization of organisms during the Permian-Triassic mass extinction,as an ecological strategy in response to environmental devastation,has been widely recognized in diverse marine invertebrates.Previous studies on the extinction process and miniaturization of foraminifers in the Permian-Triassic interval have relied on the fossil record of the low-latitude Paleotethys or a global database,although data and materials from the high-latitude Neotethys region are still rare.To reveal the evolutionary patterns and spatial variability of foraminifers at different latitudes and paleogeographic contexts,here we investigated the fossil distribution and size variation of foraminifers in the Selong Section of southern Xizang,located in the mid-latitude Neotethys of the Southern Hemisphere during the Permian-Triassic transition.The results show that the foraminifer of the Selong Section experienced a two-pulsed extinction(total species extinction rate of 71%),consistent with the time in South China but with a lower magnitude of extinction.Meanwhile,the data show that foraminiferal test volume was significantly miniaturized following the first pulse of extinction event:the mean size of post-extinction foraminifer was only 15%of that in the pre-extinction,mainly reflected by the disappearance of large forms as well as occurrences of smaller survivors and originators.Combined with the South China record,size data from southern Xizang indicate that the miniaturization of foraminifera is synchronous in the Paleotethys and Neotethys but smaller in magnitude in the Neotethys.We propose that ocean anoxia and acidification may be the environmental pressures leading to local and global foraminiferal miniaturizations,along with global warming,which might play a dominant role. 展开更多
关键词 mass extinction Lilliput effect global warming NEOTETHYS FORAMINIFERA
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Correlates of avian extinction timing around the world since 1500 CE
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作者 Kyle D.Kittelberger Colby J.Tanner +2 位作者 Amy N.Buxton Amira Prewett Çagan Hakkı Sekercio glu 《Avian Research》 SCIE CSCD 2024年第4期403-412,共10页
Avian extinctions have been relatively well documented in modern history,and in the past millennia,more bird species are known to have gone extinct than species in any other vertebrate class.We examined the biological... Avian extinctions have been relatively well documented in modern history,and in the past millennia,more bird species are known to have gone extinct than species in any other vertebrate class.We examined the biological correlates of extinction timing among 216 bird species that recently were either observed to go extinct or dis-appeared since 1500 CE,performing a novel analysis for examining the extinction trends of birds by modelling traits against the number of years since present day during which species have been extinct.We analyzed a broad range of traits and characteristics that have previously been associated with extinction and extinction risk in birds and compared the effects of these traits simultaneously against one another.In order to provide a more comprehensive and robust assessment of trait-based drivers of global bird loss in comparison to prior studies,we included extinct species recognized by any of the three major avian taxonomies as well as those birds that lack recent confirmed sightings and are at least functionally extinct.We found that insular,flightless,larger-bodied,ecologically specialized species,as well as those with high aspect ratio wings,were likely to go extinct earlier in time.Besides identifying the key locations and time periods over the past five centuries where birds have gone extinct,and highlighting specific extinction-prone taxonomic groups,we provide a complete and unified dataset of traits used in this study that helps address the lack of extensive public data on modern extinct species. 展开更多
