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Audiovisual Art Event Classification and Outreach Based on Web Extracted Data
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作者 Andreas Giannakoulopoulos Minas Pergantis +1 位作者 Aristeidis Lamprogeorgos Stella Lampoura 《Journal of Software Engineering and Applications》 2025年第1期24-43,共20页
The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information m... The World Wide Web provides a wealth of information about everything, including contemporary audio and visual art events, which are discussed on media outlets, blogs, and specialized websites alike. This information may become a robust source of real-world data, which may form the basis of an objective data-driven analysis. In this study, a methodology for collecting information about audio and visual art events in an automated manner from a large array of websites is presented in detail. This process uses cutting edge Semantic Web, Web Search and Generative AI technologies to convert website documents into a collection of structured data. The value of the methodology is demonstrated by creating a large dataset concerning audiovisual events in Greece. The collected information includes event characteristics, estimated metrics based on their text descriptions, outreach metrics based on the media that reported them, and a multi-layered classification of these events based on their type, subjects and methods used. This dataset is openly provided to the general and academic public through a Web application. Moreover, each event’s outreach is evaluated using these quantitative metrics, the results are analyzed with an emphasis on classification popularity and useful conclusions are drawn concerning the importance of artistic subjects, methods, and media. 展开更多
关键词 Web data Extraction Art events Classification Artistic Outreach Online Media
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A class of transformation rate models for recurrent event data 被引量:2
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作者 ZHANG Hu YANG QingLong QU LianQiang 《Science China Mathematics》 SCIE CSCD 2016年第11期2227-2244,共18页
Recurrent event data frequently occur in longitudinal studies, and it is often of interest to estimate the effects of covariates on the recurrent event rate. This paper considers a class of semiparametric transformati... Recurrent event data frequently occur in longitudinal studies, and it is often of interest to estimate the effects of covariates on the recurrent event rate. This paper considers a class of semiparametric transformation rate models for recurrent event data, which uses an additive AMen model as its covariate dependent baseline. The new models are flexible in that they allow for both additive and multiplicative covariate effects, and some covariate effects are allowed to be nonparametric and time-varying. An estimating procedure is proposed for parameter estimation, and the resulting estimators are shown to be consistent and asymptotically normal. Simulation studies and a real data analysis demonstrate that the proposed method performs well and is appropriate for practical use. 展开更多
关键词 Aalen model estimating equations recurrent event data time-varying coefficients transformation rate models
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Design and development of JUNO event data model 被引量:1
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作者 李腾 夏鑫 +5 位作者 黄性涛 邹佳恒 李卫东 林韬 张坤 邓子艳 《Chinese Physics C》 SCIE CAS CSCD 2017年第6期142-147,共6页
The Jiangmen Underground Neutrino Observatory(JUNO) detector is designed to determine the neutrino mass hierarchy and precisely measure oscillation parameters. The general purpose design also allows measurements of ... The Jiangmen Underground Neutrino Observatory(JUNO) detector is designed to determine the neutrino mass hierarchy and precisely measure oscillation parameters. The general purpose design also allows measurements of neutrinos from many terrestrial and non-terrestrial sources. The JUNO Event Data Model(EDM) plays a central role in the offline software system. It describes the event data entities through all processing stages for both simulated and collected data, and provides persistency via the input/output system. Also, the EDM is designed to enable flexible event handling such as event navigation, as well as the splitting of MC IBD signals and mixing of MC backgrounds. This paper describes the design, implementation and performance of the JUNO EDM. 展开更多
关键词 JUNO event data model offline software ROOT
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VARIABLE SELECTION FOR RECURRENT EVENT DATA WITH INFORMATIVE CENSORING
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作者 Ximing CHENG Li LUO 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2012年第5期987-997,共11页
Recurrent events data with a terminal event (e.g., death) often arise in clinical and ob- servational studies. Variable selection is an important issue in all regression analysis. In this paper, the authors first pr... Recurrent events data with a terminal event (e.g., death) often arise in clinical and ob- servational studies. Variable selection is an important issue in all regression analysis. In this paper, the authors first propose the estimation methods to select the significant variables, and then prove the asymptotic behavior of the proposed estimator. Furthermore, the authors discuss the computing algorithm to assess the proposed estimator via the linear function approximation and generalized cross validation method for determination of the tuning parameters. Finally, the finite sample estimation for the asymptotical covariance matrix is also proposed. 展开更多
关键词 Backward exclusion estimating equation forward inclusion informative censoring oracleproperties recurrent event data sparsity.
