Objective:To investigate the positive eff ect of mindfulness training and exercise therapy on functional recovery and quality of life in elderly patients with fractures of the lower back.Methods:Collection of medical ...Objective:To investigate the positive eff ect of mindfulness training and exercise therapy on functional recovery and quality of life in elderly patients with fractures of the lower back.Methods:Collection of medical records of patients with lumbar vertebral fractures in Suzhou Municipal Hospital(North District),60 patients underwent percutaneous vertebroplasty(PVP/PKP),they were divided into control and experimental groups according to a random number table,30 people per group;In addition to traditional care method,Also intervened with behavioural awareness training and exercise therapy,By comparing the Oswestry dysfunction index score(ODI),visual simulation score(VAS),ability of daily living score(ADL),quality of life score(SF-36),To evaluate the eff ectiveness of the intervention.Results:Before the intervention,the ODI,VAS,ADL,and SF-36 scores were basically the same,with no significant diff erence(P>0.05).After treatment,the ODI and VAS scores of the experimental group and the control group were signifi cantly lower,and the experimental group was significantly lower than the control group(P<0.05);the ADL scores of the experimental group were signifi cantly higher than those of the control group(P<0.05);their SF-36 quality of life scores in all dimensions were signifi cantly higher(P<0.05).Conclusion:Through the rehabilitation treatment method combining mindfulness behavior training and exercise intervention,it can eff ectively promote the functional recovery of osteoporotic lumbar fractures in the elderly,thus reducing their pain and improving their quality of life.展开更多
Background Exercise during neoadjuvant chemoradiotherapy(NCRT)has potential to mitigate treatment-related declines in physical fitness,and to improve clinical outcomes,including toxicity and tumor response.However,opt...Background Exercise during neoadjuvant chemoradiotherapy(NCRT)has potential to mitigate treatment-related declines in physical fitness,and to improve clinical outcomes,including toxicity and tumor response.However,optimal frequency and timing of exercise remains to be determined.Therefore,this pilot trial aimed to assess feasibility of 2 different exercise interventions during NCRT in patients with esophageal and rectal cancer and to evaluate potential clinical effects.Methods Patients were randomized into 1 of 3 study arms during NCRT:(a)30-min aerobic exercise in-hospital within 1 h prior to each radiotherapy fraction(ExPR),(b)two 60-min supervised combined aerobic and resistance exercise sessions per week(AE+RE),and(c)usual care(UC).Feasibility was assessed by examining participation rate and exercise adherence.Intervention effects on physical fitness,health-related quality of life,treatment-related toxicity,and tumor response in patients with esophageal cancer were explored using regression analyses and 85%confidence intervals(85%CIs).Results Thirty-seven patients with esophageal cancer(participation rate=45%)and 2 patients with rectal cancer(participation rate=14%)were included.Median session attendance was 98%(interquartile range(IQR):96%–100%)in the ExPR and 78%(IQR:33%–100%)in the AE+RE group.We found clinically relevant benefits of exercise on maximal oxygen uptake(VO2_(max),mL/kg/min)(ExPR:β=9.7,85%CI:6.9–12.6;AE+RE:β=5.6,85%CI:2.6–8.5)and treatment-related toxicity(ExPR:β=–2.8,85%CI:–5.4 to–0.2;AE+RE:β=–2.6,85%CI:–5.3 to 0.0).Additionally,good tumor response was found in 70%in AE+RE and ExPR vs.55%in UC(odds ratio(OR)=1.9,85%CI:0.5–7.7).Conclusion Starting prehabilitation during NCRT is feasible,can increase starting fitness of traditional pre-surgical programs,and has potential to improve clinical outcomes.展开更多
Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postpra...Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)levels.Methods:Ninety cases of gestational diabetes mellitus diagnosed between June 2022 and June 2023 were selected and randomly divided into two groups of 45 cases each.The control group received conventional intervention,while the observation group received combined standardized nutritional care and exercise intervention.Blood glucose levels,adverse pregnancy outcomes,and adverse neonatal outcomes were compared.Results:On the day before delivery,the FPG,2hPG,and HbA1c levels of patients in the observation group were lower than those of patients in the control group(P<0.05).The incidence of adverse pregnancy outcomes(4.44%)and adverse neonatal outcomes(2.22%)in the observation group was lower than in the control group(P<0.05).Conclusion:The blood glucose levels of gestational diabetes mellitus patients can be controlled through standardized nutritional care and exercise interventions,leading to improved pregnancy and neonatal outcomes.展开更多
Lower back pain(LBP)has a relatively high incidence across various age groups,characterized by discomfort in the lumbosacral and iliosacral regions above the gluteal striatum and within the region below the costal mar...Lower back pain(LBP)has a relatively high incidence across various age groups,characterized by discomfort in the lumbosacral and iliosacral regions above the gluteal striatum and within the region below the costal margins.Some patients also experience varying degrees of leg pain,with many experiencing prolonged and recurrent symptoms.International consensus confirms that exercise intervention is an effective treatment method for lower back pain,offering safe and efficient physical therapy.Extensive practical experience suggests that Pilates exercises can effectively regulate the strength of muscle tissue in the peripheral region of the spine,improve muscle endurance,and alleviate low back pain caused by muscular factors.This study analyzes the effects of exercise intervention on the function and pain of patients with lower back pain.It explores various exercise modalities,utilizes SPSS26 statistics to gather data,and draws conclusions with the aim of providing theoretical references for exercise interventions in patients with lower back pain.展开更多
Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they...Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to "in 10 years,^ and one that sorted the results as "best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans.展开更多
Objective: to analyze the effect of combined physical therapy and exercise intervention on patients with cervical spondylosis. Methods: 62 patients with cervical spondylosis were randomly selected from January 2021 to...Objective: to analyze the effect of combined physical therapy and exercise intervention on patients with cervical spondylosis. Methods: 62 patients with cervical spondylosis were randomly selected from January 2021 to March 2022. They were randomly divided into group A (physical therapy) and group B (physical therapy + exercise intervention) by bicolor ball method. The effects of the two groups were compared. Results: after treatment, the cervical joint range of motion, quality of life score, NDI index, JOA score and VAS score in group B were better than those in group A (P0.05). Conclusion: the combination of physical therapy and exercise intervention has a better effect on improving cervical function, pain degree and quality of life in patients with cervical spondylosis.展开更多
