1 Introduction Drug resistance hinders treating diseases like cancer,infections,and autoimmune disorders[1].Small-molecule drugs exert evolutionary pressure on rapidly evolving systems,leading to the emergence of drug...1 Introduction Drug resistance hinders treating diseases like cancer,infections,and autoimmune disorders[1].Small-molecule drugs exert evolutionary pressure on rapidly evolving systems,leading to the emergence of drug resistance[2].Drug resistance can compromise the therapeutic outcomes and increase the mortality of patients(Fig.1).Understanding these mechanisms and identifying resistance-conferring mutations is crucial.展开更多
基金supported by grants from STI 2030—Major Projects(No.2022ZD0209100)the National Natural Science Foundation of China(Grant Nos.81971292,82150610506,and 62372099)+3 种基金the Natural Science Foundation of Shanghai(No.21ZR1428600)the Medical-Engineering Cross Foundation of Shanghai Jiao Tong University(Nos.YG2022ZD026 and YG2023ZD27)SJTU Trans-med Awards Research(No.20220103)Shanghai Clinical Research Center for Mental Health(19MC1911100).
文摘1 Introduction Drug resistance hinders treating diseases like cancer,infections,and autoimmune disorders[1].Small-molecule drugs exert evolutionary pressure on rapidly evolving systems,leading to the emergence of drug resistance[2].Drug resistance can compromise the therapeutic outcomes and increase the mortality of patients(Fig.1).Understanding these mechanisms and identifying resistance-conferring mutations is crucial.
