OBJECTIVE:To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty. METHODS:A total of 120 patie...OBJECTIVE:To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty. METHODS:A total of 120 patients with osteoporotic vertebral compression fractures treated by vertebroplasty at our hospital were divided into four groups. The control group received non-steroidal anti-inflammatory drugs, the Treatment Group Ⅰ received acupuncture alone, Treatment Group Ⅱ was treated with medicated wine for warming meridians alongside polarized light physiotherapy, and Treatment Group Ⅲ received a combination of medicated wine for warming meridians, polarized light therapy, and acupuncture. The clinical efficacy, pain thresholds at various time points, temperature pain threshold, electric pain threshold, quality of life, sleep quality index, lumbar dysfunction index, visual analog scale(VAS) scores, and incidence of adverse reactions were compared and analyzed across the four groups. RESULTS:The total clinical effective rate in Treatment Group Ⅲ was significantly higher than that in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). At 24 and 72 h post-treatment, the VAS scores, temperature pain thresholds, and electric pain thresholds in Treatment Group Ⅲ were significantly lower than those in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). Additionally, quality-of-life scores in Treatment Group Ⅲ were markedly higher compared to the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ, while the Pittsburgh Sleep Quality Index scores, Oswestry Disability Index scores, and incidence of adverse reactions in Treatment Group Ⅲ were significantly lower than in the other groups(P < 0.05). CONCLUSION:The external application of warm meridian medicated wine and polarized light therapy combined with acupuncture significantly reduces postoperative pain following vertebroplasty, enhances lumbar function, and improves both sleep quality and overall quality of life for patients. This approach is recommended for clinical application.展开更多
Objective To systematically evaluate the overall efficacy of external application of traditional Chinese medicine(EA-TCM)in combination with oral three-step analgesic ladder therapy for patients suffering from cancer-...Objective To systematically evaluate the overall efficacy of external application of traditional Chinese medicine(EA-TCM)in combination with oral three-step analgesic ladder therapy for patients suffering from cancer-induced bone pain(CIBP).Methods We conducted a literature search of randomized controlled trials on the combination of EA-TCM and three-step analgesic ladder therapy for CIBP across ten databases and two registration systems.It included four Chinese databases[Chinese Biomedical Literature Database(SinoMed),China National Knowledge Infrastructure(CNKI),Wanfang Database,and China Science and Technology Journal Database(VIP)],six English databases(Scopus,Embase,Web of Science,PubMed,Cochrane Library,and OpenGrey),and two registration systems(Chinese Clinical Trial Registry and ClinicalTrials.gov).The timeframe for the literature search extended from the inception of each database to December 31,2023.Meta-analysis was performed using RevMan(v5.4.1),and the outcome indicators(pain relief rate,analgesic duration,quality of life,pain intensity,breakthrough pain frequency,and adverse reactions)were graded using GRADE profiler(v3.6).Results According to the established inclusion and exclusion criteria,a total of 43 studies was deemed eligible,involving 3142 participants with CIBP.The results of meta-analysis showed that compared with oral three-step analgesic ladder therapy alone,the combined therapy of EA-TCM and three-step analgesic ladder has a significant improvement in pain relief rate[risk ratio(RR)=1.32,95%confidence interval(CI):1.24 to 1.41,P<0.00001],analgesic duration[mean difference(MD)=1.33,95%CI:0.97 to 1.69,P<0.00001],and quality of life(MD=5.66,95%CI:4.88 to 6.44,P<0.00001).Furthermore,the combined therapy significantly reduced pain intensity(MD=-1.00,95%CI:-1.19 to-0.80,P<0.00001),breakthrough pain frequency(MD=-0.43,95%CI:-0.51 to-0.36,P<0.00001),and adverse reactions(RR=0.60,95%CI:0.53 to 0.68,P<0.00001)in CIBP patients.Based on the GRADE assessment,the level of evidence varied from low to moderate.Conclusion EA-TCM combined with the three-step analgesic ladder therapy can effectively alleviate pain symptoms in patients with CIBP and improve their quality of life.Additionally,the EA-TCM can effectively reduce the incidence of adverse reactions associated with threestep analgesic therapy.展开更多
The purpose of this study is to analyze the clinical effect of external application of Granulation-Promoting Jade and Red paste in the treatment of diabetic foot.This study was carried out in Pingdingshan Traditional ...The purpose of this study is to analyze the clinical effect of external application of Granulation-Promoting Jade and Red paste in the treatment of diabetic foot.This study was carried out in Pingdingshan Traditional Chinese Medicine Hospital from December 2023 to December 2024.A total of 80 patients were selected as research objects,all of whom were diagnosed diabetic foot patients.They were treated and divided into two groups based on different methods,the group names were“experimental group”and“control group”.Patients in the control group were treated with Vaseline on the basis of external treatment,and patients in the experimental group were treated with Granulation-Promoting Jade and Red paste on the basis of external treatment,and the clinical effects of different treatment methods were compared and analyzed.The results showed that the effective rate in the experimental group was significantly higher(95.00%)compared to the control group(75.00%)(P<0.05).Furthermore,the experimental group exhibited notably shorter wound healing time and granulation tissue growth time,indicating faster and better recovery(P<0.05).Additionally,post-treatment Wagner grading revealed that the proportion of patients in advanced grades(4,5,and 6)was significantly lower in the experimental group,whereas a higher proportion of patients achieved lower grades(0,1,and 2),demonstrating improved clinical outcomes(P<0.05).In conclusion,Granulation-Promoting Jade and Red Paste shows a significant therapeutic effect in treating diabetic foot,effectively promoting wound healing,improving clinical symptoms,and enhancing overall recovery.展开更多
