To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was struct...To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was structured around a project titled"Influenza Virus Analysis",comprising four progressive modules:database utilization and information retrieval,sequence alignment and phylogenetic analysis,functional and structural prediction,and omics data analysis.These modules were integrated into a coherent research workflow that connected fragmented knowledge and technical skills.During implementation,flipped classroom and group collaboration methods were employed,alongside the establishment of a diversified assessment system emphasizing process evaluation.Teaching practice indicates that the reform effectively enhances students professional application skills,learning experience,and scientific literacy,facilitating a shift from"tool operation"to"problem-solving"capabilities.This study provides a reference model for the reform of bioinformatics experimental teaching in local universities.展开更多
OBJECTIVE:To explore the potential molecular mechanism of Qigu capsule(芪骨胶囊,QGC) in the treatment of sarcopenia through network pharmacology and to verify it experimentally.METHODS:The active compounds of QGC and ...OBJECTIVE:To explore the potential molecular mechanism of Qigu capsule(芪骨胶囊,QGC) in the treatment of sarcopenia through network pharmacology and to verify it experimentally.METHODS:The active compounds of QGC and common targets between QGC and sarcopenia were screened from databases.Then the herbs-compounds-targets network,and protein-protein interaction(PPI) network was constructed.Gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were performed by R software.Next,we used a dexamethasone-induced sarcopenia mouse model to evaluate the anti-sarcopenic mechanism of QGC.RESULTS:A total of 57 common targets of QGC and sarcopenia were obtained.Based on the enrichment analysis of GO and KEGG,we took the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt) signaling pathway as a key target to explore the mechanism of QGC on sarcopenia.Animal experiments showed that QGC could increase muscle strength and inhibit muscle fiber atrophy.In the model group,the expression of muscle ring finger-1 and Atrogin-1 were increased,while myosin heavy chain was decreased,QGC treatment reversed these changes.Moreover,compared with the model group,the expressions of pPI3K,p-Akt,p-mammalian target of rapamycin and pForkhead box O3 in the QGC group were all upregulated.CONCLUSION:QGC exerts an anti-sarcopenic effect by activating PI3K/Akt signaling pathway to regulate skeletal muscle protein metabolism.展开更多
In the development framework of engineering colleges,the cultivation of students’practical ability has received unprecedented attention.Based on the actual situation of the experimental teaching of the bridge directi...In the development framework of engineering colleges,the cultivation of students’practical ability has received unprecedented attention.Based on the actual situation of the experimental teaching of the bridge direction of the road and bridge specialty in our school,the targeted teaching experiment reform was carried out,and the comprehensive experiment of the positioning of the crack observation grade steel bar of the reinforced concrete beam was customized,so that the students were fully trained in the application of professional software,experimental hands-on skills,information data analysis and processing,and bridge detection ability.It broadens students’practical ability and professional vision,and lays a good foundation for future work and employment.展开更多
In comparison with conventional experimental teaching methods,the implementation of the Motic digital microscope mutual system in the experimental teaching of medicinal botany has been demonstrated to be a highly effi...In comparison with conventional experimental teaching methods,the implementation of the Motic digital microscope mutual system in the experimental teaching of medicinal botany has been demonstrated to be a highly efficacious approach to enhance the teaching level of experimental courses in medicinal botany.The implementation of a digital microscope mutual system in experimental teaching not only enhances students practical skills in laboratory operations but also increases classroom efficiency.Furthermore,it supports personalized development among students while fostering innovative thinking,independent learning capabilities,and analysis and problem-solving skills.Additionally,this approach contributes to the enhancement of students scientific literacy.展开更多
Artificial intelligence(AI)technology is increasingly used in the field of education,but its application in molecular biology experimental teaching still faces challenges.In order to explore the application prospects ...Artificial intelligence(AI)technology is increasingly used in the field of education,but its application in molecular biology experimental teaching still faces challenges.In order to explore the application prospects of AI technology in molecular biology experimental teaching,this paper discusses the application of AI technology in molecular biology experimental teaching,focusing on the construction and application of virtual laboratories.At the same time,the advantages,challenges and future development directions of AI technology application are analyzed.The study found that AI technology has broad application prospects in molecular biology experimental teaching.AI technology can overcome many limitations in traditional experimental teaching,and can also provide personalized learning experience,real-time feedback and evaluation,and simulate complex molecular processes.However,the application of AI technology also faces challenges such as technology cost,teacher training,and curriculum design.In summary,the application of AI technology in molecular biology experimental teaching has significant advantages and can effectively improve teaching quality and learning effects.In the future,we should strengthen the integration of AI technology and traditional teaching methods,develop more AI teaching tools suitable for the characteristics of molecular biology,and focus on cultivating students’practical ability and innovative thinking.This study provides new ideas and directions for promoting the reform and innovation of molecular biology experimental teaching.展开更多
