A simultaneous increase of both stiffness and extensibility ofpoly（ethylene glycol-co-cyclohexane-1,4-dimethanol terephthalate） （PETG）/polycarbonate （PC） blends prepared through the slit die extrusion-uniaxial c...A simultaneous increase of both stiffness and extensibility ofpoly（ethylene glycol-co-cyclohexane-1,4-dimethanol terephthalate） （PETG）/polycarbonate （PC） blends prepared through the slit die extrusion-uniaxial cold stretching process was observed. The stretched sheets have a unique mechanical character that an increased tensile modulus is accompanied by an increased extensibility with increasing the draw ratio. Especially, a sharp increasing of the extensibility is observed for PETG/PC （70/30 wt%） blends at draw ratios between 8.2 and 20.0, where a nine times increase of extensibility is achieved. The mechanism of stretching-induced superior extensibility is investigated via micrograph observation, rheometry and calorimetric analysis. The observed superior extensibility could be tentatively explained by the bridging effect of the PC microfibrils on the crack development during tensile failure.展开更多
Floating platform system has been extensively used in ocean exploitation, particularly for a tension-leg platform （TLP） system in deep water. Most of the TLPs are multi-mooring systems, where multi-joints are connec...Floating platform system has been extensively used in ocean exploitation, particularly for a tension-leg platform （TLP） system in deep water. Most of the TLPs are multi-mooring systems, where multi-joints are connected to the tension-legs so that the platform is not allowed to twist freely and may subject to enormous force induced by large incident waves in the weak-direction of the structure. This study aims to exploit a single moored offshore platform system that may attract less force and can be operated with less effort. In our analysis, in addition to mechanical properties of the tether, two important properties are also taken into consideration for the single mooring tether with expanded cross sectional dimension and utilization of stronger material, namely, the sag-extensibility and the flexural rigidity. Finally, the dynamic structural behavior produced by the mechanical effects on the new system is investigated and compared with that of traditional design while the wave-structure interactions of large body are also accounted for. Our study finds that the neglect of sag-extensibility or the flexural rigidity of large, strong mooring cable may result in a conservative but not necessarily safe design.展开更多
Pressure garments are functional garments designed for medical purposes and arc normally used under prolonged stress. The stress across seams is related to the size of the wearer and the fit and the garment, the more ...Pressure garments are functional garments designed for medical purposes and arc normally used under prolonged stress. The stress across seams is related to the size of the wearer and the fit and the garment, the more close fitting a garment, the greater stress is put on the seam. Since pressure garments are subjected to appreciable stress during wear, seams with the required strength and extensiblity are particular important.The seam type, stitch type, stitch density and thread strength are the main factors determining the strength and extensibility of a seam. In this paper, investigation of seam strength and extensibility are made on four types of seams which have been used for making pressure garments. Five different types of stitch densities and two sizes of sewing thread are used on each type of scam to be tested. The seaming conditions of the selected fabric are also examined.展开更多
Redox homeostasis is crucial for cellular function,and its disruption is associated with numerous diseases and age-related pathologies.Superoxide(·O_(2)-),a key reactive oxygen species(ROS),functions as a crucial...Redox homeostasis is crucial for cellular function,and its disruption is associated with numerous diseases and age-related pathologies.Superoxide(·O_(2)-),a key reactive oxygen species(ROS),functions as a crucial signaling molecule under normal physiological processes;however,both its excessive accumulation and deficiency can lead to significant detrimental effects on organismal health.Inspired by the natural enzyme superoxide dismutase(SOD),which alleviates oxidative stress by neutralizing excess free radicals and modulates intracellular ROS levels to activate anti-aging pathways,we bioengineered a novel"superoxide buffering formulation"(SOD Buffer)to precisely regulate mitochondrial superoxide levels.Using C.elegans as a model,we show that SOD Buffer reduces superoxide accumulation under oxidative stress(e.g.,UV exposure)and restores superoxide levels under its depletion(e.g.,post-MitoQ treatment),without affecting general ROS level.Mechanistically,SOD Buffer modulates superoxide levels to activate the mitochondrial unfolded protein response(UPR^(mt)),evidenced by the increased HSP-6 expression.This activation is mediated by the transcription regulators ATFS-1 and DVE-1,which govern mitochondrial stress responses.Functionally,SOD Buffer extends average lifespan by 36.98% and improves aging-related behaviors in C.elegans in a UPR^(mt) dependent manner.These findings highlight the therapeutic promise of targeted superoxide modulation to maintain mitochondrial health and promote longevity.展开更多
BACKGROUND With the increasing use of laparoscopic techniques in living-donor kidney transplantation,limitations in donor vessel length,particularly of the right renal vein,pose significant challenges for vascular ana...BACKGROUND With the increasing use of laparoscopic techniques in living-donor kidney transplantation,limitations in donor vessel length,particularly of the right renal vein,pose significant challenges for vascular anastomosis to the recipient’s external iliac vein.These anatomical constraints can complicate graft implantation and increase the risk of postoperative complications.CASE SUMMARY To address the issue of short right renal veins,several surgical strategies have been proposed.In this report,we describe our experience with three cases in which venous extension was successfully achieved using a venous cuff interposition technique during back-table reconstruction.This approach was used to facilitate secure vascular anastomosis and improve graft positioning in anatomically complex transplant scenarios.CONCLUSION Venous cuff interposition represents an effective technique for managing short renal veins in living-donor kidney transplantation.It provides additional length and flexibility,easing anastomotic tension and supporting successful transplantation.展开更多
Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protei...Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protein 4(HE4),a key diagnostic biomarker for ovarian cancer,is involved in fibrotic processes in several non-malignant diseases.Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis,this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC.Methods:A total of 126 patients with gynecological conditions were included and divided into normal,benign,and EOC groups.Tissue stiffness was quantitatively measured and analyzed for its correlation with clinicopathological features.We further investigated the correlation between tumor stiffness and the expression levels of HE4 and fibroblast activation markers(α-smooth muscle actin(α-SMA)and fibroblast activation protein(FAP))in tumor tissues from 22 HGSOC patients.In vitro,primary fibroblasts were treated with recombinant HE4(rHE4)or conditioned media from HE4-knockdown ovarian cancer cells to assess fibroblasts activation and matrix contractility(Collagen gel contraction assays).In vivo,a subcutaneous xenograft model using HE4-knockdown cells was established to evaluate the effects of HE4 suppression on tumor growth and extensive extracellular matrix(ECM)remodeling.Results:Ovarian cancer tissues showed significantly increased stiffness compared to benign/normal groups,showing positive correlation with serum HE4 levels.High-stiffness HGSOC tumors exhibited upregulated expression of HE4,α-SMA,FAP,and collagen I.rHE4 stimulated fibroblast activation and enhanced matrix contractility,whereas HE4 knockdown in cancer cells abrogated these pro-fibrotic effects.In vivo,HE4-silenced xenografts displayed restricted tumor growth accompanied by reduced stromal expression ofα-SMA,FAP,and collagen I.Conclusion:Our findings suggest that HE4 may facilitate ECM remodeling in HGSOC through promoting fibroblast activation and increasing collagen deposition.展开更多
In order to solve the problems of high coupling and poor scalability of the traditional monomer early warning release system architecture,multi-level deployment in a complex network environment will lead to high inves...In order to solve the problems of high coupling and poor scalability of the traditional monomer early warning release system architecture,multi-level deployment in a complex network environment will lead to high investment in software and hardware and cannot achieve intensive multi-level deployment.This paper realizes the goal of system scalability by introducing micro service architecture and technology stack and realizes the goal of resource intensification by introducing the idea of a data forwarding agent.The designed architecture scheme has been practically applied in the“Jiangxi emergency early warning information release system software platform(phase I)project”(hereinafter referred to as“provincial emergency”),which meets the needs of flexible deployment of multi-level applications across meteorological wide area network(WAN),business private network of other commissions,offices,and bureaus,government extranet,Internet and other complex networks,and fully verifies the scientificity and rationality of the scheme.It has achieved the goal of intensive and scalable construction of provincial emergencies under the complex network environment,greatly improved the early warning capacity and communication capacity of emergencies and comprehensive disasters,provided a reliable guarantee for disaster prevention and reduction,and provided a reference for the construction of current and future early warning release system and capacity improvement project.展开更多
Semenov-Tian-Shansky has given the solution of the modified classical Yang-Baxter equation, which was called the modified r-matrix. Relevant studies have been extensive in recent times. In this paper, we introduce the...Semenov-Tian-Shansky has given the solution of the modified classical Yang-Baxter equation, which was called the modified r-matrix. Relevant studies have been extensive in recent times. In this paper, we introduce the concept and representations of modified RotaBaxter Hom-Lie algebras. We develop a cohomology of modified Rota-Baxter Hom-Lie algebras with coefficients in a suitable representation. As applications, we study formal deformations and abelian extensions of modified Rota-Baxter Hom-Lie algebras in terms of second cohomology groups.展开更多
How the subduction direction of the Paleo-Pacific plate beneath the Eurasian plate changes in the Early Cretaceous remains highly controversial due to the disappearance of the subducted oceanic plate.Intraplate deform...How the subduction direction of the Paleo-Pacific plate beneath the Eurasian plate changes in the Early Cretaceous remains highly controversial due to the disappearance of the subducted oceanic plate.Intraplate deformation structures in the east Asian continent,however,provide excellent opportunities for reconstructing paleostress fields in continental interior in relation to the Paleo-Pacific/Eurasian plate interaction.Anisotropy of magnetic susceptibility(AMS),geological,and geochronological analyses of post-kinematic mafic dykes intruding the detachment fault zone of the Wulian metamorphic core complex(WL MCC)in Jiaodong Peninsula exemplify emplacement of mantle-sourced dykes in a WNW-ESE(301°-121°)oriented tectonic extensional setting at ca.120 Ma.In combination with the results from our previous kinematic analysis of the MCC,a ca.21°clockwise change in the direction of intraplate extension is obtained for early(135-122 Ma)extensional exhumation of the MCC to late(122-108 Ma)emplacement of the dykes.Such a change is suggested to be related to the variation in subduction direction of the Paleo-Pacific plate beneath the Eurasian plate,from westward(pre-122 Ma)to west-northwestward(post-122 Ma).展开更多
This paper introduced the concept of generalized quasidiagonal extension of C^(*)-algebras and gave some basic properties.We show that the extension algebra preserves quasidiagonality and finitary in generalized quasi...This paper introduced the concept of generalized quasidiagonal extension of C^(*)-algebras and gave some basic properties.We show that the extension algebra preserves quasidiagonality and finitary in generalized quasidiagonal extension.We give also an example of generalized quasidiagonal extension,which is not quasidiagonal extension.展开更多
