Temporal relation computation is one of the tasks of the extraction of temporal arguments from event, and it is also the ultimate goal of temporal information processing. However, temporal relation computation based o...Temporal relation computation is one of the tasks of the extraction of temporal arguments from event, and it is also the ultimate goal of temporal information processing. However, temporal relation computation based on machine learning requires a lot of hand-marked work, and exploring more features from discourse. A method of two-stage machine learning based on temporal relation computation （TSMLTRC） is proposed in this paper for the shortcomings of current temporal relation computation between two events. The first stage is to get the main temporal attributes of event based on classification learning. The second stage is to compute the event temporal relation in the discourse through employing the result of the first stage as the basic features, and also employing some new linguistic characteristics. Experiments show that, compared with the artificial golden rule, the computational efficiency in the first stage is much higher, and the F1-Score of event temporal relation which is computed through combining multi-features may be increased at 85.8% in the second stage.展开更多
Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscien...Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.展开更多
Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupunctu...Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.展开更多
Objective To develop a nomogram based on the monocyte-to-lymphocyte ratio(MLR)for predicting the risk of aortic-related adverse events within 30 days in patients with acute uncomplicated type B aortic intramural hemat...Objective To develop a nomogram based on the monocyte-to-lymphocyte ratio(MLR)for predicting the risk of aortic-related adverse events within 30 days in patients with acute uncomplicated type B aortic intramural hematoma.Methods This single-center retrospective cohort study screened consecutive patients with acute uncomplicated type B aortic intramural hematoma treated at the EmergencyyandCardiovascular Medicine Departments of the General Hospital of the Northern Theater Command from April 2018 to April 2024.Patients were divided into two groups based on the optimal MLR cut-off value for predicting aortic-related adverse events:low MLR and high MLR group.MLR was defined as the ratio of monocytes to lymphocytes.Aortic-related adverse events were defined as a composite of aortic-related death or aortic intramural hematoma progression(including aortic dissection and penetrating aortic ulcers)within 30 days.The receiver operating characteristic(ROC)curve identified the optimal MLR cut-off value.Multivariate logistic regression was used to identify independent predictors of aortic-related adverse events within 30 days,based on which nomogram models were constructed:the clinical characteristics model and the clinical characteristics-MLR model.The DeLong test was used to evaluate the diagnostic performance of different risk models.The additional predictive value of MLR was assessed using the net reclassification index(NRI)and integrated discrimination improvement(IDI).Results A total of 332 patients were included,of whom 217 were male(65.4%),with an average age of(64.3±9.4)years.A total of 107 aortic-related adverse events occurred during the 30-day follow-up period.The optimal cut-off value for MLR was 0.529.There were 189 cases in the low MLR group(MLR<0.529)and 143 cases in the high MLR group(MLR≥0.529).The rate of aortic-related adverse events was higher in the high MLR group compared to.the low MLR group(44.1%(63/143)vs.23.3%(44/189),P<0.001),mainly due to a higher rate of progression to aortic dissection(9.8%(14/143)vs.1.1%(2/189),P<0.001)and penetrating aortic ulcers(31.5%(45/143)vs.20.6%(39/189),P=0.025).Multivariate analysis identified diabetes(OR=0.25,95%CI 0.08-0.78,P=0.017),anemia(0R=3.45,95%CI 1.28-9.27,P=0.014),maximum descending aorta diameter(0R=1.08,95%CI 1.02-1.15,P=0.007),ulcerlike projections(OR=4.04,95%CI 2.26-7.24,P<0.001),and MLR(0R=6.61,95%CI 2.50-17.46,P<0.001)as independent predictors of aortic-related adverse events during the 30-day follow-up period.The clinical characteristics model includes diabetes,anemia,ulcer-like projections and maximum diameter of the descending aorta,and the clinical characteristics-MLR model includes the above clinical characteristics and MLR.The results of the DeLong test showed that the clinical characteristic-MLR model demonstrated a higher area under the ROC curve compared to the clinical characteristic model alone(0.784(95%CI 0.736-0.841)vs.0.742(95%CI0.691-0.788),P=0.031).The continuous NRI was 0.461(95%CI 0.237-0.685,P<0.001)and the IDI was 0.077(95%CI 0.043-0.112,P<0.001),indicating that the inclusion of the MLR in the model significantly improved the predictive accuracy.Conclusion The integration of MLR with other clinical characteristics improves the early identification ofhigh-risk patients with acute uncomplicated type B aortic intramural hematoma,optimizing clinical decisions and improving patient outcomes.展开更多
Objective To observe therapeutic effects of acupuncture combined with language training on aphasia induced by ischemic apoplexy and investigate the mechanisms. Methods 60 patients were randomly divided into a treatmen...Objective To observe therapeutic effects of acupuncture combined with language training on aphasia induced by ischemic apoplexy and investigate the mechanisms. Methods 60 patients were randomly divided into a treatment group treated by acupuncture associated with language training and a control group treated by simple language training. Tongue-acupuncture was applied as the main therapy, and language training included speech organ training, mouth-shape and voice training, spoken language expression training and practical communication ability training. According to Aphosio Bottery of Chinese （ABC）, language ex- amination evaluation was made, and event related potential （P300） was detected before and after