关键词 Anthropocene extinction Bird conservation Body mass Ecological specialization Flightlessness ISLANDS ORNITHOLOGY
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Memory Trace for Fear Extinction:Fragile yet Reinforceable
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作者 Ying Liu Shuai Ye +1 位作者 Xin-Ni Li Wei-Guang Li 《Neuroscience Bulletin》 SCIE CAS CSCD 2024年第6期777-794,共18页
Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing situations.Based on the behavioral hypothesis that... Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing situations.Based on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear memory.The brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain unclear.Intriguing questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction memory.In this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses. 展开更多
关键词 Fear extinction memory Memory trace Fear relapse Medial prefrontal cortex Basolateral amygdala Ventral hippocampus Insular cortex Synaptic adaptations
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Universal Hyperthermal Model for Mass Extinctions
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作者 Michael J.Benton 《Journal of Earth Science》 SCIE CAS CSCD 2024年第2期704-707,共4页
INTRODUCTION Earth scientists have long sought universal features of past extinction crises.It can be argued that each past extinction event was a singularity,caused by combinations of circumstances that are unique in... INTRODUCTION Earth scientists have long sought universal features of past extinction crises.It can be argued that each past extinction event was a singularity,caused by combinations of circumstances that are unique in each case,and therefore that the search for common causes is futile.However,a key feature of the uniformitarian approach to geology is that past processes are the same as modern-day processes and,with that in mind,earth scientists are keen to use their knowledge to contribute some understanding to the study of the present and future climate crisis. 展开更多
关键词 extinction SINGULARITY extinction
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High polarization extinction ratio achieved base on thin-film lithium niobate
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作者 YANG Yong-Kang GUO Hong-Jie +5 位作者 CHEN Wen-Bin QU Bai-Ang YU Zhi-Guo TAN Man-Qing GUO Wen-Tao LIU Hai-Feng 《红外与毫米波学报》 CSCD 北大核心 2024年第6期827-831,共5页
This article introduces a method of achieving high polarization extinction ratio using a subwavelength grating structure on a lithium niobate thin film platform,and the chip is formed on the surface of the lithium nio... This article introduces a method of achieving high polarization extinction ratio using a subwavelength grating structure on a lithium niobate thin film platform,and the chip is formed on the surface of the lithium niobate thin film.The chip,with a length of just 20μm,achieved a measured polarization extinction ratio of 29 dB at 1550 nm wavelength.This progress not only proves the possibility of achieving a high extinction ratio on a lithium niobate thin film platform,but also offers important technical references for future work on polarization beam splitters,integrated fiber optic gyroscopes,and so on. 展开更多
