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糖尿病与恶性外耳炎相关性的循证医学评价
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作者 李晨曦 于靖雯 +1 位作者 张维娜 孙家琳 《中华耳科学杂志》 北大核心 2025年第2期207-213,共7页
目的恶性外耳道炎(malignant otitis externa,MOE)是少见的累及外耳道和颅底的侵袭性、进行性感染,主要见于老年糖尿病(diabetes mellitus,DM)患者及免疫力低下者。文章对MOE患者临床特点及DM与MOE的相关性进行系统评价。方法通过计算... 目的恶性外耳道炎(malignant otitis externa,MOE)是少见的累及外耳道和颅底的侵袭性、进行性感染,主要见于老年糖尿病(diabetes mellitus,DM)患者及免疫力低下者。文章对MOE患者临床特点及DM与MOE的相关性进行系统评价。方法通过计算机检索各医学数据库,筛选已发表的评估DM与MOE结果的相关数据并进行合并,分析MOE病因、症状和体征、治疗方式、并发症及与DM的相关性。结果共纳入47项研究,总样本量10672例。MOE患者队列DM总体患病率为63%,DM平均病程(12.24±6.91)年,糖化血红蛋白合并均值(8.62±2.49)%,常见症状是耳痛(96.1%)、外耳道肿胀(75.8%)、耳脓溢(62.3%)。绿脓杆菌是最常分离出的病原菌(71.6%)。氟喹诺酮类和第三代头孢菌素类是首选抗生素。抗菌药物治愈率的合并均值为75.9%。除药物治疗外,24.6%的患者需要清创术。MOE患者总体病死率约1.6%。结论基于循证医学证据,MOE与DM控制不佳有关,对伴DM的MOE患者的治疗策略具有一定指导价值。 展开更多
关键词 恶性外耳炎 糖尿病 回顾性分析 系统评价
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派瑞松软膏不同给药方式治疗真菌性外耳道炎的疗效比较
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作者 叶子菁 陈婷婷 +1 位作者 杨家庆 张锦 《中国现代药物应用》 2025年第24期94-97,共4页
目的比较派瑞松外耳道涂抹与外耳道内推注两种给药方式用于真菌性外耳道炎治疗的效果。方法选取真菌性外耳道炎患者96例为研究对象,将其用随机抽样法分为对照组和观察组,各48例。两组均用派瑞松软膏治疗,对照组的给药方式是外耳道涂抹,... 目的比较派瑞松外耳道涂抹与外耳道内推注两种给药方式用于真菌性外耳道炎治疗的效果。方法选取真菌性外耳道炎患者96例为研究对象,将其用随机抽样法分为对照组和观察组,各48例。两组均用派瑞松软膏治疗,对照组的给药方式是外耳道涂抹,观察组的给药方式是外耳道内推注。比较两组临床疗效、用药不良反应发生情况、治疗后复发率、临床症状评分、听力改善情况。结果两组治疗后第7、14天耳道红肿、耳屏压痛、耳周淋巴结肿大评分明显低于治疗前,且治疗后观察组的各项得分显著小于对照组(P<0.05)。两组治疗后第7、14天气导听阈较治疗前有显著性改善,且观察组治疗后第7、14天的气导听阈(24.15±5.14)、(20.79±5.41)dB显著优于对照组的(28.58±5.13)、(25.79±6.30)dB(P<0.05)。观察组总有效率97.92%高于对照组的85.42%(P<0.05)。观察组用药不良反应发生率4.17%低于对照组的16.67%(P<0.05)。治疗后,观察组复发率低于对照组(P<0.05)。结论相比于外耳道涂抹的给药方式,经外耳道内推注派瑞松软膏治疗真菌性外耳道炎的效果更为理想,更有利于缓解症状,改善听力水平,降低治疗后疾病复发风险,安全可靠,有进一步推广的价值。 展开更多
关键词 派瑞松软膏 外耳道涂抹 外耳道内推注 真菌性外耳道炎 听力 临床疗效
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复方黄柏祛癣搽剂联合耳内镜治疗真菌性外耳道炎临床研究
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作者 廖辉煌 刘遗斌 +2 位作者 黄振河 潘其彬 游龙贵 《中西医结合研究》 2025年第5期296-299,共4页
目的探讨复方黄柏祛癣搽剂联合耳内镜治疗真菌性外耳道炎的临床疗效。方法采用随机数字表法将90例真菌性外耳道炎患者分为治疗组(n=45)和对照组(n=45)。2组均使用耳内镜进行治疗,治疗组采用复方黄柏祛癣搽剂治疗,对照组采用硝酸咪康唑... 目的探讨复方黄柏祛癣搽剂联合耳内镜治疗真菌性外耳道炎的临床疗效。方法采用随机数字表法将90例真菌性外耳道炎患者分为治疗组(n=45)和对照组(n=45)。2组均使用耳内镜进行治疗,治疗组采用复方黄柏祛癣搽剂治疗,对照组采用硝酸咪康唑乳膏治疗。早晚各用药1次,持续2周。比较2组治疗前后血清炎症指标[肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reaction protein,CRP)、白细胞介素2(interleukin-2,IL-2)]、耳道内pH值、疼痛视觉模拟量表(visual analogue scale,VAS)评分、以及临床疗效和不良反应发生率。结果治疗后,2组TNF-α、CRP、IL-2水平、VAS评分均低于治疗前(P均<0.05),且治疗组上述指标均明显低于对照组(P均<0.05);2组耳道内pH值高于治疗前(P均<0.05),但治疗组耳道内pH值低于对照组(P<0.05)。治疗组临床总有效率明显高于对照组(P<0.05)。2组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论复方黄柏祛癣搽剂治疗真菌性外耳道炎能降低患者的血清炎症因子,缓解临床症状,疗效显著。 展开更多
关键词 复方黄柏祛癣搽剂 硝酸咪康唑乳膏 真菌性外耳道炎 耳内镜
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耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的疗效观察
