Objective:To summarize evidence on the prevention and management of intradialytic hypotension in maintenance hemodialysis patients,providing reference for clinical practice.Method:Chinese and English databases,guideli...Objective:To summarize evidence on the prevention and management of intradialytic hypotension in maintenance hemodialysis patients,providing reference for clinical practice.Method:Chinese and English databases,guideline websites,and professional society websites were systematically searched for literature on intradialytic hypotension guidance,including clinical decisions,guidelines,evidence summaries,systematic reviews,and expert consensuses,from database inception to October 1,2024.Evidence was extracted after literature quality evaluation.Results:A total of 11 publications were included:2 clinical decisions,7 guidelines,1 systematic review,and 1 expert consensus.38 pieces of evidence were summarized across 4 themes:pre-dialysis assessment and prevention,monitoring and management during dialysis,medication use,and patient self-management.Conclusion:The best evidence for prevention and management of intradialytic hypotension in maintenance hemodialysis patients is scientific and comprehensive.Healthcare professionals are advised to apply this evidence judiciously in conjunction with clinical realities to ensure patient safety.展开更多
Objective:To explore the obstructive factors in the behavior of medical staff during the implementation of respiratory rehabilitation process,and to provide a basis for the rehabilitation management intervention of CO...Objective:To explore the obstructive factors in the behavior of medical staff during the implementation of respiratory rehabilitation process,and to provide a basis for the rehabilitation management intervention of COPD.Methods:A descriptive nature research method was adopted.An interview outline was formulated based on the theoretical domain framework.From October to December 2024,15 medical staff from the respiratory department of a tertiary hospital in Shaanxi Province were selected for semi-structured interviews.The interview data were analyzed using the Colaizzi 7-step analysis method.Result:The analysis of this study found that the obstructive factors for medical staff to implement respiratory rehabilitation include five theoretical domains.The problems are respectively the lack of knowledge about respiratory rehabilitation and insufficient training intensity,the insufficient self-recognition of implementing respiratory rehabilitation,the low awareness rate of patients and the low cooperation degree,the insufficient provision of instruments and facilities,the lack of rehabilitation training venues and respiratory rehabilitation clinics,and the lack of scientific and standardized respiratory rehabilitation management processes.Conclusion:There are many obstructive factors affecting the implementation of respiratory rehabilitation by medical staff.Clinical managers should take corresponding measures,continuously improve the rehabilitation management strategies for COPD,and promote the clinical application of the best evidence for respiratory rehabilitation.展开更多
Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA)...Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA).However,the research on the uncertainty measure of complex evidence theory is still an open issue.Therefore,in this paper,first,the Fractal-based Complex Belief(FCB)entropy as a generalization of Fractal-based Belief(FB)entropy,which has superiority in uncertainty measurement of CBBA,is proposed.Second,on the basis of FCB entropy,we propose Fractal-based Supremum Complex Belief(FSCB)entropy and Fractal-based Infimum Complex Belief(FICB)entropy,with FSCB entropy as the upper bound and FICB entropy as the lower bound.They are collectively called the proposed FCB entropy.Furthermore,we analyze the properties,physical interpretation and numerical examples to prove the rationality of the proposed method.Finally,a practical information fusion application is proposed to prove that the proposed FCB entropy can reasonably measure the uncertainty of CBBA.The results show that,the proposed FCB entropy can handle the uncertainty measure of CBBA,which can be a reasonable way for uncertainty measure in complex evidence theory.展开更多
Objective: In the Healthy Child Action Enhancement Program (2021-2025), it is proposed to ensure the safety and health of newborns and to promote high-quality development of health. Our department established risk ass...Objective: In the Healthy Child Action Enhancement Program (2021-2025), it is proposed to ensure the safety and health of newborns and to promote high-quality development of health. Our department established risk assessment criteria for medical adhesives in neonates by applying the best evidence in the management program for the reduction of medical adhesive-associated skin injuries in neonates, in terms of the use and removal of adhesives. Methods: A systematic search and quality assessment of topics related to medical adhesive-related skin injury in neonates was conducted to summarize the best evidence and to conduct a quality review in the neonatal unit. Results: After 2 rounds of review, medical and nursing staff in the neonatal unit had a 98% compliance rate for the knowledge of neonatal medical adhesive-related skin injury and a satisfactory compliance rate for the other 9 indicators;after the application of the evidence, the incidence of neonatal medical adhesive-related skin injury was significantly lower than that before the application of the evidence, and the differences were statistically significant (P Conclusion: The application of the best evidence-based management program in neonatal medical adhesive-associated skin injury can reduce the incidence of neonatal medical adhesive-associated skin injury, reduce neonatal infections, and improve the integrity of the protective skin barrier in neonates.展开更多
