Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination...Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination and comprehensive radiological diagnosis and analysis play an important role in early correction of childhood malocclusion.This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence,aiming to provide general guidance on appropriate imaging examination selection,comprehensive and accurate imaging assessment for early orthodontic treatment patients.展开更多
Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcom...Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.展开更多
This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis comp...This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis complex(TSC)combined with primary lymphedema(PLE).Additionally,it retrospectively analyzes the data of 16 previously reported cases of children with TSC combined with PLE to summarize the epidemiology,genetic diagnosis,and current main treatments of these patients.The report also speculates on the pathological and physiological mechanisms underlying TSC combined with PLE.TSC combined with PLE is rare;therefore,the report provides a theoretical basis for understanding the pathophysiological mechanisms and treatment options for patients with TSC and PLE.Comprehensive clinical management of TSC is essential due to the diverse and multiorgan nature of its manifestations,often requiring a multidisciplinary approach for newly diagnosed cases.展开更多
This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis.Currently,pancreatic cancer still has a...This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis.Currently,pancreatic cancer still has a poor prognosis,mainly due to late diagnosis in an advanced stage.Two main precancerous routes have been identified as pathways to pancreatic adenocarcinoma:The first encompasses a large group of mucinous cystic lesions:intraductal papillary mucinous neoplasm and mucinous cystic neoplasm,and the second is pancreatic intraepithelial neoplasia.In the last decade the focus of research has been to identify high-risk patients,using advanced imaging techniques(magnetic resonance cholangiopancreatography or endoscopic ultrasonography)which could be helpful in finding“indirect signs”of early stage pancreatic lesions.Nevertheless,the survival rate still remains poor,and alternative screening methods are under investigation.Endoscopic retrograde cholangiopancreatography followed by serial pancreatic juice aspiration cytology could be a promising tool for identifying precursor lesions such as intraductal papillary mucinous neoplasm,but confirming data are still needed to validate its role.Probably a combination of cross-sectional imaging,endoscopic techniques(old and new ones)and genetic and biological biomarkers also in pancreatic juice)could be the best solution to reach an early diagnosis.Biomarkers could help to predict and follow the progression of early pancreatic lesions.However,further studies are needed to validate their diagnostic reliability and to establish diagnostic algorithms to improve prognosis and survival in patients with pancreatic cancer.展开更多
This paper aims at re-examining the properties of the-celebrated Goodwin model in econmics.We improve the results of Flaschel by applying the bifurcation method of Iooss and Joseph. It isshown that under appropriate c...This paper aims at re-examining the properties of the-celebrated Goodwin model in econmics.We improve the results of Flaschel by applying the bifurcation method of Iooss and Joseph. It isshown that under appropriate conditions endogeneous limit cycles appear after structural changeshave teken place in the economic system.展开更多
Objective:To study the application value and application path of pathological examination in gynecological physical examination.Methods:A total of 1200 patients undergoing gynecological physical examination in X Hospi...Objective:To study the application value and application path of pathological examination in gynecological physical examination.Methods:A total of 1200 patients undergoing gynecological physical examination in X Hospital from January 2024 to December 2024 were selected.All patients received cervical Pap smear examination,and patients with abnormal examination results underwent colposcopic biopsy and HPV infection test for cervical cancer screening.Results:The results of cervical Pap smear showed that a total of 780 patients among 1200 patients showed cervical abnormalities.The Pap smear combined with colposcopy was used for pathological examination to detect cervical cancer lesions in time,and biopsy and HPV infection examination were arranged for high-risk patients to provide data reference for clinical treatment.Conclusions:Pathological examination has a good screening effect in gynecological physical examination.It can detect lesions early and take timely intervention measures,which is helpful to reduce the incidence and mortality of the disease.展开更多
As a severe neurological disease,cerebral hemorrhage is dangerous and progresses rapidly,with high disability and fatality rates.Its occurrence seriously harms patients’lives and health,and also causes a heavy social...As a severe neurological disease,cerebral hemorrhage is dangerous and progresses rapidly,with high disability and fatality rates.Its occurrence seriously harms patients’lives and health,and also causes a heavy social burden.Timely diagnosis and treatment of cerebral hemorrhage are essential for improving patients’prognosis.This article reviews the research progress in emergency treatment for patients with cerebral hemorrhage,providing a basis for diagnosis and treatment.展开更多