Objective:To study the clinical effect on old ankle injury treated with collateral bloodletting at ashi point combined with the external application of Sānqī(三七Radix et Rhizoma Notoginseng)powder.Methods:120 outpa...Objective:To study the clinical effect on old ankle injury treated with collateral bloodletting at ashi point combined with the external application of Sānqī(三七Radix et Rhizoma Notoginseng)powder.Methods:120 outpatients with old ankle injury were collected from the Department of Disease Prevention of Shenzhen Pingle Orthopaedics and Traumatology Hospital.Ashi points were selected.The threeedged needle or the syringe needle for single use was used to prick the ashi points for 5-10 times till the slight bleeding presented in local area.Afterwards,the cupping was used at the pricked area for 10-15 min to ensure the complete elimination of stagnant blood.Such therapies were given once a week.On the day after the day of bleeding and cuping,Sanqi powder was applied externally,once a day.The pain score(visual analogue scale,VAS)and the clinical effect were observed in the patients.Results:A total of 115 patients accomplished the whole procedure of treatment The pain mean score of VAS was(3.2±0.4)points before treatment and it were(0.28±0.5)points after treatment.Of them,104 cases were cured completely,8 cases effective significantly and 3 cases failed.Conclusion:The combined treatment with bloodletting therapy at ashi point and the external application of Sanqi powder achieves the satisfactory clinical effect on old ankle injury and this therapy deserves to be promoted in clinical practice.展开更多
Diabetic foot ulcers are one of the most severe complications of diabetes that have imposed great financial and psychological burdens on diabetic patients.A Nocardia rubra cell wall skeleton(Nr-CWS)can be externally a...Diabetic foot ulcers are one of the most severe complications of diabetes that have imposed great financial and psychological burdens on diabetic patients.A Nocardia rubra cell wall skeleton(Nr-CWS)can be externally applied to accelerate wound healing.However,its clinical application has not yet been reported.Herein,we report two patients with diabetic foot ulcers treated with Nr-CWS.After wound debridement,the wound was covered with a sterile cotton ball infiltrated with an Nr-CWS that was diluted with 2.0 mL of saline.The covers were changed every two days until complete wound healing occurred.The two wounds healed after 3 and 12 weeks,respectively.This article aims to provide a new treatment for diabetic foot ulcers,with the hope that physicians may consider an Nr-CWS as a complementary method for the treatment of chronic wounds.展开更多
Objective:This paper mainly analyzes the effect of infrared radiation combined with external application nursing on maintenance of vascular access in hemodialysis patients.Methods:A total of 150 hemodialysis patients ...Objective:This paper mainly analyzes the effect of infrared radiation combined with external application nursing on maintenance of vascular access in hemodialysis patients.Methods:A total of 150 hemodialysis patients in our hospital from December 2019 to September 2020 were divided into the conventional group and the study group,75 cases in each group.The conventional group was given external application nursing alone,and the study group was given infrared radiation combined with external application nursing,and the effect on the maintenance of vascular access was counted.Results:After the intervention,the indexes of URR,kt/V and human albumin in the study group were higher than those in the routine group,and the indexes of β2-mg and MIS in the study group were lower than those in the routine group,P<0.05;The improvement of vascular elasticity and quality of life in the study group was higher than that in the conventional group,and the incidence of complications was lower than that in the conventional group,P<0.05.Conclusion:Infrared radiation combined with external application of nursing care in hemodialysis patients with vascular access maintenance effect is significant,can effectively improve vascular elasticity.展开更多
Objective: for patients with peripheral facial paralysis, the clinical effect of combined treatment with external application of Chinese medicine acupoints and acupuncture in the treatment process is to provide basis ...Objective: for patients with peripheral facial paralysis, the clinical effect of combined treatment with external application of Chinese medicine acupoints and acupuncture in the treatment process is to provide basis for clinical treatment. Methods: the subjects of this research experiment were 120 patients with peripheral facial paralysis who received outpatient treatment in our hospital from January 2020 to December 2021. According to the order of admission, the patients were divided into two groups and then marked separately, and the clinical effects of different treatment methods were compared. Results: the treatment efficiency of the study group was higher than that of the control group, and the treatment duration was shorter than that of the control group (p < 0.05). Conclusion: for patients with peripheral facial paralysis, in the process of receiving clinical treatment, the combination of external application of traditional Chinese medicine acupoints and acupuncture has higher clinical effect, which can effectively shorten the treatment time of patients and is worthy of clinical promotion and application.展开更多
Objective: to analyze the clinical consequences of apoplectic arthritis in the course of treatment of Chinese drug topcoat. Methods: 100 patients with rheumatoid arthritis were cultured from January 20 to March 2021 a...Objective: to analyze the clinical consequences of apoplectic arthritis in the course of treatment of Chinese drug topcoat. Methods: 100 patients with rheumatoid arthritis were cultured from January 20 to March 2021 and treated in our hospital. 100 patients were randomly divided into two groups. The control group of 50 patients received routine treatment. A group of 50 patients with external coating of traditional Chinese medicine treatment, observe the symptoms and state indicators of the two groups. Results: after treatment, the difference between the disease index of the joint tumor obtained from the tissue and the joint pain index of the control group at dawn was statistical (N < 0.05). Conclusion: the application of external coating in the treatment of rheumatoid arthritis can quickly improve the clinical symptoms of patients with ideal effect, which is worthy of clinical publicity.展开更多