Objective: To develop a best-evidence-based optimal nutrition management plan for patients with chronic heart failure, apply it in clinical practice, and evaluate its effectiveness. Methods: Use the KTA knowledge tran...Objective: To develop a best-evidence-based optimal nutrition management plan for patients with chronic heart failure, apply it in clinical practice, and evaluate its effectiveness. Methods: Use the KTA knowledge translation model to guide evidence-based practice in nutrition management, and compare the nutritional status, cardiac function status, quality of life, and quality review indicators of chronic heart failure patients before and after the application of evidence. Results: After the application of evidence, the nutritional status indicators (MNA-SF score, albumin, hemoglobin) of two groups of heart failure patients significantly increased compared to before the application of evidence, with statistically significant differences (p Conclusion: The KTA knowledge translation model provides methodological guidance for the implementation of evidence-based practice for heart failure patients. This evidence-based practice project is beneficial for improving the outcomes of malnutrition in chronic heart failure patients and is conducive to standardizing nursing pathways, thereby promoting the improvement of nursing quality.展开更多
D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane （CBM） concentrated...D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane （CBM） concentrated areas. First, we choose seismic attributes that are most sensitive to CBM content changes with the guidance of CBM content measured at well sites. Then the selected seismic attributes are fused using D-S evidence theory and the fusion results are used to predict CBM-enriched area. The application shows that the predicted CBM content and the measured values are basically consistent. The results indicate that using D-S evidence theory in seismic multi-attribute fusion to predict CBM-enriched areas is feasible.展开更多
The concept and development history of rehabilitation environment were summarized in this study,principles and techniques of applying evidence-based design in the design of rehabilitation environment were analyzed,cla...The concept and development history of rehabilitation environment were summarized in this study,principles and techniques of applying evidence-based design in the design of rehabilitation environment were analyzed,classification and functions of landscape elements in rehabilitation environment were particularly discussed.展开更多
Reversible data hiding(RDH)enables secret data embedding while preserving complete cover image recovery,making it crucial for applications requiring image integrity.The pixel value ordering(PVO)technique used in multi...Reversible data hiding(RDH)enables secret data embedding while preserving complete cover image recovery,making it crucial for applications requiring image integrity.The pixel value ordering(PVO)technique used in multi-stego images provides good image quality but often results in low embedding capability.To address these challenges,this paper proposes a high-capacity RDH scheme based on PVO that generates three stego images from a single cover image.The cover image is partitioned into non-overlapping blocks with pixels sorted in ascending order.Four secret bits are embedded into each block’s maximum pixel value,while three additional bits are embedded into the second-largest value when the pixel difference exceeds a predefined threshold.A similar embedding strategy is also applied to the minimum side of the block,including the second-smallest pixel value.This design enables each block to embed up to 14 bits of secret data.Experimental results demonstrate that the proposed method achieves significantly higher embedding capacity and improved visual quality compared to existing triple-stego RDH approaches,advancing the field of reversible steganography.展开更多
Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,ta...Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,tau is not an easy target because it dynamically interacts with microtubules and other cellular components,which presents a challenge for tau-targeted drugs.New cellular models could aid the development of mechanism-based tau-targeted therapies.展开更多
Aiming at the problem that the traditional Dempster Shafer (D-S) evidence theory cannot deal with conflicted evidences effectively and correctly, this paper points out that the key issue of this problem is to measure ...Aiming at the problem that the traditional Dempster Shafer (D-S) evidence theory cannot deal with conflicted evidences effectively and correctly, this paper points out that the key issue of this problem is to measure the degree of conflict between evidences correctly after analyzing various improved methods. The existing evidence conflict measure methods are analyzed, and a new evidence conflict measure method called evidence similarity measure based on the Tanimoto measure is proposed, while a new evidence combination method is proposed on the basis of evidence similarity measure. Firstly, the conflict degrees between evidences are obtained through the evidence similarity measure. Then the evidence sources are modified based on the credibility of different evidences and the weights of conflicted parts of evidences on different focal elements are determined. Finally, the fusion result is obtained by this method. Numerical examples show that the proposed method can effectively fuse evidences when evidences are consistent or highly conflicted, and it has a fast convergence speed, a high degree of accuracy and good adaptability.展开更多