The modifiedλ-differential Lie-Yamaguti algebras are considered,in which a modifiedλ-differential Lie-Yamaguti algebra consisting of a Lie-Yamaguti algebra and a modifiedλ-differential operator.First we introduce t...The modifiedλ-differential Lie-Yamaguti algebras are considered,in which a modifiedλ-differential Lie-Yamaguti algebra consisting of a Lie-Yamaguti algebra and a modifiedλ-differential operator.First we introduce the representation of modifiedλ-differential Lie-Yamaguti algebras.Furthermore,we establish the cohomology of a modifiedλ-differential Lie-Yamaguti algebra with coefficients in a representation.Finally,we investigate the one-parameter formal deformations and Abelian extensions of modifiedλ-differential Lie-Yamaguti algebras using the second cohomology group.展开更多
To address the issues of peak overlap caused by complex matrices in agricultural product terahertz(THz)spectral signals and the dynamic,nonlinear interference induced by environmental and system noise,this study explo...To address the issues of peak overlap caused by complex matrices in agricultural product terahertz(THz)spectral signals and the dynamic,nonlinear interference induced by environmental and system noise,this study explores the feasibility of adaptive-signal-decomposition-based denoising methods to improve THz spectral quality.THz time-domain spectroscopy(THz-TDS)combined with an attenuated total reflection(ATR)accessory was used to collect THz absorbance spectra from 48 peanut samples.Taking the quantitative prediction model of peanut moisture content based on THz-ATR as an example,wavelet transform(WT),empirical mode decomposition(EMD),local mean decomposition(LMD),and its improved methods-segmented local mean decomposition(SLMD)and piecewise mirror extension local mean decomposition(PME-LMD)-were employed for spectral denoising.The applicability of different denoising methods was evaluated using a support vector regression(SVR)model.Experimental results show that the peanut moisture content prediction model constructed after PME-LMD denoising achieved the best performance,with a root mean square error(RMSE),coefficient of determination(R^(2)),and mean absolute percentage error(MAPE)of 0.010,0.912,and 0.040,respectively.Compared with traditional methods,PME-LMD significantly improved spectral quality and model prediction performance.The PME-LMD denoising strategy proposed in this study effectively suppresses non-uniform noise interference in THz spectral signals,providing an efficient and accurate preprocessing method for THz spectral analysis of agricultural products.This research provides theoretical support and technical guidance for the application of THz technology for detecting agricultural product quality.展开更多
The tectonic setting of the Himalaya during the Early Paleozoic has been a subject of enduring debate within the scientific community.Newly discovered bimodal intrusive rocks from comprehensive field geological invest...The tectonic setting of the Himalaya during the Early Paleozoic has been a subject of enduring debate within the scientific community.Newly discovered bimodal intrusive rocks from comprehensive field geological investigation in the central mountain range were subjected to petrology,zircon U-Pb geochronology,zircon Hf isotopes and whole-rock geochemistry analyses.The Palie bimodal intrusive rocks,comprising amphibolite and granitic gneiss,were formed at~489 Ma.The amphibolite exhibits geochemical characteristics consistent with N-MORB,while the granitic gneiss is classified as high potassium calc-alkaline peraluminous S-type granite.Both igneous rocks exhibit negative zirconε_(Hf)(t)values and display ancient T_(DM)^(C)ages.In conjunction with regional geological survey findings,it can be inferred that the formation of the Palie bimodal intrusive rocks occurred within a post-collision extensional tectonic setting.The amphibolite genesis involved partial melting of an enriched lithospheric mantle with some crustal assimilation,whereas the origin of the granitic gneiss can be attributed to partial melting of pre-existing felsic crust.Our data indicate that during the Early Paleozoic,the Himalaya underwent a transition from a pan-African collisional setting to post-collisional extensional tectonics.展开更多
In this paper,we call a tuple consisting of 3-Lie algebra and a higher derivation on it a 3-LieHDer pair.We introduce a cohomology theory of 3-LieHDer pairs.Next,we interpret the second cohomology group as the space o...In this paper,we call a tuple consisting of 3-Lie algebra and a higher derivation on it a 3-LieHDer pair.We introduce a cohomology theory of 3-LieHDer pairs.Next,we interpret the second cohomology group as the space of all isomorphism classes of abelian extensions.Finally,we consider formal deformations of 3-LieHDer pairs that are governed by the cohomology with self-coefficient.展开更多
BACKGROUND Gallbladder cancer is a highly malignant and aggressive tumor,often diagnosed at an advanced stage.The prognosis for advanced gallbladder cancer remains poor,with limited options for effective treatment.CAS...BACKGROUND Gallbladder cancer is a highly malignant and aggressive tumor,often diagnosed at an advanced stage.The prognosis for advanced gallbladder cancer remains poor,with limited options for effective treatment.CASE SUMMARY A 65-year-old male patient presented with a soft tissue mass in the gallbladder.Following laparoscopic exploration,he underwent radical surgery for gallbladder cancer,with the tumor staged as pT2N1M0(stage III).Post-surgery,the patient received four cycles of adjuvant chemotherapy.However,one month later,over 60 metastatic lesions were detected in the liver,lungs,and lymph nodes.In response to the widespread metastasis,he underwent six cycles of combination therapy consisting of sintilimab,albumin-bound paclitaxel,and cisplatin.After two cycles,a partial response was achieved.Maintenance therapy was initiated with a combination of sintilimab and albumin-bound paclitaxel for four cycles.Monotherapy with sintilimab was continued thereafter until October 2023.Complete remission was confirmed in September 2021.The patient sustained this complete response for more than three years,including an eleven-month period without disease progression following the discontinuation of sintilimab.Genetic analysis revealed a tumor mutational burden of 15.4 mutations/megabase,which indicates a potentially favorable response to immunotherapy.CONCLUSION This case demonstrates the potential of combining immunotherapy(sintilimab)with chemotherapy to achieve durable remission in metastatic gallbladder cancer,even in a patient with extensive metastasis.In addition,it indicated the importance of tumor mutational burden as a predictive biomarker of immunotherapy.展开更多