Objective：To observe the clinical efficacy of Chinese medicine（CM） treatment of Hongyou Ointment（红油膏） and Shengji Powder（生肌散） on diabetic ulcers,and to observe the influence of CM treatment on the express...Objective：To observe the clinical efficacy of Chinese medicine（CM） treatment of Hongyou Ointment（红油膏） and Shengji Powder（生肌散） on diabetic ulcers,and to observe the influence of CM treatment on the expressions of proteins associated with the Wnt signaling pathway,such asβ-catenin,c-myc and K6.Methods：sixty-two patients fitting the registration standards were randomly divided into the CM group（31 patients） and the Western medicine（WM） group（31 patients） by a random number table.The patients in the CM group were treated with Hongyou Ointment and Shengji Powder externally.The patients in the WM group were treated with mupirocin ointment,growth factor（bFGF）,and Vaseline gauze for external use and with basic therapies.Wound-healing time and four-week healing rate were recorded.The wounds were measured by digital photography and ImageJ software.Skin biopsies were obtained from 24 patients before CM treatment and 20 patients after CM treatment.Immunohistochemical tests and semi-quantitative imaging with NIH ImageJ 1.42 software were used to analyze the changes in protein expression ofβ-catenin,c-myc,and K6.Results：Fifty-three patients completed the trial;four patients in the CM treatment group and five patients in the WM group dropped out.Among them,four were dissatisfied with the treatment process,two could not continue because of their jobs,two failed to complete the course of follow-up appointments,and one was diagnosed with squamous cell carcinoma during treatment.The comparison of ulcer healing rates between the two groups showed insignificant differences（P=0.77）.The ulcer healing rates were 33.33%（9/27） in the CM group and 26.92%（7/26） in the WM group.However,the effective rate was significantly higher in the CM group（81.48%,22/27） than in the WM group（57.69%,15/26,P=0.04）.The mean wound healing time was shorter in the CM group（22.71±5.46 days） than in the WM group（26.56±7.56 days,P=0.04）.CM treatment was well tolerated,and there was no withdrawal due to adverse reactions.Immunohistochemical analysis in the refractory wound indicated higher expressions ofβ-catenin,c-myc and K6 compared with the normal skin.β-catenin was abnormally expressed in the nuclei of the keratinocytes and fibroblasts at the wound margins,and the expressions of c-myc and K6 were highly expressed in the full hyperplastic epidermis,especially in the granular layer（P0.05）.The expressions of these proteins decreased after CM treatment.The expression levels ofβ-catenin,c-myc,and K6 proteins before and after the treatment were 101.88±10.76 vs.140.42±8.45;113.27±16.75 vs.153.79±8.32; 90.39±11.07 vs.151.29±7.39,respectively.Conclusions：CM treatment using Hongyou Ointment and Shengji Powder was efficient in the management of diabetic skin ulcers.The mechanism of action might be related to the inhibition of the Wnt signaling pathway.展开更多
Objective： To investigate the efficacy of external application of Eleutherosides ointment on Shenque （CV 8） for treating sleep deprivation. Methods： Twenty four healthy young male volunteers at the age of 19-22 ye...Objective： To investigate the efficacy of external application of Eleutherosides ointment on Shenque （CV 8） for treating sleep deprivation. Methods： Twenty four healthy young male volunteers at the age of 19-22 years old were randomly allocated to 4 groups （normal, model, treatment and control groups）. Sleep was deprived for 48 hours except the normal group. Self-made Eleutherosides compound preparation was applied externally on Shenque （CV 8）, to observe its influence on psychology and blood biochemical indices of cortisol and testosterone of the human body in sleep deprivation. Results： After sleep deprivation for 48 hours, an increment in cortisol concentration was lower in the Eleutherosides group （44.482±96.065 nmol/L） than in the control group （146.809 ±71.075 nmol/L）; an increment in the self-evaluated depression scale was also lower in the Eleutherosides group （2.833 ± 16.746） than in the control group （20.417 ±10.358）. There were significant differences （P〈0.05）. But, there was no significant difference between the treatment group and control group （P〉0.05） in the decrement of testosterone concentration and the increment of the anxiety scale. Conclusion： External application of Eleutherosides preparation on Shenque （CV 8） can regulate the stress reaction level and psychological endurance of the human body and produce an effect to resist sleep deprivation.展开更多
The doctor used gauze with Semen Sinapis （ 白芥了） mastic to scrape emphatically on pro-shoulder, post- shoulder and deltoid muscle. After the skin became red, the shoulder was massaged for 5-10 min. When the patien...The doctor used gauze with Semen Sinapis （ 白芥了） mastic to scrape emphatically on pro-shoulder, post- shoulder and deltoid muscle. After the skin became red, the shoulder was massaged for 5-10 min. When the patient was asked to abduce the upper arm 30°-45°, Taijian- raising shoulder acupoint was selected. The needle 0.5-1 mm in diameter and 90-100 mm in length was inserted vertically from down to up till touching bone. After backed off slightly, the needle was twisted a little. The patient was asked to raise shoulder when the needle was twisted. The needle was stopped twisting after the arm was raised overhead. Seventy patients with shoulder periarthritis were treated by this method. The result showed that pain disappeared and the function of shoulder recovered to normal in 35 cases, pain alleviated obviously and the function of shoulder improved distinctly in 25 cases, pain alleviated and the function of shoulder improved slightly in 8 cases and pain didn＇t alleviated and the function of shoulder didn＇t improved distinctly in 2 cases.展开更多
Objective:To explore the clinical efficacy and characteristics of Tuina and herbal and magnetic application in the treatment of cervical spondylopathy.Method:302 subjects were treated with above methods and their effi...Objective:To explore the clinical efficacy and characteristics of Tuina and herbal and magnetic application in the treatment of cervical spondylopathy.Method:302 subjects were treated with above methods and their efficacy were assessed according to the patterns.Results:Among the 302 cases,153 cases were cured,131 got marked effects,14 cases were improvcd and 4 cases failed;the total effective rate was 98.7%.Conclusion:Tuina in combination with herbal and magnetic application has good effects on various pattern of cervical spondylopathy.展开更多
Objective： To observe the clinical efficacy of external application of Chinese medicine following tapping using a plum-blossom needle for allergic rhinitis. Methods： All 328 cases were randomized into an observation...Objective： To observe the clinical efficacy of external application of Chinese medicine following tapping using a plum-blossom needle for allergic rhinitis. Methods： All 328 cases were randomized into an observation group of 206 cases, Chinese medicine group of 70 cases and point application group of 52 cases. Results： The differences between the observation and Chinese medicine groups （P〈0.01） and between the observation and point application group （P〈0.05） were both of statistical meaning. The cases in the observation obtained the best effect, the point application group obtained a moderate effect and the Chinese medicine group obtained the least effect. A younger age and an increased number of treatments contributed to a better effect. Conclusion： External application of Chinese medicine following tapping using a plum-blossom needle is safe and effective for allergic rhinitis.展开更多
