The global automotive sector is moving towards zero-emission transportation,which has led to the rapid growthof the electric vehidles(EVs)market,projected to reach USD1,318 billion in 2028.However,behind the booming d...The global automotive sector is moving towards zero-emission transportation,which has led to the rapid growthof the electric vehidles(EVs)market,projected to reach USD1,318 billion in 2028.However,behind the booming develop-ment of the electric vehicle market,its safety issues havealways been the focal point of consumers'concern and alsothe cornerstone for the sustained and healthy developmentof the new energy vehicle industry.展开更多
为了解决地质建模软件Earth Volumetric Studio (EVS)建立的地质模型与实际地形地貌、地层倾向不符的问题,以贵州金象煤矿为研究对象,提出一种能真实反映地形地貌与地层倾向的建模方法(EVS耦合地形–优化钻孔数据的建模法)。通过工程实...为了解决地质建模软件Earth Volumetric Studio (EVS)建立的地质模型与实际地形地貌、地层倾向不符的问题,以贵州金象煤矿为研究对象,提出一种能真实反映地形地貌与地层倾向的建模方法(EVS耦合地形–优化钻孔数据的建模法)。通过工程实例将该方法与地层建模进行对比分析,结果表明采用耦合地形–优化钻孔数据的建模方法建立的模型比地层建模方法建立的模型更能反映实际的地质情况,与勘探方法探测的地质情况也更相近,且模型误差更小。展开更多
Extracellular vesicles(EVs)are nano-sized bilayer vesicles that are shed or secreted by virtually every cell type.A variety of biomolecules,including proteins,lipids,coding and non-coding RNAs,and mitochondrial DNA,ca...Extracellular vesicles(EVs)are nano-sized bilayer vesicles that are shed or secreted by virtually every cell type.A variety of biomolecules,including proteins,lipids,coding and non-coding RNAs,and mitochondrial DNA,can be selectively encapsulated into EVs and delivered to nearby and distant recipient cells,leading to alterations in the recipient cells,suggesting that EVs play an important role in intercellular communication.EVs play effective roles in physiology and pathology and could be used as diagnostic and therapeutic tools.At present,although the mechanisms of exosome biogenesis and secretion in donor cells are well understood,the molecular mechanism of EV recognition and uptake by recipient cells is still unclear.This review summarizes the current understanding of the molecular mechanisms of EVs’biological journey in recipient cells,from recognition to uptake and cargo release.Furthermore,we highlight how EVs escape endolysosomal degradation after uptake and thus release cargo,which is crucial for studies applying EVs as drug-targeted delivery vehicles.Knowledge of the cellular processes that govern EV uptake is important to shed light on the functions of EVs as well as on related clinical applications.展开更多
目的:比较TIPSS和EVS治疗食管静脉曲张破裂出血的疗效,治疗前后两组患者肝功能的变化和术后患者的死亡原因方法:回顾性分析两组各18例经TIPSS和EVS治疗的食管静脉曲张破裂出血患者在治疗后不同时间的死亡率,再出血率及治疗前后血浆白蛋...目的:比较TIPSS和EVS治疗食管静脉曲张破裂出血的疗效,治疗前后两组患者肝功能的变化和术后患者的死亡原因方法:回顾性分析两组各18例经TIPSS和EVS治疗的食管静脉曲张破裂出血患者在治疗后不同时间的死亡率,再出血率及治疗前后血浆白蛋白和胆红素的变化。结果:TIPSS组在术后30 d的死亡率略低于硬化剂治疗组(16.67％ vs 22.22％),术后1a,两组的死亡率比较有显著差异(22.22％ vs 44.44％);术后2a,TIPSS组仍略低于EVS组(38.89％ vs 50.00％),但差异无显著性,在术后2a的随诊期内,EVS组的再出血率高于TIPSS组。与EVS组比较,TIPSS组患者术后肝功能的降低更明显。结论:TIPSS治疗的近期疗效优于EVS治疗,中远期疗效的对比尚需进一步的观察。TIPSS术后肝功能的衰竭是本组患者治疗后死亡的主要原因,而EVS组患者的术后死亡与再出血密切相关。展开更多
文摘The global automotive sector is moving towards zero-emission transportation,which has led to the rapid growthof the electric vehidles(EVs)market,projected to reach USD1,318 billion in 2028.However,behind the booming develop-ment of the electric vehicle market,its safety issues havealways been the focal point of consumers'concern and alsothe cornerstone for the sustained and healthy developmentof the new energy vehicle industry.
文摘为了解决地质建模软件Earth Volumetric Studio (EVS)建立的地质模型与实际地形地貌、地层倾向不符的问题,以贵州金象煤矿为研究对象,提出一种能真实反映地形地貌与地层倾向的建模方法(EVS耦合地形–优化钻孔数据的建模法)。通过工程实例将该方法与地层建模进行对比分析,结果表明采用耦合地形–优化钻孔数据的建模方法建立的模型比地层建模方法建立的模型更能反映实际的地质情况,与勘探方法探测的地质情况也更相近,且模型误差更小。
基金supported by the National Natural Science Foundation of China(No.32070182)the Key Project of Jiangsu Commission of Health(No.ZD2021049)+3 种基金the Highlevel Talent Program at Affiliated Kunshan Hospital of Jiangsu University(No.gccrc2022002)the Suzhou Municipal Science and Technology Development Plan(No.SKYD2023002)the Suzhou Municipal Key Discipline Construction Project(No.SZXK202124)the Talent Research Project of Suzhou Health Talent Plan(No.GSWS2023005),China.
文摘Extracellular vesicles(EVs)are nano-sized bilayer vesicles that are shed or secreted by virtually every cell type.A variety of biomolecules,including proteins,lipids,coding and non-coding RNAs,and mitochondrial DNA,can be selectively encapsulated into EVs and delivered to nearby and distant recipient cells,leading to alterations in the recipient cells,suggesting that EVs play an important role in intercellular communication.EVs play effective roles in physiology and pathology and could be used as diagnostic and therapeutic tools.At present,although the mechanisms of exosome biogenesis and secretion in donor cells are well understood,the molecular mechanism of EV recognition and uptake by recipient cells is still unclear.This review summarizes the current understanding of the molecular mechanisms of EVs’biological journey in recipient cells,from recognition to uptake and cargo release.Furthermore,we highlight how EVs escape endolysosomal degradation after uptake and thus release cargo,which is crucial for studies applying EVs as drug-targeted delivery vehicles.Knowledge of the cellular processes that govern EV uptake is important to shed light on the functions of EVs as well as on related clinical applications.
文摘目的:比较TIPSS和EVS治疗食管静脉曲张破裂出血的疗效,治疗前后两组患者肝功能的变化和术后患者的死亡原因方法:回顾性分析两组各18例经TIPSS和EVS治疗的食管静脉曲张破裂出血患者在治疗后不同时间的死亡率,再出血率及治疗前后血浆白蛋白和胆红素的变化。结果:TIPSS组在术后30 d的死亡率略低于硬化剂治疗组(16.67％ vs 22.22％),术后1a,两组的死亡率比较有显著差异(22.22％ vs 44.44％);术后2a,TIPSS组仍略低于EVS组(38.89％ vs 50.00％),但差异无显著性,在术后2a的随诊期内,EVS组的再出血率高于TIPSS组。与EVS组比较,TIPSS组患者术后肝功能的降低更明显。结论:TIPSS治疗的近期疗效优于EVS治疗,中远期疗效的对比尚需进一步的观察。TIPSS术后肝功能的衰竭是本组患者治疗后死亡的主要原因,而EVS组患者的术后死亡与再出血密切相关。