Mechanism of discontinuous precipitation(DP) in AZ80 alloy was investigated by phase-orientation correlated characterization.The results show DPs nucleate by turning the original grain boundaries(GBs) as reaction fron...Mechanism of discontinuous precipitation(DP) in AZ80 alloy was investigated by phase-orientation correlated characterization.The results show DPs nucleate by turning the original grain boundaries(GBs) as reaction front(RF),and further driving the RF to realize their growth.The DPs regions retained the same orientations as their parent grains.The misorientation angle and rotation axis of RFs had strong influence on DPs nucleation.The low-angle GBs,twin boundaries(TBs) and the GBs with specific misorientation axis which are known as low energy and low mobility GBs can hardly initiate DPs.In addition,the TBs had a strong ability to inhibit the growth of DPs,but it should be noticed that the growth of DPs cannot be totally inhibited by TBs.DPs can engulf the twins when the growth direction is approximately parallel to the long axis of TBs.The inhibition behavior is related to the distribution of Al solute atoms near the RF,boundary interactions of the TBs and twin tips with the RF,and the morphology of the continuous precipitations within the twins.展开更多
This study aimed to investigate the anti-aging effects of black rice-anthocyanin(BRA)in Drosophila melanogaster and HUVEC cells.In this study,the strong antioxidant activity of BRA in HUVEC cells,D.melanogaster of lif...This study aimed to investigate the anti-aging effects of black rice-anthocyanin(BRA)in Drosophila melanogaster and HUVEC cells.In this study,the strong antioxidant activity of BRA in HUVEC cells,D.melanogaster of lifespan extension,and molecular mechanism were elucidated.Firstly,the BRA increased enzyme activities of superoxide dismutase(SOD)and catalase(CAT),as well as the expression of phosphatidyl inositol 3-kinase(PI3K)/protein kinase B(Akt)protein while decreasing the accumulation of reactive oxygen species(ROS)and malondialdehyde(MDA)in both H_(2)O_(2)-induced HUVEC cells and D.melanogaster.Secondly,the BRA extended the lifespan of D.melanogaster by improving crawling ability and intestine abilities in the microbial environment,barrier function,and number of autophagic lysosomes,as well as inhibiting the abnormal multiplication of stem cells in the intestine.Thirdly,the BRA downregulated expression levels of Akt-1 and mTOR in D.melanogaster while upregulated downstream autophagy gene expression levels of Atg1,Atg5,Atg8a,and Atg8b,as well as the expression levels of SOD,CAT,and 4E-binding protein.Lastly,the anti-aging mechanism was also verified by both the computerized molecular simulation and network pharmacology.Thus,the prolonged lifespan of D.melanogaster by blocking the mTOR pathway and activating autophagy,which could be further used for improving health and prolonging life.展开更多
The fatigue characteristics of rock materials significantly impact the economy and safety of underground structures during construction.Hence,it is essential to conduct further investigation into the progressive damag...The fatigue characteristics of rock materials significantly impact the economy and safety of underground structures during construction.Hence,it is essential to conduct further investigation into the progressive damage processes of rocks under cyclic loading conditions.This research utilised both laboratory experiments and discrete element simulations to investigate how confining pressure and fatigue upper limit stress influence the mechanical behaviour and crack development of marble under low-cycle fatigue conditions.By introducing synthetic displacement and reasonable assumptions,the classical damage evolution law was updated,resulting in a fatigue life prediction formula applicable to various rock materials and loading conditions.The results indicate that lower fatigue upper limit stress can delay the accumulation of damage and extend the fatigue life of the rock,but it results in more severe ultimate failure.The damage variable’s correlation with the relative number of loading cycles for different fatigue load upper limits under the same confining pressure can be approximated by the same functional relationship.The modified damage evolution model provides an effective characterisation of this trend.The proposed fatigue life prediction method comprehensively accounts for different rock materials,confining pressures,loading frequencies,and initial damage,showing a close match with actual results.展开更多
After excavation,some of the surrounding rock mass is in a state of triaxial extension,exhibiting tensile or shear fracture modes.To study the energy mechanism of tensile fracture turning to shear fracture,a series of...After excavation,some of the surrounding rock mass is in a state of triaxial extension,exhibiting tensile or shear fracture modes.To study the energy mechanism of tensile fracture turning to shear fracture,a series of triaxial extension tests were conducted on sandstone under confining pressures of 10,30,50 and 70 MPa.Elastic energy and dissipated energy were separated by single unloading,the input energy u_(t),elastic energy u_(e),and dissipated energy u_(d)at different unloading stress levels were calculated by the integrating stress−strain curves.The results show that tensile cracks dominate fracture under lower confining pressure(10 MPa),and shear cracks play an increasingly important role in fracture as confining pressure increases(30,50 and 70 MPa).Based on the phenomenon that u_(e)and u_(d)increase linearly with increasing u_(t),a possible energy distribution mechanism of fracture mode transition under triaxial extension was proposed.In addition,it was found that peak energy storage capacity is more sensitive to confining pressure compared to elastic energy conversion capacity.展开更多
基金supported by the National Natural Science Foundation of China(Nos.50533050,20874064 and 50873063)
文摘A simultaneous increase of both stiffness and extensibility ofpoly（ethylene glycol-co-cyclohexane-1,4-dimethanol terephthalate） （PETG）/polycarbonate （PC） blends prepared through the slit die extrusion-uniaxial cold stretching process was observed. The stretched sheets have a unique mechanical character that an increased tensile modulus is accompanied by an increased extensibility with increasing the draw ratio. Especially, a sharp increasing of the extensibility is observed for PETG/PC （70/30 wt%） blends at draw ratios between 8.2 and 20.0, where a nine times increase of extensibility is achieved. The mechanism of stretching-induced superior extensibility is investigated via micrograph observation, rheometry and calorimetric analysis. The observed superior extensibility could be tentatively explained by the bridging effect of the PC microfibrils on the crack development during tensile failure.