One hundred forty-four patients of cancer pain were treated with external application of QuTong Ling, and the effect of pain remission was observed. The total remission rate was 79. 2% with themaintaining time of 6. 4...One hundred forty-four patients of cancer pain were treated with external application of QuTong Ling, and the effect of pain remission was observed. The total remission rate was 79. 2% with themaintaining time of 6. 42 1 . 24 hours, proving it was superior to butycinnamyl pyrazirum.展开更多
OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorde...OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorded from January 2002 to December 2012. A total of 126 patients(116 females and 10 males) with skin and soft-tissue necrosis due to Chinese cobra bite were divided into two groups. The control group was treated externally with 40% glyceride magnesium sulfate(n=52), and the treatment group was given Jidesheng anti-venom externally(n=74). The data collected included maximum local necrotic area of skin and soft tissues, de-tumescence time, healing time,and skin-grafting rate.RESULTS: There were no significant differences in gender, age, and disease condition between the control and treatment groups(P>0.05). No statistically significant difference was found in de-tumescence time between the two groups(P>0.05). The maximum local necrotic area of skin and soft tissues was(19.9 ± 7.3) cm2in the treatment group,while it was(23.3±6.4) cm2in the control group.The healing time of the treatment group was shorter than that of the control group [(32.1 ± 3.7) vs(34.4±4.5) days)] The skin-grafting rate in the treatment group was lower than that of the control group(10.81% vs 25.00%). There were statistically significant differences in maximum local necrotic area of skin and soft tissues, healing time, and skin-grafting rate between the control and treatment groups(all P<0.05).CONCLUSION: External application of Jidesheng anti-venom may help to promote wound healing and reduce the skin-grafting rate in cases of skin and soft-tissue necrosis due to Chinese cobra bite.展开更多
A case of Sluder’s syndrome in a female patient,aged 56 years old,suffered from intermittent headache for over 20 years.The therapeutic methods include acupuncture with filiform needle mainly applied to the acupoints...A case of Sluder’s syndrome in a female patient,aged 56 years old,suffered from intermittent headache for over 20 years.The therapeutic methods include acupuncture with filiform needle mainly applied to the acupoints on governor vessel,foot-shaoyang meridian and foot-yangrning meridian,the external application of Wuzhuyu(吴茱萸Fructus Evodiae)on Yongquan(涌泉KI1),as well as the pricking and bleeding method with the three-edge needle on Touwei(头维ST8).The alliance of these three therapies co-act on promoting the circulation of shaoyang and yangming meridians and governor vessel and have obtained an satisfactory clinical effect.After treated for 5 weeks,the symptoms all disappeared completely,such as headache,vertigo and discomfort on eyes and they were not recurred in 1-year follow-up.展开更多
Cotton bolls exhibit the lowest insecticidal efficacy among all organs of Bt cotton,which would ultimately affect the yield formation.The objective of this study was to investigate the effects of different urea concen...Cotton bolls exhibit the lowest insecticidal efficacy among all organs of Bt cotton,which would ultimately affect the yield formation.The objective of this study was to investigate the effects of different urea concentrations on the seed Bt protein contents,seed cotton yield and the corresponding protein metabolism mechanism.The experiments were conducted during 2017–2018 cotton growing seasons.Two cultivars,Sikang 3(hybrid,SK3)and Sikang 1(conventional,SK1),were treated with six urea concentrations and their seed Bt protein contents were compared during boll formation period.The urea spray concentration had a significant effect on the seed Bt toxin content and seed cotton yield.Spraying of either 5 or 6%urea led to higher insecticidal protein contents and higher seed cotton yield for both cultivars.Moreover,the highest amino acid and soluble protein contents,as well as GPT and GOT activities,and lower protease and peptidase activities were observed at the 5 to 6%urea levels.Significant positive correlations between the seed Bt toxin and amino acid contents,and between the seed Bt toxin content and GPT activities were detected.The lower boll worm number and hazard boll rate were also observed with the 5 to 6%urea treatments,which may be the reason why nitrogen spraying increased the seed cotton yield.Therefore,our results suggested that the seed Bt toxin content and insect resistance were impacted markedly by external nitrogen application,and 5 to 6%urea had the greatest effect on insect resistance.展开更多
Open Air Interface(OAI)alliance recently introduced a new disaggregated Open Radio Access Networks(O-RAN)framework for next generation telecommunications and networks.This disaggregated architecture is open,automated,...Open Air Interface(OAI)alliance recently introduced a new disaggregated Open Radio Access Networks(O-RAN)framework for next generation telecommunications and networks.This disaggregated architecture is open,automated,software defined,virtual,and supports the latest advanced technologies like Artificial Intelligence(AI)Machine Learning(AI/ML).This novel intelligent architecture enables programmers to design and customize automated applications according to the business needs and to improve quality of service in fifth generation(5G)and Beyond 5G(B5G).Its disaggregated and multivendor nature gives the opportunity to new startups and small vendors to participate and provide cheap hardware software solutions to keep the market competitive.This paper presents the disaggregated and programmable O-RAN architecture focused on automation,AI/ML services,and applications with Flexible Radio access network Intelligent Controller(FRIC).We schematically demonstrate the reinforcement learning,external applications(xApps),and automation steps to implement this disaggregated O-RAN architecture.The idea of this research paper is to implement an AI/ML enabled automation system for software defined disaggregated O-RAN,which monitors,manages,and performs AI/ML-related services,including the model deployment,optimization,inference,and training.展开更多