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作者 张思思 周宇 +2 位作者 许应鹏 林川耀 高下 《中国内镜杂志》 2025年第5期1-7,共7页
目的探讨耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的临床疗效。方法收集2023年1月-2023年12月于该院耳鼻咽喉头颈外科就医,诊断为外耳道真菌病的患者130例(166耳),随机分为观察组65例(86耳,采用耳内镜下耳道推注式... 目的探讨耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的临床疗效。方法收集2023年1月-2023年12月于该院耳鼻咽喉头颈外科就医,诊断为外耳道真菌病的患者130例(166耳),随机分为观察组65例(86耳,采用耳内镜下耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗)和对照组65例(80耳,采用沾有相同乳膏的清洁棉签,患者自行涂抹外耳道治疗)。所有患者均治疗4周,并随访半年,比较两组患者临床疗效、复发率和不良反应等指标。结果观察组总有效率为97.67%,明显高于对照组的73.75%,差异有统计学意义(P<0.05)。两组患者治疗过程中均未出现明显的不良反应。随访期间,两组患者均未见明显复发。结论耳道推注式给药器联合使用曲安奈德益康唑乳膏治疗外耳道真菌病的疗效好,相比较传统方式涂药,其具有不良反应小、治愈率高和复发率低等优势,值得临床推广应用。 展开更多
关键词 耳内镜 推注式给药器 曲安奈德益康唑 外耳道真菌病 疗效观察
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Haplotypic Variation of Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) in Different Geographic Locations
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作者 Mariah Valente Baggio Sergio Freitas 《Journal of Agricultural Science and Technology(B)》 2014年第10期804-810,共7页
Chrysoperla externa is found in environment, their populations may experience several Brazilian agroecosystems and feeds on many agricultural pests. In each different environmental pressures that can favor the emergen... Chrysoperla externa is found in environment, their populations may experience several Brazilian agroecosystems and feeds on many agricultural pests. In each different environmental pressures that can favor the emergence of genetic mutations and interfere in insect's ecological plasticity. Such genetic phenomena can be observed through the use of molecular markers, in particular mitochondrial genes, which are easy to handle and extract. The aim of this work was to study haplotype diversity of Chrysoperla externa in the cities of Jaboticabal (SP), Brotas (SP), Rifaina (SP), Sao Carlos (SP), Sao Jose dos Campos (SP) and Sao Sebastiao do Paraiso (MG), and evaluate the degree of genetic differentiation between these populations. Two mitochondrial genes were sequenced to compare these populations. It was found that there were eight haplotypes, six mutations for cytochrome c oxidase subunit 1 (COl) gene and a greater haplotype diversity was found in Brotas and Sao Sebastiao do Paraiso. There were four mutations and six haplotypes for 16S gene and the highest haplotype diversity was found in the city of San Sebastiao do Paraiso. No pattern of haplotype distribution for the populations analyzed was found. The genetic distance between populations of C. externa was not significant, showing that they are genetically compatible. 展开更多
关键词 BIOGEOGRAPHY mitochondrial DNA molecular ecology Chrysoperla externa.