关键词 lithium niobate thin film lithium niobate subwavelength grating polarization extinction ratio photonic integrated circuits
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Stochastic Model of Dengue: Analysing the Probability of Extinction and LLN
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作者 Ragnimwendé Sawadogo Fourtoua Victorien Konané Wahabo Baguian 《Applied Mathematics》 2024年第9期594-613,共20页
In this article, we develop and analyze a continuous-time Markov chain (CTMC) model to study the resurgence of dengue. We also explore the large population asymptotic behavior of probabilistic model of dengue using th... In this article, we develop and analyze a continuous-time Markov chain (CTMC) model to study the resurgence of dengue. We also explore the large population asymptotic behavior of probabilistic model of dengue using the law of large numbers (LLN). Initially, we calculate and estimate the probabilities of dengue extinction and major outbreak occurrence using multi-type Galton-Watson branching processes. Subsequently, we apply the LLN to examine the convergence of the stochastic model towards the deterministic model. Finally, theoretical numerical simulations are conducted exploration to validate our findings. Under identical conditions, our numerical results demonstrate that dengue could vanish in the stochastic model while persisting in the deterministic model. The highlighting of the law of large numbers through numerical simulations indicates from what population size a deterministic model should be considered preferable. 展开更多
关键词 Dengue Fever Continuous-Time Markov Chain Multitype Branching Process Probability of Disease extinction Law of Large Numbers
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A Speculation: Avian Migration and the K-T Extinction
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作者 Laurence Stephenson 《Natural Resources》 2024年第5期125-129,共5页
One caveat to the dinosaur’s extinction is the conclusion that avian dinosaurs survived and became ancestors of birds. Their mobility enabled them to migrate great distances and find the nutrients needed to survive. ... One caveat to the dinosaur’s extinction is the conclusion that avian dinosaurs survived and became ancestors of birds. Their mobility enabled them to migrate great distances and find the nutrients needed to survive. Given this scenario, could the current observable migration of birds (the “dinosaurian offspring”) now be related? Migration is the regular seasonal movement undertaken by many species of birds, with the most common pattern, flying north in the Northern spring to breed in the temperate or Arctic summer and returning in the Northern autumn to wintering grounds in warmer regions of the south. The primary motivation for migration appears to be food. None of the major North-South migratory pathways fly over the Caribbean but three main fly ways, past to the west of the theorized K-T impact centre. Due to their ability to fly, the “avian Dinosaurs” adapted and survived very quickly in response to the disaster that marked the K-T boundary. It is an interesting speculation that the avian migration that we witness today is rooted in an event that occurred 66 million years ago! But it does explain why the migratory birds mostly fly from Polar summer to polar summer when they could just be as easily fly from Polar zone to the warmer equatorial region and back. In the recent article in Nature by Melanie During about identifying the late spring timing of the “Astro disaster”, it can be cited as consistent with my speculation. A late April early May Impact as suggested by During would have seen these migrations completely. The western migratory routes would have been found to be “luxurious” in vegetation in that first northern autumn after the “Astro-impact” while all eastern routes would have still been barren. 展开更多