treatment. Results The therapeutic effect in the treatment group was significantly better than that in the control group （P〈O. 05）, and the scores of ABC items including information content, speech fluency, repetition, vocabula- ry denomination, color naming, response denomination, confirmation or negation, acoustic recognition and carrying out instruction in the treatment group were obviously higher than those in the control group （P〈0.05）. After one course of treatment, the latencies of N2 and P3 waves in P300 were significantly short- ened and the amplitude of P3 was significantly elevated in the treatment group, compared with those in the control group （P〈0.05）. Conclusion Acupuncture combined with language training provided remarkable therapeutic effects in treating cerebral infarction-induced motor aphasia, and it was better than simple lan- guage training. The results of enhancing of the ABC scores including information content, speech fluency, repetition, vocabulary denomination, color naming, response denomination, confirmation or negation, acous- tic recognition and carrying out instruction, and shortening of the latencies of N2 and P3 waves in P300 and ele- vation of P3 amplitude may be taken as the indices for evaluating and anticipating clinical therapeutic effects of the therapy for treating the disease, which may also be some of the mechanisms.展开更多
In this paper, we used SVM method to detect P300 signal. Before training a classification parameter for the SVM, several preprocessing operations were applied to the data including filtering, downsampling, single tria...In this paper, we used SVM method to detect P300 signal. Before training a classification parameter for the SVM, several preprocessing operations were applied to the data including filtering, downsampling, single trial extraction, windsorizing, electrode selection et al. With the SVM algorithm, the classification accuracy could be up to above 80%. In some cases, the accuracy could reach 100%. It is suitable to use SVM for P300 EEG recognition in the P300-based brain-computer interface (BCI) system. Our further work will include the improvement to yield higher classification accuracy using fewer trials.展开更多
To better understand repeatability of strong earthquakes in previously ruptured zones during one seismogenic period, we studied the rupture zones of the doublet of M6 earthquakes in Zhongba region of southcentral Tibe...To better understand repeatability of strong earthquakes in previously ruptured zones during one seismogenic period, we studied the rupture zones of the doublet of M6 earthquakes in Zhongba region of southcentral Tibet, China, in 11 July 2004 and 7 April 2005, respectively. We focused on the overlapping degree of two strong quakes’ aftershock areas one week after the mainshocks by using the SQH station in China Seismic Network and a 68-stations temporary broadband seismic array, a part of the international HI-CLIMB project. About 115 local earthquakes were recorded in one week after the mainquakes, and we located these earthquakes by master event relative location （MERL） method. We also used this method to relocate 31 other M3.7 ＋ earthquakes from 1 July 2004 to 1 July 2005. Meanwhile, we studied two mainshocks’ coseismic ruptures with satellite interferometric synthetic aperture radar （InSAR）. Our results show that the ruptured zones of the two earthquakes do not overlapp substantially, either from early aftershock data or from InSAR inversions.展开更多
Objective： To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma. Methods： A retrospective chart review was conducted of 62 patie...Objective： To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma. Methods： A retrospective chart review was conducted of 62 patients receiving intravenous pamidronate disodium for metastatic breast cancer. The proportion of patients experiencing at least one skeletal related event （SRE） after 12 months of therapy was determined. Results： The proportion of patients who had an SRE was 29.00% （18 individuals） and the median time to first event was greater than 350 days. Radiotherapy（ll individuals）and pathologic fracture（6 individuals）were the most frequent type of SRE, while cord compression（1 individuals） and hypercalcaemia（0 individuals） were rare. A total of 37 individuals had transient hypocalcaemia without any clinical symptom. No significant creatinine abnormalities were encountered. There were no clinically relevant changes of calcium ,phosphate and creatinine before and after therapy. Conclusion： Long-term treatment with pamidronate disodium significantly reduces and delays skeletal morbidity from osteolytic metastases . Prolonged therapy was well tolerated. This study suggests that the rate of clinically relevant SREs is substantially lower than the event rate observed in phase llI clinical trials.展开更多
Objective:This survey was a non-intervention study,which aimed to investigate symptom burden and treatment status in cancer patient with bone metastasis,and to make out whether patients received the normative treatmen...Objective:This survey was a non-intervention study,which aimed to investigate symptom burden and treatment status in cancer patient with bone metastasis,and to make out whether patients received the normative treatment.Methods:We designed a questionnaire,the main items of which include patient's symptom burden,previous and ongoing treatment.We used it to investigate 120 patients from six different medical agencies.We examined the association between symptoms using Spearman's rank correlation.SPSS software was used to analyze data.Results:The data of one hundred one questionnaires were completed and fitted for analysis.The five most prevalent symptoms were fatigue(84.2%),unhappiness(83.2%),pain(77.2%),dry mouth(77.2%) and lack of appetite(73.3%).Three symptom clusters were identified.Cluster 1 included anxiety and unhappiness and accounted for 61.4% in all patients.Cluster 2 included pain,fatigue and constipation and accounted for 39.6% in all patients.Cluster 3 included nausea,vomiting,lack of appetite and accounted for 