Thirty-six randomized controlled trials and two metaanalyses were reviewed. With respect to adult patients undergoing first orthotopic liver transplantation(OLT), steroid replacement resulted in fewer cases of overall...Thirty-six randomized controlled trials and two metaanalyses were reviewed. With respect to adult patients undergoing first orthotopic liver transplantation(OLT), steroid replacement resulted in fewer cases of overall acute rejection in the corticosteroid free-immunosuppression arm. Initial steroid administration for two weeks and early tacrolimus monotherapy is a feasible immunosuppression regimen without steroid replacement, although further investigations are needed in view of chronic rejections. No significant differences were noted between the treatment groups in terms of patient and graft survival independently of steroid replacement. Renal insufficiency, de novo hypertension, neurological disorders and infectious complications did not differ significantly among steroid and steroidfree groups. Diabetes mellitus, cholesterol levels and cytomegalovirus infection are more frequent in patients within the steroid group. With respect to diabetes mellitus and hypercholesterolemia, the difference was independent of steroid replacement. In relation to transplanted hepatitis C virus patients, mycophenolate mofetil does not appear to have a significant antiviral effect despite early reports. Male gender of donors and recipients, living donors, cold ischemia times, acute rejection, and early histological recurrence were related to the development of advanced hepatitis. There is sufficient scientific clinical evidence advocating avoidance of the ab initio use of steroids in OLT.展开更多
Dysmenorrhea refers to periodic abdominal pain,or radiating to lumbosacral region.For the severe case,it is intolerable,combined with nausea and vomiting sometimes.This disease is commonly seen in unmarried young wome...Dysmenorrhea refers to periodic abdominal pain,or radiating to lumbosacral region.For the severe case,it is intolerable,combined with nausea and vomiting sometimes.This disease is commonly seen in unmarried young women.Epidemiological studies have shown that dysmenorrhea is the most common gynecological disease,especially in young women[1].Acupuncture and moxibustion have a long history in the treatm ent of primary dysmenorrhea(hereinafter referred to as PD),and compared with medication,the advantages are presented in the treatment.Entrusted by the Standardization Working Committee of China Association for Acupuncture and Moxibustion(CAAM),Department of Acupuncture and Moxibustion,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine has undertaken the drafting of Evidence-Based Clinical Practice Guideline of Acupuncture and Moxibustion:Primary Dysmenorrhea(hereinafter referred to as the Guideline).The Guideline was issued in 2014 by CAAM.It summarizes the research achievements in acupuncture-moxibustion treatm ent for dysmenorrhea in recent decades and is intended to standardize the clinical regimen of treatm ent with acupuncture and moxibustion so as to improve the clinical effect.展开更多
In the theory of belief functions, the measure of uncertainty is an important concept, which is used for representing some types of uncertainty incorporated in bodies of evidence such as the discord and the non-specif...In the theory of belief functions, the measure of uncertainty is an important concept, which is used for representing some types of uncertainty incorporated in bodies of evidence such as the discord and the non-specificity. For the non-specificity part, some traditional measures use for reference the Hartley measure in classical set theory; other traditional measures use the simple and heuristic function for joint use of mass assignments and the cardinality of focal elements. In this paper, a new non-specificity measure is proposed using lengths of belief intervals, which represent the degree of imprecision. Therefore, it has more intuitive physical meaning. It can be proved that our new measure can be rewritten in a general form for the non-specificity. Our new measure is also proved to be a strict non-specificity measure with some desired properties. Numerical examples, simulations, the related analyses and proofs are provided to show the characteristics and good properties of the new non-specificity definition. An example of an application of the new non- specificity measure is also presented.展开更多
An improvement method for the combining rule of Dempster evidence theory is proposed. Different from Dempster theory, the reliability of evidences isn't identical; and varies with the event. By weight evidence acc...An improvement method for the combining rule of Dempster evidence theory is proposed. Different from Dempster theory, the reliability of evidences isn't identical; and varies with the event. By weight evidence according to their reliability, the effect of unreliable evidence is reduced, and then get the fusion result that is closer to the truth. An example to expand the advantage of this method is given. The example proves that this method is helpful to find a correct result.展开更多
Evidence theory has been widely used in the information fusion for its effectiveness of the uncertainty reasoning. However, the classical DS evidence theory involves counter-intuitive behaviors when the high conflict ...Evidence theory has been widely used in the information fusion for its effectiveness of the uncertainty reasoning. However, the classical DS evidence theory involves counter-intuitive behaviors when the high conflict information exists. Based on the analysis of some modified methods, Assigning the weighting factors according to the intrinsic characteristics of the existing evidence sources is proposed, which is determined on the evidence distance theory. From the numerical examples, the proposed method provides a reasonable result with good convergence efficiency. In addition, the new rule retrieves to the Yager's formula when all the evidence sources contradict to each other completely.展开更多