关键词 Dinosaur Clades K-T Mass extinction Avian Migration Migratory Pathways Avian Dinosaurs K-T Impact Centre
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Development of a Gas Monitoring and Removal Device to Reduce the Effect of Extinction Coefficient
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作者 Fenghe Liu Simin Wang +3 位作者 Yaoyu Liu Zhicheng Wang Yuxin Xia Xianbin Zhao 《Journal of Applied Mathematics and Physics》 2024年第11期4042-4055,共14页
At present, the use of furnaces in the northern rural areas of China is very common, due to the insufficient burning of fuel (coal, wood, etc.), carbon monoxide (CO) and other toxic gases are produced, CO colorless an... At present, the use of furnaces in the northern rural areas of China is very common, due to the insufficient burning of fuel (coal, wood, etc.), carbon monoxide (CO) and other toxic gases are produced, CO colorless and odorless, difficult to find in time, and bring huge safety risks to the life and health of residents. Based on the above problems, we developed a gas monitoring and removal device which could reduce the effect of extinction coefficient. The device was composed of ash settling area, gas disturbance area, spectral absorption identification area and gas removal area. After the air entered the device, the large-size particles were first settled to purify the solid particles in the gas, the gas was disturbed through the multi-layer separator to achieve the turbulent production of the gas, and then the gas was identified through the optical element of the direct absorption spectrum technology. When the toxic gas component reached the threshold, the spray device would automatically start for chemical removal to achieve the role of purifying the gas. At the same time, the device’s alarm could be alerted by buzzer and flash to remind users to evacuate in time. By improving the optical device, the effect of extinction coefficient on measurement was reduced and the monitoring accuracy was improved. 展开更多
关键词 Atmospheric Monitoring Carbon Monoxide Direct Absorption Spectros-copy Gas Removal extinction Coefficient
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2022年1月21—24日北京市一次气溶胶污染过程城区站与郊区站污染特征对比分析 被引量:1
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作者 贾小芳 李杨 +4 位作者 孙晓晴 步志超 荆俊山 郭伟 胡树贞 《气象与环境学报》 2025年第2期74-80,共7页
对比分析2022年1月21—24日北京市一次气溶胶污染过程的城区站与郊区站PM2.5质量浓度和地面气象条件变化特征,结合垂直消光系数、探空气象数据及后向轨迹探讨此次污染过程成因。结果表明:北京市城区站(南郊站)污染期间的PM_(2.5)质量浓... 对比分析2022年1月21—24日北京市一次气溶胶污染过程的城区站与郊区站PM2.5质量浓度和地面气象条件变化特征,结合垂直消光系数、探空气象数据及后向轨迹探讨此次污染过程成因。结果表明:北京市城区站(南郊站)污染期间的PM_(2.5)质量浓度为118.5μg·m^(-3),浓度水平和持续时间明显高于郊区站(上甸子站)。城区站上空存在气溶胶输送,气溶胶消光系数高值区向地面沉降直至近地面,地面气溶胶浓度增大。此次污染过程开始时的风向为偏南风,北京南部地区的气溶胶污染物输送至南郊站,由近地面风速减小、相对湿度增大、逆温层出现并下移等气象条件共同作用,污染程度加剧。污染过程中,城区站风速明显小于郊区站,扩散条件较差。在排放源相对稳定情况下,污染过程持续期间的气象条件变化对污染天气变化有较好的指示作用。 展开更多
关键词 消光系数 探空气象要素 后向轨迹 逆温
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野外灭绝级植物爪耳木的繁育
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作者 汤欢 羊青 +3 位作者 王茂媛 王祝年 刘咲頔 王清隆 《热带农业科学》 2025年第2期11-16,共6页
