The uniaxial compression tests were conducted on the cylindrical shale specimens with bedding plane inclined at 0° and 90° to the axial loading direction, respectively. Effect of the bedding orientation on t...The uniaxial compression tests were conducted on the cylindrical shale specimens with bedding plane inclined at 0° and 90° to the axial loading direction, respectively. Effect of the bedding orientation on the mechanical property and energy evolution characteristics of shales was revealed. The failure mechanisms of the specimens with layers in 0° orientation showed splitting failure along weak bedding, while the specimens with layers in 90° orientation were failed by shearing sliding. The values of compressive strength, elastic modulus and shear modulus of samples at 0° were higher than those of samples at 90°and there was little difference of Poisson's ratio between samples at 0° and 90°. The analysis of the stress–strain energy and acoustic emission(AE) energy indicated that the growth rate of absorbed energy density and elastic energy density at 0° was significantly faster than that at 90°, hence their final values at 0°were relatively larger than the latter. Moreover, higher energy release was observed for specimens at 0°.The energy release and rapid growth of energy dissipation also appeared more early at 0°. The stress ratio63% was a critical point of energy distribution at which differences started to arise between samples at 0°and 90°. These results indicated that the failure of shale at 0° was more violent and devastative than the failure of shale at 90°.展开更多
Gangdise tectonic belt, located in the middle part of Tibet—Qinghai plateau Tethys tectonic domain, is the most representative region in Tibet—Qinghai plateau Tethyan evolution especially in Mesozoic era. It is main...Gangdise tectonic belt, located in the middle part of Tibet—Qinghai plateau Tethys tectonic domain, is the most representative region in Tibet—Qinghai plateau Tethyan evolution especially in Mesozoic era. It is mainly covered by thick Jurassic—Cretaceous system layer. During the Mesozoic to Cenozoic era, strong island\|arc types volcanism and volcanic rocks and intrusive rocks belt.. Geologists had divided the Tibet Tethyan evolution into three or four stages (Huang, Jiqing, 1987; Pan Guitang, Li Xinzheng, 1993), according to the ocean\|land conversion process of Tethyan evolution .The Tethyan evolution and the nature of Gangdise tectonic belt had been well\|studied by geologists (Huang Jiqing, 1987; Deng Wanming, 1984; Xia Daixiang, 1986; Cheng Changlun 1987; ZhouXiang 1993; Pan Guitang, 1996). Studies showed that Gangdise tectonic belt, from upper Paleozoic to Mesozoic era, had been developed alternate multiple island arc\|basin system, and characterized by many basin types and strong tectonic\|magma activity. Based on the study of Gangdise multiple island arc\|basin system, I present another version of Gangdise tectonic belt tectonic units division and evolution here.展开更多
氢能作为一种清洁、无污染、资源丰富、应用广泛的二次能源,因其能量密度高、节能、环保、可回收利用等特点,在新能源领域具有非常重要的地位.尽管碱性电解水制氢技术在我国得到了广泛应用,但其能耗和成本较高的问题亟待解决.为了提升...氢能作为一种清洁、无污染、资源丰富、应用广泛的二次能源,因其能量密度高、节能、环保、可回收利用等特点,在新能源领域具有非常重要的地位.尽管碱性电解水制氢技术在我国得到了广泛应用,但其能耗和成本较高的问题亟待解决.为了提升电解水过程的反应速率,迫切需要开发出低成本且高效的电催化剂,用于促进电解水析氧反应(OER).采用以三维多孔的泡沫镍(NF)为基底,恒电流的脉冲电沉积技术制备镍钴合金作为电催化剂,研究表明:当电沉积时间为900 s,电沉积电流密度为60 m A/cm^(2)时,Ni-Co/NF电极催化剂在10 m A/cm^(2)电流密度下的过电位为233 m V,此时Tafel斜率较低,显示出了较好的析氧催化性能.展开更多
Pancreatic cancer is one of the most devastating solid tumors, and it remains one of the most difficult to treat. The treatment of metastatic pancreatic cancer (MPC) is systemic, based on chemotherapy or best supporti...Pancreatic cancer is one of the most devastating solid tumors, and it remains one of the most difficult to treat. The treatment of metastatic pancreatic cancer (MPC) is systemic, based on chemotherapy or best supportive care, depending on the performance status of the patient. Two chemotherapeutical regimens have produced substantial benefits in the treatment of MPC: gemcitabine in 1997; and FOLFIRIONOX in 2011. FOLFIRINOX improved the natural history of MPC, with overall survival (OS) of 11.1 mo. Nab-paclitaxel associated with gemcitabine is a newly approved regimen for MPC, with a median OS of 8.6 mo. Despite multiple trials, this targeted therapy was not efficient in the treatment of MPC. Many new molecules targeting the proliferation and survival pathways, immune response, oncofetal signaling and the epigenetic changes are currently undergoing phase I and II trials for the treatment of MPC, with many promising results.展开更多
