Genome assembly is a fundamental step in decoding the genetic information of life.Its significance lies in constructing a complete DNA sequence map of organisms,providing the foundation for elucidating the mechanisms ...Genome assembly is a fundamental step in decoding the genetic information of life.Its significance lies in constructing a complete DNA sequence map of organisms,providing the foundation for elucidating the mechanisms of species evolution,exploring gene functions,and identifying disease-related variations.However,some of the repetitive DNA sequences remain“dark materials”in the genome as they are difficult to reveal by the second-generation sequencing approaches.In recent years,breakthroughs in third-generation sequencing technologies have significantly improved the accuracy and continuity of genome assemblies,therefore,being able to resolve the“last piece of the puzzle”in the genome.展开更多
基金supported by the National Natural Science Foundation of China(32090034)Zhejiang Provincial Natural Science Foundation of China(2022XHSJJ001)+3 种基金Hangzhou City Leading Innovation and Entrepreneurship Team(TD2020004)“Pioneer”and“Leading Goose”Research and Development Program of Zhejiang(2024SSYS0033)Westlake Education FoundationWestlake Laboratory of Life Sciences and Biomedicine.
文摘Genome assembly is a fundamental step in decoding the genetic information of life.Its significance lies in constructing a complete DNA sequence map of organisms,providing the foundation for elucidating the mechanisms of species evolution,exploring gene functions,and identifying disease-related variations.However,some of the repetitive DNA sequences remain“dark materials”in the genome as they are difficult to reveal by the second-generation sequencing approaches.In recent years,breakthroughs in third-generation sequencing technologies have significantly improved the accuracy and continuity of genome assemblies,therefore,being able to resolve the“last piece of the puzzle”in the genome.
