Beryllium(^(9)Be)serves as a crucial neutron multiplier and reflection material,being extensively employed in the nuclear industry.The evaluated nuclear data are utilized in the design of the nuclear devices.Following...Beryllium(^(9)Be)serves as a crucial neutron multiplier and reflection material,being extensively employed in the nuclear industry.The evaluated nuclear data are utilized in the design of the nuclear devices.Following the interaction between neutrons and^(9)Be,all neutrons generated stem from the^(9)Be(n,2n)^(8)Be reaction channel,except for the elastic scattering reaction channel.Nevertheless,the data of the outgoing neutron double differential cross section of the reaction channel provided by the latest internationally evaluated libraries still exhibit considerable discrepancies.A shielding integral experiment based on slab^(9)Be samples with measurements of neutron spectra leaked from different angles is an effective approach to verify the double differential cross-section data.Hence,in this study,a shielding integral experiment of^(9)Be samples of different thicknesses was conducted using a nanosecond pulsed deuterium-tritium neutron source established by the China Institute of Atomic Energy.The neutron time-of-flight spectra of three thicknesses(4.4 cm,8.8 cm,and 13.2 cm)and six angles(47°,58°,73°,107°,122°,and 133°)were measured by the neutron time-of-flight method,and 18 sets of experimental data were obtained.Additionally,the MCNP-4C program was used to obtain the simulated results of the leakage neutron spectra using the evaluated nuclear data of^(9)Be from the CENDL-3.2,ENDF/B-Ⅷ.0,JENDL-5,and JEFF-3.3 libraries.The simulated results of the leakage neutron spectra were compared with the experimental results,and the results showed that in the elastic scattering energy region,the simulated results from the CENDL-3.2,ENDF/B-Ⅷ.0,and JENDL-5 libraries were slightly higher at small angles and slightly lower at large angles.In the(n,2n)energy region,the simulated results from the CENDL-3.2 library were significantly different from the experimental results in terms of spectral shape,and the simulated results from the ENDF/B-Ⅷ.0 and the JENDL-5 libraries were in good agreement with the experimental results at small angles but low at large angles.The simulated results from the JEFF-3.3 library showed serious underestimation at all angles.展开更多
An experimental program was initiated to investigate the seismic performance of built-up laced steel brace members. Quasi-static testing of twelve typical steel built-up laced member （BLM） specimens was conducted. T...An experimental program was initiated to investigate the seismic performance of built-up laced steel brace members. Quasi-static testing of twelve typical steel built-up laced member （BLM） specimens was conducted. These were designed to span a range of parameters typically encountered for such members based on findings from a survey of commonly used shapes and details that have been historically used. The specimens were subdivided into groups of three different cross-sectional shapes, namely built-up I-shape section, and built-up box shapes buckling about the x or the y axis. Within each group, global and local buckling slenderness ratios had either kl/r values of 60 or 120, and b/t ratios of 8 or 16. The specific inelastic cyclic behavior germane to each specimen, and general observations on overall member hysteretic behavior as a function of the considered parameters, are reported. A companion paper （Lee and Bruneau 2008） investigates this observed response against predictions from analytical models, and behavior in the perspective of system performance.展开更多
Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Thl cells play an important role in the pathogenesis of experimental allergic encephalomyel...Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Thl cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund＇s adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed in- flammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot anatysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of ex- perimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis.展开更多
[目的]针对《生物统计与试验设计》课程中数据处理复杂、学生参与度低等问题,开发一款轻量化教学工具,探索数字化教学改革的有效路径。[方法]基于Uniapp跨平台框架,结合豆包人工智能辅助开发技术,构建集成生物统计计算、试验设计模拟及...[目的]针对《生物统计与试验设计》课程中数据处理复杂、学生参与度低等问题,开发一款轻量化教学工具,探索数字化教学改革的有效路径。[方法]基于Uniapp跨平台框架,结合豆包人工智能辅助开发技术,构建集成生物统计计算、试验设计模拟及案例实操功能的微信小程序,在实验班(医动2211,n=23)与对照班(医动2212,n=26)开展对比教学实验,评估小程序的应用效果。[结果]教学实践数据显示:实验组学生完成数据处理任务的平均耗时较对照组缩短43.75%(45 min vs.80 min),课堂主动提问频次提升149%(2.64次/课vs.1.06次/课),理论知识考核成绩提高21.4%(85分vs.70分),实践操作成绩提升33.3%(40分vs.30分),差异均具有统计学意义(P<0.05);问卷调查表明,实验组学生课堂参与积极性达70%,显著高于对照组的35%。[结论]基于Uniapp和豆包AI的轻量化开发的微信小程序,显著提升了学生的理论理解深度与实践能力,为职业院校专业课程的数字化转型提供了可复制的解决方案。未来可进一步优化小程序功能,深化工具与教学场景的融合。展开更多