基金supported by the National Key Basic Research Program of China (No. 2011CB201205)National Natural Science Foundation of China (No. 51204161)+1 种基金Innovation Project for Graduates in Jiangsu Province of China (No. KYLX15_1404) the Natural Science Foundation of Jiangsu Province of China (No. BK20140189)
文摘The uniaxial compression tests were conducted on the cylindrical shale specimens with bedding plane inclined at 0° and 90° to the axial loading direction, respectively. Effect of the bedding orientation on the mechanical property and energy evolution characteristics of shales was revealed. The failure mechanisms of the specimens with layers in 0° orientation showed splitting failure along weak bedding, while the specimens with layers in 90° orientation were failed by shearing sliding. The values of compressive strength, elastic modulus and shear modulus of samples at 0° were higher than those of samples at 90°and there was little difference of Poisson's ratio between samples at 0° and 90°. The analysis of the stress–strain energy and acoustic emission(AE) energy indicated that the growth rate of absorbed energy density and elastic energy density at 0° was significantly faster than that at 90°, hence their final values at 0°were relatively larger than the latter. Moreover, higher energy release was observed for specimens at 0°.The energy release and rapid growth of energy dissipation also appeared more early at 0°. The stress ratio63% was a critical point of energy distribution at which differences started to arise between samples at 0°and 90°. These results indicated that the failure of shale at 0° was more violent and devastative than the failure of shale at 90°.
文摘Gangdise tectonic belt, located in the middle part of Tibet—Qinghai plateau Tethys tectonic domain, is the most representative region in Tibet—Qinghai plateau Tethyan evolution especially in Mesozoic era. It is mainly covered by thick Jurassic—Cretaceous system layer. During the Mesozoic to Cenozoic era, strong island\|arc types volcanism and volcanic rocks and intrusive rocks belt.. Geologists had divided the Tibet Tethyan evolution into three or four stages (Huang, Jiqing, 1987; Pan Guitang, Li Xinzheng, 1993), according to the ocean\|land conversion process of Tethyan evolution .The Tethyan evolution and the nature of Gangdise tectonic belt had been well\|studied by geologists (Huang Jiqing, 1987; Deng Wanming, 1984; Xia Daixiang, 1986; Cheng Changlun 1987; ZhouXiang 1993; Pan Guitang, 1996). Studies showed that Gangdise tectonic belt, from upper Paleozoic to Mesozoic era, had been developed alternate multiple island arc\|basin system, and characterized by many basin types and strong tectonic\|magma activity. Based on the study of Gangdise multiple island arc\|basin system, I present another version of Gangdise tectonic belt tectonic units division and evolution here.
文摘氢能作为一种清洁、无污染、资源丰富、应用广泛的二次能源,因其能量密度高、节能、环保、可回收利用等特点,在新能源领域具有非常重要的地位.尽管碱性电解水制氢技术在我国得到了广泛应用,但其能耗和成本较高的问题亟待解决.为了提升电解水过程的反应速率,迫切需要开发出低成本且高效的电催化剂,用于促进电解水析氧反应(OER).采用以三维多孔的泡沫镍(NF)为基底,恒电流的脉冲电沉积技术制备镍钴合金作为电催化剂,研究表明:当电沉积时间为900 s,电沉积电流密度为60 m A/cm^(2)时,Ni-Co/NF电极催化剂在10 m A/cm^(2)电流密度下的过电位为233 m V,此时Tafel斜率较低,显示出了较好的析氧催化性能.
文摘Pancreatic cancer is one of the most devastating solid tumors, and it remains one of the most difficult to treat. The treatment of metastatic pancreatic cancer (MPC) is systemic, based on chemotherapy or best supportive care, depending on the performance status of the patient. Two chemotherapeutical regimens have produced substantial benefits in the treatment of MPC: gemcitabine in 1997; and FOLFIRIONOX in 2011. FOLFIRINOX improved the natural history of MPC, with overall survival (OS) of 11.1 mo. Nab-paclitaxel associated with gemcitabine is a newly approved regimen for MPC, with a median OS of 8.6 mo. Despite multiple trials, this targeted therapy was not efficient in the treatment of MPC. Many new molecules targeting the proliferation and survival pathways, immune response, oncofetal signaling and the epigenetic changes are currently undergoing phase I and II trials for the treatment of MPC, with many promising results.