This study explores the application of Production-Oriented Approach(POA)in teaching German to nursing students in colleges and universities.Focusing on the requirements of the German B1 exam,the study takes the themat...This study explores the application of Production-Oriented Approach(POA)in teaching German to nursing students in colleges and universities.Focusing on the requirements of the German B1 exam,the study takes the thematic unit of“Movement”as an example,and designs the teaching through the links of“drive-enable-evaluate”.The results show that POA effectively improves students’speaking and writing output,but there are still deficiencies in reading and listening.Accordingly,this study has proposed the strategies of“vocabulary in-depth facilitation”and“accurate matching of listening and writing”to optimize the input materials and skills training,achieve the goal of“learning and using”,and provide a practical path for teaching German for Special Purposes.This provides a practical path for the teaching of German for special purposes.展开更多
Objective:To study the application effect of the multi-role positioning service model in hypertensive patients in the health examination center.Methods:A total of 152 hypertensive patients admitted to the hospital’s ...Objective:To study the application effect of the multi-role positioning service model in hypertensive patients in the health examination center.Methods:A total of 152 hypertensive patients admitted to the hospital’s health examination center from January 2024 to January 2025 were selected as the subjects.They were randomly divided into two groups using a random number table method.The control group(76 cases)received conventional physical examination service mode,while the observation group(76 cases)adopted the multi-role positioning service model.The nurse proficiency and physical examination quality were compared between the two groups.Results:The nurse proficiency scores in the observation group were higher than those in the control group(P<0.05).The physical examination quality scores in the observation group were higher than those in the control group(P<0.05).Conclusion:The adoption of the multi-role positioning service model for hypertensive patients in the health examination center can improve nurse proficiency and physical examination quality.展开更多
Background:To evaluate the feasibility and safety of a novel cable-transmitted magnetically controlled capsule endoscopy(CTMCE)system for upper gastrointestinal examination.Methods:Twenty-six participants(19 healthy v...Background:To evaluate the feasibility and safety of a novel cable-transmitted magnetically controlled capsule endoscopy(CTMCE)system for upper gastrointestinal examination.Methods:Twenty-six participants(19 healthy volunteers and seven patients with gastrointestinal symptoms)willing to undergo upper gastrointestinal endoscopy were recruited.Each participant underwent CT-MCE followed by conventional gastroscopy within 24 h.Maneuverability and visibility of the CT-MCE capsule in the upper gastrointestinal tract,adverse events,and discomfort during the procedure were evaluated.The sensitivity and specificity of CT-MCE for diagnosing upper gastrointestinal lesions were evaluated using conventional gastroscopy findings as the standard.Results:Maneuverability was graded as“good”for all segments of the esophagus.The percentage of participants in which maneuverability was good according to gastric region was as follows:cardia(100.00%),pylorus(96.15%),angulus(92.31%),antrum(88.46%),fundus(84.62%),and body(73.08%).In the duodenal bulb and descending duodenum,it was good in only 20.83% and 16.67% of participants,respectively.Visibility was graded as“excellent”or“good”in the esophagus,Z line,and duodenal bulb in all participants;excellent/good visibility was achieved in the stomach and descending duodenum in 96.15% and 79.17% of participants,respectively.Forty-one lesions were detected overall.The sensitivity and specificity of CT-MCE in diagnosing upper gastrointestinal lesions were 85.00% and 98.15%,respectively.The CT-MCE capsule was successfully removed through the mouth in all participants.No serious adverse events or capsule retention occurred.Conclusions:CT-MCE showed good feasibility and safety for upper gastrointestinal examination.The system was effective in examining the esophagus and stomach with no risk of capsule retention.展开更多
As the world transitions to a more environment-friendly and sustainable global economy,innovations in green technology are playing a crucial role.Recognizing this,China,along with many other nations,is adapting its pa...As the world transitions to a more environment-friendly and sustainable global economy,innovations in green technology are playing a crucial role.Recognizing this,China,along with many other nations,is adapting its pat⁃ent system to better support green innovations,establishing what is known as a green patent regime.While extensive empirical research highlights the significance of China's green patent regime in achieving environmental sustainabil⁃ity,there is a noticeable lack of normative studies on enhancing its efficacy.This work aims to fill this gap by conduct⁃ing a normative study using doctrinal analysis and proposing that transparency and accessibility are key factors in evaluating the effectiveness of a green patent regime.Through a doctrinal analysis of China's green patent legislation and regulations,this work assesses the legal rights conferred by this regime and identifies how these rights are con⁃strained by substantive and procedural norms.The findings reveal significant limitations to the transparency and acces⁃sibility of China's green patent regime and propose improvements.These recommendations offer insights for policymak⁃ers in China and other countries.The doctrinal analysis conducted in this research could stimulate further theoretical discussion in the field of sustainable development and intellectual property law.Moreover,it might enlighten more hy⁃potheses for future empirical studies.展开更多