This study explores the reform and innovation of experimental and practical teaching for the Teochew Gongfu Tea course within the framework of intangible cultural heritage(ICH)education.Through the construction of a&q...This study explores the reform and innovation of experimental and practical teaching for the Teochew Gongfu Tea course within the framework of intangible cultural heritage(ICH)education.Through the construction of a"Three-Dimensional Synergy,Four-Competency Progression,and Five-Integration"model,the research aims to establish a comprehensive and sustainable system that integrates ICH inheritance,technical training,and innovation education.Drawing on Outcome-Based Education(OBE)and constructivism learning theory,the reform introduces multi-source collaboration,hybrid learning,and competence-oriented assessment mechanisms.Through case-based teaching and iterative feedback,the model effectively enhances students cultural cognition,technical proficiency,creative thinking,and professional development.The findings demonstrate that this model not only improves students practical performance and engagement but also deepens their understanding and appreciation of traditional culture,offering a replicable model for other ICH-related programs in higher education.展开更多
Epimedium Herba(EH)demonstrates significant therapeutic potential against prostate cancer(PC),though its mechanisms of action remain incompletely understood.This study investigates the pharmacological mechanisms of EH...Epimedium Herba(EH)demonstrates significant therapeutic potential against prostate cancer(PC),though its mechanisms of action remain incompletely understood.This study investigates the pharmacological mechanisms of EH in treating PC through network pharmacology analysis and experimental validation.Active components and potential targets of EH were identified using network pharmacology from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).The STRING database facilitated the construction of a protein-protein interaction(PPI)network for shared targets and the identification of core anti-PC targets.Messenger ribonucleic acid(mRNA)and protein expression of core target genes in normal prostate and PC tissues,along with their correlation to overall PC survival,were analyzed using The Cancer Genome Atlas(TCGA),Human Protein Atlas(HPA),and Gene Expression Profiling Interactive Analysis(GEPIA)databases.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed on the potential targets.Molecular docking of quercetin with key targets(TP53,TNF,heat shock protein 90 alpha family class A member 1(HSP90 AA1),AKT1,CASP3,and ESR1)was conducted,with results visualized using PyMOL.In vitro experiments validated the network pharmacology predictions.Twenty-three active ingredients of EH were identified,and the intersection of potential targets with PC targets yielded 183 potential targets.PPI network analysis revealed six key genes:targets(TP53),TNF,HSP90 AA1,AKT1,CASP3,and ESR1.GO enrichment analysis identified 2369 biological processes(BP),77 cellular components(CC),and 215 molecular functions(MF).KEGG pathway enrichment analysis demonstrated that EH's anti-cancer effects were mediated through interleukin-17(IL-17),TNF,phosphatidylinositol 3-kinase(PI3K)-AKT,apoptosis,p53,HIF-1,mitogen-activated protein kinase(MAPK),nuclear factorκB(NF-κB),and EGFR tyrosine kinase inhibitor resistance pathways.Core target validation confirmed consistency with the study's findings.Molecular docking indicated stable binding between the six core targets and quercetin.In vitro experiments confirmed quercetin's inhibition of proliferation and induction of apoptosis in ACT-1 cells.This investigation identifies potential therapeutic targets for PC through network pharmacology and experimental validation.resistance,and enhancing patient prognosis.展开更多
Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January ...Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.展开更多
Objective Forsythia suspensa has long been utilized in traditional Chinese medicine(TCM)for the treatment of IgA nephropathy(IgAN),the most prevalent form of primary glomerular disease.However,the precise mechanisms r...Objective Forsythia suspensa has long been utilized in traditional Chinese medicine(TCM)for the treatment of IgA nephropathy(IgAN),the most prevalent form of primary glomerular disease.However,the precise mechanisms remain inadequately understood.This study seeks to elucidate the underlying mechanisms of Forsythia suspensa extract(FSE)in the treatment of IgAN by employing an integrated approach that combines network pharmacology with in vivo experimental validation.Methods The chemical components of FSE were identified using high-performance liquid chromatography-mass spectrometry(HPLC–MS/MS).Additional chemical components and targets were determined through the Traditional Chinese Medicine Systems Pharmacology database.Potential therapeutic targets for IgAN were sourced from GeneCards and the Comparative Toxicogenomics Database.Subsequently,the enrichment analyses were conducted to evaluate the biological functions and pathways associated with the core targets.Finally,a mousemodel of IgAN was developed to validate the findings of the network pharmacology analysis.Results Through network analysis and HPLC–MS/MS,31 chemical components of FSE were identified.A total of 99 common targets were discovered between FSE and IgAN.The enrichment analyses suggested that FSE may mitigate IgAN primarily by inhibiting the TLR and NF-κB signaling pathways.In vivo experiments demonstrated that FSE reduced inflammation and preserved renal function in mice with IgAN through the Tolllike receptor 9(TLR9)/NF-κB pathway.Conclusion The integration of network pharmacology and animal experiments suggests that FSE alleviates renal inflammation and damage in IgAN through the TLR9/NF-κB signaling pathway.展开更多