In order to achieve the information fusion in the time domain based on the evidence theory, an evidence combination method in the time domain based on reliability and importance is proposed according to the idea of ev...In order to achieve the information fusion in the time domain based on the evidence theory, an evidence combination method in the time domain based on reliability and importance is proposed according to the idea of evidence discount. Firstly, the distortion of the time-domain evidence is judged based on single exponential smoothing. The real-time reliability of the evidence at the adjacent time is obtained by the real-time reliability assessment method of the evidence based on the credibility decay model.Then, the relative importance of the evidence at the adjacent time is obtained by comprehensively considering improved conflict degree and uncertainty. Finally, based on the criterion of evidence discount and the Dempster’s rule of combination, the evidence combination is carried out to achieve the sequential combination of time-domain evidence. The numerical simulation and analysis show that this method has fully embodied the dynamic characteristics of time-domain evidence combination, and it has strong processing ability for conflict information and anti-disturbing ability.The proposed method has good applicability to information fusion in the time domain.展开更多
Based on the framework of evidence theory, data fusion aims at obtaining a single Basic Probability Assignment (BPA) function by combining several belief functions from distinct information sources. Dempster’s rule o...Based on the framework of evidence theory, data fusion aims at obtaining a single Basic Probability Assignment (BPA) function by combining several belief functions from distinct information sources. Dempster’s rule of combination is the most popular rule of combinations, but it is a poor solution for the management of the conflict between various information sources at the normalization step. Even when it faces high conflict information, the classical Dempster-Shafer’s (D-S) evidence theory can involve counter-intuitive results. This paper presents a modified averaging method to combine conflicting evidence based on the distance of evidences; and also gives the weighted average of the evidence in the system. Numerical examples showed that the proposed method can realize the modification ideas and also will provide reasonable results with good convergence efficiency.展开更多
Biochar application to soil is commonly recognized to improve soil fertility and consequently biomass and food production sustainably.We re-examined the robustness of the underlying data and found that,of the 12000+ p...Biochar application to soil is commonly recognized to improve soil fertility and consequently biomass and food production sustainably.We re-examined the robustness of the underlying data and found that,of the 12000+ publications on“biochar and agriculture”used in meta-studies,only 109 Institute for Scientific Information(ISI)papers(or 0.9%)provide experimental data on the impacts on crop yield and/or biomass production.展开更多
The existing early-warning system in metro construction are generally based on traditional single-sensor data and simple analytic model, which makes it difficult to deal with the complex and comprehensive environment ...The existing early-warning system in metro construction are generally based on traditional single-sensor data and simple analytic model, which makes it difficult to deal with the complex and comprehensive environment in metro construction. In this paper, the framework of early-warning threshold for metro construction collapse risk based on D-S evidence theory and rough set is built. By combining the primary data fusion collected based on rough set with the secondary data fusion which is based on D-S evidence theory, the integration of multiple information in metro construction is realized and the risk assessment methods are optimized. A case trial based on Hangzhou metro construction collapse accident is also carried out to exemplify the framework. The empirical analysis guarantees the completeness and independence of the prediction information, and realizes the dynamic prediction of the variation trend of metro construction collapse risk.展开更多
文摘Objective:To summarize evidence on the prevention and management of intradialytic hypotension in maintenance hemodialysis patients,providing reference for clinical practice.Method:Chinese and English databases,guideline websites,and professional society websites were systematically searched for literature on intradialytic hypotension guidance,including clinical decisions,guidelines,evidence summaries,systematic reviews,and expert consensuses,from database inception to October 1,2024.Evidence was extracted after literature quality evaluation.Results:A total of 11 publications were included:2 clinical decisions,7 guidelines,1 systematic review,and 1 expert consensus.38 pieces of evidence were summarized across 4 themes:pre-dialysis assessment and prevention,monitoring and management during dialysis,medication use,and patient self-management.Conclusion:The best evidence for prevention and management of intradialytic hypotension in maintenance hemodialysis patients is scientific and comprehensive.Healthcare professionals are advised to apply this evidence judiciously in conjunction with clinical realities to ensure patient safety.
