The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the...The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness,promote heat dissipation,and unblock the fu organs.The herbs selected primarily include honeysuckle,Forsythia,and mint to relieve the exterior and promote heat dissipation;Agastache and magnolia bark to transform and dry dampness;Scutellaria,blackberry lily,and licorice to clear heat,detoxify,and benefit the throat;and magnolia bark and bitter orange to unblock the fu organs and purge heat.The flexible combination of these herbs with acupoints such as Shenque,Zhongwan,Tiantu,and Feishu fully leverages the synergistic effects of both the herbs and acupoints,resulting in a significant therapeutic effect.This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.展开更多
OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary d...OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying mechanism.METHODS: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were evaluated.RESULTS: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated group.CONCLUSION: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.展开更多
A 30-year-old female patient with Bartholin’s abscess was treated by acupuncture.Before visit,she had taken wuwei xiaodu yin for 4 consecutive days,but the symptoms were not alleviated markedly and pain was worsening...A 30-year-old female patient with Bartholin’s abscess was treated by acupuncture.Before visit,she had taken wuwei xiaodu yin for 4 consecutive days,but the symptoms were not alleviated markedly and pain was worsening.According to the conditions of tongue and pulse,and physical signs,the case was differ-entiated as pathogenic heat invading blood phase;and the injury of qi and yin by the herbal decoction the patient took before.In treatment with acupuncture,the treatment principle focused on benefiting qi,nourishing yin,expelling pus from the interior and draining toxin,and promoting the circulations of meridians to stop pain.He-sea points were selected to clear heat and resolve damp,and replenish the liver and kidney;and the acupoints of bladder meridian were combined under the guidance of“taiyang dominating the openings,”aiming at elevating qi and expelling toxin from the interior.Acupuncture was given once daily.After treated for 4 days,abscess was ruptured,pain disappeared,and no recurrence was presented and no sequelae happened during over 2 years of follow-up.This case shows that acupuncture is effective on Bartholin’s abscess.By reviewing this case,it is put forward that there may by the signs before the onset of Bartholin’s abscess,and the treatment should focus on opening a way for eliminating pathogens.Moreover,the clinical trial is required to verify acupuncture effect on this disease.展开更多
该研究基于药效、血浆药物化学、网络药理学及药代动力学等方法探讨咳宁颗粒止咳祛痰的质量标志物(Q-marker)。通过浓氨水引咳和酚红排泌试验评估咳宁颗粒的止咳、祛痰药效作用。采用超高效液相色谱-四极杆-静电场轨道阱串联质谱(UHPLC-...该研究基于药效、血浆药物化学、网络药理学及药代动力学等方法探讨咳宁颗粒止咳祛痰的质量标志物(Q-marker)。通过浓氨水引咳和酚红排泌试验评估咳宁颗粒的止咳、祛痰药效作用。采用超高效液相色谱-四极杆-静电场轨道阱串联质谱(UHPLC-Q-Exactive Plus Orbitrap HRMS)技术分析鉴定到咳宁颗粒的原型入血成分26个。网络药理学筛选出咳宁颗粒止咳祛痰的11个潜在活性成分,涉及IL6、TLR4、STAT3等40个共同靶点,主要参与PI3K/Akt、HIF-1、EGFR等信号通路。利用药代动力学定量分析了7个原型入血成分。通过有效性、传递性、可测性将壬二酸、咖啡酸、香草醛3个化合物作为咳宁颗粒止咳祛痰的质量标志物。该研究结果对于深入明确咳宁颗粒的药效物质基础、优化质量标准以及推动其临床应用具有重要意义。展开更多
[目的]综述胡柚皮化学成分、药理作用的研究进展,推进胡柚皮中药开发和临床应用。[方法]检索1994至2024年中国知网、万方、PubMed、Web of Science和Google Scholar等数据库中胡柚皮化学成分、药理活性及临床应用相关的研究报道,归纳总...[目的]综述胡柚皮化学成分、药理作用的研究进展,推进胡柚皮中药开发和临床应用。[方法]检索1994至2024年中国知网、万方、PubMed、Web of Science和Google Scholar等数据库中胡柚皮化学成分、药理活性及临床应用相关的研究报道,归纳总结胡柚皮的研究现状。[结果]现代研究表明,胡柚皮中含有多种生理活性成分,包括黄酮类化合物、柠檬苦素类化合物、香豆素类化合物、挥发油类化合物、酚酸类化合物、果胶、膳食纤维、类胡萝卜素等,具有抗氧化、抗菌、降血脂、降血糖、调节免疫、调节胃肠运动、保肝护肝、止咳祛痰等药理作用。目前胡柚皮的临床研究较少,偶有应用胡柚皮治疗呼吸系统疾病与运动系统疾病的文献报道。[结论]胡柚皮具有丰富的功能性化学成分、广泛的药理作用和一定的药用价值,随着研究的不断深入,胡柚皮在传统医药、临床应用及保健食品等方面的开发和利用将有着广阔的前景。展开更多
文摘The high incidence of hand,foot,and mouth disease(HFMD)in children,coupled with improper management,can lead to complications,causing significant distress to both patients and their parents.This article reports on the successful treatment of a case of HFMD with dampness-heat accumulation in the spleen type using a therapeutic approach of applying herbal patches to acupoints to disperse dampness,promote heat dissipation,and unblock the fu organs.The herbs selected primarily include honeysuckle,Forsythia,and mint to relieve the exterior and promote heat dissipation;Agastache and magnolia bark to transform and dry dampness;Scutellaria,blackberry lily,and licorice to clear heat,detoxify,and benefit the throat;and magnolia bark and bitter orange to unblock the fu organs and purge heat.The flexible combination of these herbs with acupoints such as Shenque,Zhongwan,Tiantu,and Feishu fully leverages the synergistic effects of both the herbs and acupoints,resulting in a significant therapeutic effect.This approach provides valuable insights and methodologies for the prevention and treatment of HFMD in children.