Objective: The clinical effects of rubbing therapy with ointment in treating patella strain were obserbed.Method: Forty-two cases of patella strain were treated by local rubbing with ointment and the changes of the cl...Objective: The clinical effects of rubbing therapy with ointment in treating patella strain were obserbed.Method: Forty-two cases of patella strain were treated by local rubbing with ointment and the changes of the clinical symptoms were observed.Results: After 3 courses of treatment, the total effective rate was 95.2%.Conclusion: It is indicated that rubbing therapy with ointment has good effects in the treatment of patella strain. Key Words Tuina - Massage - External Applications (TCD) - Wounds and Injuries - Patella Sun De-bin, born in 1964, junior consultant doctor, engaged in treating soft tissue injury with TCM therapy.Translator: Xiao Yuan-chun展开更多
文摘OBJECTIVE:To evaluate the effects of external application of warm meridian medicated wine and polarized light therapy combined with acupuncture on pain management following vertebroplasty. METHODS:A total of 120 patients with osteoporotic vertebral compression fractures treated by vertebroplasty at our hospital were divided into four groups. The control group received non-steroidal anti-inflammatory drugs, the Treatment Group Ⅰ received acupuncture alone, Treatment Group Ⅱ was treated with medicated wine for warming meridians alongside polarized light physiotherapy, and Treatment Group Ⅲ received a combination of medicated wine for warming meridians, polarized light therapy, and acupuncture. The clinical efficacy, pain thresholds at various time points, temperature pain threshold, electric pain threshold, quality of life, sleep quality index, lumbar dysfunction index, visual analog scale(VAS) scores, and incidence of adverse reactions were compared and analyzed across the four groups. RESULTS:The total clinical effective rate in Treatment Group Ⅲ was significantly higher than that in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). At 24 and 72 h post-treatment, the VAS scores, temperature pain thresholds, and electric pain thresholds in Treatment Group Ⅲ were significantly lower than those in the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ(P < 0.05). Additionally, quality-of-life scores in Treatment Group Ⅲ were markedly higher compared to the control group, Treatment Group Ⅰ, and Treatment Group Ⅱ, while the Pittsburgh Sleep Quality Index scores, Oswestry Disability Index scores, and incidence of adverse reactions in Treatment Group Ⅲ were significantly lower than in the other groups(P < 0.05). CONCLUSION:The external application of warm meridian medicated wine and polarized light therapy combined with acupuncture significantly reduces postoperative pain following vertebroplasty, enhances lumbar function, and improves both sleep quality and overall quality of life for patients. This approach is recommended for clinical application.
基金Provincial Key Research and Development Project of Hunan(2018SK2127)Hunan Province Traditional Chinese Medicine Research and Development Project(201946).
文摘Objective To systematically evaluate the overall efficacy of external application of traditional Chinese medicine(EA-TCM)in combination with oral three-step analgesic ladder therapy for patients suffering from cancer-induced bone pain(CIBP).Methods We conducted a literature search of randomized controlled trials on the combination of EA-TCM and three-step analgesic ladder therapy for CIBP across ten databases and two registration systems.It included four Chinese databases[Chinese Biomedical Literature Database(SinoMed),China National Knowledge Infrastructure(CNKI),Wanfang Database,and China Science and Technology Journal Database(VIP)],six English databases(Scopus,Embase,Web of Science,PubMed,Cochrane Library,and OpenGrey),and two registration systems(Chinese Clinical Trial Registry and ClinicalTrials.gov).The timeframe for the literature search extended from the inception of each database to December 31,2023.Meta-analysis was performed using RevMan(v5.4.1),and the outcome indicators(pain relief rate,analgesic duration,quality of life,pain intensity,breakthrough pain frequency,and adverse reactions)were graded using GRADE profiler(v3.6).Results According to the established inclusion and exclusion criteria,a total of 43 studies was deemed eligible,involving 3142 participants with CIBP.The results of meta-analysis showed that compared with oral three-step analgesic ladder therapy alone,the combined therapy of EA-TCM and three-step analgesic ladder has a significant improvement in pain relief rate[risk ratio(RR)=1.32,95%confidence interval(CI):1.24 to 1.41,P<0.00001],analgesic duration[mean difference(MD)=1.33,95%CI:0.97 to 1.69,P<0.00001],and quality of life(MD=5.66,95%CI:4.88 to 6.44,P<0.00001).Furthermore,the combined therapy significantly reduced pain intensity(MD=-1.00,95%CI:-1.19 to-0.80,P<0.00001),breakthrough pain frequency(MD=-0.43,95%CI:-0.51 to-0.36,P<0.00001),and adverse reactions(RR=0.60,95%CI:0.53 to 0.68,P<0.00001)in CIBP patients.Based on the GRADE assessment,the level of evidence varied from low to moderate.Conclusion EA-TCM combined with the three-step analgesic ladder therapy can effectively alleviate pain symptoms in patients with CIBP and improve their quality of life.Additionally,the EA-TCM can effectively reduce the incidence of adverse reactions associated with threestep analgesic therapy.
基金Special Research Project of Traditional Chinese Medicine in Henan Province(Project No.:2022ZY1191)。
文摘The purpose of this study is to analyze the clinical effect of external application of Granulation-Promoting Jade and Red paste in the treatment of diabetic foot.This study was carried out in Pingdingshan Traditional Chinese Medicine Hospital from December 2023 to December 2024.A total of 80 patients were selected as research objects,all of whom were diagnosed diabetic foot patients.They were treated and divided into two groups based on different methods,the group names were“experimental group”and“control group”.Patients in the control group were treated with Vaseline on the basis of external treatment,and patients in the experimental group were treated with Granulation-Promoting Jade and Red paste on the basis of external treatment,and the clinical effects of different treatment methods were compared and analyzed.The results showed that the effective rate in the experimental group was significantly higher(95.00%)compared to the control group(75.00%)(P<0.05).Furthermore,the experimental group exhibited notably shorter wound healing time and granulation tissue growth time,indicating faster and better recovery(P<0.05).Additionally,post-treatment Wagner grading revealed that the proportion of patients in advanced grades(4,5,and 6)was significantly lower in the experimental group,whereas a higher proportion of patients achieved lower grades(0,1,and 2),demonstrating improved clinical outcomes(P<0.05).In conclusion,Granulation-Promoting Jade and Red Paste shows a significant therapeutic effect in treating diabetic foot,effectively promoting wound healing,improving clinical symptoms,and enhancing overall recovery.
