The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the...The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness,promote heat dissipation,and unblock the fu organs.The herbs selected primarily include honeysuckle,Forsythia,and mint to relieve the exterior and promote heat dissipation;Agastache and magnolia bark to transform and dry dampness;Scutellaria,blackberry lily,and licorice to clear heat,detoxify,and benefit the throat;and magnolia bark and bitter orange to unblock the fu organs and purge heat.The flexible combination of these herbs with acupoints such as Shenque,Zhongwan,Tiantu,and Feishu fully leverages the synergistic effects of both the herbs and acupoints,resulting in a significant therapeutic effect.This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.展开更多
OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary d...OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying mechanism.METHODS: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were evaluated.RESULTS: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated group.CONCLUSION: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.展开更多
目的研究补肾祛痰化瘀健脑法在治疗阿尔茨海默病中作用及对患者智力状态及生活能力的影响。方法选取2023年4月—2024年1月医院诊治的阿尔茨海默病患者80例,采用单双号法对患者进行分组,分为观察组、对照组,每组40例。对照组采用西药盐...目的研究补肾祛痰化瘀健脑法在治疗阿尔茨海默病中作用及对患者智力状态及生活能力的影响。方法选取2023年4月—2024年1月医院诊治的阿尔茨海默病患者80例,采用单双号法对患者进行分组,分为观察组、对照组,每组40例。对照组采用西药盐酸多奈哌齐治疗,观察组采用补肾祛痰化瘀健脑法联合西药盐酸多奈哌齐治疗,均用药12周,比较两组患者症状(中医证候评分)、智力状态[阿尔茨海默病评定量表认知分表(Alzheimer's Disease Assessment Scale-cognitive subscale,ADAS-Cog)、简易精神状态检查量表(Mini-Mental State Examination,MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)]、生活能力[日常生活能力量表(Activity of Daily Living Scale,ADL)]、血清指标[β-淀粉样蛋白(amyloid β-protein,Aβ)、磷酸化Tau(phosphorylated Tau protein,p-Tau)蛋白、促肾上腺皮质激素释放因子(corticotropin-releasing factor,CRF)、促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)和皮质醇(cortisol,CORT)]及不良反应情况。结果治疗后,观察组中医证候二便失禁、腰膝酸软、耳鸣耳聋、夜尿频多评分均显著下降(P<0.05),并且观察组低于对照组(P<0.05);治疗后,两组ADAS-Cog、MMSE、MoCA评分以及ADL评分均显著改善(P<0.05),观察组优于对照组(P<0.05);治疗后,两组血清Aβ、p-Tau蛋白、CRF、ACTH、CORT水平均显著改善(P<0.05),观察组优于对照组(P<0.05)。两组均无严重不良反应发生。结论补肾祛痰化瘀健脑法治疗阿尔茨海默病能够显著改善患者症状,提高其智力状态及生活能力,可以作为安全、有效的优选治疗方案。展开更多
The objective of this study was to compare the effect of linseed and canola expeller on average daily weight gain(ADG),concentrate intakes,incidence of diarrhea,serum haptoglobin,interleukin(IL)-1,and resolvin-E1 in f...The objective of this study was to compare the effect of linseed and canola expeller on average daily weight gain(ADG),concentrate intakes,incidence of diarrhea,serum haptoglobin,interleukin(IL)-1,and resolvin-E1 in female Holstein calves from birth to weaning.A sample size of 20 calves per group was calculated and were randomly allocated at the time of birth.Linseed group(LIN)was fed a starter with linseed expeller,while canola group(CAN)received a similar concentrate,but with canola expeller.Both expellers were included at a rate of 25%dry matter(DM)basis of the starter.Pasteurized waste milk was fed twice a day until weaning.Calves were weighed at birth,30,and 60 d of age.Starter intake was evaluated daily from 5 to 60 d.A blood sample was obtained at birth,14,28,35,and 49 d of age,and bovine serum resolvin-El,haptoglobin,and IL-1 were assayed by commercial enzyme-linked immunosorbent assay(ELISA)kits.Incidence of diarrhea and the duration of the events were also recorded.The effect of the interaction group by time on body weight(BW)and starter intake was not significant(P>0.05).Average daily gains(ADG)from 0 to 60 d for CAN and LIN groups were 0.680 and 0.675 kg/d(P>0.05),respectively.Incidences of diarrhea were 25%and 45%for CAN and LIN groups,respectively(P=0.18).LIN group had greater concentrations of IL-1 at d 21,haptoglobin at d 7,and resolving-El at d 14 and 49 than CAN group,respectively.It is concluded that BW at weaning,ADG,and concentrate intakes were not different between groups fed starters containing linseed or canola expeller(25%inclusion).The concentrations of cytokines and haptoglobin were the greatest in LIN group.展开更多
On August 30, the Graduate School of Huazhong University of Science and Technology announced it would expel students who were taking too long to complete advanced degrees. The relevant regulations say completing a mas...On August 30, the Graduate School of Huazhong University of Science and Technology announced it would expel students who were taking too long to complete advanced degrees. The relevant regulations say completing a master’s degree shouldn’t take longer than four years and a doctor’s degree eight.展开更多
文摘The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness,promote heat dissipation,and unblock the fu organs.The herbs selected primarily include honeysuckle,Forsythia,and mint to relieve the exterior and promote heat dissipation;Agastache and magnolia bark to transform and dry dampness;Scutellaria,blackberry lily,and licorice to clear heat,detoxify,and benefit the throat;and magnolia bark and bitter orange to unblock the fu organs and purge heat.The flexible combination of these herbs with acupoints such as Shenque,Zhongwan,Tiantu,and Feishu fully leverages the synergistic effects of both the herbs and acupoints,resulting in a significant therapeutic effect.This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.