This work was supported by the National Key Research and Development Program of China(2022YFC3500401),the National Natural Science Foundation of China(No.82205250)and the Natural Science Foundation of Shandong Provinc...This work was supported by the National Key Research and Development Program of China(2022YFC3500401),the National Natural Science Foundation of China(No.82205250)and the Natural Science Foundation of Shandong Province,China(No.ZR2021QH056).展开更多
Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in ...Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in the first phase of insulin secretion,is a primary contributor to the progression of T2D and its associated complications.Pancreaticβ-cells undergo dynamic compensation and decompensation processes during the development of T2D,in which metabolic stresses such as endoplasmic reticulum stress,oxidative stress,and inflammatory signals are key regulators ofβ-cell dynamics.Dietary and exercise interventions have been shown to be effective approaches for the treatment of obesity and T2D,especially in the early stages.Whilst the targeted tissues and underlying mechanisms of dietary and exercise interventions remain somewhat vague,accumulating evidence has implicated the improvement ofβ-cell functional capacity.In this review,we summarize recent advances in the understanding of the dynamic adaptations ofβ-cell function in T2D progression and clarify the effects and mechanisms of dietary and exercise interventions onβ-cell dysfunction in T2D.This review provides molecular insights into the therapeutic effects of dietary and exercise interventions on T2D,and more importantly,it paves the way for future research on the related underlying mechanisms for developing precision prevention and treatment of T2D.展开更多
Purpose： This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance （HOMA-IR） are maintained after discontinuation of intervention in the overweight/obese （OWOB） women...Purpose： This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance （HOMA-IR） are maintained after discontinuation of intervention in the overweight/obese （OWOB） women. Methods： The study subjects were from 2 independent studies with similar aerobic exercise （AE） intervention programs. In study I, I50WOB postmenopausal women with pre-diabetes （body mass index, BMI = 24-33 kg/m2, aged 52-65 years） completed an 8-month exercise intervention and were followed for 2 years after the intervention. In study lI, 12 OWOB （BM1 = 25-35 kg/m2, aged 30-50 years） premenopausal women participated in a 6-week AE and were followed for 4 years after the intervention. The exercise program consisted of progressive AE with intensity of 60%-75% of initial fitness level, 30-60 min/time and 3-5 times/week. Fat mass （FM） was assessed by Dual Energy X-ray Absorptiometry （DXA Prodigy; study I） or bioelectrical impedance device （Inbody 720; study II）. Plasma glucose and insulin were assessed by chemiluminescent immunoassay and HOMA-IR was calculated. Results： Both 8-month and 6-week moderate AE were effective in reducing HOMA-IR （-18.9%, p = 0.012 and -26.7%, p = 0.046, respectively）, and 8-month AE reduced FM at upper abdominal region （-6.2%, p = 0.021）. However, these improvements were not maintained in either study at the follow-up. Conclusion： The AE program used in these studies was effective to reduce insulin resistance and/or FM in central body region among overweight and obese women. However, when exercise intervention was discontinued, the beneficial effects following both short- and long-term intervention disappeared. Thus maintaining exercise seems to be required if one wants to reap the benefits of exercise in the long-term.展开更多
Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,th...Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.展开更多
Obesity,caused by excessive energy,leads to body weight gain and various diseases,including cognitive impairment.Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial f...Obesity,caused by excessive energy,leads to body weight gain and various diseases,including cognitive impairment.Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity.However,further exploration is needed to understand the specific mechanisms of high fat diet(HFD)-induced cognitive decline in obesity.In the present study,4-month-old mice were subjected to HFD feeding for 18 weeks,followed by aerobic exercise and high-intensity intermittent exercise,regular diet feeding,and intermittent fasting for 8 weeks,and then used to evaluate cognitive capacity,inflammation,compromised insulin signaling pathway,and apoptosis in hippocampal tissue,as well as AMPK/SIRT1 and TLR4 signal pathways.Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets.In contrast,aerobic exercise,high-intensity intermittent exercise,regular diet,and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway,thereby rescuing the cognitive impairment of obese mice.Therefore,diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.展开更多
The purpose of this study was to determine whether interventions could improve peroneal reaction time in both healthy and those with injured ankle participants based on a systematic review and meta-analysis.An electro...The purpose of this study was to determine whether interventions could improve peroneal reaction time in both healthy and those with injured ankle participants based on a systematic review and meta-analysis.An electronic search of the following database was carried out:MEDLINE,ScienceDirect and SPORTDiscus(1965–2020).Studies utilising sudden ankle inversion to measure peroneal reaction times were selected.28 studies were included for the systematic review,and 18 studies for the meta-analysis.The peroneal reaction time for pre-and post-intervention were compared into two groups,Group 1 was therapeutic exercise intervention,and Group 2 was prophylactic devices.The results showed a statistically significant difference in reduced peroneal reaction time in favour of participants in the exercise group(SMD=0.74,95%CI[1.09,0.39],p<0.001,I^(2)80%),while the prophylactic devices group showed no significant difference between control and intervention group.The effect size measured was 0.81 and 0.31 in Group 1 and Group 2,respectively.Faster peroneal muscle onset reaction time post-intervention,which was found following therapeutic exercise,should be considered for rehabilitation and preventing of ankle sprain injury.展开更多