The widespread application of artificial intelligence(AI)technology in exams has significantly improved the efficiency and fairness of exams;it has also brought challenges of ethics and privacy protection.The article ...The widespread application of artificial intelligence(AI)technology in exams has significantly improved the efficiency and fairness of exams;it has also brought challenges of ethics and privacy protection.The article analyzes the fairness,transparency,and privacy protection issues caused by AI in exams and proposes strategic solutions.This article aims to provide guidance for the rational application of AI technology in exams,ensuring a balance between technological progress and ethical protection by strengthening laws and regulations,enhancing technological transparency,strengthening candidates’privacy rights,and improving the management measures of educational examination institutions.展开更多
Digital rectal examination(DRE)is essential for diagnosing anorectal diseases,yet its widespread adoption remains suboptimal among practitioners.While modalities such as anorectal manometry,rectal balloon expulsion te...Digital rectal examination(DRE)is essential for diagnosing anorectal diseases,yet its widespread adoption remains suboptimal among practitioners.While modalities such as anorectal manometry,rectal balloon expulsion tests,pelvic floor electromyography,and dynamic imaging(defecography/pelvic floor magnetic resonance imaging)enable comprehensive assessment of anorectal function,many healthcare facilities lack advanced diagnostic tools and specialized personnel.DRE has notable diagnostic value in the primary evaluation of functional defecation disorders(FDDs),particularly for detecting dyssynergic defecation and structural pelvic floor defects.Its cost efficiency and universal accessibility render it indispensable in resource-limited environments where high-resolution diagnostic technologies(e.g.,high-resolution manometry)are unavailable.This review delineates standardized DRE protocols for assessing FDDs and highlights characteristic imaging features of FDDs with the aim of improving the understanding of DRE.This review will hopefully encourage clinicians to perform DREs in diverse clinical settings.展开更多
Objective:The objective of this research is to thoroughly investigate the extent of mutual interference among clinical internships,postgraduate entrance examinations,and employment by examining engineering contradicti...Objective:The objective of this research is to thoroughly investigate the extent of mutual interference among clinical internships,postgraduate entrance examinations,and employment by examining engineering contradictions,thus offering theoretical insights and guidance for medical students to attain high-quality outcomes in clinical internships.Methods:A combination of literature reviews,questionnaires,interviews,and observations of internships was utilized,followed by a statistical analysis to assess the levels of interference among the three factors.Results:The senior participants achieved significantly higher scores than their junior counterparts in evaluations of comprehensive humanistic quality,understanding professional values,communication abilities,clinical skills,and attitudes towards learning,with differences that were statistically significant(p<0.05).After applying an interactive training approach that merges early clinical practice with foundational medical education,both groups displayed notable enhancements in activity content,formats,instructor attitudes,clinical performance,and the blending of theory with practice(p<0.05).Conclusion:By emphasizing‘early clinical’education,students are effectively engaged in clinical practice through active involvement,leading to feedback-oriented training.This strategy not only improves the overall quality of internships but also reduces the risk of scheduling conflicts with postgraduate entrance examinations and employment opportunities.展开更多
BACKGROUND The incidence of gastric polyps(GPs)has ranged from 0.30%to 6.8%in various studies.Most GPs include hyperplastic polyps(HPs),fundic gland polyps(FGPs),and adenomatous polyps(APs).Although APs have a high ma...BACKGROUND The incidence of gastric polyps(GPs)has ranged from 0.30%to 6.8%in various studies.Most GPs include hyperplastic polyps(HPs),fundic gland polyps(FGPs),and adenomatous polyps(APs).Although APs have a high malignant potential,HPs have a low risk of potential harm,whereas sporadic FGPs have no malignant potential.It is not enough to determine the type and displacement of a polyp by biopsy alone;therefore,some polyps may require an extensive biopsy or complete resection.AIM To evaluate the detection rate and pathological features of polyps in patients undergoing upper gastrointestinal endoscopy.METHODS This retrospective study included patients with GPs or polyphenic lesions with polyps or malignant histology