A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), ...A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monoamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats展开更多
A new remote sensing method is described to determine the vertical distribution and total content of atmospheric ozone. The method combines surface infrared, satellite infrared and ultraviolet channels. The width of t...A new remote sensing method is described to determine the vertical distribution and total content of atmospheric ozone. The method combines surface infrared, satellite infrared and ultraviolet channels. The width of the infrared channels is 0.01 cm-1, less than Lorentz half-width at the earth's surface, rather than the present width, because these channels can obtain information about variations in the ozone profile below the profile main-peak. The numerical experiments show that the method has a satisfactory precision in determining total ozone content, just about I percent error, and vertical distribution from the earth to 65 km space. In addition, some semi-analysis functions lor calculating backscattered ultraviolet and a relaxation equation are described in this paper.展开更多
The effects of single dose of PGE2 combined with vitamin E and with estradiol on experimental atherosclerosis were studied by means of morphological, ultrastructural, autoradiographic and several functional techniques...The effects of single dose of PGE2 combined with vitamin E and with estradiol on experimental atherosclerosis were studied by means of morphological, ultrastructural, autoradiographic and several functional techniques. The results showed that two combined treatment groups had more coordinative inhibition on aortic and coronary atherosclerotic lesions, as well as on platelet aggregation, smooth muscle cell proliferation and lipid peroxidation than that of single dose of PGE2. It was revealed that the coordinative mechanism might be closely related to the synergistic inhibitory function of above-metioned drugs on endothelial permeability, platelet aggregation, smooth muscle cell proliferation and lipid peroxidation.展开更多
In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosen...In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosenberg's approach a. cold digestion with collagenase at 4C for 24 hours; b. sedimentation instead of centrifugation; c. elimination of tumor cells before the cultivation procedure. Compared with the original approach, the proliferation, activity and cytotoxicity of TILs obtained by the modified procedure were much improved. TILs' expansion-old was greater than that with the original approach. Cytotoxicity against rumor cells was more potent. Increased TILs' subsets were CD3 and CD8 cells. Meanwhile, we took tumor cells from tumor tissues to test their in vitro chemosensitivities to different drugs in order to select highly sensitive antitumor drugs for treatment of cases with advanced tumors. According to the design of using highly active TILs and highly sensitive drugs (H & H therapy), preliminary clinical results of 50 cases showed higher response rates than those in treatment with TIL / IL2, LAK / 1L2 and TIL+IL2+CTX. Less toxic side effects were observed in 14 patients.展开更多
The chemical-electronic structures of functional modules and their spatial arrangement mainly determine the functional performance of materials.Tetrahedral structural units in borates can be used to widen the band gap...The chemical-electronic structures of functional modules and their spatial arrangement mainly determine the functional performance of materials.Tetrahedral structural units in borates can be used to widen the band gap for designing deep-ultraviolet/ultraviolet(UV)nonlinear optical(NLO)materials,but they are rarely favored due to their weak optical nonlinearity.In this study,we investigate the second-harmonic generation(SHG)response of LiGeBO_(4) with a combined experimental and computational approach.LiGeBO_(4) achieves a balance between a large band gap(6.2 eV)and a strong SHG coefficient(double that of KH_(2)PO_(4)(KDP)),which rarely exists in tetrahedral-based crystals.The origin of the SHG effect in LiGeBO_(4) is analyzed in detail using density functional theory(DFT)calculations.The calculated frequency dependent SHG efficiency of LiGeBO_(4) is 1.1 pm V^(−1),which is in accordance with the experimental value.Based on the modern polarization theory,the nonlinear electronic polarization induced by an external electric field along the[001]direction is about 4 pm V^(−1),which indicates the SHG susceptibility is 2 pm V^(−1) along the z-direction.Moreover,the SHG-density result shows that the SHG effect of LiGeBO_(4) mostly comes from the Ge–B–O tetrahedral units.展开更多
A new highly solid-state luminescent dicationic Cu(I)_(4)metallacycle A based on a mixed P,As ligand assembly is reported for the first time.Surprisingly,as compared to a previously described related Cu(I)_(4)metallac...A new highly solid-state luminescent dicationic Cu(I)_(4)metallacycle A based on a mixed P,As ligand assembly is reported for the first time.Surprisingly,as compared to a previously described related Cu(I)_(4)metallacycle B based on a similar P,P ligand,a moderate effect of the presence of arsenic atoms in the photophysical processes is observed.A thorough combined experimental and theoretical study is conducted revealing that,in Cu(I)polymetallic assemblies bearing pnictogen ligands,the substitution of a phosphorus atom by an arsenic atom does not cause systematically an alteration of the SOC values and therefore an improvement of the radiative relaxation