Objective: to explore the application of exercise and diet intervention in elderly patients with COPD complicated with sarcopenia. Methods: the study period was from June 2019 to January 2021. Sixty-four elderly patie...Objective: to explore the application of exercise and diet intervention in elderly patients with COPD complicated with sarcopenia. Methods: the study period was from June 2019 to January 2021. Sixty-four elderly patients with COPD complicated with sarcopenia were randomly divided into the control group (n = 32) and the observation group (n = 32) according to the hospital label. The patients in the control group received routine care, while the patients in the observation group received exercise and diet intervention on the basis of routine care. The respiratory and motor functions and quality of life of the two groups of patients were evaluated. Results: after the nursing intervention, the lung function index of the observation group was improved more obviously than that of the control group (P < 0.05). It was better than the control group in activity, prevention and disease influence (P < 0.05). Conclusion: exercise and diet intervention for elderly COPD patients with sarcopenia can significantly improve the pulmonary function of patients, enhance vitality and disease prevention ability, and thus promote the early recovery of patients.展开更多
In recent years,the prevalence of diabetes in China has continued to rise,with the adult prevalence expected to reach 12.8%by 2023.To control this trend,the government has introduced several policies and invested subs...In recent years,the prevalence of diabetes in China has continued to rise,with the adult prevalence expected to reach 12.8%by 2023.To control this trend,the government has introduced several policies and invested substantial funds in the prevention and treatment of diabetes,achieving certain results.Prediabetes is a stage where blood glucose metabolism can still be restored.For individuals in this stage,dietary and exercise intervention programs are recommended to prevent or delay the onset of diabetes,improve quality of life,and reduce the burden of disease on individuals,families,and society.展开更多
Background Evidence on the effects of different exercise interventions on cognitive function is insufficient.Aims To evaluate the feasibility and effects of remotely supervised aerobic exercise(AE)and resistance exerc...Background Evidence on the effects of different exercise interventions on cognitive function is insufficient.Aims To evaluate the feasibility and effects of remotely supervised aerobic exercise(AE)and resistance exercise(RE)interventions in older adults with mild cognitive impairment(MCI).Methods This study is a 6-month pilot three-arm randomised controlled trial.Eligible participants(n=108)were recruited and randomised to the AE group,RE group or control(CON)group with a 1:1:1 ratio.Interventions were delivered at home with remote supervision.We evaluated participants’global cognition,memory,executive function,attention,physical activity levels,physical performance and muscle strength of limbs at baseline,3 months(T1)and 6 months(T2)after randomisation.A linear mixed-effects model was adopted for data analyses after controlling for covariates.Tukey’s method was used for adjusting for multiple comparisons.Sensitivity analyses were performed after excluding individuals with low compliance rates.Results 15(13.89%)participants dropped out.The median compliance rates in the AE group and RE group were 67.31%and 93.27%,respectively.After adjusting for covariates,the scores of the Alzheimer’s Disease Assessment Scale-Cognitive subscale in the AE group decreased by 2.04(95%confidence interval(CI)−3.41 to−0.67,t=−2.94,p=0.004)and 1.53(95%CI−2.88 to−0.17,t=−2.22,p=0.028)points more than those in the CON group at T1 and T2,respectively.The effects of AE were still significant at T1(estimate=−1.70,95%CI−3.20 to−0.21,t=−2.69,p=0.021),but lost statistical significance at T2 after adjusting for multiple comparisons.As for executive function,the Stroop time interference in the RE group decreased by 11.76 s(95%CI−21.62 to−1.90,t=−2.81,p=0.015)more than that in the AE group at T2 after Tukey’s adjustment.No other significant effects on cognitive functions were found.Conclusions Both remotely supervised AE and RE programmes are feasible in older adults with MCI.AE has positive effects on global cognition,and RE improves executive function.展开更多
With the wide spread of the epidemic,the long-term closed lifestyle and the sharp reduction of physical activities,many people have mental health problems such as panic,anxiety and depression.At present,there are few ...With the wide spread of the epidemic,the long-term closed lifestyle and the sharp reduction of physical activities,many people have mental health problems such as panic,anxiety and depression.At present,there are few studies on the effect of exercise on depression.Therefore,the study selected exercise intervention therapy and other intervention methods to evaluate the intervention effect of depression,and explored the effect of exercise intervention by evaluating depression scale and effective indicators.Hope this can provide a new idea for exercise intervention as an adjunctive therapy for depression on drug treatment.展开更多
In recent years, the rapid transformation and upgrading of social economy, promote peoples quality of life is improved significantly, to further improve peoples living standards, in this development situation, patient...In recent years, the rapid transformation and upgrading of social economy, promote peoples quality of life is improved significantly, to further improve peoples living standards, in this development situation, patients with coronary heart disease gradually tend to be younger, cardiac rehabilitation including exercise interventions in young clinical treatment of coronary heart disease patients plays a vital role. Through the review of coronary heart disease, this paper briefly expounds the impact of exercise measures in young and middle-aged coronary heart disease, and describes the role of different exercise and exercise methods in young and middle-aged patients with coronary heart disease.展开更多
Cancer-related fatigue is the most prevalent and persistently symptom in cancer survivors than any other symptom,which is caused by both the disease and its treatment.Patients with cancer show a severe symptom of fati...Cancer-related fatigue is the most prevalent and persistently symptom in cancer survivors than any other symptom,which is caused by both the disease and its treatment.Patients with cancer show a severe symptom of fatigue,which cannot be relieved by general rest or sleep.Cancer-related fatigue negatively impacts a patient's physical and emotional function,social ability and even patients’prognosis.At present,the mechanism of cancer-related fatigue remain unclear despite much research,and a variety of mechanisms may contribute to its occurrence and development,including inflammatory reaction,metabolism dysregulation,immune activation,hormonal changes,central nervous system dysfunction,etc.Now a broad variety of drugs and non-drugs interventions are used against cancer-related fatigue.The intervention of conventional western medicine mainly contains hematopoietic stimulants,hormones,mental stimulants,and antidepressants,but their widely clinical application is limited by their effectiveness and possible side effects to a certain degree.There are also many forms of non-drug interventions for managing cancer-related fatigue,such as exercise intervention,psychological intervention,sleep intervention,nutrition intervention,bright white light therapy,etc.The aim of this review is to provide recommendations of non-drug interventions for patients with CRF during and after cancer treatment,in order to provide an evidence-based guideline for clinicians.展开更多