爪耳木作为国家二级保护珍稀濒危物种,为我国特有植物,目前在IUCN上仍被列为灭绝级(EX)植物。爪耳木在2013年被科研人员再次发现后,科研人员围绕爪耳木的资源调查以及生物学特性、种苗繁育等方面开展了相关研究。爪耳木目前作为一种在... 爪耳木作为国家二级保护珍稀濒危物种,为我国特有植物,目前在IUCN上仍被列为灭绝级(EX)植物。爪耳木在2013年被科研人员再次发现后,科研人员围绕爪耳木的资源调查以及生物学特性、种苗繁育等方面开展了相关研究。爪耳木目前作为一种在野外已灭绝的植物,对其开展相关研究和重新回归野外具有重要价值,对爪耳木属植物系统发育和进化的研究也有重要参考价值。文章对爪耳木开展繁育经验总结发现,爪耳木可以通过种子繁殖、叶和根扦插、根蘖繁殖获得新植株。爪耳木的成功大量繁育将为爪耳木后期的野外回归做好准备,并有助于其野外种群的恢复和保护以及濒危机制探讨等一系列研究的深入开展。 展开更多
关键词 爪耳木 灭绝级 扦插 根蘖 野外回归
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一个包含先天免疫因素的Markov切换传染病模型
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作者 陈丽君 《四川大学学报(自然科学版)》 北大核心 2025年第4期812-822,共11页
一些传染病具有变异快、烈度高、传播迅速及发病隐匿等典型特征.为了更好预防和控制传染病的传播扩散,利用数学模型来研究传染病的传播规律是一种基本方法.本文建立了一种同时包含疫苗接种效果、Beddington-DeAngelis发生率及饱和先天... 一些传染病具有变异快、烈度高、传播迅速及发病隐匿等典型特征.为了更好预防和控制传染病的传播扩散,利用数学模型来研究传染病的传播规律是一种基本方法.本文建立了一种同时包含疫苗接种效果、Beddington-DeAngelis发生率及饱和先天免疫因素的Markov切换传染病模型.结合停时理论,本文通过构造Lyapunov函数证明模型的解具有全局正性.在适当条件下,本文运用一般伊藤公式证明:当基本再生数大于1时,模型的解是一个平稳Markov过程,具有遍历性;当基本再生数小于1时,潜伏者与感染者的数量趋于绝灭.数值模拟验证了理论结果. 展开更多
关键词 随机传染病模型 先天免疫 疫苗接种 平稳Markov过程 绝灭
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miR-155-5p靶向调控SPI1在糖尿病心肌缺血再灌注损伤中的机制研究
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作者 苏晓琳 雷玲艳 +2 位作者 谭妍妍 罗玉琨 覃凯 《糖尿病新世界》 2025年第11期18-24,共7页
目的研究miR-155-5p靶向调控原癌基因(SPI-1 proto-oncogene,SPI1)在糖尿病心肌缺血再灌注损伤中的作用机制。方法选取2024年1—6月于广西壮族自治区民族医院临床实验中心体外培养H9C2细胞并分为对照组、高糖+缺氧6 h复氧6 h缺血再灌注(... 目的研究miR-155-5p靶向调控原癌基因(SPI-1 proto-oncogene,SPI1)在糖尿病心肌缺血再灌注损伤中的作用机制。方法选取2024年1—6月于广西壮族自治区民族医院临床实验中心体外培养H9C2细胞并分为对照组、高糖+缺氧6 h复氧6 h缺血再灌注(Ischemia/Reperfusion,I/R)损伤模型组。模型组细胞造模完成后进行miR-155-5p和SPI1基因干扰处理分组,分为I/R+inhibitor NC组、I/R+miR-155-5p Inh组、I/R+miR-155-5p Inh+OE-NC组、I/R+miR-155-5p Inh+OE-SPI1组、I/R+miR-155-5p Inh+siRNA NC组、I/R+miR-155-5p Inh+siRNA SPI1组。采用细胞计数试剂盒-8检测细胞增殖能力,反转录聚合酶链式反应检测miR-155-5p mRNA表达水平,流式细胞术评估细胞凋亡情况,蛋白质印迹法检测SPI1、溶质载体家族31成员1(solute carrier family 31 member 1,SLC31A1)、铁氧还蛋白1(ferredoxin 1,FDX1)蛋白的表达。通过双荧光素酶报告基因实验来证实miR-155-5p与SPI1之间的靶向作用关系。结果与对照组相比,高糖+缺氧6 h复氧6 h模型组H9C2细胞内铜含量显著增加,差异有统计学意义(P<0.05)。与对照组、I/R+inhibitor NC组相比,I/R+miR-155-5p Inh组细胞转染miR-155-5p inhibitor后能显著促进细胞增殖、降低细胞凋亡、增加三磷酸腺苷(adenosine triphosphate,ATP)含量、降低细胞内miR-155-5p mRNA及SLC31A1、FDX1蛋白表达水平,显著升高SPI1蛋白表达水平,差异均有统计学意义(P均<0.05)。双荧光素酶报告基因检测表明miR-155-5p与SPI1有靶向结合作用。与I/R+miR-155-5p Inh+OE-NC组相比,I/R+miR-155-5p Inh+OE-SPI1组过表达SPI1显著促进细胞增殖、抑制细胞凋亡、增加ATP含量、降低细胞内miR-155-5p mRNA及SLC31A1、FDX1蛋白表达水平,显著升高SPI1蛋白表达水平,差异均有统计学意义(P均<0.05)。结论miR-155-5p可通过靶向上调SPI1改善H9C2心肌细胞I/R损伤,其机制可能与激活SPI1/SLC31A1/FDX1通路,进而调节细胞内铜离子稳态有关。 展开更多
关键词 miR-155-5P SPI1 糖尿病 缺血再灌注损伤 增殖 凋亡
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具有标准发生率及饱和治疗函数的随机SIS传染病模型的灭绝性和持久性
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作者 谭杨 杨林 郭子君 《中北大学学报(自然科学版)》 2025年第2期245-253,共9页
研究了一类具有标准发生率和饱和治疗函数的随机易感-感染-易感(SIS)传染病模型。首先,利用构造李雅普诺夫函数方法证明了模型正解的存在、唯一性。然后,在灭绝性方面得到了感染种群趋于普通灭绝和依指数灭绝的充分条件,其结果表明,随... 研究了一类具有标准发生率和饱和治疗函数的随机易感-感染-易感(SIS)传染病模型。首先,利用构造李雅普诺夫函数方法证明了模型正解的存在、唯一性。然后,在灭绝性方面得到了感染种群趋于普通灭绝和依指数灭绝的充分条件,其结果表明,随机基本再生数小于1时,感染种群必将趋于灭绝,而依指数灭绝则需要更强的条件。在持久性方面,得到了感染种群趋于依平均持久和随机持久的充分条件,其结果表明,随机基本再生数大于1时,感染种群随机持久,而依平均持久需要更强的条件才能满足。最后,通过数值模拟进行了结果验证。 展开更多
关键词 SIS模型 标准发生率 饱和治疗函数 灭绝性 持久性
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三维石墨烯复合材料的制备及其红外消光性能研究
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作者 胡乃红 李健 《延边大学学报(自然科学版)》 2025年第2期41-44,共4页
采用氧化还原法,通过在混合石墨烯粉末中加入PVA和采用抗坏血酸溶液作为还原剂,制备了一种三维石墨烯复合材料.研究显示:该三维石墨烯复合材料的红外消光性能与烟幕质量浓度呈正相关,且红外消光性能显著优于其他墨烯材料;当烟幕质量浓... 采用氧化还原法,通过在混合石墨烯粉末中加入PVA和采用抗坏血酸溶液作为还原剂,制备了一种三维石墨烯复合材料.研究显示:该三维石墨烯复合材料的红外消光性能与烟幕质量浓度呈正相关,且红外消光性能显著优于其他墨烯材料;当烟幕质量浓度达到0.9 g/L时,样品的消光系数为0.98 m^(2)·g^(-1).由此表明,所制备的三维石墨烯复合材料具有优异的红外消光性能. 展开更多
关键词 石墨烯 复合材料 氧化还原法 红外消光性能
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