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A Marine or Continental Nature of the Deltas in the Early Cretaceous Lingshandao Formation--Evidences from Trace Elements 被引量:12
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作者 YANG Renchao FAN Aiping +1 位作者 HAN Zuozhen A.J.(Tom)VAN LOON 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第1期367-368,共2页
Objective A succession with well-developed soft-sediment deformation structures and well-exposed gravity-flow deposits in the Early Cretaceous Lingshandao Formation has caused considerable controversy on whether the n... Objective A succession with well-developed soft-sediment deformation structures and well-exposed gravity-flow deposits in the Early Cretaceous Lingshandao Formation has caused considerable controversy on whether the nondisputed deltaic environment was marine or continental.This dispute cannot be solved by mere sedimentological analysis and,moreover,too few fossils are present to be decisive. 展开更多
关键词 Cr PPM evidences from Trace Elements
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Experiments and evidences: jellyfish (Nemopilema nomurai) decomposing and nutrients (nitrogen and phosphorus) released 被引量:1
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作者 LI Xuegang SONG Jinming +4 位作者 MA Qingxia LI Ning YUAN Huamao DUAN Liqin QU Baoxiao 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2015年第8期1-12,共12页
The aim of this study was to investigate nitrogen and phosphorus released in the process of the decomposition of giant jellyfish in the laboratory and found the evidence to verify the influence of nutrients released b... The aim of this study was to investigate nitrogen and phosphorus released in the process of the decomposition of giant jellyfish in the laboratory and found the evidence to verify the influence of nutrients released by the decomposition of jellyfish on the ecosystem in the field. The release of nitrogen and phosphorus from the decomposition of Nernopilerna nomurai was examined in a series of experiments under different incubation conditions such as different pH values, salinity values, temperatures and nitrogen and phosphorus concentrations. The results showed that the complete decomposition of Nemopilema nomurai generally took about 4-8 d. The release of nitrogen and phosphorus from the decomposition of Nemopilema nomurai could be divided into two stages: the early stage and the later stage, although the efflux rate of nitrogen was one order more than phosphorus. In the early stage of the decomposition of Nemopilema nomurai, the concentrations of dissolved nitrogen, dissolved phosphorus, total nitrogen and total phosphorus in seawater increased rapidly, and the concentration of nitrogen could reach the highest level in the whole degradation process. In the later stage of the decomposition, the concentrations of dissolved nitrogen and total nitrogen declined slowly, while the concentration of phosphorus in water could reach a maximum in the degradation process. High pH, low salinity, high temperature and N/P will promote the release of nitrogen; low pH is unfavorable to the release of nitrogen but favorable to the release of phosphorus. In addition, we found the concentrations of ammonium and phosphate in the bottom water were higher than those in the surface water during the period of jellyfish bloom in the ]iaozhou Bay, proving that nutrients released by the decomposition of jellyfish have significant influence on nitrogen and phosphorus in the field. For the whole Yellow Sea, nutrients released by jellyfish carcasses may reach up to (2.63±2.98)x10^7 mol/d of dissolved nitrogen (DN) and (0.74±0.84)x10^8 mol/d of dissolved phosphorus (DP) during the period of jellyfish bloom. The values are comparable to riverine inputs in a day, but much higher than sediment-water exchange flux in the Yellow Sea. The great amounts of nutrients must have significant influence on the nutrients balance of the Yellow Sea during the period of jellyfish dead and decomposition. Both the experimental data and field observations proved that the decomposition of jellyfish may release a great amount of nutrient to the surrounding environment during the period of jellyfish decomposition. 展开更多
关键词 Nemopilema nomurai DECOMPOSITION nitrogen PHOSPHORUS EXPERIMENTS evidences
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Wavelet Density Estimation and Statistical Evidences Role for a GARCH Model in the Weighted Distribution 被引量:1
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作者 Mohammad Abbaszadeh Mahdi Emadi 《Applied Mathematics》 2013年第2期410-416,共7页
We consider n observations from the GARCH-type model: Z = UY, where U and Y are independent random variables. We aim to estimate density function Y where Y have a weighted distribution. We determine a sharp upper boun... We consider n observations from the GARCH-type model: Z = UY, where U and Y are independent random variables. We aim to estimate density function Y where Y have a weighted distribution. We determine a sharp upper bound of the associated mean integrated square error. We also make use of the measure of expected true evidence, so as to determine when model leads to a crisis and causes data to be lost. 展开更多
