Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupunctu...Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.展开更多
We detected the event-related potential mismatch negativity （MMN） of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and durati...We detected the event-related potential mismatch negativity （MMN） of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and duration MMN were lower in depression patients compared with control patients,indicating abnormality in auditory processing （i.e.,cognitive impairment）.Following escitalopram treatment for 8 weeks,the amplitudes of frequency and duration MMN were significantly increased and Hamilton Rating Scale for Depression scores were significantly decreased in depression patients.These data suggest that escitalopram can improve cognitive function of patients with depression.Further,MMN may be a useful tool for evaluating cognitive function and treatment effects.展开更多
A heavy rainfall event that occurred over the middle and lower reaches of the Yangtze River Basin （YRB） during July 11-13 2000 is explored in this study. The potential/stream function is used to analyze the upstream...A heavy rainfall event that occurred over the middle and lower reaches of the Yangtze River Basin （YRB） during July 11-13 2000 is explored in this study. The potential/stream function is used to analyze the upstream ＂strong signals＂ of the water vapor transport in the Tibetan Plateau （TP）. The studied time period covers from 2000 LST 5 July to 2000 LST 15 July （temporal resolution： 6 hours）. By analyzing the three-dimensional structure of the water vapor flux, vorticity and divergence prior to and during the heavy rainfall event, the upstream ＂strong signals＂ related to this heavy rainfall event are revealed. A strong correlation exists between the heavy rainfall event in the YRB and the convective clouds over the TE The ＂convergence zone＂ of the water vapor transport is also identified, based on correlation analysis of the water vapor flux two days and one day prior to, and on the day of, the heavy rainfall. And this ＂convergence zone＂ coincides with the migration of the maximum rainfall over the YRB. This specific coupled structure actually plays a key role in generating heavy rainfall over the YRB. The eastward movement of the coupled system with a divergence]convergence center of the potential function at the upper/lower level resembles the spatiotemporal evolution of the heavy rainfall event over the YRB. These upstream ＂strong signals＂ are clearly traced in this study through analyzing the three-dimensional structure of the potential/stream function of upstream water vapor transport.展开更多
Event-related potential （ERP） studies of cognitive function in Parkinson＇s disease （PD） have focused on P300 and N270. However, little is known regarding face recognition ERP in PD. The present study assessed cog...Event-related potential （ERP） studies of cognitive function in Parkinson＇s disease （PD） have focused on P300 and N270. However, little is known regarding face recognition ERP in PD. The present study assessed cognitive function in PD patients using neuropsychological scales and analyzed N170 of visuospatial function impairment （VFI） in PD. Results showed that Montreal cognitive assessment can be used for assessing cognitive impairment when visuospatial functioning is changed during the early stage of PD. Face recognition has clinical significance for detecting changes in visuospatial functioning. However, N170 is not sensitive for detection of VFI in PD, which implies that VFI does not appear in the stage of structure coding in face recognition. In addition, VFI affects face recognition.展开更多
The method for rapidly, precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research. Cortical electrostimulation is the optimal localization method during brain surge...The method for rapidly, precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research. Cortical electrostimulation is the optimal localization method during brain surgery, with a degree of accuracy of approximately 5 mm. However, electrostimulation can damage the cerebral cortex, trigger epilepsy, and extend the operation time. Studies are required to determine whether cortical motor regions can be localized by wavelet analysis from electrocorticograms. In this study, based on wavelet analysis of electrocorticograms, a selection of algorithms for classification of the mu rhythm in the motor regions utilizing experimental data was verified. Results demonstrated that a characteristic quantity of energy ratio in the reconstructed signal was filtered in the d6 （7.81-15.62 Hz） band prior to and following motion events. A characteristic threshold was considered to be 40%. The accuracy of localization detection was 93%. The degree of accuracy was less than 5 mm. The present study avoided the problems of cerebral cortex injury and epilepsy onset, with an operation time of 60 seconds. Therefore, wavelet analysis on electrocorticogram is feasible for localizing cortical motor regions. Furthermore, this localization technique is accurate, safe and rapid.展开更多
文摘Acupuncture can be used to treat various nervous system diseases.Here,168 vascular dementia patients were orally administered donepezil hydrochloride alone（5 mg/day,once a day for 56 days）,or combined with acupuncture at Shenting（DU24）,Tianzhu（BL10）,Sishencong（Extra）,Yintang（Extra）,Renzhong（DU26）,Neiguan（PC6）,Shenmen（HT7）,Fengchi（GB20）,Wangu（GB12） and Baihui（DU20）（once a day for 56 days）.Compared with donepezil hydrochloride alone,P300 event related potential latency was shorter with an increased amplitude in patients treated with donepezil hydrochloride and acupuncture.Mini-Mental State Examination score was also higher.Moreover,these differences in P300 latency were identified within different infarcted regions in patients treated with donepezil hydrochloride and acupuncture.These findings indicate that acupuncture combined with donepezil hydrochloride noticeably improves cognitive function in patients with vascular dementia,and exerts neuroprotective effects against vascular dementia.