27.7% in all patients.Cronbach's alpha coefficient demonstrated high internal reliability in the clusters,with a coefficient ranging from 0.65 to 0.84.The proportion of patients receiving analgesic therapy,bisphosphates therapy,palliative chemotherapy and radiotherapy were 70.3%,63.4%,58.4% and 36.6% respectively.Pain in various degree was obviously alleviated(P < 0.01) after analgesic therapy.Among the surveyed patients,64 patients received bisphosphates therapy,while the administration of zoledronic acid accounted for the most large proportion.The average duration of bisphosphates administration was 5.79 months(SD = 7.43).Patients who received radiotherapy adopted multiple fractions treating mode.Conclusion:Symptom burden was common and severe in patients with bone metastasis,which often appeared as symptom cluster,and significantly affected their quality of life(QOL).The normative treatment should be strengthened to manage and control patients' symptoms and improve their QOL.The analgesic therapy was normative in patients with bone metastasis.Reasons impeding patients to receive bisphosphates were in varieties.More propaganda should be done to generalized bisphosphates therapy for patients with bone metastasis.展开更多
A BCI （brain computer interface） established a new direct communication channel using the brain activity between the human brain and machine. The visual stimulus with a certain frequency is present to the BCI users;...A BCI （brain computer interface） established a new direct communication channel using the brain activity between the human brain and machine. The visual stimulus with a certain frequency is present to the BCI users; it exists in a particular condition to observe a continuous brain response respect to frequent of visual stimuli. A significant problem when engaged the SSVEP （steady-state visual evoked potential） based on BCI, it will be exhausted and may suffer for the users when staring at flashing stimuli. This experimental study investigates how the differences in LED＇s-colors influence of SSVEP with respect to （i.e., frequencies and phases）. The result shows that the visualization of phase delays in lower frequencies greater than in higher frequencies.展开更多
<strong>Background</strong><strong>:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Type B aortic</span><b&...<strong>Background</strong><strong>:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Type B aortic</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">intramural hematoma (IMH-B) is recognized as a subset of aortic dissection. The evolution of uncomplicated IMH-B is very difficult to predict. How and when to deal with this disease is unclear. The present study constructed two models to explore this problem. One is the</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">morphology evolution model, which explored the risk factors and predictors for the IMH-B patients. Another is the predictive model confirmed the predictors and the time for invasive treatment of uncomplicated IMH-B patients.</span></span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:Verdana;">To explore the evolution predictors and detect the time for invasive treatment of uncomplicated IMH-B patients.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">The</span><b></b><span style="font-family:Verdana;">morphology evolution model demonstrated that all 81 patients were diagnosis with CTA images. The initial and follow-up data were retrospectively studied. The evolution data were collection and measurement from initial and follow-up CTA images data. The predictive model showed that predictors of progression were detected with cox regression analysis.</span></span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">All 81IMH-B patients were followed-up ranged from 1.2 to 36 months (median, 22 months). 26 patients accepted invasive treatment (24 underwent TEVAR and 2 underwent Surgery)</span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">55 patients received medical treatment. Invasive treatment (IT) group overall events </span><span style="font-family:Verdana;">are </span><span style="font-family:Verdana;">1</span><span style="font-family:Verdana;">/</span><span style="font-family:Verdana;">26 (3.8%)</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> medical treatment</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">(MT) group overall events </span><span style="font-family:Verdana;">are </span><span style="font-family:Verdana;">33</span><span style="font-family:Verdana;">/</span><span style="font-family:Verdana;">55 (60.0%)</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> IT group</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">vs.</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">MT group</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> p < 0.001</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> Moreover,</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">we found that most events related aorta occurred within 30 days. Multivariate Cox regression analysis MDAD (hazard ratio, 3.58;95% CI, 1.25</span><span style="font-family:;" "=""></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">5.78;p < 0.001), MDAHT (hazard ratio, 4.26;95% CI, 0.85</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">7.84;p < 0.001), and IMH with PAU (hazard ratio, 3.58;95% CI, 1.02</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">5.63;p < 0.001) were confirmed as the independent predictors. </span><b><span style="font-family:Verdana;">Conclusions: </span></b><span style="font-family:Verdana;">MDAD > 45 mm, MDAHT > 10</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">mm, and IMH with PAU may be the important predictors for uncomplicated IMH-B patients. Most adverse aorta related events occurred within 30 days. It would be careful follow-up, closely observe for these patients within 30 days, and take necessary treatment strategies in time.</span>展开更多