Adolescence is an important stage for brain maturation.To investigate the effect of different exercise doses on inhibitory control in adolescents aged 12 to 14-year old,an after-school exercise program was offered 5 d...Adolescence is an important stage for brain maturation.To investigate the effect of different exercise doses on inhibitory control in adolescents aged 12 to 14-year old,an after-school exercise program was offered 5 days per week for 12 weeks during a school semester.Thirsty-four adolescents(17 boys)from the first six classes were randomly divided into low-dose exercise group(LE group,one 30-min aerobic exercise bout per day,n=16)and high-dose exercise group(HE group,two 30-min aerobic exercise bouts per day,n=18),while 23 adolescents(10 boys)in the control group(CON,zero 30-min exercise bout,n=23)were from the last two classes.All the participants in different classes received the same physical education with the same contents,duration,and intensity at class.All the participants completed flanker tests and cardiorespiratory tests before and after exercise intervention.The HE group showed more significant improvements on inhibitory control and VO_(2peak)than CON(p<0.05).Changes in physical activity(PA)were significantly correlated with changes in interference scores(Spearman rho=-0.30,p<0.05),VO_(2peak)(Spearman rho=0.31,p<0.05),and BF percentage(Spearman rho=-0.32,p<0.05).This study demonstrated that effect of exercise on inhibitory control in adolescents is dose-dependent,which highlights the need to focus on the exercise dose in daily life for improving cognition among adolescents.展开更多
Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metfor...Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metformin and exercise treatment may have neither additive effect nor even cause adverse effects in T2D patients.This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment.A 67-years old woman was followed-up for five months,including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin.The findings were four-fold:1)During a high-intensity interval training bout,blood glucose systematically decreased,while blood lactate concentrations fluctuated randomly;2)Basal blood lactate levels were well above 2 mmol/L on days with medication only;3)Combined exercise and metformin administration induced additive effects on the normalization of glucose and 4)high levels of physical activity had a positive impact on the continuous glucose fluctuations,while decreased levels of physical activity induced a large fluctuation of glucose due to home confinement of an infectious disease caused by the SARS-CoV-2 virus.Our findings showed that when combined with exercise and metformin treatment for T2D patients,exercise may contribute to improving glycemic control while metformin may elevate lactate levels in the long term.The observed results underline the need to prescribe exercise and monitor lactate levels for reducing possible risks associated with metformin treatment and reinforce the importance of tailoring exercise therapy.展开更多
文摘Objective:To investigate the positive eff ect of mindfulness training and exercise therapy on functional recovery and quality of life in elderly patients with fractures of the lower back.Methods:Collection of medical records of patients with lumbar vertebral fractures in Suzhou Municipal Hospital(North District),60 patients underwent percutaneous vertebroplasty(PVP/PKP),they were divided into control and experimental groups according to a random number table,30 people per group;In addition to traditional care method,Also intervened with behavioural awareness training and exercise therapy,By comparing the Oswestry dysfunction index score(ODI),visual simulation score(VAS),ability of daily living score(ADL),quality of life score(SF-36),To evaluate the eff ectiveness of the intervention.Results:Before the intervention,the ODI,VAS,ADL,and SF-36 scores were basically the same,with no significant diff erence(P>0.05).After treatment,the ODI and VAS scores of the experimental group and the control group were signifi cantly lower,and the experimental group was significantly lower than the control group(P<0.05);the ADL scores of the experimental group were signifi cantly higher than those of the control group(P<0.05);their SF-36 quality of life scores in all dimensions were signifi cantly higher(P<0.05).Conclusion:Through the rehabilitation treatment method combining mindfulness behavior training and exercise intervention,it can eff ectively promote the functional recovery of osteoporotic lumbar fractures in the elderly,thus reducing their pain and improving their quality of life.
基金supported by the Hypatia Fellowship grant from Radboudumc awarded to LB.
文摘Background Exercise during neoadjuvant chemoradiotherapy(NCRT)has potential to mitigate treatment-related declines in physical fitness,and to improve clinical outcomes,including toxicity and tumor response.However,optimal frequency and timing of exercise remains to be determined.Therefore,this pilot trial aimed to assess feasibility of 2 different exercise interventions during NCRT in patients with esophageal and rectal cancer and to evaluate potential clinical effects.Methods Patients were randomized into 1 of 3 study arms during NCRT:(a)30-min aerobic exercise in-hospital within 1 h prior to each radiotherapy fraction(ExPR),(b)two 60-min supervised combined aerobic and resistance exercise sessions per week(AE+RE),and(c)usual care(UC).Feasibility was assessed by examining participation rate and exercise adherence.Intervention effects on physical fitness,health-related quality of life,treatment-related toxicity,and tumor response in patients with esophageal cancer were explored using regression analyses and 85%confidence intervals(85%CIs).Results Thirty-seven patients with esophageal cancer(participation rate=45%)and 2 patients with rectal cancer(participation rate=14%)were included.Median session attendance was 98%(interquartile range(IQR):96%–100%)in the ExPR and 78%(IQR:33%–100%)in the AE+RE group.We found clinically relevant benefits of exercise on maximal oxygen uptake(VO2_(max),mL/kg/min)(ExPR:β=9.7,85%CI:6.9–12.6;AE+RE:β=5.6,85%CI:2.6–8.5)and treatment-related toxicity(ExPR:β=–2.8,85%CI:–5.4 to–0.2;AE+RE:β=–2.6,85%CI:–5.3 to 0.0).Additionally,good tumor response was found in 70%in AE+RE and ExPR vs.55%in UC(odds ratio(OR)=1.9,85%CI:0.5–7.7).Conclusion Starting prehabilitation during NCRT is feasible,can increase starting fitness of traditional pre-surgical programs,and has potential to improve clinical outcomes.