基金Shaanxi Provincial People’s Hospital Science and Technology Development Incubation Fund Program 2023(Project No.:2023HL-12)。
文摘Objective:To explore the obstructive factors in the behavior of medical staff during the implementation of respiratory rehabilitation process,and to provide a basis for the rehabilitation management intervention of COPD.Methods:A descriptive nature research method was adopted.An interview outline was formulated based on the theoretical domain framework.From October to December 2024,15 medical staff from the respiratory department of a tertiary hospital in Shaanxi Province were selected for semi-structured interviews.The interview data were analyzed using the Colaizzi 7-step analysis method.Result:The analysis of this study found that the obstructive factors for medical staff to implement respiratory rehabilitation include five theoretical domains.The problems are respectively the lack of knowledge about respiratory rehabilitation and insufficient training intensity,the insufficient self-recognition of implementing respiratory rehabilitation,the low awareness rate of patients and the low cooperation degree,the insufficient provision of instruments and facilities,the lack of rehabilitation training venues and respiratory rehabilitation clinics,and the lack of scientific and standardized respiratory rehabilitation management processes.Conclusion:There are many obstructive factors affecting the implementation of respiratory rehabilitation by medical staff.Clinical managers should take corresponding measures,continuously improve the rehabilitation management strategies for COPD,and promote the clinical application of the best evidence for respiratory rehabilitation.
基金supported by the National Natural Science Foundation of China (No. 62473067)Chongqing Talents: Exceptional Young Talents Project, China (No. cstc2022ycjh-bgzxm0070)Chongqing Overseas Scholars Innovation Program, China (No. cx2022024)
文摘Complex evidence theory is a generalized Dempster-Shafer evidence theory,which has the ability to express uncertain information.One of the key issues is the uncertainty measure of Complex Basic Belief Assignment(CBBA).However,the research on the uncertainty measure of complex evidence theory is still an open issue.Therefore,in this paper,first,the Fractal-based Complex Belief(FCB)entropy as a generalization of Fractal-based Belief(FB)entropy,which has superiority in uncertainty measurement of CBBA,is proposed.Second,on the basis of FCB entropy,we propose Fractal-based Supremum Complex Belief(FSCB)entropy and Fractal-based Infimum Complex Belief(FICB)entropy,with FSCB entropy as the upper bound and FICB entropy as the lower bound.They are collectively called the proposed FCB entropy.Furthermore,we analyze the properties,physical interpretation and numerical examples to prove the rationality of the proposed method.Finally,a practical information fusion application is proposed to prove that the proposed FCB entropy can reasonably measure the uncertainty of CBBA.The results show that,the proposed FCB entropy can handle the uncertainty measure of CBBA,which can be a reasonable way for uncertainty measure in complex evidence theory.