Objective: It is well known that patients with Cochlear Implant (CI) have a large inter-individual variability in linguistic and auditory performances. This can be related to individual auditory processing abilities a...Objective: It is well known that patients with Cochlear Implant (CI) have a large inter-individual variability in linguistic and auditory performances. This can be related to individual auditory processing abilities and integrity of auditory system from auditory nerve to cerebral cortex. P300 can be used for the evaluation of central auditory functions in people with hearing loss and CI. No studies considered the P300 in the population of prelingually deafened adults that underwent CI in old age. The aim of this study is to assess Event Related Potential (ERP) in patients with congenital profound hearing loss with early or late implantation and evaluate these results respect to an age-matched normal hearing group. Methods: ERPs (N100, N200 and P300) and auditory benefit testing (pure tone average and speech audiometric test) and auditory perception testing (Categories of Auditory Performance—CAP) were evaluated in all subjects with their device. Results: All mean latencies (N100, N200 and P300) were found greater in patients group compared to control group. When analyzing all measures in patient group, we did not find any significant differences according to age of implant while significant difference (p > 0.05) in N100 amplitude (p = 0.045) and P300 latency (p = 0.035) were found according to time of CI use. A linear correlation between N200 and P300 latency in control and patients groups was found. Conclusion: In summary, ERPs analysis in the evaluation of CI showed a great importance of long use of the device in addiction to an early time of implant.展开更多
On May 21,1951, China and Pakistan established diplomatic relations. In April 1955, Chinese Premier Zhou Enlai held talks with Pakistani Prime Minister M. Ali during the Bandung Conference in Indonesia, and both sides...On May 21,1951, China and Pakistan established diplomatic relations. In April 1955, Chinese Premier Zhou Enlai held talks with Pakistani Prime Minister M. Ali during the Bandung Conference in Indonesia, and both sides agreed that bilateral ties should be strengthened. In October 1956, at the invitation of the Chinese Government, Pakistani Prime Minister H.E.Sulawadi paid an official visit to China.展开更多
Immune checkpoint inhibitors(ICIs)have revolutionized the treatment landscape for various malignancies by demonstrating exceptional antitumor effects and significant improvement in patient survival.Despite their overt...Immune checkpoint inhibitors(ICIs)have revolutionized the treatment landscape for various malignancies by demonstrating exceptional antitumor effects and significant improvement in patient survival.Despite their overt therapeutic advantages,ICIs also induce immune-related adverse events(irAEs).Of these,checkpoint inhibitor pneumonitis(CIP)represents a prominent manifestation of pulmonary toxicity following ICI therapy,with inci-dence rates ranging from 2.7%to 20.0%.Notably,a substantial proportion of CIP cases show severe manifesta-tions,often leading to life-threatening complications,which emphasizes its clinical significance.Understanding the risk factors and potential pathogenetic mechanisms of CIP,combined with vigilant monitoring during im-munotherapy,is pivotal for early detection and management of this condition.Proactive strategies for the timely identification,accurate diagnosis,and effective management of CIP are essential to optimize patient outcomes.However,several challenges persist in CIP management,including management of severe and refractory cases,determining the timing of ICI rechallenge after CIP,management of long-term chronic CIP,and mitigating sec-ondary infections.In order to manage this potentially life-threatening irAE effectively,it is urgent to establish multi-disciplinary treatment(MDT)management,precision CIP management,and practical surveillance systems for CIP monitoring,diagnosis,and management and to call for prospective multi-center clinical trials.展开更多
CONSPECTUS:Immunotherapy has become a crucial strategy for cancer and infectious diseases due to its ability to leverage the power of the immune system to combat diseases,particularly when conventional therapeutic opt...CONSPECTUS:Immunotherapy has become a crucial strategy for cancer and infectious diseases due to its ability to leverage the power of the immune system to combat diseases,particularly when conventional therapeutic options have been ineffective.Nonetheless,low immune response rates and immune-related adverse events(irAEs)remain significant challenges for immunotherapeutics.Therefore,there is an urgent need to develop new strategies for improving the immunotherapy.Extracellular vesicles(EVs),secreted by living cells,are small membrane-bound vesicles.展开更多
基金Project supported the National Natural Science Foundation of China(Grant No.60975033)the Basic Scientific Research Project of International Centre for Bamboo Rattan(Grant No.1632009006)the Shanghai Leading Academic Discipline Project(Grant No.J50103)
文摘Temporal relation computation is one of the tasks of the extraction of temporal arguments from event, and it is also the ultimate goal of temporal information processing. However, temporal relation computation based on machine learning requires a lot of hand-marked work, and exploring more features from discourse. A method of two-stage machine learning based on temporal relation computation （TSMLTRC） is proposed in this paper for the shortcomings of current temporal relation computation between two events. The first stage is to get the main temporal attributes of event based on classification learning. The second stage is to compute the event temporal relation in the discourse through employing the result of the first stage as the basic features, and also employing some new linguistic characteristics. Experiments show that, compared with the artificial golden rule, the computational efficiency in the first stage is much higher, and the F1-Score of event temporal relation which is computed through combining multi-features may be increased at 85.8% in the second stage.