文摘Objective:To study the application effect of standardized nutritional care combined with exercise intervention in patients with gestational diabetes mellitus and the effect on fasting blood glucose(FPG),2-hour postprandial blood glucose(2hPG),and glycated hemoglobin(HbA1c)levels.Methods:Ninety cases of gestational diabetes mellitus diagnosed between June 2022 and June 2023 were selected and randomly divided into two groups of 45 cases each.The control group received conventional intervention,while the observation group received combined standardized nutritional care and exercise intervention.Blood glucose levels,adverse pregnancy outcomes,and adverse neonatal outcomes were compared.Results:On the day before delivery,the FPG,2hPG,and HbA1c levels of patients in the observation group were lower than those of patients in the control group(P<0.05).The incidence of adverse pregnancy outcomes(4.44%)and adverse neonatal outcomes(2.22%)in the observation group was lower than in the control group(P<0.05).Conclusion:The blood glucose levels of gestational diabetes mellitus patients can be controlled through standardized nutritional care and exercise interventions,leading to improved pregnancy and neonatal outcomes.
基金(Hainan Medical University)“Effect of Exercise Intervention on Function and Pain in Patients with Low Back Pain”(Project No.X202211810054)。
文摘Lower back pain(LBP)has a relatively high incidence across various age groups,characterized by discomfort in the lumbosacral and iliosacral regions above the gluteal striatum and within the region below the costal margins.Some patients also experience varying degrees of leg pain,with many experiencing prolonged and recurrent symptoms.International consensus confirms that exercise intervention is an effective treatment method for lower back pain,offering safe and efficient physical therapy.Extensive practical experience suggests that Pilates exercises can effectively regulate the strength of muscle tissue in the peripheral region of the spine,improve muscle endurance,and alleviate low back pain caused by muscular factors.This study analyzes the effects of exercise intervention on the function and pain of patients with lower back pain.It explores various exercise modalities,utilizes SPSS26 statistics to gather data,and draws conclusions with the aim of providing theoretical references for exercise interventions in patients with lower back pain.
基金supported by the Major Research Plan of the National Natural Science Foundation of China (91749104)the Emergency Management Project of the National Natural Science Foundation of China (31842034)+3 种基金the Shanghai Pujiang Talent Project (18PJ1400700)the Science and Technology Innovation Action Plan of Shanghai Science and Technology Committee (18140901300)the Open Research Fund of the National Key Laboratory of Genetic Engineering (SKLGE1803)the Open Research Fund of the State Key Laboratory of Pharmaceutical Biotechnology (KF-GN201701) to TML
文摘Background'. In recent years, much evidence has emerged to indicate that exercise can benefit people when performed properly. This reviewsummarizes the exercise interventions used in studies involving mice as they are related to special diseases or physiological status. To furtherunderstand the effects of exercise interventions in treating or preventing diseases, it is important to establish a template for exercise interventionsthat can be used in future exercise-related studies.Methods'. PubMed was used as the data resource for articles. To identify studies related to the effectiveness of exercise interventions for treatingvarious diseases and organ functions in mice, we used the following search language: (exercise [Title] OR training [Title] OR physical activity[Title]) AND (mice [title/abstract] OR mouse [title/abstract] OR mus [title/abstract]). To limit the range of search results, we included 2 filters:one that limited publication dates to "in 10 years,^ and one that sorted the results as "best match^^. Then we grouped the commonly used exercisemethods according to their similarities and differences. We then evaluated the effectiveness of the exercise interventions for their impact on diseasesand organ functions in 8 different systems.Results'. A total of 331 articles were included in the analysis procedure. The articles were then segmented into 8 systems for which the exerciseinterventions were used in targeting and treating disorders: motor system (60 studies), metabolic system (45 studies), cardio-cerebral vascularsystem (58 studies), nervous system (74 studies), immune system (32 studies), respiratory system (7 studies), digestive system (1 study), and thesystem related to the development of cancer (54 studies). The methods of exercise interventions mainly involved the use of treadmills, voluntarywheel-running, forced wheel-running, swimming, and resistance training. It was found that regardless of the specific exercise method used, mostof them demonstrated positive effects on various systemic diseases and organ functions. Most diseases were remitted with exercise regardless ofthe exercise method used, although some diseases showed the best remission effects when a specific method was used.Conclusion-. Our review strongly suggests that exercise intervention is a cornerstone in disease prevention and treatment in mice. Because exerciseinterventions in humans typically focus on chronic diseases, national fitness, and body weight loss, and typically have low intervention com・pliance rates, it is important to use mice models to investigate the molecular mechanisms underlying the health benefits from exerciseinterventions in humans.
文摘Objective: to analyze the effect of combined physical therapy and exercise intervention on patients with cervical spondylosis. Methods: 62 patients with cervical spondylosis were randomly selected from January 2021 to March 2022. They were randomly divided into group A (physical therapy) and group B (physical therapy + exercise intervention) by bicolor ball method. The effects of the two groups were compared. Results: after treatment, the cervical joint range of motion, quality of life score, NDI index, JOA score and VAS score in group B were better than those in group A (P0.05). Conclusion: the combination of physical therapy and exercise intervention has a better effect on improving cervical function, pain degree and quality of life in patients with cervical spondylosis.
基金supported by the National Key Research and Development Program of China(2022YFC3500401)the National Natural Scence Foundation of China(No.82205250)the Natural Science Foundation of Shandong Province,China(No.ZR2021QH056).
文摘This work was supported by the National Key Research and Development Program of China(2022YFC3500401),the National Natural Science Foundation of China(No.82205250)and the Natural Science Foundation of Shandong Province,China(No.ZR2021QH056).