found in polyps or by gastroscopy at the Department of Gastroenterology at the Shaanxi Provincial Hospital of Traditional Chinese Medicine from 2019 to 2023.RESULTS In a series of 10000 patients who underwent upper gastrointestinal endoscopy,384(3.84%)had GPs.There were 98 males(25.5%)and 286 females(74.5%).The mean age of patients was 62.8±10.4(36-75)years.The frequencies of HPs,APs,and FGPs were 88.5%,5.2%,and 2.1%,respectively.The polyp size of 274 patients(71.3%)was≤1 cm.Polyps were found in 262 cases(68.2%).The most common sites for polyps were the lumen and body of the intestine.Endoscopic polypectomy was performed in 128 patients.Bleeding events were observed and endoscopic treatment was required after endoscopic polypectomy.CONCLUSION The incidence of GPs was low.HPs were the most common types of GPs.Of note,as GPs have the potential to develop into adenocarcinoma or precancerous lesions,we suggest that appropriate GP resection technology(e.g.,biopsy forceps or mesenchymal resection)be applied.展开更多
Gastritis cystica profunda(GCP)is a rare gastric disorder.It is characterized by non-specific symptoms and diagnostic complexity.This case report enriches the medical literature by highlighting challenges in diagnosin...Gastritis cystica profunda(GCP)is a rare gastric disorder.It is characterized by non-specific symptoms and diagnostic complexity.This case report enriches the medical literature by highlighting challenges in diagnosing and treating GCP.CASE SUMMARY Two patients presented with non-specific abdominal symptoms,such as abdominal distension and epigastric discomfort.Initial misdiagnosis occurred due to GCP’s non-typical manifestations.After thorough investigations,GCP was diagnosed.Endoscopic mucosal resection and endoscopic submucosal dissection were carried out.Both patients recovered uneventfully.CONCLUSION GCP diagnosis demands caution,and endoscopic treatment is effective.展开更多
During the process of urbanization,community environments encounter challenges such as data disconnection and the underutilization of small and micro spaces.The establishment of“complete communities”necessitates the...During the process of urbanization,community environments encounter challenges such as data disconnection and the underutilization of small and micro spaces.The establishment of“complete communities”necessitates the implementation of refined governance strategies.This research develops a path for the precise establishment of community micro-gardens driven by mobile measurement.It involves the collection of environmental data via mobile devices equipped with various types of sensors,the generation of visualization maps that are adjusted for spatio-temporal synchronization,and the identification of environmental paint points,including areas of excessive temperature exposure and zones with elevated noise levels.Based on the aforementioned considerations,various plant allocation strategies have been proposed for distinct areas.For instance,the implementation of a composite shade and cooling vegetation system is recommended for regions experiencing high temperatures,while a triple protection structure is suggested for areas affected by odor contamination.The efficacy of these strategies is demonstrated through a case study of the micro-garden transformation in the Dongjie Community of Wulituo Street,Shijingshan,Beijing.The study presents operational technical pathways and plant response solutions aimed at facilitating data-driven governance of community micro-environments.展开更多
BACKGROUND Appendiceal signet-ring cell carcinoma(SRCC)with terminal ileum metastasis is extremely rare.There have been no reported cases in domestic and foreign literature.CASE SUMMARY In this case report,we present ...BACKGROUND Appendiceal signet-ring cell carcinoma(SRCC)with terminal ileum metastasis is extremely rare.There have been no reported cases in domestic and foreign literature.CASE SUMMARY In this case report,we present an 88-year-old man with appendiceal SRCC with terminal ileum metastasis.The tumour stage was stage pT4bN2M1bG3 IVB,and the Tumour,Node,Metastasis staging system was used.The patient was admitted to our hospital on 12 July,2022 and underwent laparoscopic appendectomy under general anaesthesia after the examination.The pathological examination that took place 1 week after the operation showed that SRCC of the appendix invaded the whole layer,vessels and nerves of the appendix wall.It was suggested that the primary appendix should be considered after excluding metastasis.Based on the postoperative pathology findings,the patient underwent a secondary surgery on 2 August,2022.The second pathological examination showed residual SRCC in the appendiceal area of the ileocecal region,which infiltrated the serosal fibres and adipose tissue of the ileocecal region to the surface mesothelium.The tumour infiltrated the whole layer of the ileum wall,serosa fibres,adipose tissue and the surface mesothelium.Postoperative follow-up showed no signs of tumour recurrence or metastasis.CONCLUSION In clinical practice,a heightened awareness of rare diseases,coupled with thorough intraoperative exploration and rapid pathological examination,enables more accurate judgments,potentially sparing patients from unnecessary secondary surgery and ensuring optimal treatment.展开更多
基金supports by the National Natural Science Foundation of China(Nos.82201135)"2015"Cultivation Program for Reserve Talents for Academic Leaders of Nanjing Stomatological School,Medical School of Nanjing University(No.0223A204).