基金supported by the National Natural Science Foundation of China (81874514)
文摘Objective: To investigate how medical students process Western medicine(WM) terms vs. traditional Chinese medicine(TCM) terms and how this is impacted by analogical priming from the perspective of cognitive neuroscience.Methods: The experiments were designed as a 2(TCM terms vs. WM terms) × 2(correct terms vs.incorrect terms) × 2(analogical priming task vs. non-priming task) scheme. A total of 26 medical students completed a non-priming judgment task and an analogical priming judgment task on medical terms. During the tasks, the participants were asked to make correct/incorrect judgments on WM terms and TCM terms, and their behavioral data and event-related potentials(ERPs) were recorded.Results: Behaviorally, the response speed and accuracy of WM terms were higher than those of TCM terms(both P <.001), indicating a prominent concreteness effect. Analogical priming shortened the response time to medical terms(P <.001), and the response time to TCM terms was shortened more significantly(P =.001). For ERPs, WM terms induced a larger P200(an early positive ERP component), a smaller N400(a negative ERP component), and a higher late positive ERP component, indicating superiority of attention adjustment, smaller-scale semantic activation, and a higher cost of late semantic analysis and integration. However, the analogical priming eliminated the difference between WM and TCM terms in P200 and N400 while maintaining it in the LPC. This suggests that WM terms are sensitive to analogical attention adjustment, and TCM terms are susceptible to analogical semantic integration.Conclusion: Our findings suggest that WM and TCM disease behavior terms may initially differ in concreteness or the use of a verbal-linguistic system. Analogy is more conducive to understanding TCM terms. This research provides important neuroscientific evidence of the difference in thinking between TCM and WM.
文摘Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.
文摘Objective To develop a nomogram based on the monocyte-to-lymphocyte ratio(MLR)for predicting the risk of aortic-related adverse events within 30 days in patients with acute uncomplicated type B aortic intramural hematoma.Methods This single-center retrospective cohort study screened consecutive patients with acute uncomplicated type B aortic intramural hematoma treated at the EmergencyyandCardiovascular Medicine Departments of the General Hospital of the Northern Theater Command from April 2018 to April 2024.Patients were divided into two groups based on the optimal MLR cut-off value for predicting aortic-related adverse events:low MLR and high MLR group.MLR was defined as the ratio of monocytes to lymphocytes.Aortic-related adverse events were defined as a composite of aortic-related death or aortic intramural hematoma progression(including aortic dissection and penetrating aortic ulcers)within 30 days.The receiver operating characteristic(ROC)curve identified the optimal MLR cut-off value.Multivariate logistic regression was used to identify independent predictors of aortic-related adverse events within 30 days,based on which nomogram models were constructed:the clinical characteristics model and the clinical characteristics-MLR model.The DeLong test was used to evaluate the diagnostic performance of different risk models.The additional predictive value of MLR was assessed using the net reclassification index(NRI)and integrated discrimination improvement(IDI).Results A total of 332 patients were included,of whom 217 were male(65.4%),with an average age of(64.3±9.4)years.A total of 107 aortic-related adverse events occurred during the 30-day follow-up period.The optimal cut-off value for MLR was 0.529.There were 189 cases in the low MLR group(MLR<0.529)and 143 cases in the high MLR group(MLR≥0.529).The rate of aortic-related adverse events was higher in the high MLR group compared to.the low MLR group(44.1%(63/143)vs.23.3%(44/189),P<0.001),mainly due to a higher rate of progression to aortic dissection(9.8%(14/143)vs.1.1%(2/189),P<0.001)and penetrating aortic ulcers(31.5%(45/143)vs.20.6%(39/189),P=0.025).Multivariate analysis identified diabetes(OR=0.25,95%CI 0.08-0.78,P=0.017),anemia(0R=3.45,95%CI 1.28-9.27,P=0.014),maximum descending aorta diameter(0R=1.08,95%CI 1.02-1.15,P=0.007),ulcerlike projections(OR=4.04,95%CI 2.26-7.24,P<0.001),and MLR(0R=6.61,95%CI 2.50-17.46,P<0.001)as independent predictors of aortic-related adverse events during the 30-day follow-up period.The clinical characteristics model includes diabetes,anemia,ulcer-like projections and maximum diameter of the descending aorta,and the clinical characteristics-MLR model includes the above clinical characteristics and MLR.The results of the DeLong test showed that the clinical characteristic-MLR model demonstrated a higher area under the ROC curve compared to the clinical characteristic model alone(0.784(95%CI 0.736-0.841)vs.0.742(95%CI0.691-0.788),P=0.031).The continuous NRI was 0.461(95%CI 0.237-0.685,P<0.001)and the IDI was 0.077(95%CI 0.043-0.112,P<0.001),indicating that the inclusion of the MLR in the model significantly improved the predictive accuracy.Conclusion The integration of MLR with other clinical characteristics improves the early identification ofhigh-risk patients with acute uncomplicated type B aortic intramural hematoma,optimizing clinical decisions and improving patient outcomes.