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曲安奈德益康唑乳膏不同给药频率治疗真菌性外耳道炎的临床疗效观察
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作者 潘逵莲 汪国庆 +4 位作者 刘青山 刘广良 计莉 王亮 刘忠意 《保健医学研究与实践》 2025年第4期63-68,共6页
目的 探讨不同频率(每7 d给药1次、每4 d给药1次、每2 d给药1次)曲安奈德益康唑乳膏给药治疗真菌性外耳道炎(FOE)的临床效果,以期为临床治疗提供参考。方法 选取2020年6月—2023年6月宣城市人民医院收治的105例FOE患者为研究对象,采用... 目的 探讨不同频率(每7 d给药1次、每4 d给药1次、每2 d给药1次)曲安奈德益康唑乳膏给药治疗真菌性外耳道炎(FOE)的临床效果,以期为临床治疗提供参考。方法 选取2020年6月—2023年6月宣城市人民医院收治的105例FOE患者为研究对象,采用随机数字表法将患者分为3组,每组35例。所有患者均接受耳内镜下外耳道清理,后接受曲安奈德益康唑乳膏局部注入治疗。3组患者注入曲安奈德益康唑乳膏的频率如下:对照组患者给药频率为每7 d给药1次,观察1组患者给药频率为每4 d给药1次,观察2组患者给药频率为每2 d给药1次,共治疗2周。叮嘱患者每隔2 d定期复查,如有分泌物需及时清洗。若治疗期间患者有复发,则按原曲安奈德益康唑乳膏治疗方案再治疗3周,每次治疗由同一门诊医生完成。比较3组患者治疗2周后的治疗效果;比较3组患者症状缓解时间;比较3组患者治疗后2周、4周、3个月、6个月内复发率;比较3组患者治疗前后气导听阈和骨导听阈差值及听力分级;比较3组患者治疗期间常见不良反应发生情况。结果 观察1组患者(91.43%)、观察2组患者(94.29%)临床总有效率高于对照组(74.29%),差异有统计学意义(P<0.05)。观察1组、观察2组患者耳痒缓解、闷胀感缓解、听力减退缓解、耳溢缓解时间均短于对照组(P<0.05)。而观察1组与观察2组比较,差异无统计学意义(P>0.05)。3组患者治疗后2周、4周、3个月、6个月内复发率比较,差异均无统计学意义(P>0.05)。3组患者治疗前后气导听阈差值、骨导听阈差值比较,差异均有统计学意义(P<0.05);观察1组、观察2组患者气导听阈差值、骨导听阈差值均高于对照组,差异均有统计学意义(P<0.05)。3组患者AAO-HNS听力分级比较,差异有统计学意义(P<0.05)。3组患者不良反应发生情况比较,差异无统计学意义(P>0.05)。结论 耳内镜下外耳道清理联合曲安奈德益康唑乳膏局部注入每7 d给药1次治疗FOE的效果欠佳,而联合曲安奈德益康唑乳膏局部注入每4 d给药1次和每2 d给药1次治疗FOE的效果类似,均能有效改善患者的耳痒、闷胀感、听力减退等症状,其临床疗效良好。 展开更多
关键词 曲安奈德益康唑乳膏 给药频率 真菌性外耳道炎 听力状况
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外耳道冲洗+曲安奈德益康唑乳膏灌注治疗霉菌性外耳道炎的临床研究
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作者 张皓 吕祎梅 《系统医学》 2025年第2期80-83,共4页
目的分析外耳道冲洗+曲安奈德益康唑乳膏治疗霉菌性外耳道炎的效果。方法目的选取内蒙古兴安盟人民医院于2023年1—12月收治的100例霉菌性外耳道炎患者为研究对象,按治疗方法分为两组,每组50例。观察组使用0.9%氯化钠注射液外耳道冲洗+... 目的分析外耳道冲洗+曲安奈德益康唑乳膏治疗霉菌性外耳道炎的效果。方法目的选取内蒙古兴安盟人民医院于2023年1—12月收治的100例霉菌性外耳道炎患者为研究对象,按治疗方法分为两组,每组50例。观察组使用0.9%氯化钠注射液外耳道冲洗+曲安奈德益康唑乳膏灌注治疗,对照组使用吸引器清理外耳道+3%碳酸氢钠注射液耳浴治疗。对比两组临床症状积分、炎症因子水平、临床治疗效果、不良反应发生情况和复发情况。结果治疗后,观察组临床症状积分、炎症因子水平优于对照组,差异有统计学意义(P均<0.05)。观察组临床治疗总有效率高于对照组,差异有统计学意义(P<0.05)。对照组复发率为19.51%(8/41),高于观察组的4.08%(2/49),对照组不良反应发生率为20.00%(10/50),高于观察组的4.00%(2/50),差异有统计学意义(χ^(2)=3.923、6.061,P=0.047)。结论外耳道冲洗+曲安奈德益康唑乳膏灌注治疗霉菌性外耳道炎患者可以提升治疗效果,改善炎症反应,不良反应较少。 展开更多
关键词 霉菌性外耳道炎 外耳道冲洗 灌注治疗 曲安奈德益康唑乳膏
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耳内镜下外耳道清理后碘酊烧灼联合曲安奈德益康唑乳膏治疗真菌性外耳道炎的临床效果
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作者 洪伟雄 姚雪榕 +1 位作者 陈莎 谢勤开 《中国医药科学》 2025年第4期127-130,共4页
目的分析真菌性外耳道炎采用曲安奈德益康唑乳膏联合碘酊烧灼的临床效果。方法选取2023年6月至2024年3月80例在东莞市滨海湾中心医院耳鼻咽喉头颈外科治疗的真菌性外耳道炎患者,随机分为对照组和试验组,每组各40例,根据单双耳真菌性外... 目的分析真菌性外耳道炎采用曲安奈德益康唑乳膏联合碘酊烧灼的临床效果。方法选取2023年6月至2024年3月80例在东莞市滨海湾中心医院耳鼻咽喉头颈外科治疗的真菌性外耳道炎患者,随机分为对照组和试验组,每组各40例,根据单双耳真菌性外耳道炎患病情况,纳入研究的总耳例数为128例。对照组使用曲安奈德益康唑乳膏,试验组在对照组基础上加用碘酊烧灼治疗。观察两组的治疗有效率、复发率,比较两组治疗前后的症状评分、听力功能指标以及血清降钙素原(PCT)、C反应蛋白(CRP)和红细胞沉降率水平变化。结果治疗后两组患者症状评分、听力功能指标、血清PCT、CRP水平与红细胞沉降率均降低,且试验组低于对照组(P<0.05)。试验组的治愈率和总有效率均高于对照组(P<0.05);试验组治疗后1个月复发率显著低于对照组(P<0.05),两组均无明显不良反应。结论经外耳道清理后,真菌性外耳道炎使用曲安奈德益康唑乳膏与碘酊烧灼共同治疗能够有效改善其症状,并且复发率低,安全性良好。 展开更多
关键词 真菌性外耳道炎 碘酊 曲安奈德益康唑乳膏 耳内镜 外耳道清理
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耳内镜下清理并涂布联苯苄唑乳膏治疗真菌性外耳道炎的疗效观察
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作者 谈旻星 林志强 《川北医学院学报》 2025年第10期1305-1308,共4页
目的:探讨耳内镜下清理并涂布联苯苄唑乳膏治疗真菌性外耳道炎(FOE)的疗效。方法:纳入102例FOE患者为研究对象,按照治疗方案不同分为对照组与研究组,每组各51例。对照组予以耳内镜下清理并涂布曲安奈德益康唑治疗;研究组予以耳内镜下清... 目的:探讨耳内镜下清理并涂布联苯苄唑乳膏治疗真菌性外耳道炎(FOE)的疗效。方法:纳入102例FOE患者为研究对象,按照治疗方案不同分为对照组与研究组,每组各51例。对照组予以耳内镜下清理并涂布曲安奈德益康唑治疗;研究组予以耳内镜下清理并涂布联苯苄唑乳膏治疗。比较两组疗效和症状评分改善情况、真菌转阴情况、不良反应发生情况及不同停药时间的复发情况。结果:治疗后,研究组总有效率和真菌转阴率高于对照组(P<0.05);研究组耳部瘙痒、听力下降、耳鸣耳痛症状评分和曲霉菌、念珠菌阳性率、不良反应总发生率和停药4周、8周复发率均低于对照组(P<0.05);研究组停药2周的复发率为4.00%,与对照组的10.53%比较,无统计学差异(P>0.05)。结论:耳内镜下清理并涂布联苯苄唑乳膏可提高FOE患者治疗效果,值得临床推广应用。 展开更多
关键词 真菌性外耳道炎 耳内镜下清理 联苯苄唑乳膏 疗效
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碳酸氢钠耳浴联合曲安奈德益康唑乳膏治疗真菌性外耳道炎的临床疗效
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作者 杨学峰 张朋兴 《医学综述》 2025年第11期1406-1408,F0003,共4页