关键词 Density Estimation GARCH Model WEIGHTED Distribution WAVELETS Statistical evidences STRONGLY MIXING
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North Atlantic Abrupt Climate Signals during the Last Glacial Period in Central Asia:Evidences from Aeolian Loess Sediments 被引量:1
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作者 SONG Yougui LI Yue +4 位作者 LI Yun AN Zhisheng CHENG Liangqing SUN Huanyu Rustam OROZBAEV 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第5期1942-1943,共2页
Objective Climate fluctuations over suborbital or millennial timescale display significant instability during the last glacial period,which are often superimposed upon the orbital periodicity.They triggered some abrup... Objective Climate fluctuations over suborbital or millennial timescale display significant instability during the last glacial period,which are often superimposed upon the orbital periodicity.They triggered some abrupt climate events, 展开更多
关键词 North Atlantic Abrupt Climate Signals during the Last Glacial Period in Central Asia:evidences from Aeolian Loess Sediments OSL
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GEOMORPHIC EVIDENCES FOR CENOZOIC UPLIFT IN THE EASTERN MARGIN OF QINGHAI—TIBET PLATEAU
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作者 Li Yong,Hou Zhongjian,Si Guangying 《地学前缘》 EI CAS CSCD 2000年第S1期277-278,共2页
The uplift history has been becoming the key for the geological science of Qinghai—Tibet plateau. The scholars abroad have reconstructed uplift history of the plateau by studying geological process of the inner globe... The uplift history has been becoming the key for the geological science of Qinghai—Tibet plateau. The scholars abroad have reconstructed uplift history of the plateau by studying geological process of the inner globe, they considered that the altitude of the plateau got up to the maximum at 14Ma (M.Coleman et al, 1995; S.Turner et al, 1993)or the plateau got to the present elevation at about 8Ma (T.M.Harrison,1992). The Chinese geologists make use of substitutes of outer environmental elements to deduce that the uplift of Qinghai—Tibet plateau began from 3 4Ma(Li Jijun,1995). It is obvious that there are the different views and controversies about the plateau uplift history. 展开更多
关键词 geomorphic evidences CENOZOIC UPLIFT Qinghai—Tibet PLATEAU Western SICHUAN
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STRUCTURAL EVIDENCES OF Ru (H)_2(H_2) (PPh_3)_3 AT LOW TEMPERATURE
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作者 Quan Ling SUO Xing Ming LIU +2 位作者 Yuan Qi YIN Dao Sen JIN Shu Ben LI Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000 《Chinese Chemical Letters》 SCIE CAS CSCD 1993年第7期653-656,共4页
FTIR spectrum at liquid nitrogen temperature and IH NMR of air-sensitive polyhydride Ru(H)_2(H_2)(PPh_3)_3 have been measured for the first time. It is found that a fluxional process happens at room temperature, but t... FTIR spectrum at liquid nitrogen temperature and IH NMR of air-sensitive polyhydride Ru(H)_2(H_2)(PPh_3)_3 have been measured for the first time. It is found that a fluxional process happens at room temperature, but the structure of Ru(H)_2(H_2)(PPh_3)_3 with non-equivalent hydrogens is discernible at low temperature. 展开更多
关键词 STRUCTURAL evidences OF Ru PPH3 H2 AT LOW TEMPERATURE
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Element-Combinations from Evidences of Tectono-geochemistry of The Lekai Pb-Zn Deposit in Northwestern Guizhou, China
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作者 WAN Xin HAN Runsheng LI Bo 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第S1期231-232,共2页
1 Introduction The Pb-Zn metallogenic area in Northwest Guizhou is located in the southwest margin of the Yangtze block,which is an important part of the Sichuan-Yunnan-Guizhou(SYG)Pb-Zn metallogenic province.So far,
关键词 Pb China Element-Combinations from evidences of Tectono-geochemistry of The Lekai Pb-Zn Deposit in Northwestern Guizhou Zn
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New Evidences for the Adsorption of Methane over Oxide Surfaces
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作者 Fa Qiang XU Shi Kong SHEN Jin Zhen XUE(National Synchrotron Radiation Laboratory.University of Science and Technology of China.Hefei 230029.)(Key State Laboratory for Oxo Synthesis and Selective Oxidation. Lanzhou Institute of Chemical Physics.Chinese Ac 《Chinese Chemical Letters》 SCIE CAS CSCD 1996年第9期875+873-874,共3页
It is indicative of the TSR result that CH4 was strongly adsorbed on well degassed SrCO3 surface at high temperatUre.A desorption peak of CH4 was found in CH4TPD profile which appeared at ca. 310℃.The strong adsorpti... It is indicative of the TSR result that CH4 was strongly adsorbed on well degassed SrCO3 surface at high temperatUre.A desorption peak of CH4 was found in CH4TPD profile which appeared at ca. 310℃.The strong adsorption of CH4 over the surface of SrCO3 was attributed to the strong basicity of SrO sites resulted from decomposition of SrCO_3 展开更多