文摘Objective:To study the clinical effect on old ankle injury treated with collateral bloodletting at ashi point combined with the external application of Sānqī(三七Radix et Rhizoma Notoginseng)powder.Methods:120 outpatients with old ankle injury were collected from the Department of Disease Prevention of Shenzhen Pingle Orthopaedics and Traumatology Hospital.Ashi points were selected.The threeedged needle or the syringe needle for single use was used to prick the ashi points for 5-10 times till the slight bleeding presented in local area.Afterwards,the cupping was used at the pricked area for 10-15 min to ensure the complete elimination of stagnant blood.Such therapies were given once a week.On the day after the day of bleeding and cuping,Sanqi powder was applied externally,once a day.The pain score(visual analogue scale,VAS)and the clinical effect were observed in the patients.Results:A total of 115 patients accomplished the whole procedure of treatment The pain mean score of VAS was(3.2±0.4)points before treatment and it were(0.28±0.5)points after treatment.Of them,104 cases were cured completely,8 cases effective significantly and 3 cases failed.Conclusion:The combined treatment with bloodletting therapy at ashi point and the external application of Sanqi powder achieves the satisfactory clinical effect on old ankle injury and this therapy deserves to be promoted in clinical practice.
基金This study was sponsored by the National Natural Science Foundation of China(grant no.82172224).
文摘Diabetic foot ulcers are one of the most severe complications of diabetes that have imposed great financial and psychological burdens on diabetic patients.A Nocardia rubra cell wall skeleton(Nr-CWS)can be externally applied to accelerate wound healing.However,its clinical application has not yet been reported.Herein,we report two patients with diabetic foot ulcers treated with Nr-CWS.After wound debridement,the wound was covered with a sterile cotton ball infiltrated with an Nr-CWS that was diluted with 2.0 mL of saline.The covers were changed every two days until complete wound healing occurred.The two wounds healed after 3 and 12 weeks,respectively.This article aims to provide a new treatment for diabetic foot ulcers,with the hope that physicians may consider an Nr-CWS as a complementary method for the treatment of chronic wounds.
文摘Objective:This paper mainly analyzes the effect of infrared radiation combined with external application nursing on maintenance of vascular access in hemodialysis patients.Methods:A total of 150 hemodialysis patients in our hospital from December 2019 to September 2020 were divided into the conventional group and the study group,75 cases in each group.The conventional group was given external application nursing alone,and the study group was given infrared radiation combined with external application nursing,and the effect on the maintenance of vascular access was counted.Results:After the intervention,the indexes of URR,kt/V and human albumin in the study group were higher than those in the routine group,and the indexes of β2-mg and MIS in the study group were lower than those in the routine group,P<0.05;The improvement of vascular elasticity and quality of life in the study group was higher than that in the conventional group,and the incidence of complications was lower than that in the conventional group,P<0.05.Conclusion:Infrared radiation combined with external application of nursing care in hemodialysis patients with vascular access maintenance effect is significant,can effectively improve vascular elasticity.
文摘Objective: for patients with peripheral facial paralysis, the clinical effect of combined treatment with external application of Chinese medicine acupoints and acupuncture in the treatment process is to provide basis for clinical treatment. Methods: the subjects of this research experiment were 120 patients with peripheral facial paralysis who received outpatient treatment in our hospital from January 2020 to December 2021. According to the order of admission, the patients were divided into two groups and then marked separately, and the clinical effects of different treatment methods were compared. Results: the treatment efficiency of the study group was higher than that of the control group, and the treatment duration was shorter than that of the control group (p < 0.05). Conclusion: for patients with peripheral facial paralysis, in the process of receiving clinical treatment, the combination of external application of traditional Chinese medicine acupoints and acupuncture has higher clinical effect, which can effectively shorten the treatment time of patients and is worthy of clinical promotion and application.
文摘Objective: to analyze the clinical consequences of apoplectic arthritis in the course of treatment of Chinese drug topcoat. Methods: 100 patients with rheumatoid arthritis were cultured from January 20 to March 2021 and treated in our hospital. 100 patients were randomly divided into two groups. The control group of 50 patients received routine treatment. A group of 50 patients with external coating of traditional Chinese medicine treatment, observe the symptoms and state indicators of the two groups. Results: after treatment, the difference between the disease index of the joint tumor obtained from the tissue and the joint pain index of the control group at dawn was statistical (N < 0.05). Conclusion: the application of external coating in the treatment of rheumatoid arthritis can quickly improve the clinical symptoms of patients with ideal effect, which is worthy of clinical publicity.