rates.Intermolecular constraints applied on the gross molecular backbones can play a major role,inducing subtle but noticeable structural alteration impacting optical changes that may differentiate the photophysics of the assemblies regarding the pnictogen atom present.In line with this point,luminescence thermochromism and mechanochromism are observed and analyzed for both A and B assemblies,which moreover also display in the solid state at high temperature an original irreversible thermal crystalline transition that impacts photophysical properties.All in all,this study highlights the subtle and competitive effects that can rule out the photophysics of Cu(I)polymetallic assemblies based on organo-pnictogen ligands and reveals their stimuli-sensitive behaviours,allowing the facile preparation of different phases bearing contrast efficient luminescence properties.展开更多
Tailoring material properties often requires understanding the solidification process.Herein,we introduce the geometric descriptor Soliquidy,which numerically captures the Euclidean transport cost between the translat...Tailoring material properties often requires understanding the solidification process.Herein,we introduce the geometric descriptor Soliquidy,which numerically captures the Euclidean transport cost between the translationally disordered versus ordered states of a materials.As a testbed,we apply Soliquidy to the classification of glass-forming metal alloys.By extending and combining an experimental library of metallic thin films(glass/no-glass)with the aflow.org computational database(geometrical and energetic information of mixtures)we found that the combination of Soliquity and formation enthalpies generates an effective classifier for glass formation.Such a classifier is then used to tackle a public dataset of metallic glasses showing that the glass-agnostic assumptions of Soliquity can be useful for understanding kinetically-controlled phase transitions.展开更多
文摘A better understanding is needed to explain the mechanism of therapeutic effect of combined use of tetradrine-PVNO and tetradrine-QOHP which play very important roles in treatment of silicosis. Blood prolidase (PLD), monoamine oxidase (MAO) and plasminogen (PLG) in silicotic rats after treatment with tetradrine-PVNO or tetradrine-QOHP were measured. The values obtained were compared with the untreated silicotic rats. It was found that the silicotic rats that received tetradrine-PVNO showed significant increase in PLD and decrease in PLG, but no significant change in MAO. The PLD in plasma of silicotic rats that received tetradrine-QOHP were elevated significantly, but PLG and MAO did not change appreciably. These findings suggest that the combined use of tetradrine-PVNO and tetradrine-QOHP can accelerate the degradation of collagen in silicotic rats
文摘A new remote sensing method is described to determine the vertical distribution and total content of atmospheric ozone. The method combines surface infrared, satellite infrared and ultraviolet channels. The width of the infrared channels is 0.01 cm-1, less than Lorentz half-width at the earth's surface, rather than the present width, because these channels can obtain information about variations in the ozone profile below the profile main-peak. The numerical experiments show that the method has a satisfactory precision in determining total ozone content, just about I percent error, and vertical distribution from the earth to 65 km space. In addition, some semi-analysis functions lor calculating backscattered ultraviolet and a relaxation equation are described in this paper.
基金This work was supported by grants form the National Natural Science Foundation of China
文摘The effects of single dose of PGE2 combined with vitamin E and with estradiol on experimental atherosclerosis were studied by means of morphological, ultrastructural, autoradiographic and several functional techniques. The results showed that two combined treatment groups had more coordinative inhibition on aortic and coronary atherosclerotic lesions, as well as on platelet aggregation, smooth muscle cell proliferation and lipid peroxidation than that of single dose of PGE2. It was revealed that the coordinative mechanism might be closely related to the synergistic inhibitory function of above-metioned drugs on endothelial permeability, platelet aggregation, smooth muscle cell proliferation and lipid peroxidation.
文摘In recent years, tumor-nfiltrating lymphocytes (TILs) have been reported to be effective for tumors in experimental and clinical research. In order to increase the therapeutical effect, we modified some steps of Rosenberg's approach a. cold digestion with collagenase at 4C for 24 hours; b. sedimentation instead of centrifugation; c. elimination of tumor cells before the cultivation procedure. Compared with the original approach, the proliferation, activity and cytotoxicity of TILs obtained by the modified procedure were much improved. TILs' expansion-old was greater than that with the original approach. Cytotoxicity against rumor cells was more potent. Increased TILs' subsets were CD3 and CD8 cells. Meanwhile, we took tumor cells from tumor tissues to test their in vitro chemosensitivities to different drugs in order to select highly sensitive antitumor drugs for treatment of cases with advanced tumors. According to the design of using highly active TILs and highly sensitive drugs (H & H therapy), preliminary clinical results of 50 cases showed higher response rates than those in treatment with TIL / IL2, LAK / 1L2 and TIL+IL2+CTX. Less toxic side effects were observed in 14 patients.