A quadratic bilevel programming problem is transformed into a single level complementarity slackness problem by applying Karush-Kuhn-Tucker（KKT） conditions.To cope with the complementarity constraints,a binary encod...A quadratic bilevel programming problem is transformed into a single level complementarity slackness problem by applying Karush-Kuhn-Tucker（KKT） conditions.To cope with the complementarity constraints,a binary encoding scheme is adopted for KKT multipliers,and then the complementarity slackness problem is simplified to successive quadratic programming problems,which can be solved by many algorithms available.Based on 0-1 binary encoding,an orthogonal genetic algorithm,in which the orthogonal experimental design with both two-level orthogonal array and factor analysis is used as crossover operator,is proposed.Numerical experiments on 10 benchmark examples show that the orthogonal genetic algorithm can find global optimal solutions of quadratic bilevel programming problems with high accuracy in a small number of iterations.展开更多
An integer linear bilevel programming problem is firstly transformed into a binary linear bilevel programming problem, and then converted into a single-level binary implicit programming. An orthogonal genetic algorith...An integer linear bilevel programming problem is firstly transformed into a binary linear bilevel programming problem, and then converted into a single-level binary implicit programming. An orthogonal genetic algorithm is developed for solving the binary linear implicit programming problem based on the orthogonal design. The orthogonal design with the factor analysis, an experimental design method is applied to the genetic algorithm to make the algorithm more robust, statistical y sound and quickly convergent. A crossover operator formed by the orthogonal array and the factor analysis is presented. First, this crossover operator can generate a smal but representative sample of points as offspring. After al of the better genes of these offspring are selected, a best combination among these offspring is then generated. The simulation results show the effectiveness of the proposed algorithm.展开更多
基金supported by the National Natural Science Foundation of China(Nos.11775311,U2167203,U2067205 and 12075105)Research and development project of China National Nuclear Corporation(FD010241222552)+2 种基金Continuous-Support Basic Scientific Research Project(BJ010261223282)Major Science and Technology Projects of Gansu Province(22ZD6GB020)Fundamental Research Funds for the Central Universities(lzujbky-2024-jdzx10)。
文摘Beryllium(^(9)Be)serves as a crucial neutron multiplier and reflection material,being extensively employed in the nuclear industry.The evaluated nuclear data are utilized in the design of the nuclear devices.Following the interaction between neutrons and^(9)Be,all neutrons generated stem from the^(9)Be(n,2n)^(8)Be reaction channel,except for the elastic scattering reaction channel.Nevertheless,the data of the outgoing neutron double differential cross section of the reaction channel provided by the latest internationally evaluated libraries still exhibit considerable discrepancies.A shielding integral experiment based on slab^(9)Be samples with measurements of neutron spectra leaked from different angles is an effective approach to verify the double differential cross-section data.Hence,in this study,a shielding integral experiment of^(9)Be samples of different thicknesses was conducted using a nanosecond pulsed deuterium-tritium neutron source established by the China Institute of Atomic Energy.The neutron time-of-flight spectra of three thicknesses(4.4 cm,8.8 cm,and 13.2 cm)and six angles(47°,58°,73°,107°,122°,and 133°)were measured by the neutron time-of-flight method,and 18 sets of experimental data were obtained.Additionally,the MCNP-4C program was used to obtain the simulated results of the leakage neutron spectra using the evaluated nuclear data of^(9)Be from the CENDL-3.2,ENDF/B-Ⅷ.0,JENDL-5,and JEFF-3.3 libraries.The simulated results of the leakage neutron spectra were compared with the experimental results,and the results showed that in the elastic scattering energy region,the simulated results from the CENDL-3.2,ENDF/B-Ⅷ.0,and JENDL-5 libraries were slightly higher at small angles and slightly lower at large angles.In the(n,2n)energy region,the simulated results from the CENDL-3.2 library were significantly different from the experimental results in terms of spectral shape,and the simulated results from the ENDF/B-Ⅷ.0 and the JENDL-5 libraries were in good agreement with the experimental results at small angles but low at large angles.The simulated results from the JEFF-3.3 library showed serious underestimation at all angles.