文摘Objective: In the Healthy Child Action Enhancement Program (2021-2025), it is proposed to ensure the safety and health of newborns and to promote high-quality development of health. Our department established risk assessment criteria for medical adhesives in neonates by applying the best evidence in the management program for the reduction of medical adhesive-associated skin injuries in neonates, in terms of the use and removal of adhesives. Methods: A systematic search and quality assessment of topics related to medical adhesive-related skin injury in neonates was conducted to summarize the best evidence and to conduct a quality review in the neonatal unit. Results: After 2 rounds of review, medical and nursing staff in the neonatal unit had a 98% compliance rate for the knowledge of neonatal medical adhesive-related skin injury and a satisfactory compliance rate for the other 9 indicators;after the application of the evidence, the incidence of neonatal medical adhesive-related skin injury was significantly lower than that before the application of the evidence, and the differences were statistically significant (P Conclusion: The application of the best evidence-based management program in neonatal medical adhesive-associated skin injury can reduce the incidence of neonatal medical adhesive-associated skin injury, reduce neonatal infections, and improve the integrity of the protective skin barrier in neonates.
文摘Objective: To develop a best-evidence-based optimal nutrition management plan for patients with chronic heart failure, apply it in clinical practice, and evaluate its effectiveness. Methods: Use the KTA knowledge translation model to guide evidence-based practice in nutrition management, and compare the nutritional status, cardiac function status, quality of life, and quality review indicators of chronic heart failure patients before and after the application of evidence. Results: After the application of evidence, the nutritional status indicators (MNA-SF score, albumin, hemoglobin) of two groups of heart failure patients significantly increased compared to before the application of evidence, with statistically significant differences (p Conclusion: The KTA knowledge translation model provides methodological guidance for the implementation of evidence-based practice for heart failure patients. This evidence-based practice project is beneficial for improving the outcomes of malnutrition in chronic heart failure patients and is conducive to standardizing nursing pathways, thereby promoting the improvement of nursing quality.
基金supported by the National Basic Research Program of China (973 Program) (No. 2009CB219603)Key Special National Project (No. 2008ZX05035)Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane （CBM） concentrated areas. First, we choose seismic attributes that are most sensitive to CBM content changes with the guidance of CBM content measured at well sites. Then the selected seismic attributes are fused using D-S evidence theory and the fusion results are used to predict CBM-enriched area. The application shows that the predicted CBM content and the measured values are basically consistent. The results indicate that using D-S evidence theory in seismic multi-attribute fusion to predict CBM-enriched areas is feasible.
基金Supported by SRT Program of Nanjing Agricultural University (2009)~~
文摘The concept and development history of rehabilitation environment were summarized in this study,principles and techniques of applying evidence-based design in the design of rehabilitation environment were analyzed,classification and functions of landscape elements in rehabilitation environment were particularly discussed.
基金funded by University of Transport and Communications(UTC)under grant number T2025-CN-004.
文摘Reversible data hiding(RDH)enables secret data embedding while preserving complete cover image recovery,making it crucial for applications requiring image integrity.The pixel value ordering(PVO)technique used in multi-stego images provides good image quality but often results in low embedding capability.To address these challenges,this paper proposes a high-capacity RDH scheme based on PVO that generates three stego images from a single cover image.The cover image is partitioned into non-overlapping blocks with pixels sorted in ascending order.Four secret bits are embedded into each block’s maximum pixel value,while three additional bits are embedded into the second-largest value when the pixel difference exceeds a predefined threshold.A similar embedding strategy is also applied to the minimum side of the block,including the second-smallest pixel value.This design enables each block to embed up to 14 bits of secret data.Experimental results demonstrate that the proposed method achieves significantly higher embedding capacity and improved visual quality compared to existing triple-stego RDH approaches,advancing the field of reversible steganography.
文摘Tau plays a crucial role in several neurodegenerative diseases,collectively referred to as tauopathies.Therefore,targeting potential pathological changes in tau could enable useful therapeutic interventions.However,tau is not an easy target because it dynamically interacts with microtubules and other cellular components,which presents a challenge for tau-targeted drugs.New cellular models could aid the development of mechanism-based tau-targeted therapies.