基金Supported by the National Natural Science Foundation of China (No.30973751)Shanghai Municipal Health Bureau of China (No.2008L055A),and Innovative Research Team in University of Shanghai Municipal Education Commission(PhaseⅡ)
文摘Objective：To observe the clinical efficacy of Chinese medicine（CM） treatment of Hongyou Ointment（红油膏） and Shengji Powder（生肌散） on diabetic ulcers,and to observe the influence of CM treatment on the expressions of proteins associated with the Wnt signaling pathway,such asβ-catenin,c-myc and K6.Methods：sixty-two patients fitting the registration standards were randomly divided into the CM group（31 patients） and the Western medicine（WM） group（31 patients） by a random number table.The patients in the CM group were treated with Hongyou Ointment and Shengji Powder externally.The patients in the WM group were treated with mupirocin ointment,growth factor（bFGF）,and Vaseline gauze for external use and with basic therapies.Wound-healing time and four-week healing rate were recorded.The wounds were measured by digital photography and ImageJ software.Skin biopsies were obtained from 24 patients before CM treatment and 20 patients after CM treatment.Immunohistochemical tests and semi-quantitative imaging with NIH ImageJ 1.42 software were used to analyze the changes in protein expression ofβ-catenin,c-myc,and K6.Results：Fifty-three patients completed the trial;four patients in the CM treatment group and five patients in the WM group dropped out.Among them,four were dissatisfied with the treatment process,two could not continue because of their jobs,two failed to complete the course of follow-up appointments,and one was diagnosed with squamous cell carcinoma during treatment.The comparison of ulcer healing rates between the two groups showed insignificant differences（P=0.77）.The ulcer healing rates were 33.33%（9/27） in the CM group and 26.92%（7/26） in the WM group.However,the effective rate was significantly higher in the CM group（81.48%,22/27） than in the WM group（57.69%,15/26,P=0.04）.The mean wound healing time was shorter in the CM group（22.71±5.46 days） than in the WM group（26.56±7.56 days,P=0.04）.CM treatment was well tolerated,and there was no withdrawal due to adverse reactions.Immunohistochemical analysis in the refractory wound indicated higher expressions ofβ-catenin,c-myc and K6 compared with the normal skin.β-catenin was abnormally expressed in the nuclei of the keratinocytes and fibroblasts at the wound margins,and the expressions of c-myc and K6 were highly expressed in the full hyperplastic epidermis,especially in the granular layer（P0.05）.The expressions of these proteins decreased after CM treatment.The expression levels ofβ-catenin,c-myc,and K6 proteins before and after the treatment were 101.88±10.76 vs.140.42±8.45;113.27±16.75 vs.153.79±8.32; 90.39±11.07 vs.151.29±7.39,respectively.Conclusions：CM treatment using Hongyou Ointment and Shengji Powder was efficient in the management of diabetic skin ulcers.The mechanism of action might be related to the inhibition of the Wnt signaling pathway.
文摘Objective： To investigate the efficacy of external application of Eleutherosides ointment on Shenque （CV 8） for treating sleep deprivation. Methods： Twenty four healthy young male volunteers at the age of 19-22 years old were randomly allocated to 4 groups （normal, model, treatment and control groups）. Sleep was deprived for 48 hours except the normal group. Self-made Eleutherosides compound preparation was applied externally on Shenque （CV 8）, to observe its influence on psychology and blood biochemical indices of cortisol and testosterone of the human body in sleep deprivation. Results： After sleep deprivation for 48 hours, an increment in cortisol concentration was lower in the Eleutherosides group （44.482±96.065 nmol/L） than in the control group （146.809 ±71.075 nmol/L）; an increment in the self-evaluated depression scale was also lower in the Eleutherosides group （2.833 ± 16.746） than in the control group （20.417 ±10.358）. There were significant differences （P〈0.05）. But, there was no significant difference between the treatment group and control group （P〉0.05） in the decrement of testosterone concentration and the increment of the anxiety scale. Conclusion： External application of Eleutherosides preparation on Shenque （CV 8） can regulate the stress reaction level and psychological endurance of the human body and produce an effect to resist sleep deprivation.
文摘The doctor used gauze with Semen Sinapis （ 白芥了） mastic to scrape emphatically on pro-shoulder, post- shoulder and deltoid muscle. After the skin became red, the shoulder was massaged for 5-10 min. When the patient was asked to abduce the upper arm 30°-45°, Taijian- raising shoulder acupoint was selected. The needle 0.5-1 mm in diameter and 90-100 mm in length was inserted vertically from down to up till touching bone. After backed off slightly, the needle was twisted a little. The patient was asked to raise shoulder when the needle was twisted. The needle was stopped twisting after the arm was raised overhead. Seventy patients with shoulder periarthritis were treated by this method. The result showed that pain disappeared and the function of shoulder recovered to normal in 35 cases, pain alleviated obviously and the function of shoulder improved distinctly in 25 cases, pain alleviated and the function of shoulder improved slightly in 8 cases and pain didn＇t alleviated and the function of shoulder didn＇t improved distinctly in 2 cases.
文摘Objective:To explore the clinical efficacy and characteristics of Tuina and herbal and magnetic application in the treatment of cervical spondylopathy.Method:302 subjects were treated with above methods and their efficacy were assessed according to the patterns.Results:Among the 302 cases,153 cases were cured,131 got marked effects,14 cases were improvcd and 4 cases failed;the total effective rate was 98.7%.Conclusion:Tuina in combination with herbal and magnetic application has good effects on various pattern of cervical spondylopathy.
文摘Objective： To observe the clinical efficacy of external application of Chinese medicine following tapping using a plum-blossom needle for allergic rhinitis. Methods： All 328 cases were randomized into an observation group of 206 cases, Chinese medicine group of 70 cases and point application group of 52 cases. Results： The differences between the observation and Chinese medicine groups （P〈0.01） and between the observation and point application group （P〈0.05） were both of statistical meaning. The cases in the observation obtained the best effect, the point application group obtained a moderate effect and the Chinese medicine group obtained the least effect. A younger age and an increased number of treatments contributed to a better effect. Conclusion： External application of Chinese medicine following tapping using a plum-blossom needle is safe and effective for allergic rhinitis.
文摘One hundred forty-four patients of cancer pain were treated with external application of QuTong Ling, and the effect of pain remission was observed. The total remission rate was 79. 2% with themaintaining time of 6. 42 1 . 24 hours, proving it was superior to butycinnamyl pyrazirum.