目的探讨碳酸氢钠耳浴联合曲安奈德益康唑乳膏治疗真菌性外耳道炎的临床疗效。方法选取2022年1月至2024年12月解放军总医院第五医学中心诊治的92例真菌性外耳道炎患者为研究对象,根据治疗方法不同分为对照组(46例)和联合组(46例)。对照... 目的探讨碳酸氢钠耳浴联合曲安奈德益康唑乳膏治疗真菌性外耳道炎的临床疗效。方法选取2022年1月至2024年12月解放军总医院第五医学中心诊治的92例真菌性外耳道炎患者为研究对象,根据治疗方法不同分为对照组(46例)和联合组(46例)。对照组采用碳酸氢钠耳浴治疗(每次15 min、每日2次),联合组在对照组基础上联合曲安奈德益康唑乳膏治疗(每日2次),两组均持续治疗2周。比较两组患者的临床疗效,耳胀和耳闷、耳痒、外耳道肿胀、听力减弱症状缓解时间,以及不良反应发生率和复发率。结果联合组患者总有效率高于对照组[100.00%(46/46)比84.78%(39/46)](χ^(2)=5.566,P=0.018)。联合组患者耳胀和耳闷、耳痒、外耳道肿胀、听力减弱症状缓解时间均短于对照组[(11.1±1.5)d比(12.4±1.8)d、(9.8±1.3)d比(11.1±2.0)d、(9.0±1.5)d比(10.3±1.8)d、(9.9±1.6)d比(11.0±1.8)d](P<0.01)。两组患者不良反应发生率和复发率比较差异无统计学意义(P>0.05)。结论碳酸氢钠耳浴联合曲安奈德益康唑乳膏可有效提高真菌性外耳道炎患者的临床疗效,促进听力恢复。 展开更多
关键词 真菌性外耳道炎 碳酸氢钠耳浴 曲安奈德益康唑乳膏
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Endoscopic vs external dacryocystorhinostomy-comparison from the patients' aspect 被引量:5
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作者 Serdar Ozer Pinar A. Ozer 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2014年第4期689-696,共8页
·AIM: To compare the success and complication rates,duration of surgeries and clinical comfort after endoscopic dacryocystorhinostomy(END-DCR) or external dacryocysto-rhinostomy(EXT-DCR).·METHODS: Fifty pati... ·AIM: To compare the success and complication rates,duration of surgeries and clinical comfort after endoscopic dacryocystorhinostomy(END-DCR) or external dacryocysto-rhinostomy(EXT-DCR).·METHODS: Fifty patients who underwent EXT- or END-DCR between January 2010-2012 were involved in the study. A questionnaire was applied to patients preoperatively, and postoperatively. Subjective success was defined by absence of epiphora, objective success by a normal nasolacrimal lavage and a positive functional endoscopic dye test(FEDT). Postoperative pain and cosmetic result of surgery were interpreted by the patients, who were also asked whether they would offer this surgery to a friend or would prefer this surgery once more if necessary.·RESULTS: Twenty-five patients underwent END-DCR and 25 underwent EXT-DCR. Mean duration of surgeries were 35 min both for EXT-DCR(30-50) and END-DCR(35-50)(P =0.778). Intraoperative bleeding were documented in 48% of EXT-DCR and 4% of END-DCR cases(P 【0.001). In total 96% of EXT-DCR and 100% of END-DCR patients had subjective success. Objective success was 100% in each group. There was no significant difference between the epiphora scorings and FDDT results in postoperative visits among the groups.END-DCR group reported less pain in first week and month(P 【0.05, P 【0.05). More patients in END-DCR group were happy with the cosmetic result in first week and month(P 【0.001, P 【0.001). More patients in END-DCR group offered this surgery to a friend(P 【0.001). All patients in END-DCR group preferred this surgery once more if necessary, only 48% in EXT-DCR preferred the same method(P 【0.001).·CONCLUSION: Although both END- and EXT-DCRs provide satisfactory outcomes with similar objective andsubjective success rates, we demonstrated that the endonasal approach caused significantly less pain in early postoperative period than the external approach.Clinical comfort defined by the patients was quite higher in END-DCR group, in which patients mainly were pleased to encounter a sutureless surgical area. 展开更多
关键词 endoscopicdacryocystorhinostomy externa dacryocystorhinostomy subjective success objective success nasolacrimal lavage functional endoscopic dye test
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Necrotising otitis externa:A single centre experience 被引量:1
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作者 Mehdi Hasnaoui Asma Ben Mabrouk +4 位作者 Jihene Chelli Fatma Larbi Ammari Rihab Lahmar Adnene Toumi Khalifa Mighri 《Journal of Otology》 CSCD 2021年第1期22-26,共5页