文摘Objective To observe therapeutic effects of acupuncture combined with language training on aphasia induced by ischemic apoplexy and investigate the mechanisms. Methods 60 patients were randomly divided into a treatment group treated by acupuncture associated with language training and a control group treated by simple language training. Tongue-acupuncture was applied as the main therapy, and language training included speech organ training, mouth-shape and voice training, spoken language expression training and practical communication ability training. According to Aphosio Bottery of Chinese （ABC）, language ex- amination evaluation was made, and event related potential （P300） was detected before and after treatment. Results The therapeutic effect in the treatment group was significantly better than that in the control group （P〈O. 05）, and the scores of ABC items including information content, speech fluency, repetition, vocabula- ry denomination, color naming, response denomination, confirmation or negation, acoustic recognition and carrying out instruction in the treatment group were obviously higher than those in the control group （P〈0.05）. After one course of treatment, the latencies of N2 and P3 waves in P300 were significantly short- ened and the amplitude of P3 was significantly elevated in the treatment group, compared with those in the control group （P〈0.05）. Conclusion Acupuncture combined with language training provided remarkable therapeutic effects in treating cerebral infarction-induced motor aphasia, and it was better than simple lan- guage training. The results of enhancing of the ABC scores including information content, speech fluency, repetition, vocabulary denomination, color naming, response denomination, confirmation or negation, acous- tic recognition and carrying out instruction, and shortening of the latencies of N2 and P3 waves in P300 and ele- vation of P3 amplitude may be taken as the indices for evaluating and anticipating clinical therapeutic effects of the therapy for treating the disease, which may also be some of the mechanisms.
基金Natural Science Foundation of Shandong Provincegrant number:Y2007G31
文摘In this paper, we used SVM method to detect P300 signal. Before training a classification parameter for the SVM, several preprocessing operations were applied to the data including filtering, downsampling, single trial extraction, windsorizing, electrode selection et al. With the SVM algorithm, the classification accuracy could be up to above 80%. In some cases, the accuracy could reach 100%. It is suitable to use SVM for P300 EEG recognition in the P300-based brain-computer interface (BCI) system. Our further work will include the improvement to yield higher classification accuracy using fewer trials.
基金supported jointly by Joint Seismological Science Foundation of China (Nos.200808078 and 200708035)
文摘To better understand repeatability of strong earthquakes in previously ruptured zones during one seismogenic period, we studied the rupture zones of the doublet of M6 earthquakes in Zhongba region of southcentral Tibet, China, in 11 July 2004 and 7 April 2005, respectively. We focused on the overlapping degree of two strong quakes’ aftershock areas one week after the mainshocks by using the SQH station in China Seismic Network and a 68-stations temporary broadband seismic array, a part of the international HI-CLIMB project. About 115 local earthquakes were recorded in one week after the mainquakes, and we located these earthquakes by master event relative location （MERL） method. We also used this method to relocate 31 other M3.7 ＋ earthquakes from 1 July 2004 to 1 July 2005. Meanwhile, we studied two mainshocks’ coseismic ruptures with satellite interferometric synthetic aperture radar （InSAR）. Our results show that the ruptured zones of the two earthquakes do not overlapp substantially, either from early aftershock data or from InSAR inversions.
文摘Objective： To evaluate the long-term efficacy and safety of pamidronate disodium in patients with bone lesions secondary to advanced breast carcinoma. Methods： A retrospective chart review was conducted of 62 patients receiving intravenous pamidronate disodium for metastatic breast cancer. The proportion of patients experiencing at least one skeletal related event （SRE） after 12 months of therapy was determined. Results： The proportion of patients who had an SRE was 29.00% （18 individuals） and the median time to first event was greater than 350 days. Radiotherapy（ll individuals）and pathologic fracture（6 individuals）were the most frequent type of SRE, while cord compression（1 individuals） and hypercalcaemia（0 individuals） were rare. A total of 37 individuals had transient hypocalcaemia without any clinical symptom. No significant creatinine abnormalities were encountered. There were no clinically relevant changes of calcium ,phosphate and creatinine before and after therapy. Conclusion： Long-term treatment with pamidronate disodium significantly reduces and delays skeletal morbidity from osteolytic metastases . Prolonged therapy was well tolerated. This study suggests that the rate of clinically relevant SREs is substantially lower than the event rate observed in phase llI clinical trials.