In Saharan climates,greenhouses face extreme diurnal temperature fluctuations that generate thermal stress,reduce crop productivity,and hinder sustainable agricultural practices.Passive thermal storage using Phase Cha...In Saharan climates,greenhouses face extreme diurnal temperature fluctuations that generate thermal stress,reduce crop productivity,and hinder sustainable agricultural practices.Passive thermal storage using Phase Change Materials(PCM)is a promising solution to stabilize microclimatic conditions.This study aims to evaluate experimentally and numerically the effectiveness of PCM integration for moderating greenhouse temperature fluctuations under Saharan climatic conditions.Two identical greenhouse prototypes were constructed in Ghardaia,Algeria:a reference greenhouse and a PCM-integrated greenhouse using calcium chloride hexahydrate(CaCl_(2)⋅6H_(2)O).Thermal performance was assessed during a five-day experimental period(7–11May 2025)under severe ambient conditions.To complement this,a Nonlinear Auto-Regressive with eXogenous inputs(NARX)neural network model was developed and trained using a larger dataset(7–25 May 2025)to predict greenhouse thermal dynamics.The PCM greenhouse reduced peak daytime air temperature by an average of 8.14℃and decreased the diurnal temperature amplitude by 53.6%compared to the reference greenhouse.The NARX model achieved high predictive accuracy(R^(2)=0.990,RMSE=0.425℃,MAE=0.223℃,MBE=0.008℃),capturing both sensible and latent heat transfer mechanisms,including PCM melting and solidification.The combined experimental and predictive modeling results confirm the potential of PCM integration as an effective passive thermal regulation strategy for greenhouses in arid regions.This approach enhances microclimatic stability,improves energy efficiency,and supports the sustainability of protected agriculture under extreme climatic conditions.展开更多
Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks co...Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks course based on Dynamips simulator.Instructors and students can access the platform by IE Browser to manage and take router experiments.On the basis of deployment and testing,the platform is effective and flexible.展开更多
As the key link of cultivating the talents, the experimental teaclamg laas become an ~mportant part m me system o~ me innovation in higher education. And it plays an indispensable role in the teaching system of the co...As the key link of cultivating the talents, the experimental teaclamg laas become an ~mportant part m me system o~ me innovation in higher education. And it plays an indispensable role in the teaching system of the computer specialty. The article analyzes the current situation of the experimental teaching in computer specialty, and puts forward the reform measures and methods of the diversified experimental teaching, which can effectively improve teaching effect.展开更多
This paper analyzes the basic interactivity connotation of network teaching from the interactive definition, function, types and level etc., and established the interaction quality evaluation index system from the fou...This paper analyzes the basic interactivity connotation of network teaching from the interactive definition, function, types and level etc., and established the interaction quality evaluation index system from the four angles between student and media, the course content, teacher and peer interaction. Similarly, network instruction interaction also needs to carry on the design from the perspective of instructional design, and take full advantage of the Internet, and finally achieved good network interaction effect. Practice shows that, research on network interactive strategy significance.展开更多
With the increasing complexity of industrial automation,planetary gearboxes play a vital role in largescale equipment transmission systems,directly impacting operational efficiency and safety.Traditional maintenance s...With the increasing complexity of industrial automation,planetary gearboxes play a vital role in largescale equipment transmission systems,directly impacting operational efficiency and safety.Traditional maintenance strategies often struggle to accurately predict the degradation process of equipment,leading to excessive maintenance costs or potential failure risks.However,existing prediction methods based on statistical models are difficult to adapt to nonlinear degradation processes.To address these challenges,this study proposes a novel condition-based maintenance framework for planetary gearboxes.A comprehensive full-lifecycle degradation experiment was conducted to collect raw vibration signals,which were then processed using a temporal convolutional network autoencoder with multi-scale perception capability to extract deep temporal degradation features,enabling the collaborative extraction of longperiod meshing frequencies and short-term impact features from the vibration signals.Kernel principal component analysis was employed to fuse and normalize these features,enhancing the characterization of degradation progression.A nonlinear Wiener process was used to model the degradation trajectory,with a threshold decay function introduced to dynamically adjust maintenance strategies,and model parameters optimized through maximum likelihood estimation.Meanwhile,the maintenance strategy was optimized to minimize costs per unit time,determining the optimal maintenance timing and preventive maintenance threshold.The comprehensive indicator of degradation trends extracted by this method reaches 0.756,which is 41.2%higher than that of traditional time-domain features;the dynamic threshold strategy reduces the maintenance cost per unit time to 55.56,which is 8.9%better than that of the static threshold optimization.Experimental results demonstrate significant reductions in maintenance costs while enhancing system reliability and safety.This study realizes the organic integration of deep learning and reliability theory in the maintenance of planetary gearboxes,provides an interpretable solution for the predictive maintenance of complex mechanical systems,and promotes the development of condition-based maintenance strategies for planetary gearboxes.展开更多