基金National Key Research and Development Programme of China(2018YFA0800403 and 2021YFC2701903)Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110)+6 种基金National Natural Science Fund for Excellent Young Scholars of China(81722012)National Natural Science Foundation of China(81670740)Zhejiang Provincial Natural Science Foundation of China(LZ21H070001)Innovative Institute of Basic Medical Sciences of Zhejiang University,the Fundamental Research Funds for the Central UniversitiesConstruction Fund of Medical Key Disciplines of Hangzhou(OO20200055)Hangzhou Science and Technology Bureau(20150733Q13 and ZD20200129)K.C.Wong Education Foundation.
文摘Pancreaticβ-cell dysfunction and insulin resistance are two of the major causes of type 2 diabetes(T2D).Recent clinical and experimental studies have suggested that the functional capacity ofβ-cells,particularly in the first phase of insulin secretion,is a primary contributor to the progression of T2D and its associated complications.Pancreaticβ-cells undergo dynamic compensation and decompensation processes during the development of T2D,in which metabolic stresses such as endoplasmic reticulum stress,oxidative stress,and inflammatory signals are key regulators ofβ-cell dynamics.Dietary and exercise interventions have been shown to be effective approaches for the treatment of obesity and T2D,especially in the early stages.Whilst the targeted tissues and underlying mechanisms of dietary and exercise interventions remain somewhat vague,accumulating evidence has implicated the improvement ofβ-cell functional capacity.In this review,we summarize recent advances in the understanding of the dynamic adaptations ofβ-cell function in T2D progression and clarify the effects and mechanisms of dietary and exercise interventions onβ-cell dysfunction in T2D.This review provides molecular insights into the therapeutic effects of dietary and exercise interventions on T2D,and more importantly,it paves the way for future research on the related underlying mechanisms for developing precision prevention and treatment of T2D.
基金financially supported by the China State Sport General Administration(No.2013B040,2015B039)the University of J yvaskyla Wellness program and the Shanghai Jiao Tong University Zhiyuan Foundation(No.CP2014013)
文摘Purpose： This study aimed to assess whether the benefits of exercise on central adiposity and insulin resistance （HOMA-IR） are maintained after discontinuation of intervention in the overweight/obese （OWOB） women. Methods： The study subjects were from 2 independent studies with similar aerobic exercise （AE） intervention programs. In study I, I50WOB postmenopausal women with pre-diabetes （body mass index, BMI = 24-33 kg/m2, aged 52-65 years） completed an 8-month exercise intervention and were followed for 2 years after the intervention. In study lI, 12 OWOB （BM1 = 25-35 kg/m2, aged 30-50 years） premenopausal women participated in a 6-week AE and were followed for 4 years after the intervention. The exercise program consisted of progressive AE with intensity of 60%-75% of initial fitness level, 30-60 min/time and 3-5 times/week. Fat mass （FM） was assessed by Dual Energy X-ray Absorptiometry （DXA Prodigy; study I） or bioelectrical impedance device （Inbody 720; study II）. Plasma glucose and insulin were assessed by chemiluminescent immunoassay and HOMA-IR was calculated. Results： Both 8-month and 6-week moderate AE were effective in reducing HOMA-IR （-18.9%, p = 0.012 and -26.7%, p = 0.046, respectively）, and 8-month AE reduced FM at upper abdominal region （-6.2%, p = 0.021）. However, these improvements were not maintained in either study at the follow-up. Conclusion： The AE program used in these studies was effective to reduce insulin resistance and/or FM in central body region among overweight and obese women. However, when exercise intervention was discontinued, the beneficial effects following both short- and long-term intervention disappeared. Thus maintaining exercise seems to be required if one wants to reap the benefits of exercise in the long-term.
基金supported by grants from the National Key Research and Development Program of China(2018YFA0800403 and 2021YFC2701903)the Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110)+5 种基金the National Natural Science Foundation of China(81670740,82100904,and 32000817)the National Natural Science Fund for Excellent Young Scholars of China(81722012)Zhejiang Provincial Natural Science Foundation of China(LZ21H070001 and LQ21C110001)the Innovative Institute of Basic Medical Sciences of Zhejiang University,the Fundamental Research Funds for the Central Universities,the Construction Fund of Medical Key Disciplines of Hangzhou,Hangzhou Science and Technology Bureau(20150733Q13 and ZD20200129)the Construction Fund of Key Medical Disciplines of Hangzhou(OO20200055)the K.C.Wong Education Foundation.
文摘Exercise intervention at the early stage of type 2 diabetes mellitus(T2DM)can aid in the maintenance of blood glucose homeostasis and prevent the development of macrovascular and microvascular complications.However,the exercise-regulated pathways that prevent the development of T2DM remain largely unclear.In this study,two forms of exercise intervention,treadmill training and voluntary wheel running,were conducted for high-fat diet(HFD)-induced obese mice.We observed that both forms of exercise intervention alleviated HFD-induced insulin resistance and glucose intolerance.Skeletal muscle is recognized as the primary site for postprandial glucose uptake and for responsive alteration beyond exercise training.Metabolomic profiling of the plasma and skeletal muscle in Chow,HFD,and HFD-exercise groups revealed robust alterations in metabolic pathways by exercise intervention in both cases.Overlapping analysis identified nine metabolites,including beta-alanine,leucine,valine,and tryptophan,which were reversed by exercise treatment in both the plasma and skeletal muscle.Transcriptomic analysis of gene expression profiles in the skeletal muscle revealed several key pathways involved in the beneficial effects of exercise on metabolic homeostasis.In addition,integrative transcriptomic and metabolomic analyses uncovered strong correlations between the concentrations of bioactive metabolites and the expression levels of genes involved in energy metabolism,insulin sensitivity,and immune response in the skeletal muscle.This work established two models of exercise intervention in obese mice and provided mechanistic insights into the beneficial effects of exercise intervention on systemic energy homeostasis.