基金supported by the Western Light Foundation of CAS(Grant No.2017-XBQNXZ-B-006)the Shanghai Cooperation Organization Science and Technology Partnership Program(Grant No.2017E01013)+2 种基金the National Natural Science Foundation of China(Grant No.11774414,11474353)the Tianshan Innovation Team Program(Grant No.2018D14001)support from the“Fujian Institute of Innovation,Chinese Academy of Sciences”(Grant No.FJCXY18010202).
文摘The chemical-electronic structures of functional modules and their spatial arrangement mainly determine the functional performance of materials.Tetrahedral structural units in borates can be used to widen the band gap for designing deep-ultraviolet/ultraviolet(UV)nonlinear optical(NLO)materials,but they are rarely favored due to their weak optical nonlinearity.In this study,we investigate the second-harmonic generation(SHG)response of LiGeBO_(4) with a combined experimental and computational approach.LiGeBO_(4) achieves a balance between a large band gap(6.2 eV)and a strong SHG coefficient(double that of KH_(2)PO_(4)(KDP)),which rarely exists in tetrahedral-based crystals.The origin of the SHG effect in LiGeBO_(4) is analyzed in detail using density functional theory(DFT)calculations.The calculated frequency dependent SHG efficiency of LiGeBO_(4) is 1.1 pm V^(−1),which is in accordance with the experimental value.Based on the modern polarization theory,the nonlinear electronic polarization induced by an external electric field along the[001]direction is about 4 pm V^(−1),which indicates the SHG susceptibility is 2 pm V^(−1) along the z-direction.Moreover,the SHG-density result shows that the SHG effect of LiGeBO_(4) mostly comes from the Ge–B–O tetrahedral units.
基金supported by the CNRS,the ANR(ANR PRC SMAC and ANR PRC ISUPRALUM),the French‘Ministère de l’Enseignement Supérieur,de la Recherche et de l’Innovation’and the French‘Ministère des Affaires Etrangères’as well as by the Deutsche Forschungsgemeinschaft within the project Sche 384/42-1C.L.thanks the Alexander von Humboldt Foundation for a fellowship for experienced researchersR.U.,K.C.,and C.P.acknowledge the support by the“Grandéquipement national de calcul intensif(GENCI)”through HPC resources of CINES,TGCC and IDRIS(grants AD010800649R1).
文摘A new highly solid-state luminescent dicationic Cu(I)_(4)metallacycle A based on a mixed P,As ligand assembly is reported for the first time.Surprisingly,as compared to a previously described related Cu(I)_(4)metallacycle B based on a similar P,P ligand,a moderate effect of the presence of arsenic atoms in the photophysical processes is observed.A thorough combined experimental and theoretical study is conducted revealing that,in Cu(I)polymetallic assemblies bearing pnictogen ligands,the substitution of a phosphorus atom by an arsenic atom does not cause systematically an alteration of the SOC values and therefore an improvement of the radiative relaxation rates.Intermolecular constraints applied on the gross molecular backbones can play a major role,inducing subtle but noticeable structural alteration impacting optical changes that may differentiate the photophysics of the assemblies regarding the pnictogen atom present.In line with this point,luminescence thermochromism and mechanochromism are observed and analyzed for both A and B assemblies,which moreover also display in the solid state at high temperature an original irreversible thermal crystalline transition that impacts photophysical properties.All in all,this study highlights the subtle and competitive effects that can rule out the photophysics of Cu(I)polymetallic assemblies based on organo-pnictogen ligands and reveals their stimuli-sensitive behaviours,allowing the facile preparation of different phases bearing contrast efficient luminescence properties.
基金supported by the Office of Naval Research under grants N00014-20-1-2200 and N00014-20-1-2225supported by high-performance computer time and resources from the DoD High-Performance Computing Modernization Program(Frontier).We acknowledge Auro Scientific,LLC for computational support.
文摘Tailoring material properties often requires understanding the solidification process.Herein,we introduce the geometric descriptor Soliquidy,which numerically captures the Euclidean transport cost between the translationally disordered versus ordered states of a materials.As a testbed,we apply Soliquidy to the classification of glass-forming metal alloys.By extending and combining an experimental library of metallic thin films(glass/no-glass)with the aflow.org computational database(geometrical and energetic information of mixtures)we found that the combination of Soliquity and formation enthalpies generates an effective classifier for glass formation.Such a classifier is then used to tackle a public dataset of metallic glasses showing that the glass-agnostic assumptions of Soliquity can be useful for understanding kinetically-controlled phase transitions.