The development of information technology, especially the rise of online teaching platforms, has changed the way people read and the methods they use. Under this influence, primary school students’ independent readin...The development of information technology, especially the rise of online teaching platforms, has changed the way people read and the methods they use. Under this influence, primary school students’ independent reading has also been changed. However, due to limited self-control and understanding, primary school students face certain difficulties when using online teaching platforms for independent reading. Advantages and disadvantages of distance learning based on the network teaching platform were summarized in this paper. A one-year experiment study was carried out on our school fifth-grade students in independent reading using WeChat campus platform considering their current situation and existing problems of independent reading. In experiment study an independent reading mode was introduced. The results show that this reading mode can significantly improve students’ independent reading ability.展开更多
Aiming at the issue of professional engineering certification,this article introduces the hybrid teaching method to the teaching of Principles of Computer Composition,as the core course of computer specialty in applie...Aiming at the issue of professional engineering certification,this article introduces the hybrid teaching method to the teaching of Principles of Computer Composition,as the core course of computer specialty in applied undergraduate colleges,as well as discusses the experimental teaching method of this course.The teaching scheme is designed in the aspects of experimental teaching platform,teaching content,and student achievement assessment.By making full use of online and offline resources,this teaching method realizes the diversification of learning materials and learning means,the three-dimensional learning space and learning time,as well as effectively improves the teaching effect and quality.展开更多
The Computer Network course is widely offered in colleges and universities.This course is both theoretical and practical.It organically combines theory and practice in order to achieve the goal of teaching.The main ob...The Computer Network course is widely offered in colleges and universities.This course is both theoretical and practical.It organically combines theory and practice in order to achieve the goal of teaching.The main objective of the course is to train students to have various skills,including those of enterprise scale network construction,network management,and network maintenance.Influenced by traditional teaching for a long time,the existing teaching of the course in colleges and universities urgently needs reform;otherwise,it will not be able to meet the social demand for talents in the new era.This paper focuses on the practical problems of the Computer Network teaching reform and proposes some efiective reform suggestions,hoping to engender an efficient link among the Computer Network course teaching,talent training,and the social needs in colleges and universities.展开更多
With the continuous development of computer network technology, it has been widely used in all walks of life, and gradually penetrated into people's life and learning, giving people great convenience, but it also ...With the continuous development of computer network technology, it has been widely used in all walks of life, and gradually penetrated into people's life and learning, giving people great convenience, but it also poses a serious network security threat to people's information. Therefore, in order to avoid the threat of network security, many technical colleges in China have specially set up computer network complete teaching courses, and are teaching students relevant computer security courses. However, in the actual teaching process, many computers will have various problems in teaching network security technology, and the teaching funds of technical colleges are limited. Therefore, in order to meet the learning needs of students and good teaching effect, virtual machine technology is introduced. This technology can greatly reduce the teaching funds and promote the smooth development of computer network security teaching, in order to achieve better teaching effect.展开更多
With the continuous development of science and technology and economic level in our country, especially in recent years, the development of Internet technology has brought great convenience to people's work and li...With the continuous development of science and technology and economic level in our country, especially in recent years, the development of Internet technology has brought great convenience to people's work and life. The application of computer network technology is more and more extensive, and it plays a huge role in all walks of life, so the importance of network security is highlighted. Therefore, in vocational education, a group of talents with professional knowledge of computer network security technology will be trained by reforming the teaching mode. This paper is a discussion based on the task-driven teaching reform of computer network security technology in vocational education.展开更多
基金Supported by Undergraduate Higher Education Teaching Quality and Reform Projects of Guangdong Province(Yuejiao Gao Han[2024]No.9,Yuejiao Gao Han[2024]No.30)Guangdong Basic and Applied Basic Research Foundation(2023A1515110973)+1 种基金Guangdong Provincial Young Innovative Talents Project of General Colleges and Universities(2023KQNCX089)Quality Engineering and Teaching Reform Projects of Zhaoqing University(zlgc202239,zlgc202207,zlgc2024005,zlgc2024038).