Introduction:Necrotising otitis externa(NOE)is a rare infection of the ear canal with frequent bone erosion.This study’s objective is to describe the different features of NOE as well as its management in an ear-nose... Introduction:Necrotising otitis externa(NOE)is a rare infection of the ear canal with frequent bone erosion.This study’s objective is to describe the different features of NOE as well as its management in an ear-nose-throat department.We also tried to identify the particularities of the fungal infection.Patients and methods:It is an observational cohort that included all the patients hospitalised for the management of NOE.The study was carried out in the ear-nose-throat Department of Mahdia University Hospital in Tunisia between January 2006 and december 2019.Results:A total of 40 patients were included.The mean age was 65±12.9 years and the sex ratio was 0.9.Ninety percent of the patients included were diabetics.The most common signs found were oedema of the external canal(97.5%)and auricular discharge(92.5%).The main pathogen isolated was Pseudomonas aeruginosa(61.7%).Fungi were isolated in 9 cases(26.47%).Computed tomography was performed for 32 patients(80%).Bone erosion was seen in 26 cases(81.3%).The main complications were cerebral venous thrombosis,retropharyngeal abscess and cerebral empyema.Thirty one patients received only antibiotics,2 received only antifungal treatment,and 7 received both antibiotics and antifungal treatment.All patients had a favorable outcome.Univariate analysis showed a higher median erythrocyte sedimentation rate was associated with fungal infections.No other differences were noted.Conclusion:Our management protocol seems to be efficient since all patients had initial favorable outcome.A higher median erythrocyte sedimentation rate was associated with fungal infections. 展开更多
关键词 Otitis externa FUNGI PSEUDOMONAS Diagnosis THERAPEUTICS
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An update on microbiological causes of canine otitis externa in Campania Region,Italy
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作者 Luisa De Martino Francesca Paola Nocera +5 位作者 Karina Mallardo Sandra Nizza Eleonora Masturzo Filomena Fiorito Giuseppe Iovane Piergiorgio Catalanotti 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2016年第5期384-389,共6页
Objective: To update the recent knowledge of the microbiological causes of canine otitis externa in Campania Region(Italy) and the antibiotic susceptibility patterns of the isolated strains.Methods: A total of 122 dog... Objective: To update the recent knowledge of the microbiological causes of canine otitis externa in Campania Region(Italy) and the antibiotic susceptibility patterns of the isolated strains.Methods: A total of 122 dogs were examined by otoscopy, and auricular swab samples were collected from both ears in 74 dogs presenting clinical bilateral otitis and from single ears in 48 dogs displaying clinical unilateral otitis. Cytological examination,bacteriological analysis and antimicrobial susceptibility tests were performed.Results: Thirty-one out of 122 dogs were positive for yeast species(25.4%, 95% confidence interval(CI): 18.2%–34.2%) with a higher prevalence of Malassezia pachydermatis(21/31 isolates, 67.7%, CI: 48.5%–82.7%), and a total of 91 out of 122 dogs were positive for bacterial species(74.6%; CI: 65.8%–81.8%) with a higher prevalence of Staphylococcus pseudintermedius(45/143 isolates, 31.5%, CI: 24.1%–39.8%). These results are the first description of Streptococcus agalactiae-associated otitis. The yeasts isolated showed high levels of susceptibility to all antifungal agents tested; on the contrary all the isolated bacterial strains were highly resistant to at least four out of ten antimicrobial classes. Both Gram-positive and Gram-negative bacteria showed high resistance to amoxicillin/clavulanate and kanamycin hence they are not recommended as initial empirical therapy for the otitis treatment.Conclusions: This update illustrates an increase in antibiotic resistances providing an insight into the current knowledge of the therapeutic procedures followed on canine otitis externa in Italy. It also emphasizes the importance of considering the results of the microbiological and sensitivity tests to decide on an appropriate antibiotic therapy. 展开更多