基金supported by the National Natural Science Foundation of China(32471186,31771318)the 14^(th) Five-Year-Plan Advantageous and Characteristic Disciplines(Groups)of Colleges and Universities in Hubei Province for Exercise and Brain Science from Hubei Provincial Department of Education,and the Leading Talent Program Foundation from Wuhan Sports University to Ning Chen+3 种基金the National Natural Science Foundation of China(81701391)the Natural Science Foundation of Hubei Province(2023AFB700)Key Project of Scientific Research of Education Department of Hubei Province(D20234101)Young and Middle aged Scientific Research Team Project of Wuhan Sports University(21KT08)to Jingjing Fan.
文摘Obesity,caused by excessive energy,leads to body weight gain and various diseases,including cognitive impairment.Current studies suggest that diet restriction such as optimal fasting and regular exercise are crucial for improving cognitive capacity.However,further exploration is needed to understand the specific mechanisms of high fat diet(HFD)-induced cognitive decline in obesity.In the present study,4-month-old mice were subjected to HFD feeding for 18 weeks,followed by aerobic exercise and high-intensity intermittent exercise,regular diet feeding,and intermittent fasting for 8 weeks,and then used to evaluate cognitive capacity,inflammation,compromised insulin signaling pathway,and apoptosis in hippocampal tissue,as well as AMPK/SIRT1 and TLR4 signal pathways.Obese mice revealed impaired cognitive capacity as compared with mice fed with regular diets.In contrast,aerobic exercise,high-intensity intermittent exercise,regular diet,and intermittent fasting could inhibit apoptosis caused by inflammation-mediated compromised insulin signaling pathway in hippocampal tissues through activating the AMPK/SIRT1 signal pathway and suppressing the TLR4 signal pathway,thereby rescuing the cognitive impairment of obese mice.Therefore,diet restriction and exercise interventions may play a positive role in reverting obesity-induced cognitive impairment.
文摘The purpose of this study was to determine whether interventions could improve peroneal reaction time in both healthy and those with injured ankle participants based on a systematic review and meta-analysis.An electronic search of the following database was carried out:MEDLINE,ScienceDirect and SPORTDiscus(1965–2020).Studies utilising sudden ankle inversion to measure peroneal reaction times were selected.28 studies were included for the systematic review,and 18 studies for the meta-analysis.The peroneal reaction time for pre-and post-intervention were compared into two groups,Group 1 was therapeutic exercise intervention,and Group 2 was prophylactic devices.The results showed a statistically significant difference in reduced peroneal reaction time in favour of participants in the exercise group(SMD=0.74,95%CI[1.09,0.39],p<0.001,I^(2)80%),while the prophylactic devices group showed no significant difference between control and intervention group.The effect size measured was 0.81 and 0.31 in Group 1 and Group 2,respectively.Faster peroneal muscle onset reaction time post-intervention,which was found following therapeutic exercise,should be considered for rehabilitation and preventing of ankle sprain injury.
文摘Objective: to explore the application of exercise and diet intervention in elderly patients with COPD complicated with sarcopenia. Methods: the study period was from June 2019 to January 2021. Sixty-four elderly patients with COPD complicated with sarcopenia were randomly divided into the control group (n = 32) and the observation group (n = 32) according to the hospital label. The patients in the control group received routine care, while the patients in the observation group received exercise and diet intervention on the basis of routine care. The respiratory and motor functions and quality of life of the two groups of patients were evaluated. Results: after the nursing intervention, the lung function index of the observation group was improved more obviously than that of the control group (P < 0.05). It was better than the control group in activity, prevention and disease influence (P < 0.05). Conclusion: exercise and diet intervention for elderly COPD patients with sarcopenia can significantly improve the pulmonary function of patients, enhance vitality and disease prevention ability, and thus promote the early recovery of patients.
基金Research Results of the College Students’Innovative Entrepreneurial Training Plan Program in Heilongjiang Province in 2024“Multi-intervention Model Construction and Intervention Effect of Pre-diabetic Individual Lifestyle”(Project Number:S202410222115)。
文摘In recent years,the prevalence of diabetes in China has continued to rise,with the adult prevalence expected to reach 12.8%by 2023.To control this trend,the government has introduced several policies and invested substantial funds in the prevention and treatment of diabetes,achieving certain results.Prediabetes is a stage where blood glucose metabolism can still be restored.For individuals in this stage,dietary and exercise intervention programs are recommended to prevent or delay the onset of diabetes,improve quality of life,and reduce the burden of disease on individuals,families,and society.
基金funded by the National Natural Science Foundation of China(81871854,72374014)the National Key R&D Program of China(2020YFC2008804)+1 种基金the Shanghai Jiao Tong University Young Talent Cultivation Program in Liberal Arts(2024QN041)the Shanghai Jiao Tong University School of Medicine:Nursing Development Program(SJTUHLXK2024).