关键词 OVER New evidences for the Adsorption of Methane over Oxide Surfaces
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New Petrological and Sedimentary Evidences on the Late Cretaceous Uplift of the Tibetan Plateau
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作者 WANG Xiaonan LI Yalin +2 位作者 DU Lintao HE Haiyang LI Yubai 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2017年第4期1501-1502,共2页
The India-Asia collision and uplift of the Tibetan plateau are the most important geological events in Earth's history; it profoundly affects our understanding of global climate change during the Cenozoic. Despite a ... The India-Asia collision and uplift of the Tibetan plateau are the most important geological events in Earth's history; it profoundly affects our understanding of global climate change during the Cenozoic. Despite a research history over half a century, the uplifting history remains hotly controversial. The early uplifting model suggested that the Lhasa terrane attained an elevation of 3-4 km at -99 Ma due to the Lhasa-Qiangtang collision. However, the evidences are mainly from deformation of the Lhasa terrane and inconsistency with the palaeontological data. 展开更多
关键词 New Petrological and Sedimentary evidences on the Late Cretaceous Uplift of the Tibetan Plateau
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Research on the applicable problems of the rules of the exclusion of the illegal evidences
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作者 Guo Yujing 《International English Education Research》 2015年第6期111-114,共4页
With the full implementation of the Code of Criminal Procedure, the application of the rules of the exclusion of the illegal evidences is more inclined to the protection of the human rights. However, in the process of... With the full implementation of the Code of Criminal Procedure, the application of the rules of the exclusion of the illegal evidences is more inclined to the protection of the human rights. However, in the process of the implementation of the new laws, the problems in view of the rules of the exclusion of the illegal evidences are also prominent, which are mainly reflected in the ambiguity of the scope of the application, the start of the program of the exclusion, and the formalization the trial certificates and other aspects. Therefore, in this article, the author starts from the concept of the illegal evidences, and expounds the principles of the exclusion and the abilities of the evidences, and especially explores the abilities of the evidences and the probative forces. From the differences between the two, the author strictly proves the virtualization of the standards, in order to provide the positive solutions for strengthening the exclusionary procedure of the illegal evidences. 展开更多
关键词 Rules of the exclusion of the illegal evidences competence of the evidence slight defective evidence rule of evidence pre-court session
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Combination method of conflict evidences based on evidence similarity 被引量:10
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作者 Wenhao Bi An Zhang Yuan Yuan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2017年第3期503-513,共11页
Aiming at the problem that the traditional Dempster Shafer (D-S) evidence theory cannot deal with conflicted evidences effectively and correctly, this paper points out that the key issue of this problem is to measure ... Aiming at the problem that the traditional Dempster Shafer (D-S) evidence theory cannot deal with conflicted evidences effectively and correctly, this paper points out that the key issue of this problem is to measure the degree of conflict between evidences correctly after analyzing various improved methods. The existing evidence conflict measure methods are analyzed, and a new evidence conflict measure method called evidence similarity measure based on the Tanimoto measure is proposed, while a new evidence combination method is proposed on the basis of evidence similarity measure. Firstly, the conflict degrees between evidences are obtained through the evidence similarity measure. Then the evidence sources are modified based on the credibility of different evidences and the weights of conflicted parts of evidences on different focal elements are determined. Finally, the fusion result is obtained by this method. Numerical examples show that the proposed method can effectively fuse evidences when evidences are consistent or highly conflicted, and it has a fast convergence speed, a high degree of accuracy and good adaptability. 展开更多
关键词 evidence theory evidence conflict conflict measure evidence similarity information fusion
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Integrating Intra-and Inter-document Evidences for Improving Sentence Sentiment Classification 被引量:6
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作者 ZHAO Yan-Yan QIN Bing LIU Ting 《自动化学报》 EI CSCD 北大核心 2010年第10期1417-1425,共9页