基金financially supported by the Science Council of Taiwan (Grant No. NSC-97-2221-E-110-080)
文摘Floating platform system has been extensively used in ocean exploitation, particularly for a tension-leg platform （TLP） system in deep water. Most of the TLPs are multi-mooring systems, where multi-joints are connected to the tension-legs so that the platform is not allowed to twist freely and may subject to enormous force induced by large incident waves in the weak-direction of the structure. This study aims to exploit a single moored offshore platform system that may attract less force and can be operated with less effort. In our analysis, in addition to mechanical properties of the tether, two important properties are also taken into consideration for the single mooring tether with expanded cross sectional dimension and utilization of stronger material, namely, the sag-extensibility and the flexural rigidity. Finally, the dynamic structural behavior produced by the mechanical effects on the new system is investigated and compared with that of traditional design while the wave-structure interactions of large body are also accounted for. Our study finds that the neglect of sag-extensibility or the flexural rigidity of large, strong mooring cable may result in a conservative but not necessarily safe design.
文摘Pressure garments are functional garments designed for medical purposes and arc normally used under prolonged stress. The stress across seams is related to the size of the wearer and the fit and the garment, the more close fitting a garment, the greater stress is put on the seam. Since pressure garments are subjected to appreciable stress during wear, seams with the required strength and extensiblity are particular important.The seam type, stitch type, stitch density and thread strength are the main factors determining the strength and extensibility of a seam. In this paper, investigation of seam strength and extensibility are made on four types of seams which have been used for making pressure garments. Five different types of stitch densities and two sizes of sewing thread are used on each type of scam to be tested. The seaming conditions of the selected fabric are also examined.
基金supported by the National Key R&D Program of China(No.2022YFA1205801)the National Natural Science Foundation of China(Nos.T2225026 and 82172087)+1 种基金the Beijing Institute of Technology Research Fund Program for Young Scholars,Innovative Group Cultivation Project for Basic Medicine(No.CX25XT03)Laboratory for Clinical Medicine,Capital Medical University.
文摘Redox homeostasis is crucial for cellular function,and its disruption is associated with numerous diseases and age-related pathologies.Superoxide(·O_(2)-),a key reactive oxygen species(ROS),functions as a crucial signaling molecule under normal physiological processes;however,both its excessive accumulation and deficiency can lead to significant detrimental effects on organismal health.Inspired by the natural enzyme superoxide dismutase(SOD),which alleviates oxidative stress by neutralizing excess free radicals and modulates intracellular ROS levels to activate anti-aging pathways,we bioengineered a novel"superoxide buffering formulation"(SOD Buffer)to precisely regulate mitochondrial superoxide levels.Using C.elegans as a model,we show that SOD Buffer reduces superoxide accumulation under oxidative stress(e.g.,UV exposure)and restores superoxide levels under its depletion(e.g.,post-MitoQ treatment),without affecting general ROS level.Mechanistically,SOD Buffer modulates superoxide levels to activate the mitochondrial unfolded protein response(UPR^(mt)),evidenced by the increased HSP-6 expression.This activation is mediated by the transcription regulators ATFS-1 and DVE-1,which govern mitochondrial stress responses.Functionally,SOD Buffer extends average lifespan by 36.98% and improves aging-related behaviors in C.elegans in a UPR^(mt) dependent manner.These findings highlight the therapeutic promise of targeted superoxide modulation to maintain mitochondrial health and promote longevity.
文摘BACKGROUND With the increasing use of laparoscopic techniques in living-donor kidney transplantation,limitations in donor vessel length,particularly of the right renal vein,pose significant challenges for vascular anastomosis to the recipient’s external iliac vein.These anatomical constraints can complicate graft implantation and increase the risk of postoperative complications.CASE SUMMARY To address the issue of short right renal veins,several surgical strategies have been proposed.In this report,we describe our experience with three cases in which venous extension was successfully achieved using a venous cuff interposition technique during back-table reconstruction.This approach was used to facilitate secure vascular anastomosis and improve graft positioning in anatomically complex transplant scenarios.CONCLUSION Venous cuff interposition represents an effective technique for managing short renal veins in living-donor kidney transplantation.It provides additional length and flexibility,easing anastomotic tension and supporting successful transplantation.