关键词 CANINE OTITIS externa MALASSEZIA pachydermatis STAPHYLOCOCCUS pseudintermedius Antimicrobial resistance
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Human ophthalmomyiasis externa caused by the sheep botfly Oestrus ovis:a case report from Karachi,Pakistan
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作者 Naima Fasih Kanza Noor Qaiser +2 位作者 Syeda Aisha Bokhari Bushra Jamil Mohammad Asim Beg 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2014年第10期835-837,共3页
Ocular myiasis due to Oestrus ovis larvae infestation is an eye infection in humans.A case of ophthalmomyiasis externa in a young male from Karachi,Pakistan in winter(December 2012),without history of close proximity ... Ocular myiasis due to Oestrus ovis larvae infestation is an eye infection in humans.A case of ophthalmomyiasis externa in a young male from Karachi,Pakistan in winter(December 2012),without history of close proximity to domestic animals or visit to any rural area was reported.The condition is self-limiting and the disease is confined to the conjunctiva.The eye was locally anesthetized and washed with 5%povidine iodine solution.A total number of 27 first instar larvae of Oestrus ovis were removed with fine forceps.The patient received 0.5%moxifloxacin and diclofenac eye drops for one week.His eye was examined after one day,one week and one month and the recovery status was favorable.The present case raise the awareness among ophthalmologists regarding larval conjunctivitis as one of the causes of conjunctivitis and it can occur throughout the year in any season including winter.Moreover,it can occurr in any area either rural or urban with or without close proximity to domestic animals especially in subtropical regions with high parasitic burden. 展开更多
关键词 Ophthalmomyiasis externa Oestrus OVIS Pakistan Eye INFECTIONS
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Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy:a report and review of literature
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作者 K Devaraja Dipak Ranjan Nayak 《Journal of Otology》 CSCD 2020年第3期112-116,共5页
Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves VII.Rarely can it also effect one ... Inflammation of a part or whole of the temporal bone and surrounding soft tissue is termed as malignant otitis externa,which typically spreads to skull base to involve cranial nerves VII.Rarely can it also effect one or more of cranial nerves IX,X,XI,and XII.We present a case of malignant otitis externa which presented with symptomatic palsy of IX and XII nerves sparing the VII cranial nerve.The patient though later on had internal jugular vein thrombosis,which we presume is due to the involvement of the parapharyngeal space that prompted us to reconsider the diagnosis,and later on,to aggravate the therapy.With proper blood sugar control and appropriate long term antibiotics,not only that the patient is disease free at one year follow up,but the cranial nerve deficits also recovered.Apart from sharing the clinical and management details of this patient,we have reviewed the relevant literature in the discussion,which has shed some light onto some of the interesting facts about this condition and its prognosis. 展开更多
关键词 Skull base osteomyelitis Malignant otitis externa Hypoglossal palsy Diabetes mellitus Internal jugular vein
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Field Comparison of the Impact of Different Treatment Durations in the Treatment of Acute Otitis Externa
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作者 Erik Grandemange Florence Pillet +1 位作者 Olivier Roy Frédérique Woehrlé 《Open Journal of Veterinary Medicine》 2013年第6期289-296,共8页