文摘To meet the need for cultivating application-oriented talents in local universities,this study introduced a project-based learning approach into the reform of bioinformatics experimental teaching.The course was structured around a project titled"Influenza Virus Analysis",comprising four progressive modules:database utilization and information retrieval,sequence alignment and phylogenetic analysis,functional and structural prediction,and omics data analysis.These modules were integrated into a coherent research workflow that connected fragmented knowledge and technical skills.During implementation,flipped classroom and group collaboration methods were employed,alongside the establishment of a diversified assessment system emphasizing process evaluation.Teaching practice indicates that the reform effectively enhances students professional application skills,learning experience,and scientific literacy,facilitating a shift from"tool operation"to"problem-solving"capabilities.This study provides a reference model for the reform of bioinformatics experimental teaching in local universities.
基金Shanghai Clinical Research Center for Chronic Musculoskeletal Diseases (20MC1920600)Shanghai Key Clinical Specialty "Traditional Chinese Medicine Orthopaedic Traumatology"(shslczdzk03901)+3 种基金The Second Round of Construction Project of National TCM Academic School Inheritance Studio "Shi's Trauma Department"[Letter of the People's Education of Traditional Chinese Medicine (2019) No.62]Shanghai High-level Local Universities "Chronic Muscle and Bone Damage Research and Transformation" Innovation Team [No.3 of Shanghai Education Commission (2022)]Program for Shanghai High-Level Local University Innovation Team (SZY20220315)Shanghai Shenkang Hospital Development Center Clinical Three-year Action Plan (SHDC2020CR3090B)。
文摘OBJECTIVE:To explore the potential molecular mechanism of Qigu capsule(芪骨胶囊,QGC) in the treatment of sarcopenia through network pharmacology and to verify it experimentally.METHODS:The active compounds of QGC and common targets between QGC and sarcopenia were screened from databases.Then the herbs-compounds-targets network,and protein-protein interaction(PPI) network was constructed.Gene ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway enrichment analysis were performed by R software.Next,we used a dexamethasone-induced sarcopenia mouse model to evaluate the anti-sarcopenic mechanism of QGC.RESULTS:A total of 57 common targets of QGC and sarcopenia were obtained.Based on the enrichment analysis of GO and KEGG,we took the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt) signaling pathway as a key target to explore the mechanism of QGC on sarcopenia.Animal experiments showed that QGC could increase muscle strength and inhibit muscle fiber atrophy.In the model group,the expression of muscle ring finger-1 and Atrogin-1 were increased,while myosin heavy chain was decreased,QGC treatment reversed these changes.Moreover,compared with the model group,the expressions of pPI3K,p-Akt,p-mammalian target of rapamycin and pForkhead box O3 in the QGC group were all upregulated.CONCLUSION:QGC exerts an anti-sarcopenic effect by activating PI3K/Akt signaling pathway to regulate skeletal muscle protein metabolism.
基金Experimental Teaching Reform Project of Liaoning University of Science and Technology,Experimental Teaching Reform of Concrete Member Crack Observation and Reinforcement Location(Project No.:SYJG202419)。
文摘In the development framework of engineering colleges,the cultivation of students’practical ability has received unprecedented attention.Based on the actual situation of the experimental teaching of the bridge direction of the road and bridge specialty in our school,the targeted teaching experiment reform was carried out,and the comprehensive experiment of the positioning of the crack observation grade steel bar of the reinforced concrete beam was customized,so that the students were fully trained in the application of professional software,experimental hands-on skills,information data analysis and processing,and bridge detection ability.It broadens students’practical ability and professional vision,and lays a good foundation for future work and employment.
基金Supported by Major Project of School-level Teaching Reform and Research of Guangxi University of Chinese Medicine(2022A006)。
文摘In comparison with conventional experimental teaching methods,the implementation of the Motic digital microscope mutual system in the experimental teaching of medicinal botany has been demonstrated to be a highly efficacious approach to enhance the teaching level of experimental courses in medicinal botany.The implementation of a digital microscope mutual system in experimental teaching not only enhances students practical skills in laboratory operations but also increases classroom efficiency.Furthermore,it supports personalized development among students while fostering innovative thinking,independent learning capabilities,and analysis and problem-solving skills.Additionally,this approach contributes to the enhancement of students scientific literacy.