基金Natural Science Foundation of Jiangsu Province(No.BK20171098)Jiangsu Province 12th Five-Year Plan for the construction of Key Traditional Chinese Medicine Discipline(No.JS1302)Project of Affiliated Hospital of Nanjing University of Traditional Chinese Medicine(No.Y17002)
文摘OBJECTIVE: To investigate the effect of Daiqin phlegm-expelling pill, prepared with Traditional Chinese Medicine(TCM), on the development of inflammation in Sprague-Dawley(SD) rats with chronic obstructive pulmonary disease(COPD) induced by lipopolysaccharide(LPS) and smoke, and to identity the possible underlying mechanism.METHODS: Sixty male rats were divided into 6 groups(healthy control group, untreated group,Daiqin phlegm-expelling pill low, middle and high dose, and ambroxol hydrochloride tablet group).COPD was established in SD rats by sootiness and tracheal instillation with LPS. The rats were treated with Daiqin phlegm-expelling pill at the indicated doses for 28 d, the inflammatory cells in bronchoalveolar lavage fluid(BALF), the concentration of tumor necrosis factor-α(TNF-α), interleukin(IL)-8 and IL-6 in blood and the inflammation in lung were evaluated.RESULTS: The number of inflammatory cells in the BALF and TNF-ficantly redα, IL-8 and IL-6 level in plasma were signiuced in rats with COPD when treated with Daiqin phlegm-expelling pill or ambroxol hydrochloride tablet, compared with those without any treatment. The Daiqin phlegm-expelling pill treated rats with COPD had a attenuated inflammation in lung tissue, compared with the untreated group.CONCLUSION: Daiqin phlegm-expelling pill can significantly restrain the airway inflammation in rats with LPS-smoke induced COPD.
文摘A 30-year-old female patient with Bartholin’s abscess was treated by acupuncture.Before visit,she had taken wuwei xiaodu yin for 4 consecutive days,but the symptoms were not alleviated markedly and pain was worsening.According to the conditions of tongue and pulse,and physical signs,the case was differ-entiated as pathogenic heat invading blood phase;and the injury of qi and yin by the herbal decoction the patient took before.In treatment with acupuncture,the treatment principle focused on benefiting qi,nourishing yin,expelling pus from the interior and draining toxin,and promoting the circulations of meridians to stop pain.He-sea points were selected to clear heat and resolve damp,and replenish the liver and kidney;and the acupoints of bladder meridian were combined under the guidance of“taiyang dominating the openings,”aiming at elevating qi and expelling toxin from the interior.Acupuncture was given once daily.After treated for 4 days,abscess was ruptured,pain disappeared,and no recurrence was presented and no sequelae happened during over 2 years of follow-up.This case shows that acupuncture is effective on Bartholin’s abscess.By reviewing this case,it is put forward that there may by the signs before the onset of Bartholin’s abscess,and the treatment should focus on opening a way for eliminating pathogens.Moreover,the clinical trial is required to verify acupuncture effect on this disease.
文摘该研究基于药效、血浆药物化学、网络药理学及药代动力学等方法探讨咳宁颗粒止咳祛痰的质量标志物(Q-marker)。通过浓氨水引咳和酚红排泌试验评估咳宁颗粒的止咳、祛痰药效作用。采用超高效液相色谱-四极杆-静电场轨道阱串联质谱(UHPLC-Q-Exactive Plus Orbitrap HRMS)技术分析鉴定到咳宁颗粒的原型入血成分26个。网络药理学筛选出咳宁颗粒止咳祛痰的11个潜在活性成分,涉及IL6、TLR4、STAT3等40个共同靶点,主要参与PI3K/Akt、HIF-1、EGFR等信号通路。利用药代动力学定量分析了7个原型入血成分。通过有效性、传递性、可测性将壬二酸、咖啡酸、香草醛3个化合物作为咳宁颗粒止咳祛痰的质量标志物。该研究结果对于深入明确咳宁颗粒的药效物质基础、优化质量标准以及推动其临床应用具有重要意义。
文摘[目的]综述胡柚皮化学成分、药理作用的研究进展,推进胡柚皮中药开发和临床应用。[方法]检索1994至2024年中国知网、万方、PubMed、Web of Science和Google Scholar等数据库中胡柚皮化学成分、药理活性及临床应用相关的研究报道,归纳总结胡柚皮的研究现状。[结果]现代研究表明,胡柚皮中含有多种生理活性成分,包括黄酮类化合物、柠檬苦素类化合物、香豆素类化合物、挥发油类化合物、酚酸类化合物、果胶、膳食纤维、类胡萝卜素等,具有抗氧化、抗菌、降血脂、降血糖、调节免疫、调节胃肠运动、保肝护肝、止咳祛痰等药理作用。目前胡柚皮的临床研究较少,偶有应用胡柚皮治疗呼吸系统疾病与运动系统疾病的文献报道。[结论]胡柚皮具有丰富的功能性化学成分、广泛的药理作用和一定的药用价值,随着研究的不断深入,胡柚皮在传统医药、临床应用及保健食品等方面的开发和利用将有着广阔的前景。