Background: Acute otitis externa is a common multi-factorial disorder in the dog. Several topical preparations are available on the veterinary market, which are licensed for an either specified duration of treatment o... Background: Acute otitis externa is a common multi-factorial disorder in the dog. Several topical preparations are available on the veterinary market, which are licensed for an either specified duration of treatment or for a discretionary period that is determined by the clinician. Objectives: To compare the efficacy of two topical products, both licensed for the treatment of otitis externa in the dog, but with different treatment durations. Animal Population: One hundred and sixty dogs were enrolled in this multicentre field study from which 157 dogs were analysed in the Per Protocol sample (73 Aurizon?treated animals and 84 Easotic?treated animals). Method: Dogs were randomly assigned to Aurizon?or Easotic?treatment groups. Aurizon?(Vétoquinol SA: marbofloxacin, clotrimazole, dexamethasone) was administered daily in the affected ear(s) for 7 or 14 days, and was compared with a daily administration of Easotic?(Virbac SAS: gentamicin, miconazole, hydrocortisone aceponate) for 5 days. General and localised clinical signs were scored on days 0 (D0), 3 (D3), 7 (D7), 14 (D14) and 21 (D21). Results: Clinical cure rates at the end of treatment were 56.3% and 48.8% (p=0.35) in the Aurizon?and Easotic?groups respectively and 81.2% versus 74.7% one week after completing the course of treatment (p = 0.34). Twenty-one days after initially presenting for the study, cure rates were 84.3% in the Aurizon?group and 73.8% in the Easotic?(p=0.12). A relationship between severity of clinical signs and treatment duration was observed. Conclusion and Clinical Significance: At the end of the trial period, cure rates showed a tendency to be higher in the Aurizon?treated animals. The flexible dosage and the veterinary monitoring permitted treatment duration to be adjusted based upon the severity of otitis externa thus increasing the likelihood of clinical cure. 展开更多
关键词 ACUTE OTITIS externa TOPICAL EAR TREATMENT Efficacy FIELD Clinical Trial
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针刺联合中药耳浴治疗真菌性外耳道炎的疗效观察 被引量:3
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作者 刘娟 帕茹克·鲁提夫拉 +1 位作者 赵翠宏 马忠 《上海针灸杂志》 CSCD 2024年第8期823-829,共7页
目的观察针刺联合中药耳浴治疗真菌性外耳道炎的临床疗效。方法将108例真菌性外耳道炎患者按随机数字表法分为观察组和对照组,每组54例。两组均予硝酸舍他康唑乳膏治疗,对照组予中药耳浴治疗,观察组予针刺联合中药耳浴治疗。比较两组起... 目的观察针刺联合中药耳浴治疗真菌性外耳道炎的临床疗效。方法将108例真菌性外耳道炎患者按随机数字表法分为观察组和对照组,每组54例。两组均予硝酸舍他康唑乳膏治疗,对照组予中药耳浴治疗,观察组予针刺联合中药耳浴治疗。比较两组起效时间、临床疗效和复发率,观察两组治疗前后中医证候积分、瘙痒评分、红细胞沉降率、血清炎症因子[白介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)]水平以及血清miR-210和miR-146相对表达量的变化。结果观察组总有效率92.2%,高于对照组的82.4%,差异具有统计学意义(P<0.05)。治疗后,两组血清炎症因子水平、中医证候积分及瘙痒评分均较治疗前降低(P<0.05),且观察组均低于对照组(P<0.05)。治疗后,两组血清miR-146相对表达量较治疗前降低(P<0.05),血清miR-210相对表达量较治疗前升高(P<0.05);且观察组血清miR-146相对表达量低于对照组,血清miR-210相对表达量高于对照组(P<0.05)。观察组平均起效时间短于对照组(P<0.05),观察组复发率低于对照组(P<0.05)。结论在外用硝酸舍他康唑乳膏基础上,针刺联合中药耳浴治疗真菌性外耳道炎的临床疗效优于单纯中药耳浴,起效更快,复发更少,可有效改善瘙痒症状,调节血清炎症因子水平以及miR-210和miR-146的相对表达量。 展开更多
关键词 针刺疗法 针药并用 薰洗 外耳道炎 真菌感染 瘙痒 白介素-6 肿瘤坏死因子-α
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苦蛇治霉滴耳剂的制备及其临床疗效观察 被引量:1
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作者 牟珊 张勤修 +1 位作者 刘志庆 朱聪 《中国中西医结合耳鼻咽喉科杂志》 2024年第5期332-335,共4页
目的探讨苦蛇治霉滴耳剂的制备工艺与质量控制程序,观察该制剂治疗真菌性外耳道炎的临床疗效。方法采用常规制备工艺将该组方制备为滴耳剂,同时建立质量控制规范操作流程。收集在本院门诊就诊的真菌性外耳道炎患者300例,随机分为观察组... 目的探讨苦蛇治霉滴耳剂的制备工艺与质量控制程序,观察该制剂治疗真菌性外耳道炎的临床疗效。方法采用常规制备工艺将该组方制备为滴耳剂,同时建立质量控制规范操作流程。收集在本院门诊就诊的真菌性外耳道炎患者300例,随机分为观察组160例和对照组140例。所有患者均彻底清洁外耳道,然后各组分别接受不同治疗。对照组患者以4%硼酸酒精滴耳液耳浴,治疗组患者则以苦蛇治霉滴耳剂耳浴,均为每日2次,7d为1疗程,共治疗2疗程。疗程结束后评定两组患者的治疗效果。结果该制剂生产工艺可行,质量控制良好。观察组有效率95.43%,明显优于对照组的有效率80.74%(P<0.01)。结论苦蛇治霉滴耳剂组方合理,质量标准稳定可控,治疗真菌性外耳道炎疗效确切,无明显毒副作用。 展开更多
关键词 苦蛇治霉滴耳剂 制备工艺 质量控制 真菌性外耳道炎 临床疗效
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Double Blinded,Randomized and Controlled Comparative Study Evaluating the Cleaning Activity of Two Ear Cleaners in Client-Owned Dogs with Spontaneous Otitis Externa