文摘Objective:This survey was a non-intervention study,which aimed to investigate symptom burden and treatment status in cancer patient with bone metastasis,and to make out whether patients received the normative treatment.Methods:We designed a questionnaire,the main items of which include patient's symptom burden,previous and ongoing treatment.We used it to investigate 120 patients from six different medical agencies.We examined the association between symptoms using Spearman's rank correlation.SPSS software was used to analyze data.Results:The data of one hundred one questionnaires were completed and fitted for analysis.The five most prevalent symptoms were fatigue(84.2%),unhappiness(83.2%),pain(77.2%),dry mouth(77.2%) and lack of appetite(73.3%).Three symptom clusters were identified.Cluster 1 included anxiety and unhappiness and accounted for 61.4% in all patients.Cluster 2 included pain,fatigue and constipation and accounted for 39.6% in all patients.Cluster 3 included nausea,vomiting,lack of appetite and accounted for 27.7% in all patients.Cronbach's alpha coefficient demonstrated high internal reliability in the clusters,with a coefficient ranging from 0.65 to 0.84.The proportion of patients receiving analgesic therapy,bisphosphates therapy,palliative chemotherapy and radiotherapy were 70.3%,63.4%,58.4% and 36.6% respectively.Pain in various degree was obviously alleviated(P < 0.01) after analgesic therapy.Among the surveyed patients,64 patients received bisphosphates therapy,while the administration of zoledronic acid accounted for the most large proportion.The average duration of bisphosphates administration was 5.79 months(SD = 7.43).Patients who received radiotherapy adopted multiple fractions treating mode.Conclusion:Symptom burden was common and severe in patients with bone metastasis,which often appeared as symptom cluster,and significantly affected their quality of life(QOL).The normative treatment should be strengthened to manage and control patients' symptoms and improve their QOL.The analgesic therapy was normative in patients with bone metastasis.Reasons impeding patients to receive bisphosphates were in varieties.More propaganda should be done to generalized bisphosphates therapy for patients with bone metastasis.
文摘A BCI （brain computer interface） established a new direct communication channel using the brain activity between the human brain and machine. The visual stimulus with a certain frequency is present to the BCI users; it exists in a particular condition to observe a continuous brain response respect to frequent of visual stimuli. A significant problem when engaged the SSVEP （steady-state visual evoked potential） based on BCI, it will be exhausted and may suffer for the users when staring at flashing stimuli. This experimental study investigates how the differences in LED＇s-colors influence of SSVEP with respect to （i.e., frequencies and phases）. The result shows that the visualization of phase delays in lower frequencies greater than in higher frequencies.
文摘<strong>Background</strong><strong>:</strong><span style="font-family:;" "=""><span style="font-family:Verdana;"> Type B aortic</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">intramural hematoma (IMH-B) is recognized as a subset of aortic dissection. The evolution of uncomplicated IMH-B is very difficult to predict. How and when to deal with this disease is unclear. The present study constructed two models to explore this problem. One is the</span><b><span style="font-family:Verdana;"> </span></b><span style="font-family:Verdana;">morphology evolution model, which explored the risk factors and predictors for the IMH-B patients. Another is the predictive model confirmed the predictors and the time for invasive treatment of uncomplicated IMH-B patients.</span></span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:Verdana;">To explore the evolution predictors and detect the time for invasive treatment of uncomplicated IMH-B patients.</span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:;" "=""><span style="font-family:Verdana;">The</span><b></b><span style="font-family:Verdana;">morphology evolution model demonstrated that all 81 patients were diagnosis with CTA images. The initial and follow-up data were retrospectively studied. The evolution data were collection and measurement from initial and follow-up CTA images data. The predictive model showed that predictors of progression were detected with cox regression analysis.</span></span><span style="font-family:Verdana;"> </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">All 81IMH-B patients were followed-up ranged from 1.2 to 36 months (median, 22 months). 26 patients accepted invasive treatment (24 underwent TEVAR and 2 underwent Surgery)</span><span style="font-family:Verdana;">. </span><span style="font-family:Verdana;">55 patients received medical treatment. Invasive treatment (IT) group overall events </span><span style="font-family:Verdana;">are </span><span style="font-family:Verdana;">1</span><span style="font-family:Verdana;">/</span><span style="font-family:Verdana;">26 (3.8%)</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> medical treatment</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">(MT) group overall events </span><span style="font-family:Verdana;">are </span><span style="font-family:Verdana;">33</span><span style="font-family:Verdana;">/</span><span style="font-family:Verdana;">55 (60.0%)</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> IT group</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">vs.