基金Federal Highway Administration Under Grant No. DTFH61-98-C-00094
文摘An experimental program was initiated to investigate the seismic performance of built-up laced steel brace members. Quasi-static testing of twelve typical steel built-up laced member （BLM） specimens was conducted. These were designed to span a range of parameters typically encountered for such members based on findings from a survey of commonly used shapes and details that have been historically used. The specimens were subdivided into groups of three different cross-sectional shapes, namely built-up I-shape section, and built-up box shapes buckling about the x or the y axis. Within each group, global and local buckling slenderness ratios had either kl/r values of 60 or 120, and b/t ratios of 8 or 16. The specific inelastic cyclic behavior germane to each specimen, and general observations on overall member hysteretic behavior as a function of the considered parameters, are reported. A companion paper （Lee and Bruneau 2008） investigates this observed response against predictions from analytical models, and behavior in the perspective of system performance.
基金financially sponsored by the Natural Science Foundation of Jiangsu Province in China,(General Program),No.BK2011267
文摘Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Thl cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein, complete Freund＇s adjuvant and Bordetella pertussis toxin into C57BL/6J mice. Experimental allergic encephalomyelitis mice developed disease and showed in- flammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections, demyelination by Luxol fast-blue staining and clinical manifestations. The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry, flow cytometry and western blot anatysis. The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice. Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of ex- perimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis.
文摘[目的]针对《生物统计与试验设计》课程中数据处理复杂、学生参与度低等问题,开发一款轻量化教学工具,探索数字化教学改革的有效路径。[方法]基于Uniapp跨平台框架,结合豆包人工智能辅助开发技术,构建集成生物统计计算、试验设计模拟及案例实操功能的微信小程序,在实验班(医动2211,n=23)与对照班(医动2212,n=26)开展对比教学实验,评估小程序的应用效果。[结果]教学实践数据显示:实验组学生完成数据处理任务的平均耗时较对照组缩短43.75%(45 min vs.80 min),课堂主动提问频次提升149%(2.64次/课vs.1.06次/课),理论知识考核成绩提高21.4%(85分vs.70分),实践操作成绩提升33.3%(40分vs.30分),差异均具有统计学意义(P<0.05);问卷调查表明,实验组学生课堂参与积极性达70%,显著高于对照组的35%。[结论]基于Uniapp和豆包AI的轻量化开发的微信小程序,显著提升了学生的理论理解深度与实践能力,为职业院校专业课程的数字化转型提供了可复制的解决方案。未来可进一步优化小程序功能,深化工具与教学场景的融合。
基金supported by the National Natural Science Foundation of China (60873099)
文摘A quadratic bilevel programming problem is transformed into a single level complementarity slackness problem by applying Karush-Kuhn-Tucker（KKT） conditions.To cope with the complementarity constraints,a binary encoding scheme is adopted for KKT multipliers,and then the complementarity slackness problem is simplified to successive quadratic programming problems,which can be solved by many algorithms available.Based on 0-1 binary encoding,an orthogonal genetic algorithm,in which the orthogonal experimental design with both two-level orthogonal array and factor analysis is used as crossover operator,is proposed.Numerical experiments on 10 benchmark examples show that the orthogonal genetic algorithm can find global optimal solutions of quadratic bilevel programming problems with high accuracy in a small number of iterations.
基金supported by the Fundamental Research Funds for the Central Universities(K50511700004)the Natural Science Basic Research Plan in Shaanxi Province of China(2013JM1022)
文摘An integer linear bilevel programming problem is firstly transformed into a binary linear bilevel programming problem, and then converted into a single-level binary implicit programming. An orthogonal genetic algorithm is developed for solving the binary linear implicit programming problem based on the orthogonal design. The orthogonal design with the factor analysis, an experimental design method is applied to the genetic algorithm to make the algorithm more robust, statistical y sound and quickly convergent. A crossover operator formed by the orthogonal array and the factor analysis is presented. First, this crossover operator can generate a smal but representative sample of points as offspring. After al of the better genes of these offspring are selected, a best combination among these offspring is then generated. The simulation results show the effectiveness of the proposed algorithm.
