To the Editor:Coronary heart disease(CHD)continues to be a predominant cause of mortality in China even after recommended optimal management.Residual inflammatory risk(RIR)portends increased risk of recurrent cardiova...To the Editor:Coronary heart disease(CHD)continues to be a predominant cause of mortality in China even after recommended optimal management.Residual inflammatory risk(RIR)portends increased risk of recurrent cardiovascular events.As an indicator of pro-inflammatory nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)–interleukin(IL)-1β–IL-6 pathway activation,high-sensitivity C-reactive protein(hsCRP)has demonstrated significant value as a predictor of major adverse cardiovascular and cerebrovascular events(MACCEs).Due to the ethnic differences,East Asian populations exhibited lower hsCRP levels.It was confirmed by our previous single-center study,in which the median of hsCRP was 1 mg/L at 1-month follow-up,and the 1-month hsCRP>1 mg/L showed a better prediction of the risk of MACCE.展开更多
基金supported by grants from the Noncommunicable Chronic Diseases—National Science and Technology Major Project(No.2025ZD0548400)the National Key Research and Development Program(No.2022YFC2503501)+3 种基金Chinese Society of Cardiology’s Foundation(No.CSCF2023A04)Hubei Technology Innovation Project(No.2024BCB046)Key Research and Development Program of Wuhan(No.2024020702030092)to Xiang ChengThe National Heart,Lung,and Blood Institute(Nos.1R01HL134892 and 1R01HL163099-01),the RRM Charitable Fund,and the Simard Fund to Peter Libby.
文摘To the Editor:Coronary heart disease(CHD)continues to be a predominant cause of mortality in China even after recommended optimal management.Residual inflammatory risk(RIR)portends increased risk of recurrent cardiovascular events.As an indicator of pro-inflammatory nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)–interleukin(IL)-1β–IL-6 pathway activation,high-sensitivity C-reactive protein(hsCRP)has demonstrated significant value as a predictor of major adverse cardiovascular and cerebrovascular events(MACCEs).Due to the ethnic differences,East Asian populations exhibited lower hsCRP levels.It was confirmed by our previous single-center study,in which the median of hsCRP was 1 mg/L at 1-month follow-up,and the 1-month hsCRP>1 mg/L showed a better prediction of the risk of MACCE.