文摘Background Evidence on the effects of different exercise interventions on cognitive function is insufficient.Aims To evaluate the feasibility and effects of remotely supervised aerobic exercise(AE)and resistance exercise(RE)interventions in older adults with mild cognitive impairment(MCI).Methods This study is a 6-month pilot three-arm randomised controlled trial.Eligible participants(n=108)were recruited and randomised to the AE group,RE group or control(CON)group with a 1:1:1 ratio.Interventions were delivered at home with remote supervision.We evaluated participants’global cognition,memory,executive function,attention,physical activity levels,physical performance and muscle strength of limbs at baseline,3 months(T1)and 6 months(T2)after randomisation.A linear mixed-effects model was adopted for data analyses after controlling for covariates.Tukey’s method was used for adjusting for multiple comparisons.Sensitivity analyses were performed after excluding individuals with low compliance rates.Results 15(13.89%)participants dropped out.The median compliance rates in the AE group and RE group were 67.31%and 93.27%,respectively.After adjusting for covariates,the scores of the Alzheimer’s Disease Assessment Scale-Cognitive subscale in the AE group decreased by 2.04(95%confidence interval(CI)−3.41 to−0.67,t=−2.94,p=0.004)and 1.53(95%CI−2.88 to−0.17,t=−2.22,p=0.028)points more than those in the CON group at T1 and T2,respectively.The effects of AE were still significant at T1(estimate=−1.70,95%CI−3.20 to−0.21,t=−2.69,p=0.021),but lost statistical significance at T2 after adjusting for multiple comparisons.As for executive function,the Stroop time interference in the RE group decreased by 11.76 s(95%CI−21.62 to−1.90,t=−2.81,p=0.015)more than that in the AE group at T2 after Tukey’s adjustment.No other significant effects on cognitive functions were found.Conclusions Both remotely supervised AE and RE programmes are feasible in older adults with MCI.AE has positive effects on global cognition,and RE improves executive function.
文摘With the wide spread of the epidemic,the long-term closed lifestyle and the sharp reduction of physical activities,many people have mental health problems such as panic,anxiety and depression.At present,there are few studies on the effect of exercise on depression.Therefore,the study selected exercise intervention therapy and other intervention methods to evaluate the intervention effect of depression,and explored the effect of exercise intervention by evaluating depression scale and effective indicators.Hope this can provide a new idea for exercise intervention as an adjunctive therapy for depression on drug treatment.
文摘In recent years, the rapid transformation and upgrading of social economy, promote peoples quality of life is improved significantly, to further improve peoples living standards, in this development situation, patients with coronary heart disease gradually tend to be younger, cardiac rehabilitation including exercise interventions in young clinical treatment of coronary heart disease patients plays a vital role. Through the review of coronary heart disease, this paper briefly expounds the impact of exercise measures in young and middle-aged coronary heart disease, and describes the role of different exercise and exercise methods in young and middle-aged patients with coronary heart disease.
文摘Cancer-related fatigue is the most prevalent and persistently symptom in cancer survivors than any other symptom,which is caused by both the disease and its treatment.Patients with cancer show a severe symptom of fatigue,which cannot be relieved by general rest or sleep.Cancer-related fatigue negatively impacts a patient's physical and emotional function,social ability and even patients’prognosis.At present,the mechanism of cancer-related fatigue remain unclear despite much research,and a variety of mechanisms may contribute to its occurrence and development,including inflammatory reaction,metabolism dysregulation,immune activation,hormonal changes,central nervous system dysfunction,etc.Now a broad variety of drugs and non-drugs interventions are used against cancer-related fatigue.The intervention of conventional western medicine mainly contains hematopoietic stimulants,hormones,mental stimulants,and antidepressants,but their widely clinical application is limited by their effectiveness and possible side effects to a certain degree.There are also many forms of non-drug interventions for managing cancer-related fatigue,such as exercise intervention,psychological intervention,sleep intervention,nutrition intervention,bright white light therapy,etc.The aim of this review is to provide recommendations of non-drug interventions for patients with CRF during and after cancer treatment,in order to provide an evidence-based guideline for clinicians.
基金supported by National Key Research and Development Program Major Prevention and Control Research on Chronic Noncommunicable Diseases(2016YFC1300202).
文摘Adolescence is an important stage for brain maturation.To investigate the effect of different exercise doses on inhibitory control in adolescents aged 12 to 14-year old,an after-school exercise program was offered 5 days per week for 12 weeks during a school semester.Thirsty-four adolescents(17 boys)from the first six classes were randomly divided into low-dose exercise group(LE group,one 30-min aerobic exercise bout per day,n=16)and high-dose exercise group(HE group,two 30-min aerobic exercise bouts per day,n=18),while 23 adolescents(10 boys)in the control group(CON,zero 30-min exercise bout,n=23)were from the last two classes.All the participants in different classes received the same physical education with the same contents,duration,and intensity at class.All the participants completed flanker tests and cardiorespiratory tests before and after exercise intervention.The HE group showed more significant improvements on inhibitory control and VO_(2peak)than CON(p<0.05).Changes in physical activity(PA)were significantly correlated with changes in interference scores(Spearman rho=-0.30,p<0.05),VO_(2peak)(Spearman rho=0.31,p<0.05),and BF percentage(Spearman rho=-0.32,p<0.05).This study demonstrated that effect of exercise on inhibitory control in adolescents is dose-dependent,which highlights the need to focus on the exercise dose in daily life for improving cognition among adolescents.
基金We thank Hui Zuo and Tao Zhang for their help in managing the patient.This work was supported by the China Postdoctoral Science Foundation(2021M692090)Guided Scientific Research Project of Shiyan Science and Technology Bureau(21Y17)Shanghai Philosophy and Social Science Planning Project(2022ZTY003).
文摘Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in the patients with type 2 diabetes(T2D).However,several studies suggest that combing metformin and exercise treatment may have neither additive effect nor even cause adverse effects in T2D patients.This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment.A 67-years old woman was followed-up for five months,including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin.The findings were four-fold:1)During a high-intensity interval training bout,blood glucose systematically decreased,while blood lactate concentrations fluctuated randomly;2)Basal blood lactate levels were well above 2 mmol/L on days with medication only;3)Combined exercise and metformin administration induced additive effects on the normalization of glucose and 4)high levels of physical activity had a positive impact on the continuous glucose fluctuations,while decreased levels of physical activity induced a large fluctuation of glucose due to home confinement of an infectious disease caused by the SARS-CoV-2 virus.Our findings showed that when combined with exercise and metformin treatment for T2D patients,exercise may contribute to improving glycemic control while metformin may elevate lactate levels in the long term.The observed results underline the need to prescribe exercise and monitor lactate levels for reducing possible risks associated with metformin treatment and reinforce the importance of tailoring exercise therapy.