文摘Objectives:High-grade serous ovarian cancer(HGSOC),the most common subtype of epithelial ovarian cancer(EOC),exhibits a mesenchymal phenotype characterized by fibrotic stroma and poor prognosis.Human epididymis protein 4(HE4),a key diagnostic biomarker for ovarian cancer,is involved in fibrotic processes in several non-malignant diseases.Given the clinical significance of stromal fibrosis in HGSOC and the potential link between HE4 and fibrosis,this study aimed to investigate the role of HE4 in the formation of stromal fibrosis in HGSOC.Methods:A total of 126 patients with gynecological conditions were included and divided into normal,benign,and EOC groups.Tissue stiffness was quantitatively measured and analyzed for its correlation with clinicopathological features.We further investigated the correlation between tumor stiffness and the expression levels of HE4 and fibroblast activation markers(α-smooth muscle actin(α-SMA)and fibroblast activation protein(FAP))in tumor tissues from 22 HGSOC patients.In vitro,primary fibroblasts were treated with recombinant HE4(rHE4)or conditioned media from HE4-knockdown ovarian cancer cells to assess fibroblasts activation and matrix contractility(Collagen gel contraction assays).In vivo,a subcutaneous xenograft model using HE4-knockdown cells was established to evaluate the effects of HE4 suppression on tumor growth and extensive extracellular matrix(ECM)remodeling.Results:Ovarian cancer tissues showed significantly increased stiffness compared to benign/normal groups,showing positive correlation with serum HE4 levels.High-stiffness HGSOC tumors exhibited upregulated expression of HE4,α-SMA,FAP,and collagen I.rHE4 stimulated fibroblast activation and enhanced matrix contractility,whereas HE4 knockdown in cancer cells abrogated these pro-fibrotic effects.In vivo,HE4-silenced xenografts displayed restricted tumor growth accompanied by reduced stromal expression ofα-SMA,FAP,and collagen I.Conclusion:Our findings suggest that HE4 may facilitate ECM remodeling in HGSOC through promoting fibroblast activation and increasing collagen deposition.
文摘In order to solve the problems of high coupling and poor scalability of the traditional monomer early warning release system architecture,multi-level deployment in a complex network environment will lead to high investment in software and hardware and cannot achieve intensive multi-level deployment.This paper realizes the goal of system scalability by introducing micro service architecture and technology stack and realizes the goal of resource intensification by introducing the idea of a data forwarding agent.The designed architecture scheme has been practically applied in the“Jiangxi emergency early warning information release system software platform(phase I)project”(hereinafter referred to as“provincial emergency”),which meets the needs of flexible deployment of multi-level applications across meteorological wide area network(WAN),business private network of other commissions,offices,and bureaus,government extranet,Internet and other complex networks,and fully verifies the scientificity and rationality of the scheme.It has achieved the goal of intensive and scalable construction of provincial emergencies under the complex network environment,greatly improved the early warning capacity and communication capacity of emergencies and comprehensive disasters,provided a reliable guarantee for disaster prevention and reduction,and provided a reference for the construction of current and future early warning release system and capacity improvement project.
基金Supported by the Universities Key Laboratory of System Modeling and Data Mining in Guizhou Province(Grant No.2023013)the National Natural Science Foundation of China(Grant No.12161013)the Science and Technology Program of Guizhou Province(Grant No.ZK[2023]025)。
文摘Semenov-Tian-Shansky has given the solution of the modified classical Yang-Baxter equation, which was called the modified r-matrix. Relevant studies have been extensive in recent times. In this paper, we introduce the concept and representations of modified RotaBaxter Hom-Lie algebras. We develop a cohomology of modified Rota-Baxter Hom-Lie algebras with coefficients in a suitable representation. As applications, we study formal deformations and abelian extensions of modified Rota-Baxter Hom-Lie algebras in terms of second cohomology groups.
基金supported by the National Natural Science Foundation of China(Grant Nos:42130801,41430211,90814006,and 42072226)the“Deep-time Digital Earth”Science and Technology Leading Talents Team Funds for the Central Universities for the Frontiers Science Center for Deep-time Digital Earth,CUGB(Fundamental Research Funds for the Central UniversitiesGrant No:2652023001).
文摘How the subduction direction of the Paleo-Pacific plate beneath the Eurasian plate changes in the Early Cretaceous remains highly controversial due to the disappearance of the subducted oceanic plate.Intraplate deformation structures in the east Asian continent,however,provide excellent opportunities for reconstructing paleostress fields in continental interior in relation to the Paleo-Pacific/Eurasian plate interaction.Anisotropy of magnetic susceptibility(AMS),geological,and geochronological analyses of post-kinematic mafic dykes intruding the detachment fault zone of the Wulian metamorphic core complex(WL MCC)in Jiaodong Peninsula exemplify emplacement of mantle-sourced dykes in a WNW-ESE(301°-121°)oriented tectonic extensional setting at ca.120 Ma.In combination with the results from our previous kinematic analysis of the MCC,a ca.21°clockwise change in the direction of intraplate extension is obtained for early(135-122 Ma)extensional exhumation of the MCC to late(122-108 Ma)emplacement of the dykes.Such a change is suggested to be related to the variation in subduction direction of the Paleo-Pacific plate beneath the Eurasian plate,from westward(pre-122 Ma)to west-northwestward(post-122 Ma).
基金Supported by NSF of Jiangsu Province(No.BK20171421)。
文摘This paper introduced the concept of generalized quasidiagonal extension of C^(*)-algebras and gave some basic properties.We show that the extension algebra preserves quasidiagonality and finitary in generalized quasidiagonal extension.We give also an example of generalized quasidiagonal extension,which is not quasidiagonal extension.