文摘Early correction of childhood malocclusion is timely managing morphological,structural,and functional abnormalities at different dentomaxillofacial developmental stages.The selection of appropriate imaging examination and comprehensive radiological diagnosis and analysis play an important role in early correction of childhood malocclusion.This expert consensus is a collaborative effort by multidisciplinary experts in dentistry across the nation based on the current clinical evidence,aiming to provide general guidance on appropriate imaging examination selection,comprehensive and accurate imaging assessment for early orthodontic treatment patients.
文摘Dear Editor,Local recurrence and cervical lymph node metastases are major causes of mortality in patients with head and neck squamous cell carcinoma(HNSCC).To date,none of the proposed strategies for predicting outcomes in this disease have proven fully effective,and a comprehensive physical examination remains the primary method for early detection and monitoring of HNSCC.
文摘This editorial discusses a case report recently published in the World Journal of Clinical Cases.The report describes the clinical presentation,imaging,diagnosis,and treatment of a patient with tuberous sclerosis complex(TSC)combined with primary lymphedema(PLE).Additionally,it retrospectively analyzes the data of 16 previously reported cases of children with TSC combined with PLE to summarize the epidemiology,genetic diagnosis,and current main treatments of these patients.The report also speculates on the pathological and physiological mechanisms underlying TSC combined with PLE.TSC combined with PLE is rare;therefore,the report provides a theoretical basis for understanding the pathophysiological mechanisms and treatment options for patients with TSC and PLE.Comprehensive clinical management of TSC is essential due to the diverse and multiorgan nature of its manifestations,often requiring a multidisciplinary approach for newly diagnosed cases.
文摘This editorial is a commentary on the case report by Furuya et al focusing on the challenging diagnosis of early pancreatic adenocarcinoma and new tools for an earlier diagnosis.Currently,pancreatic cancer still has a poor prognosis,mainly due to late diagnosis in an advanced stage.Two main precancerous routes have been identified as pathways to pancreatic adenocarcinoma:The first encompasses a large group of mucinous cystic lesions:intraductal papillary mucinous neoplasm and mucinous cystic neoplasm,and the second is pancreatic intraepithelial neoplasia.In the last decade the focus of research has been to identify high-risk patients,using advanced imaging techniques(magnetic resonance cholangiopancreatography or endoscopic ultrasonography)which could be helpful in finding“indirect signs”of early stage pancreatic lesions.Nevertheless,the survival rate still remains poor,and alternative screening methods are under investigation.Endoscopic retrograde cholangiopancreatography followed by serial pancreatic juice aspiration cytology could be a promising tool for identifying precursor lesions such as intraductal papillary mucinous neoplasm,but confirming data are still needed to validate its role.Probably a combination of cross-sectional imaging,endoscopic techniques(old and new ones)and genetic and biological biomarkers also in pancreatic juice)could be the best solution to reach an early diagnosis.Biomarkers could help to predict and follow the progression of early pancreatic lesions.However,further studies are needed to validate their diagnostic reliability and to establish diagnostic algorithms to improve prognosis and survival in patients with pancreatic cancer.
文摘This paper aims at re-examining the properties of the-celebrated Goodwin model in econmics.We improve the results of Flaschel by applying the bifurcation method of Iooss and Joseph. It isshown that under appropriate conditions endogeneous limit cycles appear after structural changeshave teken place in the economic system.
文摘Objective:To study the application value and application path of pathological examination in gynecological physical examination.Methods:A total of 1200 patients undergoing gynecological physical examination in X Hospital from January 2024 to December 2024 were selected.All patients received cervical Pap smear examination,and patients with abnormal examination results underwent colposcopic biopsy and HPV infection test for cervical cancer screening.Results:The results of cervical Pap smear showed that a total of 780 patients among 1200 patients showed cervical abnormalities.The Pap smear combined with colposcopy was used for pathological examination to detect cervical cancer lesions in time,and biopsy and HPV infection examination were arranged for high-risk patients to provide data reference for clinical treatment.Conclusions:Pathological examination has a good screening effect in gynecological physical examination.It can detect lesions early and take timely intervention measures,which is helpful to reduce the incidence and mortality of the disease.