Sentence sentiment classification is an important task of sentiment analysis.It aims to classify the sentences into positive,negative,or objective.One can consider sentence sentiment classification as a standard text ... Sentence sentiment classification is an important task of sentiment analysis.It aims to classify the sentences into positive,negative,or objective.One can consider sentence sentiment classification as a standard text categorization problem.However,determining the sentiment orientation of a review sentence requires more than the features inside the sentence itself,especially for the sentences with little or ambiguous inside sentence features.Through observing,some features outside the sentence can interact with its inside features to enhance the overall performance of sentence sentiment classification.Thus in this paper,we propose two such outside sentence features:intra-document evidence and inter-document evidence.Then in order to improve the sentence sentiment classification performance,a graph-based propagation approach is presented to incorporate these inside and outside sentence features.The experimental results on camera domain show that the proposed approach performs better than the approaches without using outside sentence features,and outperforms other representational previous approaches. 展开更多
关键词 Sentence sentiment classification sentiment analysis intra-document evidence inter-document evidence graph-based propagation approach
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A new fusion approach based on distance of evidences 被引量:4
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作者 陈良洲 施文康 +1 位作者 邓勇 朱振福 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2005年第5期476-482,共7页
Based on the framework of evidence theory, data fusion aims at obtaining a single Basic Probability Assignment (BPA) function by combining several belief functions from distinct information sources. Dempster’s rule o... Based on the framework of evidence theory, data fusion aims at obtaining a single Basic Probability Assignment (BPA) function by combining several belief functions from distinct information sources. Dempster’s rule of combination is the most popular rule of combinations, but it is a poor solution for the management of the conflict between various information sources at the normalization step. Even when it faces high conflict information, the classical Dempster-Shafer’s (D-S) evidence theory can involve counter-intuitive results. This paper presents a modified averaging method to combine conflicting evidence based on the distance of evidences; and also gives the weighted average of the evidence in the system. Numerical examples showed that the proposed method can realize the modification ideas and also will provide reasonable results with good convergence efficiency. 展开更多
关键词 Data fusion Evidence distance Conflicting evidence Evidence credibility Combination rules
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An ECR-PCR rule for fusion of evidences defined on a non-exclusive framework of discernment 被引量:2
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作者 Xinyang DENG Yebi CUI Wen JIANG 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2022年第8期179-192,共14页
In the research of uncertain information processing,Dempster-Shafer Theory(DST)provides a framework for dealing with uncertain information,where evidence is defined on a Frame of Discernment(FOD)consisting of mutually... In the research of uncertain information processing,Dempster-Shafer Theory(DST)provides a framework for dealing with uncertain information,where evidence is defined on a Frame of Discernment(FOD)consisting of mutually exclusive elements.However,the requirement of exclusiveness on FOD sometimes is not satisfied,as shown in Dezert-Smarandache Theory(DSm T),a derivative of DST.In DSm T,the non-exclusiveness is expressed by propositions’intersection and the fusion of evidence is realized through a Proportional Conflict Redistribution(PCR)rule.In order to handle non-exclusive FODs,a new framework called D Number Theory(DNT)has been proposed recently,which quantifies the non-exclusive degree between propositions different from DSm T.In previous studies,an Exclusive Conflict Redistribution(ECR)rule has been designed in DNT to implement the fusion of evidence defined on a non-exclusive FOD,but there are some deficiencies in the ECR rule.In this paper,a new rule called ECR-PCR rule is proposed by combining the ECR and PCR rules to better implement the fusion of evidence defined on a nonexclusive FOD.Within the proposed rule,the definition of conflict utilizes the idea of ECR’s exclusive conflict,and the disposal of conflict is following the idea of PCR’s proportional redistribution.Properties of the ECR-PCR rule are presented.The effectiveness of the proposed new rule is verified through numerical examples and applications,in comparison with other fusion methods. 展开更多
关键词 D number theory Dempster-Shafer theory Evidence combination Non-exclusiveness Proportional Conflict Redistribution rule Information fusion
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Certainty factors of earthquake precursory anomaly evidences CF(E) 被引量:1