基金National Natural Science Foundation of China(12161013)Research Projects of Guizhou University of Commerce in 2024。
文摘The modifiedλ-differential Lie-Yamaguti algebras are considered,in which a modifiedλ-differential Lie-Yamaguti algebra consisting of a Lie-Yamaguti algebra and a modifiedλ-differential operator.First we introduce the representation of modifiedλ-differential Lie-Yamaguti algebras.Furthermore,we establish the cohomology of a modifiedλ-differential Lie-Yamaguti algebra with coefficients in a representation.Finally,we investigate the one-parameter formal deformations and Abelian extensions of modifiedλ-differential Lie-Yamaguti algebras using the second cohomology group.
基金Supported by the National Key R&D Program of China(2023YFD2101001)National Natural Science Foundation of China(32202144,61807001)。
文摘To address the issues of peak overlap caused by complex matrices in agricultural product terahertz(THz)spectral signals and the dynamic,nonlinear interference induced by environmental and system noise,this study explores the feasibility of adaptive-signal-decomposition-based denoising methods to improve THz spectral quality.THz time-domain spectroscopy(THz-TDS)combined with an attenuated total reflection(ATR)accessory was used to collect THz absorbance spectra from 48 peanut samples.Taking the quantitative prediction model of peanut moisture content based on THz-ATR as an example,wavelet transform(WT),empirical mode decomposition(EMD),local mean decomposition(LMD),and its improved methods-segmented local mean decomposition(SLMD)and piecewise mirror extension local mean decomposition(PME-LMD)-were employed for spectral denoising.The applicability of different denoising methods was evaluated using a support vector regression(SVR)model.Experimental results show that the peanut moisture content prediction model constructed after PME-LMD denoising achieved the best performance,with a root mean square error(RMSE),coefficient of determination(R^(2)),and mean absolute percentage error(MAPE)of 0.010,0.912,and 0.040,respectively.Compared with traditional methods,PME-LMD significantly improved spectral quality and model prediction performance.The PME-LMD denoising strategy proposed in this study effectively suppresses non-uniform noise interference in THz spectral signals,providing an efficient and accurate preprocessing method for THz spectral analysis of agricultural products.This research provides theoretical support and technical guidance for the application of THz technology for detecting agricultural product quality.
基金supported by the China Geological Survey Program(Grant No.DD20220989)the National Natural Science Foundation of China(Grant No.41972118)。
文摘The tectonic setting of the Himalaya during the Early Paleozoic has been a subject of enduring debate within the scientific community.Newly discovered bimodal intrusive rocks from comprehensive field geological investigation in the central mountain range were subjected to petrology,zircon U-Pb geochronology,zircon Hf isotopes and whole-rock geochemistry analyses.The Palie bimodal intrusive rocks,comprising amphibolite and granitic gneiss,were formed at~489 Ma.The amphibolite exhibits geochemical characteristics consistent with N-MORB,while the granitic gneiss is classified as high potassium calc-alkaline peraluminous S-type granite.Both igneous rocks exhibit negative zirconε_(Hf)(t)values and display ancient T_(DM)^(C)ages.In conjunction with regional geological survey findings,it can be inferred that the formation of the Palie bimodal intrusive rocks occurred within a post-collision extensional tectonic setting.The amphibolite genesis involved partial melting of an enriched lithospheric mantle with some crustal assimilation,whereas the origin of the granitic gneiss can be attributed to partial melting of pre-existing felsic crust.Our data indicate that during the Early Paleozoic,the Himalaya underwent a transition from a pan-African collisional setting to post-collisional extensional tectonics.
基金Supported by the National Natural Science Foundation of China(Grant No.12161013)the Basic Research Program(Natural Science)of Guizhou Province(Grant No.ZK[2023]025).
文摘In this paper,we call a tuple consisting of 3-Lie algebra and a higher derivation on it a 3-LieHDer pair.We introduce a cohomology theory of 3-LieHDer pairs.Next,we interpret the second cohomology group as the space of all isomorphism classes of abelian extensions.Finally,we consider formal deformations of 3-LieHDer pairs that are governed by the cohomology with self-coefficient.
文摘BACKGROUND Gallbladder cancer is a highly malignant and aggressive tumor,often diagnosed at an advanced stage.The prognosis for advanced gallbladder cancer remains poor,with limited options for effective treatment.CASE SUMMARY A 65-year-old male patient presented with a soft tissue mass in the gallbladder.Following laparoscopic exploration,he underwent radical surgery for gallbladder cancer,with the tumor staged as pT2N1M0(stage III).Post-surgery,the patient received four cycles of adjuvant chemotherapy.However,one month later,over 60 metastatic lesions were detected in the liver,lungs,and lymph nodes.In response to the widespread metastasis,he underwent six cycles of combination therapy consisting of sintilimab,albumin-bound paclitaxel,and cisplatin.After two cycles,a partial response was achieved.Maintenance therapy was initiated with a combination of sintilimab and albumin-bound paclitaxel for four cycles.Monotherapy with sintilimab was continued thereafter until October 2023.Complete remission was confirmed in September 2021.The patient sustained this complete response for more than three years,including an eleven-month period without disease progression following the discontinuation of sintilimab.Genetic analysis revealed a tumor mutational burden of 15.4 mutations/megabase,which indicates a potentially favorable response to immunotherapy.CONCLUSION This case demonstrates the potential of combining immunotherapy(sintilimab)with chemotherapy to achieve durable remission in metastatic gallbladder cancer,even in a patient with extensive metastasis.In addition,it indicated the importance of tumor mutational burden as a predictive biomarker of immunotherapy.