基金supported by the National Natural Science Foundation of China(61573283)
文摘Aiming at the problem that the traditional Dempster Shafer (D-S) evidence theory cannot deal with conflicted evidences effectively and correctly, this paper points out that the key issue of this problem is to measure the degree of conflict between evidences correctly after analyzing various improved methods. The existing evidence conflict measure methods are analyzed, and a new evidence conflict measure method called evidence similarity measure based on the Tanimoto measure is proposed, while a new evidence combination method is proposed on the basis of evidence similarity measure. Firstly, the conflict degrees between evidences are obtained through the evidence similarity measure. Then the evidence sources are modified based on the credibility of different evidences and the weights of conflicted parts of evidences on different focal elements are determined. Finally, the fusion result is obtained by this method. Numerical examples show that the proposed method can effectively fuse evidences when evidences are consistent or highly conflicted, and it has a fast convergence speed, a high degree of accuracy and good adaptability.
文摘Thirty-six randomized controlled trials and two metaanalyses were reviewed. With respect to adult patients undergoing first orthotopic liver transplantation(OLT), steroid replacement resulted in fewer cases of overall acute rejection in the corticosteroid free-immunosuppression arm. Initial steroid administration for two weeks and early tacrolimus monotherapy is a feasible immunosuppression regimen without steroid replacement, although further investigations are needed in view of chronic rejections. No significant differences were noted between the treatment groups in terms of patient and graft survival independently of steroid replacement. Renal insufficiency, de novo hypertension, neurological disorders and infectious complications did not differ significantly among steroid and steroidfree groups. Diabetes mellitus, cholesterol levels and cytomegalovirus infection are more frequent in patients within the steroid group. With respect to diabetes mellitus and hypercholesterolemia, the difference was independent of steroid replacement. In relation to transplanted hepatitis C virus patients, mycophenolate mofetil does not appear to have a significant antiviral effect despite early reports. Male gender of donors and recipients, living donors, cold ischemia times, acute rejection, and early histological recurrence were related to the development of advanced hepatitis. There is sufficient scientific clinical evidence advocating avoidance of the ab initio use of steroids in OLT.
基金State Administration of Traditional Chinese Medicine(Department of Policy,Regulation and Supervision)“Evidence-based clinical practice guideline of acupuncture and moxibustion:primary dysmenorrhea”:No.ZYYS-2009-0009-4Scientific Specific Project of China Base Business Construction for Clinical Research of Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine:No.JDZX2015063
文摘Dysmenorrhea refers to periodic abdominal pain,or radiating to lumbosacral region.For the severe case,it is intolerable,combined with nausea and vomiting sometimes.This disease is commonly seen in unmarried young women.Epidemiological studies have shown that dysmenorrhea is the most common gynecological disease,especially in young women[1].Acupuncture and moxibustion have a long history in the treatm ent of primary dysmenorrhea(hereinafter referred to as PD),and compared with medication,the advantages are presented in the treatment.Entrusted by the Standardization Working Committee of China Association for Acupuncture and Moxibustion(CAAM),Department of Acupuncture and Moxibustion,Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine has undertaken the drafting of Evidence-Based Clinical Practice Guideline of Acupuncture and Moxibustion:Primary Dysmenorrhea(hereinafter referred to as the Guideline).The Guideline was issued in 2014 by CAAM.It summarizes the research achievements in acupuncture-moxibustion treatm ent for dysmenorrhea in recent decades and is intended to standardize the clinical regimen of treatm ent with acupuncture and moxibustion so as to improve the clinical effect.
基金supported by the Grant for State Key Program for Basic Research of China(No.2013CB329405)National Natural Science Foundation of China(No.61573275)+3 种基金Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.61221063)Science and Technology Project of Shaanxi Province of China(No.2013KJXX-46)Specialized Research Fund for the Doctoral Program of Higher Education of China(20120201120036)Fundamental Research Funds for the Central Universities of China(No.xjj2014122)
文摘In the theory of belief functions, the measure of uncertainty is an important concept, which is used for representing some types of uncertainty incorporated in bodies of evidence such as the discord and the non-specificity. For the non-specificity part, some traditional measures use for reference the Hartley measure in classical set theory; other traditional measures use the simple and heuristic function for joint use of mass assignments and the cardinality of focal elements. In this paper, a new non-specificity measure is proposed using lengths of belief intervals, which represent the degree of imprecision. Therefore, it has more intuitive physical meaning. It can be proved that our new measure can be rewritten in a general form for the non-specificity. Our new measure is also proved to be a strict non-specificity measure with some desired properties. Numerical examples, simulations, the related analyses and proofs are provided to show the characteristics and good properties of the new non-specificity definition. An example of an application of the new non- specificity measure is also presented.