文摘As a severe neurological disease,cerebral hemorrhage is dangerous and progresses rapidly,with high disability and fatality rates.Its occurrence seriously harms patients’lives and health,and also causes a heavy social burden.Timely diagnosis and treatment of cerebral hemorrhage are essential for improving patients’prognosis.This article reviews the research progress in emergency treatment for patients with cerebral hemorrhage,providing a basis for diagnosis and treatment.
文摘This study explores the application of Production-Oriented Approach(POA)in teaching German to nursing students in colleges and universities.Focusing on the requirements of the German B1 exam,the study takes the thematic unit of“Movement”as an example,and designs the teaching through the links of“drive-enable-evaluate”.The results show that POA effectively improves students’speaking and writing output,but there are still deficiencies in reading and listening.Accordingly,this study has proposed the strategies of“vocabulary in-depth facilitation”and“accurate matching of listening and writing”to optimize the input materials and skills training,achieve the goal of“learning and using”,and provide a practical path for teaching German for Special Purposes.This provides a practical path for the teaching of German for special purposes.
文摘Objective:To study the application effect of the multi-role positioning service model in hypertensive patients in the health examination center.Methods:A total of 152 hypertensive patients admitted to the hospital’s health examination center from January 2024 to January 2025 were selected as the subjects.They were randomly divided into two groups using a random number table method.The control group(76 cases)received conventional physical examination service mode,while the observation group(76 cases)adopted the multi-role positioning service model.The nurse proficiency and physical examination quality were compared between the two groups.Results:The nurse proficiency scores in the observation group were higher than those in the control group(P<0.05).The physical examination quality scores in the observation group were higher than those in the control group(P<0.05).Conclusion:The adoption of the multi-role positioning service model for hypertensive patients in the health examination center can improve nurse proficiency and physical examination quality.
基金supported by the National Key Research and Development Program(2019YFC0120303)and was sponsored by the Beijing Nova Program(20240484678).
文摘Background:To evaluate the feasibility and safety of a novel cable-transmitted magnetically controlled capsule endoscopy(CTMCE)system for upper gastrointestinal examination.Methods:Twenty-six participants(19 healthy volunteers and seven patients with gastrointestinal symptoms)willing to undergo upper gastrointestinal endoscopy were recruited.Each participant underwent CT-MCE followed by conventional gastroscopy within 24 h.Maneuverability and visibility of the CT-MCE capsule in the upper gastrointestinal tract,adverse events,and discomfort during the procedure were evaluated.The sensitivity and specificity of CT-MCE for diagnosing upper gastrointestinal lesions were evaluated using conventional gastroscopy findings as the standard.Results:Maneuverability was graded as“good”for all segments of the esophagus.The percentage of participants in which maneuverability was good according to gastric region was as follows:cardia(100.00%),pylorus(96.15%),angulus(92.31%),antrum(88.46%),fundus(84.62%),and body(73.08%).In the duodenal bulb and descending duodenum,it was good in only 20.83% and 16.67% of participants,respectively.Visibility was graded as“excellent”or“good”in the esophagus,Z line,and duodenal bulb in all participants;excellent/good visibility was achieved in the stomach and descending duodenum in 96.15% and 79.17% of participants,respectively.Forty-one lesions were detected overall.The sensitivity and specificity of CT-MCE in diagnosing upper gastrointestinal lesions were 85.00% and 98.15%,respectively.The CT-MCE capsule was successfully removed through the mouth in all participants.No serious adverse events or capsule retention occurred.Conclusions:CT-MCE showed good feasibility and safety for upper gastrointestinal examination.The system was effective in examining the esophagus and stomach with no risk of capsule retention.