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作者 Geneviève Marignac Jean Yanique Petit +6 位作者 Jean Francois Jamet Loic Desquilbet Jean Luc Petit Frédérique Woehrlé Tessa Trouchon Oscar Fantini Sébastien Perrot 《Open Journal of Veterinary Medicine》 2019年第6期67-78,共12页
Ear cleaning is a therapeutic component in the management of otitis externa in dogs. The objectives of this study were to evaluate the in vivo efficacy and safety of a new ear cleanser, Sonotix? against EpiOtic? Advan... Ear cleaning is a therapeutic component in the management of otitis externa in dogs. The objectives of this study were to evaluate the in vivo efficacy and safety of a new ear cleanser, Sonotix? against EpiOtic? Advanced for the management of canine otitis externa. Eighteen clients owned dogs with a diagnosis of erythemato-ceruminous or purulent otitis externa were prospectively included and randomized to two treatment group: EpiOtic? Advanced and Sonotix?. Cytology and video-otoscopic examination (erythema, amount of cerumen and thickness and surface of ear canal covered by cerumen) of all affected ears were done at D0, both before (T0) and 30 minutes (T0 + 30 min) after ear cleaning. Then an ear medication was applied (Aurizon?, Vetoquinol). Owners were instructed to clean affected ears daily and apply the ear medication 30 minutes later for 5 days (D1-D5). Dogs were seen again at D6 for cytology and video-otoscopic examination. At T0, no significant differences were found between both ear cleansers groups regarding macroscopic and microscopic scorings. At T0 + 30 min and D6 cytological and video-otoscopic scores were significantly decreased (Wilcoxon test;p < 0.01) compared to baseline in both groups. However, the cleaning activity of Sonotix? was statistically superior to Epiotic? as evidenced by the median global scores of video-otoscopic examination at T0 + 30 min (Mann Whitney Test, p < 0.01). Effective ear cleaning is an essential part of any treatment scheme because it favours the contact between the ointment and the lining ear epidermis and speeds resolution by the removal of cerumen, microbial organisms and cellular debris. In our study, the important reductions in yeast, cocci, and rod-shaped organism counts were demonstrated in smears at T0 + 30 min and D6 in both groups. Video-otoscopic examination performed 30 minutes after ear cleaning suggests that Sonotix? seems to be more effective in removing cerumen than EpiOtic? Advanced. 展开更多
关键词 Ear Cleaning Canine Ear Cleanser Otitis externa
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Discussion on the Construction Technology of External Wall Panel in Prefabricated Building Structure
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作者 YANG Jun 《外文科技期刊数据库(文摘版)工程技术》 2021年第11期1462-1464,共5页
With the continuous improvement of China's scientific and technological level, all kinds of new technologies are gradually developed and applied to the construction industry. Among them, the construction technolog... With the continuous improvement of China's scientific and technological level, all kinds of new technologies are gradually developed and applied to the construction industry. Among them, the construction technology of external wall board is applied more in the prefabricated building structure of the house construction project. Because the prefabricated building structure has good adaptability, whether the construction quality is qualified determines the safety and stability of the whole house construction project. Therefore, in the construction process, it is necessary to strictly control the construction technology of assembling building structure external wall panels to ensure their standardization. Based on this, this paper briefly analyzes the construction technology of external wall panels for assembled building structures, and discusses the key points of construction for reference. 展开更多
关键词 house construction engineering prefabricated building structure construction technology of externa
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