基金the Medical Research Foundation of Jiangsu Provincial Department of Public Health,No.H201043
文摘We detected the event-related potential mismatch negativity （MMN） of 30 depression patients and compared to 30 age,gender,and education-matched healthy controls.Results showed that amplitudes of frequency and duration MMN were lower in depression patients compared with control patients,indicating abnormality in auditory processing （i.e.,cognitive impairment）.Following escitalopram treatment for 8 weeks,the amplitudes of frequency and duration MMN were significantly increased and Hamilton Rating Scale for Depression scores were significantly decreased in depression patients.These data suggest that escitalopram can improve cognitive function of patients with depression.Further,MMN may be a useful tool for evaluating cognitive function and treatment effects.
文摘A heavy rainfall event that occurred over the middle and lower reaches of the Yangtze River Basin （YRB） during July 11-13 2000 is explored in this study. The potential/stream function is used to analyze the upstream ＂strong signals＂ of the water vapor transport in the Tibetan Plateau （TP）. The studied time period covers from 2000 LST 5 July to 2000 LST 15 July （temporal resolution： 6 hours）. By analyzing the three-dimensional structure of the water vapor flux, vorticity and divergence prior to and during the heavy rainfall event, the upstream ＂strong signals＂ related to this heavy rainfall event are revealed. A strong correlation exists between the heavy rainfall event in the YRB and the convective clouds over the TE The ＂convergence zone＂ of the water vapor transport is also identified, based on correlation analysis of the water vapor flux two days and one day prior to, and on the day of, the heavy rainfall. And this ＂convergence zone＂ coincides with the migration of the maximum rainfall over the YRB. This specific coupled structure actually plays a key role in generating heavy rainfall over the YRB. The eastward movement of the coupled system with a divergence]convergence center of the potential function at the upper/lower level resembles the spatiotemporal evolution of the heavy rainfall event over the YRB. These upstream ＂strong signals＂ are clearly traced in this study through analyzing the three-dimensional structure of the potential/stream function of upstream water vapor transport.
文摘Event-related potential （ERP） studies of cognitive function in Parkinson＇s disease （PD） have focused on P300 and N270. However, little is known regarding face recognition ERP in PD. The present study assessed cognitive function in PD patients using neuropsychological scales and analyzed N170 of visuospatial function impairment （VFI） in PD. Results showed that Montreal cognitive assessment can be used for assessing cognitive impairment when visuospatial functioning is changed during the early stage of PD. Face recognition has clinical significance for detecting changes in visuospatial functioning. However, N170 is not sensitive for detection of VFI in PD, which implies that VFI does not appear in the stage of structure coding in face recognition. In addition, VFI affects face recognition.
文摘The method for rapidly, precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research. Cortical electrostimulation is the optimal localization method during brain surgery, with a degree of accuracy of approximately 5 mm. However, electrostimulation can damage the cerebral cortex, trigger epilepsy, and extend the operation time. Studies are required to determine whether cortical motor regions can be localized by wavelet analysis from electrocorticograms. In this study, based on wavelet analysis of electrocorticograms, a selection of algorithms for classification of the mu rhythm in the motor regions utilizing experimental data was verified. Results demonstrated that a characteristic quantity of energy ratio in the reconstructed signal was filtered in the d6 （7.81-15.62 Hz） band prior to and following motion events. A characteristic threshold was considered to be 40%. The accuracy of localization detection was 93%. The degree of accuracy was less than 5 mm. The present study avoided the problems of cerebral cortex injury and epilepsy onset, with an operation time of 60 seconds. Therefore, wavelet analysis on electrocorticogram is feasible for localizing cortical motor regions. Furthermore, this localization technique is accurate, safe and rapid.