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作者 郑兆苾 《Acta Seismologica Sinica(English Edition)》 CSCD 1994年第3期475-479,共5页
In this paper, we propose the principle, methods and calculating formulas for determining the certainty factors of earthquake precursory anomaly evidences CF (E). Based on the guidebooks for earthquake prediction, we ... In this paper, we propose the principle, methods and calculating formulas for determining the certainty factors of earthquake precursory anomaly evidences CF (E). Based on the guidebooks for earthquake prediction, we give the methods of determining the CF values of 22 evidences (including seismic gap, belt, b-value, c-value, velocity ratio, strengthen of anomalous activities, quiet of anomalous activities, seismic window, earthquake swarm,earthquake sequence, coda wave, initial motion of P wave, stress drop, geoelectricity, geomagnetism, stress,ground tilt, ground water level, radon and hydrochemistry, gravity, space environment and macroscopic anomalies), and show three examples. The purposes are to use the Expert System for Earthquake Prediction (ESEP) further. 展开更多
关键词 certainty factor of evidence earthquake precursory Expert System for Earthquake Prediction
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Reflection of the supplemem and correction of the defective evidences
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作者 Gong Hanbing 《International English Education Research》 2015年第9期66-69,共4页
Since the implementation of the rules of the supplement and correction of the defective evidences, there are many problems in the practice. The actual investigations and researches also feedback that the judges also h... Since the implementation of the rules of the supplement and correction of the defective evidences, there are many problems in the practice. The actual investigations and researches also feedback that the judges also have a lot of problems in the face of the definition of the meaning of the defective evidences, the correction application, and the degree restrictions. Behind this reflects the contradiction between the stress of the prosecution organs in the criminal detection and the deepening of the resisting mechanism in the court. And the litigation structure of the "division of responsibilities among three authorities" and the trial mode of "the centralism of the book records of the cases" exacerbated this opposition. On the basis of clarifying the origin and the meanings of the defective evidences, the author of this paper analyzes the essence and its harm of the rule. Through the reflections of the problems existing in the practice, the author further defines the two types of the "defects" that shall not be allowed to correct. 展开更多
关键词 Defective evidence supplement and correction rules illegal evidence
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NETIZEN WATCH
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《China Weekly》 2026年第2期12-13,共2页
China Expands Domestic Violence Protection to Unmarried Couples Netizen Comments:"It sounds horrible.If violence occurs between strangers,it's easier to charge intentional injury.Now if domestic violence is p... China Expands Domestic Violence Protection to Unmarried Couples Netizen Comments:"It sounds horrible.If violence occurs between strangers,it's easier to charge intentional injury.Now if domestic violence is prosecuted under the domesticviolence law,convictions will be much harder,considering how diffcult itis to prove." 展开更多
关键词 unmarried couples EVIDENCE domestic violence PROTECTION CONVICTION
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Molecular hydrogen therapy in musculoskeletal conditions:An evidence-based review and critical analysis
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作者 Naveen Jeyaraman Madhan Jeyaraman +3 位作者 Swaminathan Ramasubramanian Shrideavi Murugan Arulkumar Nallakumarasamy Sathish Muthu 《World Journal of Orthopedics》 2026年第1期40-56,共17页
Molecular hydrogen(H2)demonstrates selective antioxidant and anti-inflammatory properties with therapeutic potential across musculoskeletal conditions including osteoarthritis,rheumatoid arthritis,exercise-induced mus... Molecular hydrogen(H2)demonstrates selective antioxidant and anti-inflammatory properties with therapeutic potential across musculoskeletal conditions including osteoarthritis,rheumatoid arthritis,exercise-induced muscle damage,chronic pain syndromes,tendinopathies,and muscle atrophy.This review critically evaluates preclinical and clinical evidence for H2 therapy and identifies research gaps.A comprehensive search of PubMed,EMBASE,and Cochrane Library(up to April 2025)yielded 45 eligible studies:25 preclinical and 20 clinical trials.Preclinical models consistently showed reductions in reactive oxygen species,inflammatory cytokines,and improved cell viability.Clinical trials reported symptomatic relief in osteoarthritis,decreased Disease Activity Score 28 in rheumatoid arthritis,and accelerated clearance of muscle damage markers.Delivery methods varied-hydrogen-rich water,gas inhalation,and saline infusion-hindering direct comparison.Mechanistic biomarkers were inconsistently reported,limiting understanding of target engagement.Common limitations included small sample sizes,short durations,and protocol heterogeneity.Despite these constraints,findings suggest H2 may serve as a promising adjunctive therapy via antioxidant,anti-inflammatory,and cytoprotective mechanisms.Future research should prioritize standardized delivery protocols,robust mechanistic endpoints,and longer-term randomized trials to validate clinical efficacy and optimize therapeutic strategies. 展开更多