基金Construction Project of Teaching Quality and Teaching Reform Engineering for Undergraduate Universities in Guangdong Province(Project No.:2023-248)First-Class Undergraduate Course in Guangdong Province-Molecular Biology Experiment 2023+1 种基金Curriculum Ideology and Politics Demonstration Project of Lingnan Normal University(Project No.:2022-6&2024-44)Construction Project of Teaching Quality and Teaching Reform Engineering of Lingnan Normal University(Project No.:2024-24)。
文摘Artificial intelligence(AI)technology is increasingly used in the field of education,but its application in molecular biology experimental teaching still faces challenges.In order to explore the application prospects of AI technology in molecular biology experimental teaching,this paper discusses the application of AI technology in molecular biology experimental teaching,focusing on the construction and application of virtual laboratories.At the same time,the advantages,challenges and future development directions of AI technology application are analyzed.The study found that AI technology has broad application prospects in molecular biology experimental teaching.AI technology can overcome many limitations in traditional experimental teaching,and can also provide personalized learning experience,real-time feedback and evaluation,and simulate complex molecular processes.However,the application of AI technology also faces challenges such as technology cost,teacher training,and curriculum design.In summary,the application of AI technology in molecular biology experimental teaching has significant advantages and can effectively improve teaching quality and learning effects.In the future,we should strengthen the integration of AI technology and traditional teaching methods,develop more AI teaching tools suitable for the characteristics of molecular biology,and focus on cultivating students’practical ability and innovative thinking.This study provides new ideas and directions for promoting the reform and innovation of molecular biology experimental teaching.
文摘This study explores the reform and innovation of experimental and practical teaching for the Teochew Gongfu Tea course within the framework of intangible cultural heritage(ICH)education.Through the construction of a"Three-Dimensional Synergy,Four-Competency Progression,and Five-Integration"model,the research aims to establish a comprehensive and sustainable system that integrates ICH inheritance,technical training,and innovation education.Drawing on Outcome-Based Education(OBE)and constructivism learning theory,the reform introduces multi-source collaboration,hybrid learning,and competence-oriented assessment mechanisms.Through case-based teaching and iterative feedback,the model effectively enhances students cultural cognition,technical proficiency,creative thinking,and professional development.The findings demonstrate that this model not only improves students practical performance and engagement but also deepens their understanding and appreciation of traditional culture,offering a replicable model for other ICH-related programs in higher education.
文摘Epimedium Herba(EH)demonstrates significant therapeutic potential against prostate cancer(PC),though its mechanisms of action remain incompletely understood.This study investigates the pharmacological mechanisms of EH in treating PC through network pharmacology analysis and experimental validation.Active components and potential targets of EH were identified using network pharmacology from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).The STRING database facilitated the construction of a protein-protein interaction(PPI)network for shared targets and the identification of core anti-PC targets.Messenger ribonucleic acid(mRNA)and protein expression of core target genes in normal prostate and PC tissues,along with their correlation to overall PC survival,were analyzed using The Cancer Genome Atlas(TCGA),Human Protein Atlas(HPA),and Gene Expression Profiling Interactive Analysis(GEPIA)databases.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed on the potential targets.Molecular docking of quercetin with key targets(TP53,TNF,heat shock protein 90 alpha family class A member 1(HSP90 AA1),AKT1,CASP3,and ESR1)was conducted,with results visualized using PyMOL.In vitro experiments validated the network pharmacology predictions.Twenty-three active ingredients of EH were identified,and the intersection of potential targets with PC targets yielded 183 potential targets.PPI network analysis revealed six key genes:targets(TP53),TNF,HSP90 AA1,AKT1,CASP3,and ESR1.GO enrichment analysis identified 2369 biological processes(BP),77 cellular components(CC),and 215 molecular functions(MF).KEGG pathway enrichment analysis demonstrated that EH's anti-cancer effects were mediated through interleukin-17(IL-17),TNF,phosphatidylinositol 3-kinase(PI3K)-AKT,apoptosis,p53,HIF-1,mitogen-activated protein kinase(MAPK),nuclear factorκB(NF-κB),and EGFR tyrosine kinase inhibitor resistance pathways.Core target validation confirmed consistency with the study's findings.Molecular docking indicated stable binding between the six core targets and quercetin.In vitro experiments confirmed quercetin's inhibition of proliferation and induction of apoptosis in ACT-1 cells.This investigation identifies potential therapeutic targets for PC through network pharmacology and experimental validation.resistance,and enhancing patient prognosis.
文摘Traditional Medicine Research published an article entitled Investigation on the mechanism of Qi-Hong-Tang-Zu ointment in thetreatmentofdiabetic wound by network pharmacology and experimental validation on 24 January 2025.The author confirmed this article’s proof on 23 January 2025 without any questions.But on 06 July 2025,the editorial team found,there was an error in Figure 8.Specifically,Figure 8E,Figure 8F and Figure 8G were mistakenly duplicated.The authors acknowledge that the original version of Figure 8 was incorrect and have provided the revised,correct version in this corrigendum.The authors would like to assert that there is no change in the body text of the article.
基金supported by the Natural Science Foundation of China(82560923)Natural Science Foundation of InnerMongolia(2019MS08008)+1 种基金Natural Science Foundation of Inner Mongolia Joint Program(2023LHMS08075)General Project of Inner Mongolia Medical University(YKD2025MS026).