基金Funded by the National Key R&D Program of China (Grant No:2022YFC3303000)。
文摘As the world transitions to a more environment-friendly and sustainable global economy,innovations in green technology are playing a crucial role.Recognizing this,China,along with many other nations,is adapting its pat⁃ent system to better support green innovations,establishing what is known as a green patent regime.While extensive empirical research highlights the significance of China's green patent regime in achieving environmental sustainabil⁃ity,there is a noticeable lack of normative studies on enhancing its efficacy.This work aims to fill this gap by conduct⁃ing a normative study using doctrinal analysis and proposing that transparency and accessibility are key factors in evaluating the effectiveness of a green patent regime.Through a doctrinal analysis of China's green patent legislation and regulations,this work assesses the legal rights conferred by this regime and identifies how these rights are con⁃strained by substantive and procedural norms.The findings reveal significant limitations to the transparency and acces⁃sibility of China's green patent regime and propose improvements.These recommendations offer insights for policymak⁃ers in China and other countries.The doctrinal analysis conducted in this research could stimulate further theoretical discussion in the field of sustainable development and intellectual property law.Moreover,it might enlighten more hy⁃potheses for future empirical studies.
文摘The widespread application of artificial intelligence(AI)technology in exams has significantly improved the efficiency and fairness of exams;it has also brought challenges of ethics and privacy protection.The article analyzes the fairness,transparency,and privacy protection issues caused by AI in exams and proposes strategic solutions.This article aims to provide guidance for the rational application of AI technology in exams,ensuring a balance between technological progress and ethical protection by strengthening laws and regulations,enhancing technological transparency,strengthening candidates’privacy rights,and improving the management measures of educational examination institutions.
文摘Digital rectal examination(DRE)is essential for diagnosing anorectal diseases,yet its widespread adoption remains suboptimal among practitioners.While modalities such as anorectal manometry,rectal balloon expulsion tests,pelvic floor electromyography,and dynamic imaging(defecography/pelvic floor magnetic resonance imaging)enable comprehensive assessment of anorectal function,many healthcare facilities lack advanced diagnostic tools and specialized personnel.DRE has notable diagnostic value in the primary evaluation of functional defecation disorders(FDDs),particularly for detecting dyssynergic defecation and structural pelvic floor defects.Its cost efficiency and universal accessibility render it indispensable in resource-limited environments where high-resolution diagnostic technologies(e.g.,high-resolution manometry)are unavailable.This review delineates standardized DRE protocols for assessing FDDs and highlights characteristic imaging features of FDDs with the aim of improving the understanding of DRE.This review will hopefully encourage clinicians to perform DREs in diverse clinical settings.
基金Ministry of Education Industry-University Cooperative Education Program(Project No.:231002999080311)Xinxiang Medical University Education and Teaching Reform Research(Project No.:2021-XYJG-100)。
文摘Objective:The objective of this research is to thoroughly investigate the extent of mutual interference among clinical internships,postgraduate entrance examinations,and employment by examining engineering contradictions,thus offering theoretical insights and guidance for medical students to attain high-quality outcomes in clinical internships.Methods:A combination of literature reviews,questionnaires,interviews,and observations of internships was utilized,followed by a statistical analysis to assess the levels of interference among the three factors.Results:The senior participants achieved significantly higher scores than their junior counterparts in evaluations of comprehensive humanistic quality,understanding professional values,communication abilities,clinical skills,and attitudes towards learning,with differences that were statistically significant(p<0.05).After applying an interactive training approach that merges early clinical practice with foundational medical education,both groups displayed notable enhancements in activity content,formats,instructor attitudes,clinical performance,and the blending of theory with practice(p<0.05).Conclusion:By emphasizing‘early clinical’education,students are effectively engaged in clinical practice through active involvement,leading to feedback-oriented training.This strategy not only improves the overall quality of internships but also reduces the risk of scheduling conflicts with postgraduate entrance examinations and employment opportunities.
基金Supported by the Shaanxi Province Traditional Chinese Medicine Research and Innovation Talent Plan Project,No.TZKN-CXRC-16Project of Shaanxi Administration of Traditional Chinese Medicine,No.SZYKJCYC-2025-JC-010+2 种基金Shaanxi Province Outstanding TCM Talents Training Project Training Object in 2025Xi’an Science and Technology Plan Project,No.23YXYJ0162Shaanxi Province Key Research and Development Plan Project-Social Development Field,No.S2025-YF-YBSF-0391.