基金Supported by Guangxi Natural Science Foundation (No.2012GXNSFAA276011 and No.2013GXNSFBA019163)Youth Science Foundation of Guangxi Medical University (No.GXMUYSF201216)
文摘OBJECTIVE: To evaluate the effects of Jidesheng anti-venom used externally for skin and soft-tissue necrosis from Chinese cobra bite.METHODS: A retrospective review was performed according to the clinical data recorded from January 2002 to December 2012. A total of 126 patients(116 females and 10 males) with skin and soft-tissue necrosis due to Chinese cobra bite were divided into two groups. The control group was treated externally with 40% glyceride magnesium sulfate(n=52), and the treatment group was given Jidesheng anti-venom externally(n=74). The data collected included maximum local necrotic area of skin and soft tissues, de-tumescence time, healing time,and skin-grafting rate.RESULTS: There were no significant differences in gender, age, and disease condition between the control and treatment groups(P>0.05). No statistically significant difference was found in de-tumescence time between the two groups(P>0.05). The maximum local necrotic area of skin and soft tissues was(19.9 ± 7.3) cm2in the treatment group,while it was(23.3±6.4) cm2in the control group.The healing time of the treatment group was shorter than that of the control group [(32.1 ± 3.7) vs(34.4±4.5) days)] The skin-grafting rate in the treatment group was lower than that of the control group(10.81% vs 25.00%). There were statistically significant differences in maximum local necrotic area of skin and soft tissues, healing time, and skin-grafting rate between the control and treatment groups(all P<0.05).CONCLUSION: External application of Jidesheng anti-venom may help to promote wound healing and reduce the skin-grafting rate in cases of skin and soft-tissue necrosis due to Chinese cobra bite.
基金National natural science foundation of China:No.81674088Project of Shaanxi Administration Bureau of Traditional Chinese Medicine:No.2019-ZZ-JC023Youth Talent Support Plan of Shannxi University Science and Technology Association:No.20180308。
文摘A case of Sluder’s syndrome in a female patient,aged 56 years old,suffered from intermittent headache for over 20 years.The therapeutic methods include acupuncture with filiform needle mainly applied to the acupoints on governor vessel,foot-shaoyang meridian and foot-yangrning meridian,the external application of Wuzhuyu(吴茱萸Fructus Evodiae)on Yongquan(涌泉KI1),as well as the pricking and bleeding method with the three-edge needle on Touwei(头维ST8).The alliance of these three therapies co-act on promoting the circulation of shaoyang and yangming meridians and governor vessel and have obtained an satisfactory clinical effect.After treated for 5 weeks,the symptoms all disappeared completely,such as headache,vertigo and discomfort on eyes and they were not recurred in 1-year follow-up.
基金the National Natural Science Foundation of China(31671613 and 31901462)the National Key Research and Development Program of China(2018YFD0100406 and 2017YFD0201306)+3 种基金the Natural Science Foundation of Jiangsu Province,China(BK20191439)the Natural Science Foundation of Jiangsu Higher Education Institutions,China(17KJA210003)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China(PAPD)the Brand Professional Construction Program of Jiangsu Higher Education Institutions,China。
文摘Cotton bolls exhibit the lowest insecticidal efficacy among all organs of Bt cotton,which would ultimately affect the yield formation.The objective of this study was to investigate the effects of different urea concentrations on the seed Bt protein contents,seed cotton yield and the corresponding protein metabolism mechanism.The experiments were conducted during 2017–2018 cotton growing seasons.Two cultivars,Sikang 3(hybrid,SK3)and Sikang 1(conventional,SK1),were treated with six urea concentrations and their seed Bt protein contents were compared during boll formation period.The urea spray concentration had a significant effect on the seed Bt toxin content and seed cotton yield.Spraying of either 5 or 6%urea led to higher insecticidal protein contents and higher seed cotton yield for both cultivars.Moreover,the highest amino acid and soluble protein contents,as well as GPT and GOT activities,and lower protease and peptidase activities were observed at the 5 to 6%urea levels.Significant positive correlations between the seed Bt toxin and amino acid contents,and between the seed Bt toxin content and GPT activities were detected.The lower boll worm number and hazard boll rate were also observed with the 5 to 6%urea treatments,which may be the reason why nitrogen spraying increased the seed cotton yield.Therefore,our results suggested that the seed Bt toxin content and insect resistance were impacted markedly by external nitrogen application,and 5 to 6%urea had the greatest effect on insect resistance.
文摘Open Air Interface(OAI)alliance recently introduced a new disaggregated Open Radio Access Networks(O-RAN)framework for next generation telecommunications and networks.This disaggregated architecture is open,automated,software defined,virtual,and supports the latest advanced technologies like Artificial Intelligence(AI)Machine Learning(AI/ML).This novel intelligent architecture enables programmers to design and customize automated applications according to the business needs and to improve quality of service in fifth generation(5G)and Beyond 5G(B5G).Its disaggregated and multivendor nature gives the opportunity to new startups and small vendors to participate and provide cheap hardware software solutions to keep the market competitive.This paper presents the disaggregated and programmable O-RAN architecture focused on automation,AI/ML services,and applications with Flexible Radio access network Intelligent Controller(FRIC).We schematically demonstrate the reinforcement learning,external applications(xApps),and automation steps to implement this disaggregated O-RAN architecture.The idea of this research paper is to implement an AI/ML enabled automation system for software defined disaggregated O-RAN,which monitors,manages,and performs AI/ML-related services,including the model deployment,optimization,inference,and training.
文摘Objective: The clinical effects of rubbing therapy with ointment in treating patella strain were obserbed.Method: Forty-two cases of patella strain were treated by local rubbing with ointment and the changes of the clinical symptoms were observed.Results: After 3 courses of treatment, the total effective rate was 95.2%.Conclusion: It is indicated that rubbing therapy with ointment has good effects in the treatment of patella strain. Key Words Tuina - Massage - External Applications (TCD) - Wounds and Injuries - Patella Sun De-bin, born in 1964, junior consultant doctor, engaged in treating soft tissue injury with TCM therapy.Translator: Xiao Yuan-chun