文摘Objective Forsythia suspensa has long been utilized in traditional Chinese medicine(TCM)for the treatment of IgA nephropathy(IgAN),the most prevalent form of primary glomerular disease.However,the precise mechanisms remain inadequately understood.This study seeks to elucidate the underlying mechanisms of Forsythia suspensa extract(FSE)in the treatment of IgAN by employing an integrated approach that combines network pharmacology with in vivo experimental validation.Methods The chemical components of FSE were identified using high-performance liquid chromatography-mass spectrometry(HPLC–MS/MS).Additional chemical components and targets were determined through the Traditional Chinese Medicine Systems Pharmacology database.Potential therapeutic targets for IgAN were sourced from GeneCards and the Comparative Toxicogenomics Database.Subsequently,the enrichment analyses were conducted to evaluate the biological functions and pathways associated with the core targets.Finally,a mousemodel of IgAN was developed to validate the findings of the network pharmacology analysis.Results Through network analysis and HPLC–MS/MS,31 chemical components of FSE were identified.A total of 99 common targets were discovered between FSE and IgAN.The enrichment analyses suggested that FSE may mitigate IgAN primarily by inhibiting the TLR and NF-κB signaling pathways.In vivo experiments demonstrated that FSE reduced inflammation and preserved renal function in mice with IgAN through the Tolllike receptor 9(TLR9)/NF-κB pathway.Conclusion The integration of network pharmacology and animal experiments suggests that FSE alleviates renal inflammation and damage in IgAN through the TLR9/NF-κB signaling pathway.
文摘In Saharan climates,greenhouses face extreme diurnal temperature fluctuations that generate thermal stress,reduce crop productivity,and hinder sustainable agricultural practices.Passive thermal storage using Phase Change Materials(PCM)is a promising solution to stabilize microclimatic conditions.This study aims to evaluate experimentally and numerically the effectiveness of PCM integration for moderating greenhouse temperature fluctuations under Saharan climatic conditions.Two identical greenhouse prototypes were constructed in Ghardaia,Algeria:a reference greenhouse and a PCM-integrated greenhouse using calcium chloride hexahydrate(CaCl_(2)⋅6H_(2)O).Thermal performance was assessed during a five-day experimental period(7–11May 2025)under severe ambient conditions.To complement this,a Nonlinear Auto-Regressive with eXogenous inputs(NARX)neural network model was developed and trained using a larger dataset(7–25 May 2025)to predict greenhouse thermal dynamics.The PCM greenhouse reduced peak daytime air temperature by an average of 8.14℃and decreased the diurnal temperature amplitude by 53.6%compared to the reference greenhouse.The NARX model achieved high predictive accuracy(R^(2)=0.990,RMSE=0.425℃,MAE=0.223℃,MBE=0.008℃),capturing both sensible and latent heat transfer mechanisms,including PCM melting and solidification.The combined experimental and predictive modeling results confirm the potential of PCM integration as an effective passive thermal regulation strategy for greenhouses in arid regions.This approach enhances microclimatic stability,improves energy efficiency,and supports the sustainability of protected agriculture under extreme climatic conditions.
文摘Practice training is very important for students learning Computer networks.But building a real laboratory is constrained and expensive.In this paper,we present an online experimental platform for computer networks course based on Dynamips simulator.Instructors and students can access the platform by IE Browser to manage and take router experiments.On the basis of deployment and testing,the platform is effective and flexible.
文摘As the key link of cultivating the talents, the experimental teaclamg laas become an ~mportant part m me system o~ me innovation in higher education. And it plays an indispensable role in the teaching system of the computer specialty. The article analyzes the current situation of the experimental teaching in computer specialty, and puts forward the reform measures and methods of the diversified experimental teaching, which can effectively improve teaching effect.
文摘This paper analyzes the basic interactivity connotation of network teaching from the interactive definition, function, types and level etc., and established the interaction quality evaluation index system from the four angles between student and media, the course content, teacher and peer interaction. Similarly, network instruction interaction also needs to carry on the design from the perspective of instructional design, and take full advantage of the Internet, and finally achieved good network interaction effect. Practice shows that, research on network interactive strategy significance.
基金funded by scientific research projects under Grant JY2024B011.