</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">MT group</span><span style="font-family:Verdana;">:</span><span style="font-family:Verdana;"> p < 0.001</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> Moreover,</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">we found that most events related aorta occurred within 30 days. Multivariate Cox regression analysis MDAD (hazard ratio, 3.58;95% CI, 1.25</span><span style="font-family:;" "=""></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">5.78;p < 0.001), MDAHT (hazard ratio, 4.26;95% CI, 0.85</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">7.84;p < 0.001), and IMH with PAU (hazard ratio, 3.58;95% CI, 1.02</span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;"> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">5.63;p < 0.001) were confirmed as the independent predictors. </span><b><span style="font-family:Verdana;">Conclusions: </span></b><span style="font-family:Verdana;">MDAD > 45 mm, MDAHT > 10</span></span><span style="font-family:Verdana;"> </span><span style="font-family:Verdana;">mm, and IMH with PAU may be the important predictors for uncomplicated IMH-B patients. Most adverse aorta related events occurred within 30 days. It would be careful follow-up, closely observe for these patients within 30 days, and take necessary treatment strategies in time.</span>
文摘Objective: It is well known that patients with Cochlear Implant (CI) have a large inter-individual variability in linguistic and auditory performances. This can be related to individual auditory processing abilities and integrity of auditory system from auditory nerve to cerebral cortex. P300 can be used for the evaluation of central auditory functions in people with hearing loss and CI. No studies considered the P300 in the population of prelingually deafened adults that underwent CI in old age. The aim of this study is to assess Event Related Potential (ERP) in patients with congenital profound hearing loss with early or late implantation and evaluate these results respect to an age-matched normal hearing group. Methods: ERPs (N100, N200 and P300) and auditory benefit testing (pure tone average and speech audiometric test) and auditory perception testing (Categories of Auditory Performance—CAP) were evaluated in all subjects with their device. Results: All mean latencies (N100, N200 and P300) were found greater in patients group compared to control group. When analyzing all measures in patient group, we did not find any significant differences according to age of implant while significant difference (p > 0.05) in N100 amplitude (p = 0.045) and P300 latency (p = 0.035) were found according to time of CI use. A linear correlation between N200 and P300 latency in control and patients groups was found. Conclusion: In summary, ERPs analysis in the evaluation of CI showed a great importance of long use of the device in addiction to an early time of implant.
文摘On May 21,1951, China and Pakistan established diplomatic relations. In April 1955, Chinese Premier Zhou Enlai held talks with Pakistani Prime Minister M. Ali during the Bandung Conference in Indonesia, and both sides agreed that bilateral ties should be strengthened. In October 1956, at the invitation of the Chinese Government, Pakistani Prime Minister H.E.Sulawadi paid an official visit to China.
基金support from the National High Level Hospital Clinical Research(No.2022-PUMCH–C-054).
文摘Immune checkpoint inhibitors(ICIs)have revolutionized the treatment landscape for various malignancies by demonstrating exceptional antitumor effects and significant improvement in patient survival.Despite their overt therapeutic advantages,ICIs also induce immune-related adverse events(irAEs).Of these,checkpoint inhibitor pneumonitis(CIP)represents a prominent manifestation of pulmonary toxicity following ICI therapy,with inci-dence rates ranging from 2.7%to 20.0%.Notably,a substantial proportion of CIP cases show severe manifesta-tions,often leading to life-threatening complications,which emphasizes its clinical significance.Understanding the risk factors and potential pathogenetic mechanisms of CIP,combined with vigilant monitoring during im-munotherapy,is pivotal for early detection and management of this condition.Proactive strategies for the timely identification,accurate diagnosis,and effective management of CIP are essential to optimize patient outcomes.However,several challenges persist in CIP management,including management of severe and refractory cases,determining the timing of ICI rechallenge after CIP,management of long-term chronic CIP,and mitigating sec-ondary infections.In order to manage this potentially life-threatening irAE effectively,it is urgent to establish multi-disciplinary treatment(MDT)management,precision CIP management,and practical surveillance systems for CIP monitoring,diagnosis,and management and to call for prospective multi-center clinical trials.
基金supported by the National Natural Science Foundation of China(No.82222035)the Shenzhen Medical Research Fund(No.B2302041).
文摘CONSPECTUS:Immunotherapy has become a crucial strategy for cancer and infectious diseases due to its ability to leverage the power of the immune system to combat diseases,particularly when conventional therapeutic options have been ineffective.Nonetheless,low immune response rates and immune-related adverse events(irAEs)remain significant challenges for immunotherapeutics.Therefore,there is an urgent need to develop new strategies for improving the immunotherapy.Extracellular vesicles(EVs),secreted by living cells,are small membrane-bound vesicles.