基金Natural Science Foundation of Jiangsu Province(No.BK20171098)Jiangsu Province 12th Five-Year Plan for the construction of Key Traditional Chinese Medicine Discipline(No.JS1302)Project of Affiliated Hospital of Nanjing University of Traditional Chinese Medicine(No.Y17002)
文摘OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying mechanism.METHODS: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were evaluated.RESULTS: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated group.CONCLUSION: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.
文摘目的研究补肾祛痰化瘀健脑法在治疗阿尔茨海默病中作用及对患者智力状态及生活能力的影响。方法选取2023年4月—2024年1月医院诊治的阿尔茨海默病患者80例,采用单双号法对患者进行分组,分为观察组、对照组,每组40例。对照组采用西药盐酸多奈哌齐治疗,观察组采用补肾祛痰化瘀健脑法联合西药盐酸多奈哌齐治疗,均用药12周,比较两组患者症状(中医证候评分)、智力状态[阿尔茨海默病评定量表认知分表(Alzheimer's Disease Assessment Scale-cognitive subscale,ADAS-Cog)、简易精神状态检查量表(Mini-Mental State Examination,MMSE)、蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)]、生活能力[日常生活能力量表(Activity of Daily Living Scale,ADL)]、血清指标[β-淀粉样蛋白(amyloid β-protein,Aβ)、磷酸化Tau(phosphorylated Tau protein,p-Tau)蛋白、促肾上腺皮质激素释放因子(corticotropin-releasing factor,CRF)、促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)和皮质醇(cortisol,CORT)]及不良反应情况。结果治疗后,观察组中医证候二便失禁、腰膝酸软、耳鸣耳聋、夜尿频多评分均显著下降(P<0.05),并且观察组低于对照组(P<0.05);治疗后,两组ADAS-Cog、MMSE、MoCA评分以及ADL评分均显著改善(P<0.05),观察组优于对照组(P<0.05);治疗后,两组血清Aβ、p-Tau蛋白、CRF、ACTH、CORT水平均显著改善(P<0.05),观察组优于对照组(P<0.05)。两组均无严重不良反应发生。结论补肾祛痰化瘀健脑法治疗阿尔茨海默病能够显著改善患者症状,提高其智力状态及生活能力,可以作为安全、有效的优选治疗方案。
文摘The objective of this study was to compare the effect of linseed and canola expeller on average daily weight gain(ADG),concentrate intakes,incidence of diarrhea,serum haptoglobin,interleukin(IL)-1,and resolvin-E1 in female Holstein calves from birth to weaning.A sample size of 20 calves per group was calculated and were randomly allocated at the time of birth.Linseed group(LIN)was fed a starter with linseed expeller,while canola group(CAN)received a similar concentrate,but with canola expeller.Both expellers were included at a rate of 25%dry matter(DM)basis of the starter.Pasteurized waste milk was fed twice a day until weaning.Calves were weighed at birth,30,and 60 d of age.Starter intake was evaluated daily from 5 to 60 d.A blood sample was obtained at birth,14,28,35,and 49 d of age,and bovine serum resolvin-El,haptoglobin,and IL-1 were assayed by commercial enzyme-linked immunosorbent assay(ELISA)kits.Incidence of diarrhea and the duration of the events were also recorded.The effect of the interaction group by time on body weight(BW)and starter intake was not significant(P>0.05).Average daily gains(ADG)from 0 to 60 d for CAN and LIN groups were 0.680 and 0.675 kg/d(P>0.05),respectively.Incidences of diarrhea were 25%and 45%for CAN and LIN groups,respectively(P=0.18).LIN group had greater concentrations of IL-1 at d 21,haptoglobin at d 7,and resolving-El at d 14 and 49 than CAN group,respectively.It is concluded that BW at weaning,ADG,and concentrate intakes were not different between groups fed starters containing linseed or canola expeller(25%inclusion).The concentrations of cytokines and haptoglobin were the greatest in LIN group.
文摘On August 30, the Graduate School of Huazhong University of Science and Technology announced it would expel students who were taking too long to complete advanced degrees. The relevant regulations say completing a master’s degree shouldn’t take longer than four years and a doctor’s degree eight.