文摘With the increasing complexity of industrial automation,planetary gearboxes play a vital role in largescale equipment transmission systems,directly impacting operational efficiency and safety.Traditional maintenance strategies often struggle to accurately predict the degradation process of equipment,leading to excessive maintenance costs or potential failure risks.However,existing prediction methods based on statistical models are difficult to adapt to nonlinear degradation processes.To address these challenges,this study proposes a novel condition-based maintenance framework for planetary gearboxes.A comprehensive full-lifecycle degradation experiment was conducted to collect raw vibration signals,which were then processed using a temporal convolutional network autoencoder with multi-scale perception capability to extract deep temporal degradation features,enabling the collaborative extraction of longperiod meshing frequencies and short-term impact features from the vibration signals.Kernel principal component analysis was employed to fuse and normalize these features,enhancing the characterization of degradation progression.A nonlinear Wiener process was used to model the degradation trajectory,with a threshold decay function introduced to dynamically adjust maintenance strategies,and model parameters optimized through maximum likelihood estimation.Meanwhile,the maintenance strategy was optimized to minimize costs per unit time,determining the optimal maintenance timing and preventive maintenance threshold.The comprehensive indicator of degradation trends extracted by this method reaches 0.756,which is 41.2%higher than that of traditional time-domain features;the dynamic threshold strategy reduces the maintenance cost per unit time to 55.56,which is 8.9%better than that of the static threshold optimization.Experimental results demonstrate significant reductions in maintenance costs while enhancing system reliability and safety.This study realizes the organic integration of deep learning and reliability theory in the maintenance of planetary gearboxes,provides an interpretable solution for the predictive maintenance of complex mechanical systems,and promotes the development of condition-based maintenance strategies for planetary gearboxes.
文摘The development of information technology, especially the rise of online teaching platforms, has changed the way people read and the methods they use. Under this influence, primary school students’ independent reading has also been changed. However, due to limited self-control and understanding, primary school students face certain difficulties when using online teaching platforms for independent reading. Advantages and disadvantages of distance learning based on the network teaching platform were summarized in this paper. A one-year experiment study was carried out on our school fifth-grade students in independent reading using WeChat campus platform considering their current situation and existing problems of independent reading. In experiment study an independent reading mode was introduced. The results show that this reading mode can significantly improve students’ independent reading ability.
基金This research was supported by the 2021 Ministry of Education Industry-University Cooperation Collaborative Education Project-Discussion on Online and Offline Hybrid Teaching of Customer Relationship Management”(Project Number:202101101013).
文摘Aiming at the issue of professional engineering certification,this article introduces the hybrid teaching method to the teaching of Principles of Computer Composition,as the core course of computer specialty in applied undergraduate colleges,as well as discusses the experimental teaching method of this course.The teaching scheme is designed in the aspects of experimental teaching platform,teaching content,and student achievement assessment.By making full use of online and offline resources,this teaching method realizes the diversification of learning materials and learning means,the three-dimensional learning space and learning time,as well as effectively improves the teaching effect and quality.
基金The 2021 Heilongjiang Education Scientific Planning Key Projects"Research and Practice of‘Multi-Course Fusion’Online and Ofifline Hybrid Teaching Mode Based on Improving Employment Competitiveness-Taking Computer Basic Course as An Example"(Project Number:GJB1421199 and GJB1422190)The 2019 Teaching Research Project of Heilongjiang Bayi Agricultural University"Online and Offline Hybrid Teaching of Office Automation Course"(Project Number:NDJY1918)The 2021 Teaching Research Project of Heilongjiang Bayi Agricultural University"Machine Learning Course Based on Case Teaching in Application Exploration of Big Data Specialty"(Project Number:NDJY2121)。
文摘The Computer Network course is widely offered in colleges and universities.This course is both theoretical and practical.It organically combines theory and practice in order to achieve the goal of teaching.The main objective of the course is to train students to have various skills,including those of enterprise scale network construction,network management,and network maintenance.Influenced by traditional teaching for a long time,the existing teaching of the course in colleges and universities urgently needs reform;otherwise,it will not be able to meet the social demand for talents in the new era.This paper focuses on the practical problems of the Computer Network teaching reform and proposes some efiective reform suggestions,hoping to engender an efficient link among the Computer Network course teaching,talent training,and the social needs in colleges and universities.
文摘With the continuous development of computer network technology, it has been widely used in all walks of life, and gradually penetrated into people's life and learning, giving people great convenience, but it also poses a serious network security threat to people's information. Therefore, in order to avoid the threat of network security, many technical colleges in China have specially set up computer network complete teaching courses, and are teaching students relevant computer security courses. However, in the actual teaching process, many computers will have various problems in teaching network security technology, and the teaching funds of technical colleges are limited. Therefore, in order to meet the learning needs of students and good teaching effect, virtual machine technology is introduced. This technology can greatly reduce the teaching funds and promote the smooth development of computer network security teaching, in order to achieve better teaching effect.
文摘With the continuous development of science and technology and economic level in our country, especially in recent years, the development of Internet technology has brought great convenience to people's work and life. The application of computer network technology is more and more extensive, and it plays a huge role in all walks of life, so the importance of network security is highlighted. Therefore, in vocational education, a group of talents with professional knowledge of computer network security technology will be trained by reforming the teaching mode. This paper is a discussion based on the task-driven teaching reform of computer network security technology in vocational education.