关键词 Molecular hydrogen Musculoskeletal disorders Oxidative stress ANTI-INFLAMMATION Clinical evidence
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STUDY ON THE EXCLUSION OF REPEATED VERBAL EVIDENCES
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作者 田荔枝 权艳平 《China Legal Science》 2015年第2期61-80,共20页
After the establishment and enforcement of the exclusionary rules of illegal evidences, the problems of excluding repeated verbal evidences appeared gradually. When the behaviors of illegally collecting evidences occu... After the establishment and enforcement of the exclusionary rules of illegal evidences, the problems of excluding repeated verbal evidences appeared gradually. When the behaviors of illegally collecting evidences occur,does this mean that the followed-up series of collecting evidences behaviors are illegal?This is the issue with the exclusion of repeated verbal evidences. The exclusion of repeated verbal evidences is the inevitable requirement of the effective enforcement of the exclusionary rules of illegal evidences. Also,the exclusion of illegal evidences is the key and premise program of excluding repeated verbal evidences,but in Chinese judicial practice,the negative attitude of a kind of malfeasance of the court to enforce the exclusionary rules of illegal evidences,the 'homogeneous'kind of relationship between our court system,police system and procuratorial system in current period all mean that the exclusion of repeated verbal evidence will surely face ring upon ring obstacles. Otherwise,the restriction of judicial discretion in judicial practice requires the exclusion of repeated verbal evidences to insist on the principle of absolute exclusion,and this determines that the method of depending on judicial discretion to solve the problem of the scope of exclusion is inapplicable. 展开更多
关键词 言词证据 非法证据排除 法官自由裁量权 VERBAL 排除原则 evidences EXCLUSION statements 我国法院 ORGANS
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Real-World Outcomes of First-Line Palbociclib Plus Endocrine Therapy for HR+/HER2−Metastatic Breast Cancer in Japan:A Single-Center Retrospective Study
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作者 Keiko Yanagihara Masato Yoshida +4 位作者 Kensaku Awaji Tamami Yamakawa Sena Kato Miki Tamura Koji Nagata 《Oncology Research》 2026年第1期222-236,共15页
Background:Cyclin-dependent kinase 4/6(CDK4/6)inhibitors have transformed the management of hormone receptor–positive/HER2–negative(HR+/HER2–)advanced breast cancer,yet evidence for elderly or poor-performance pati... Background:Cyclin-dependent kinase 4/6(CDK4/6)inhibitors have transformed the management of hormone receptor–positive/HER2–negative(HR+/HER2–)advanced breast cancer,yet evidence for elderly or poor-performance patients remains limited.This study examined real-world outcomes of palbociclib plus endocrine therapy in Asian patients,with additional subgroup analyses by age and performance status.Methods:We retrospectively analyzed 46 consecutive Asian patients with recurrent or de novo HR+/HER2−breast cancer treated with first-line palbociclib plus ET between April 2021 and March 2025.The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall response rate(ORR),disease control rate(DCR),and safety.Subgroup analyses were performed by age(<70 vs.≥70 years)and performance status(PS;0–1 vs.2–3).Results:The median PFS was 26.6 months(range,1.4–69.5).Stratified by age,median PFS was 26.9 months in patients<70 years and 26.2 months in those≥70 years(p=0.760).By PS,PFS was 26.9 months for PS 0–1 and 17.8 months for PS 2–3(p=0.099).ORR was 60.9%and DCR 93.5%;notably,all PS 2–3 patients achieved disease control.Hematologic toxicities were common,with neutropenia(80.4%)and leukopenia(86.7%)predominating,but grade≥3 anemia was rare(2.2%).Elderly patients experienced anemia more frequently,while overall toxicity remained manageable.Dose reductions occurred in 47.8%without loss of efficacy.Conclusions:In routine Japanese practice,palbociclib plus ET provided prolonged PFS and high disease control consistent with pivotal trials and international real-world evidence.Importantly,elderly patients tolerated treatment well,and selected PS 2–3 patients also derived clinical benefit.These findings indicate that neither age nor PS alone should preclude the use of palbociclib in carefully monitored real-world patients. 展开更多
关键词 Metastatic breast cancer cyclin-dependent kinase 4/6(CDK4/6)inhibitors real-world evidence hormone receptor-positive human epidermal growth factor receptor 2-negative breast cancer
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