文摘An improvement method for the combining rule of Dempster evidence theory is proposed. Different from Dempster theory, the reliability of evidences isn't identical; and varies with the event. By weight evidence according to their reliability, the effect of unreliable evidence is reduced, and then get the fusion result that is closer to the truth. An example to expand the advantage of this method is given. The example proves that this method is helpful to find a correct result.
文摘Evidence theory has been widely used in the information fusion for its effectiveness of the uncertainty reasoning. However, the classical DS evidence theory involves counter-intuitive behaviors when the high conflict information exists. Based on the analysis of some modified methods, Assigning the weighting factors according to the intrinsic characteristics of the existing evidence sources is proposed, which is determined on the evidence distance theory. From the numerical examples, the proposed method provides a reasonable result with good convergence efficiency. In addition, the new rule retrieves to the Yager's formula when all the evidence sources contradict to each other completely.
基金supported by the National Natural Science Foundation of China(71571190 71601183+1 种基金 L1534031)the Shanxi Province Natural Science Foundation of China(2014JQ2-7045)
文摘In order to achieve the information fusion in the time domain based on the evidence theory, an evidence combination method in the time domain based on reliability and importance is proposed according to the idea of evidence discount. Firstly, the distortion of the time-domain evidence is judged based on single exponential smoothing. The real-time reliability of the evidence at the adjacent time is obtained by the real-time reliability assessment method of the evidence based on the credibility decay model.Then, the relative importance of the evidence at the adjacent time is obtained by comprehensively considering improved conflict degree and uncertainty. Finally, based on the criterion of evidence discount and the Dempster’s rule of combination, the evidence combination is carried out to achieve the sequential combination of time-domain evidence. The numerical simulation and analysis show that this method has fully embodied the dynamic characteristics of time-domain evidence combination, and it has strong processing ability for conflict information and anti-disturbing ability.The proposed method has good applicability to information fusion in the time domain.
基金Project (No. 51476040103JW13) supported by the National DefenseKey Laboratory of Target and Environment Feature of China
文摘Based on the framework of evidence theory, data fusion aims at obtaining a single Basic Probability Assignment (BPA) function by combining several belief functions from distinct information sources. Dempster’s rule of combination is the most popular rule of combinations, but it is a poor solution for the management of the conflict between various information sources at the normalization step. Even when it faces high conflict information, the classical Dempster-Shafer’s (D-S) evidence theory can involve counter-intuitive results. This paper presents a modified averaging method to combine conflicting evidence based on the distance of evidences; and also gives the weighted average of the evidence in the system. Numerical examples showed that the proposed method can realize the modification ideas and also will provide reasonable results with good convergence efficiency.
文摘Biochar application to soil is commonly recognized to improve soil fertility and consequently biomass and food production sustainably.We re-examined the robustness of the underlying data and found that,of the 12000+ publications on“biochar and agriculture”used in meta-studies,only 109 Institute for Scientific Information(ISI)papers(or 0.9%)provide experimental data on the impacts on crop yield and/or biomass production.
基金Supported by the National Natural Science Foundation of China(71603284)the Humanity and Social Science Research Foundation of Ministry of Education(16YJC630068)
文摘The existing early-warning system in metro construction are generally based on traditional single-sensor data and simple analytic model, which makes it difficult to deal with the complex and comprehensive environment in metro construction. In this paper, the framework of early-warning threshold for metro construction collapse risk based on D-S evidence theory and rough set is built. By combining the primary data fusion collected based on rough set with the secondary data fusion which is based on D-S evidence theory, the integration of multiple information in metro construction is realized and the risk assessment methods are optimized. A case trial based on Hangzhou metro construction collapse accident is also carried out to exemplify the framework. The empirical analysis guarantees the completeness and independence of the prediction information, and realizes the dynamic prediction of the variation trend of metro construction collapse risk.