基金supported by National Natural Science Foundation of China (52201107)Research Program of Chongqing Municipal Education Commission (KJQN202201151)Natural Science Foundation of Chongqing (CSTB2023NSCQ-MSX0067).
文摘Mechanism of discontinuous precipitation(DP) in AZ80 alloy was investigated by phase-orientation correlated characterization.The results show DPs nucleate by turning the original grain boundaries(GBs) as reaction front(RF),and further driving the RF to realize their growth.The DPs regions retained the same orientations as their parent grains.The misorientation angle and rotation axis of RFs had strong influence on DPs nucleation.The low-angle GBs,twin boundaries(TBs) and the GBs with specific misorientation axis which are known as low energy and low mobility GBs can hardly initiate DPs.In addition,the TBs had a strong ability to inhibit the growth of DPs,but it should be noticed that the growth of DPs cannot be totally inhibited by TBs.DPs can engulf the twins when the growth direction is approximately parallel to the long axis of TBs.The inhibition behavior is related to the distribution of Al solute atoms near the RF,boundary interactions of the TBs and twin tips with the RF,and the morphology of the continuous precipitations within the twins.
基金supported by the Shandong Provincial Natural Science Foundation,China(ZR2023QC145).
文摘This study aimed to investigate the anti-aging effects of black rice-anthocyanin(BRA)in Drosophila melanogaster and HUVEC cells.In this study,the strong antioxidant activity of BRA in HUVEC cells,D.melanogaster of lifespan extension,and molecular mechanism were elucidated.Firstly,the BRA increased enzyme activities of superoxide dismutase(SOD)and catalase(CAT),as well as the expression of phosphatidyl inositol 3-kinase(PI3K)/protein kinase B(Akt)protein while decreasing the accumulation of reactive oxygen species(ROS)and malondialdehyde(MDA)in both H_(2)O_(2)-induced HUVEC cells and D.melanogaster.Secondly,the BRA extended the lifespan of D.melanogaster by improving crawling ability and intestine abilities in the microbial environment,barrier function,and number of autophagic lysosomes,as well as inhibiting the abnormal multiplication of stem cells in the intestine.Thirdly,the BRA downregulated expression levels of Akt-1 and mTOR in D.melanogaster while upregulated downstream autophagy gene expression levels of Atg1,Atg5,Atg8a,and Atg8b,as well as the expression levels of SOD,CAT,and 4E-binding protein.Lastly,the anti-aging mechanism was also verified by both the computerized molecular simulation and network pharmacology.Thus,the prolonged lifespan of D.melanogaster by blocking the mTOR pathway and activating autophagy,which could be further used for improving health and prolonging life.
基金supported by the Key Supported Project of the Joint Fund of the National Natural Science Foundation of China for Geology(No.U2444220)the National Natural Science Foundation of China(Nos.52374090 and 52278351)+1 种基金the Scientific Research(on Science and Technology)Projects for Young and Middle-aged Teachers in Fujian(No.JAT220464)the Engineering Innovation Center for Urban Underground Space Exploration and Evaluation,Ministry of Natural Resources of the People’s Republic of China(No.USEEOS-2024-01)。
文摘The fatigue characteristics of rock materials significantly impact the economy and safety of underground structures during construction.Hence,it is essential to conduct further investigation into the progressive damage processes of rocks under cyclic loading conditions.This research utilised both laboratory experiments and discrete element simulations to investigate how confining pressure and fatigue upper limit stress influence the mechanical behaviour and crack development of marble under low-cycle fatigue conditions.By introducing synthetic displacement and reasonable assumptions,the classical damage evolution law was updated,resulting in a fatigue life prediction formula applicable to various rock materials and loading conditions.The results indicate that lower fatigue upper limit stress can delay the accumulation of damage and extend the fatigue life of the rock,but it results in more severe ultimate failure.The damage variable’s correlation with the relative number of loading cycles for different fatigue load upper limits under the same confining pressure can be approximated by the same functional relationship.The modified damage evolution model provides an effective characterisation of this trend.The proposed fatigue life prediction method comprehensively accounts for different rock materials,confining pressures,loading frequencies,and initial damage,showing a close match with actual results.
基金Project(52074352)supported by the National Natural Science Foundation of ChinaProject(2023JJ30680)supported by the National Science and Technology Major Project of China。
文摘After excavation,some of the surrounding rock mass is in a state of triaxial extension,exhibiting tensile or shear fracture modes.To study the energy mechanism of tensile fracture turning to shear fracture,a series of triaxial extension tests were conducted on sandstone under confining pressures of 10,30,50 and 70 MPa.Elastic energy and dissipated energy were separated by single unloading,the input energy u_(t),elastic energy u_(e),and dissipated energy u_(d)at different unloading stress levels were calculated by the integrating stress−strain curves.The results show that tensile cracks dominate fracture under lower confining pressure(10 MPa),and shear cracks play an increasingly important role in fracture as confining pressure increases(30,50 and 70 MPa).Based on the phenomenon that u_(e)and u_(d)increase linearly with increasing u_(t),a possible energy distribution mechanism of fracture mode transition under triaxial extension was proposed.In addition,it was found that peak energy storage capacity is more sensitive to confining pressure compared to elastic energy conversion capacity.