文摘BACKGROUND The incidence of gastric polyps(GPs)has ranged from 0.30%to 6.8%in various studies.Most GPs include hyperplastic polyps(HPs),fundic gland polyps(FGPs),and adenomatous polyps(APs).Although APs have a high malignant potential,HPs have a low risk of potential harm,whereas sporadic FGPs have no malignant potential.It is not enough to determine the type and displacement of a polyp by biopsy alone;therefore,some polyps may require an extensive biopsy or complete resection.AIM To evaluate the detection rate and pathological features of polyps in patients undergoing upper gastrointestinal endoscopy.METHODS This retrospective study included patients with GPs or polyphenic lesions with polyps or malignant histology found in polyps or by gastroscopy at the Department of Gastroenterology at the Shaanxi Provincial Hospital of Traditional Chinese Medicine from 2019 to 2023.RESULTS In a series of 10000 patients who underwent upper gastrointestinal endoscopy,384(3.84%)had GPs.There were 98 males(25.5%)and 286 females(74.5%).The mean age of patients was 62.8±10.4(36-75)years.The frequencies of HPs,APs,and FGPs were 88.5%,5.2%,and 2.1%,respectively.The polyp size of 274 patients(71.3%)was≤1 cm.Polyps were found in 262 cases(68.2%).The most common sites for polyps were the lumen and body of the intestine.Endoscopic polypectomy was performed in 128 patients.Bleeding events were observed and endoscopic treatment was required after endoscopic polypectomy.CONCLUSION The incidence of GPs was low.HPs were the most common types of GPs.Of note,as GPs have the potential to develop into adenocarcinoma or precancerous lesions,we suggest that appropriate GP resection technology(e.g.,biopsy forceps or mesenchymal resection)be applied.
文摘Gastritis cystica profunda(GCP)is a rare gastric disorder.It is characterized by non-specific symptoms and diagnostic complexity.This case report enriches the medical literature by highlighting challenges in diagnosing and treating GCP.CASE SUMMARY Two patients presented with non-specific abdominal symptoms,such as abdominal distension and epigastric discomfort.Initial misdiagnosis occurred due to GCP’s non-typical manifestations.After thorough investigations,GCP was diagnosed.Endoscopic mucosal resection and endoscopic submucosal dissection were carried out.Both patients recovered uneventfully.CONCLUSION GCP diagnosis demands caution,and endoscopic treatment is effective.
文摘During the process of urbanization,community environments encounter challenges such as data disconnection and the underutilization of small and micro spaces.The establishment of“complete communities”necessitates the implementation of refined governance strategies.This research develops a path for the precise establishment of community micro-gardens driven by mobile measurement.It involves the collection of environmental data via mobile devices equipped with various types of sensors,the generation of visualization maps that are adjusted for spatio-temporal synchronization,and the identification of environmental paint points,including areas of excessive temperature exposure and zones with elevated noise levels.Based on the aforementioned considerations,various plant allocation strategies have been proposed for distinct areas.For instance,the implementation of a composite shade and cooling vegetation system is recommended for regions experiencing high temperatures,while a triple protection structure is suggested for areas affected by odor contamination.The efficacy of these strategies is demonstrated through a case study of the micro-garden transformation in the Dongjie Community of Wulituo Street,Shijingshan,Beijing.The study presents operational technical pathways and plant response solutions aimed at facilitating data-driven governance of community micro-environments.
文摘BACKGROUND Appendiceal signet-ring cell carcinoma(SRCC)with terminal ileum metastasis is extremely rare.There have been no reported cases in domestic and foreign literature.CASE SUMMARY In this case report,we present an 88-year-old man with appendiceal SRCC with terminal ileum metastasis.The tumour stage was stage pT4bN2M1bG3 IVB,and the Tumour,Node,Metastasis staging system was used.The patient was admitted to our hospital on 12 July,2022 and underwent laparoscopic appendectomy under general anaesthesia after the examination.The pathological examination that took place 1 week after the operation showed that SRCC of the appendix invaded the whole layer,vessels and nerves of the appendix wall.It was suggested that the primary appendix should be considered after excluding metastasis.Based on the postoperative pathology findings,the patient underwent a secondary surgery on 2 August,2022.The second pathological examination showed residual SRCC in the appendiceal area of the ileocecal region,which infiltrated the serosal fibres and adipose tissue of the ileocecal region to the surface mesothelium.The tumour infiltrated the whole layer of the ileum wall,serosa fibres,adipose tissue and the surface mesothelium.Postoperative follow-up showed no signs of tumour recurrence or metastasis.CONCLUSION In clinical practice,a heightened awareness of rare diseases,coupled with thorough intraoperative exploration and rapid pathological examination,enables more accurate judgments,potentially sparing patients from unnecessary secondary surgery and ensuring optimal treatment.