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Gender Effects on Statin-Associated Muscular Adverse Events: An Analysis of the FDA AERS Database
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作者 Hiroyuki Murakami Toshiyuki Sakaeda +1 位作者 Kaori Kadoyama Yasushi Okuno 《Pharmacology & Pharmacy》 2013年第3期340-346,共7页
Objective: The reports submitted to the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) from 1997 to 2011 were reviewed to assess the gender effects on muscular adverse events induced by t... Objective: The reports submitted to the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) from 1997 to 2011 were reviewed to assess the gender effects on muscular adverse events induced by the administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins). Methods: After the deletion of duplicated submissions and the revision of arbitrary drug names, the reports involving pravastatin, simvastatin, atorvastatin, rosuvastatin, and cerivastatin were analyzed. Data mining algorithms were applied for the quantitative detection of signals, where a signal means a drug-associated adverse event, including the proportional reporting ratio, the reporting odds ratio, the information component, and the empirical Bayes geometric mean. Myopathy, myalgia, myositis, rhabdomyolysis, and an increase in creatine phosphokinase level were focused on as the muscular adverse events. Results: The total number of reports was 3,472,494. The signal scores suggested that all 5 statins were associated with 5 muscular adverse events in both male and female patients. The scores varied among statins, but were more noteworthy for cerivastatin. Conclusion: The data strongly suggested the necessity of well-organized clinical studies on statin-associated muscular adverse events. 展开更多
关键词 ADVERSE event FAERS STATIN data Mining PHARMACOVIGILANCE
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生存资料的二次研究系列之二:R软件重建time-to-event结局的单个患者数据 被引量:6
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作者 孟详喻 田国祥 +3 位作者 拜争刚 曹越 刘小平 曾宪涛 《中国循证心血管医学杂志》 2016年第2期135-137,共3页
在原始研究中,对time-to-event结局的报道往往仅限于中位time to event和风险比。本文介绍一种使用R软件利用文献报道的Kaplan-Meier曲线、特定时间点无事件患者数(numbers at risk)和总事件数重建单个患者数据(IPD)的方法。
关键词 TIME-TO-event 单个患者数据 R软件 Kaplan-Meier曲线 生存分析
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基于Event-B与ADT的TACS形式化开发方法与验证 被引量:1
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作者 陈祖希 牛传军 +7 位作者 梅萌 刘杰 刘传振 郑黎晓 骆翔宇 潘亮 汪小勇 徐中伟 《中国铁道科学》 EI CAS CSCD 北大核心 2023年第6期172-183,共12页
为克服Event-B方法在开发全新一代列车自主运行控制系统(Train Autonomous Circumambulate System,TACS)中所出现的建模复杂性问题,提出将抽象数据类型(Abstract Data Types,ADT)实例化与Event-B相结合的方法,对TACS进行形式化开发和验... 为克服Event-B方法在开发全新一代列车自主运行控制系统(Train Autonomous Circumambulate System,TACS)中所出现的建模复杂性问题,提出将抽象数据类型(Abstract Data Types,ADT)实例化与Event-B相结合的方法,对TACS进行形式化开发和验证。首先,根据TACS的需求以及案例研究等相关内容,提取TACS的功能需求和安全需求,并将功能需求和安全需求以非形式化的语言进行描述;然后,根据TACS的功能需求和安全需求进行模型精化层次的设计,避免因在抽象模型中建模复杂的需求而导致证明困难;最后,在模型中使用形式化语言Event-B对TACS的功能需求和安全需求进行建模并验证其正确性,且在建模过程中,利用ADT的抽象概念将轨道网络、轨道区域以及移动授权(Movement Authority,MA)等复杂系统组件在初始模型中指定组件的必要属性,且在后续系统建模过程必要的精化阶段引入组件的具体定义,以降低系统开发和证明的复杂度。结果表明:提出的方法有助于在早期开发阶段减少TACS中复杂的细节部分,使得证明义务成功率为100%,自动证明成功率占比83%,手动证明成功率仅占比仅17%,在简化证明义务的同时有效提高了自动化证明的占比。 展开更多
关键词 event-B 抽象数据类型 精化策略 列车自主运行控制系统
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Poststack internal multiples attenuation based on virtual events 被引量:3
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作者 Chen Meng Liu Jia-Hui +4 位作者 Cui Yong-Fu Hu Tian-Yue Chen Fei-Xu Kuang Wei-Kang Zhang Zhen 《Applied Geophysics》 SCIE CSCD 2018年第3期491-499,共9页
The attenuation of prestack internal multiples based on virtual seismic events is computationally costly and hinders seismic data processing. We propose a multiples attenuation method for poststack seismic data by app... The attenuation of prestack internal multiples based on virtual seismic events is computationally costly and hinders seismic data processing. We propose a multiples attenuation method for poststack seismic data by approximating conventional virtual events. The proposed method is iterative. The proposed method is tested using 2D synthetic and the field poststack seismic datasets. Compared with the conventional virtual events method, the proposed method does not require data regularization and offers higher computation efficiency. The method requires to know the travel time of the primary reflection waves. The results of the application to 2D field datasets suggest that the proposed method attenuates the internal multiples while highlighting the deep primaries. 展开更多
关键词 VIRTUAL eventS poststack INTERNAL multiple LAND SEISMIC data
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Distributed event-triggered consensus tracking of second-order multi-agent systems with a virtual leader 被引量:2
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作者 曹劼 吴治海 彭力 《Chinese Physics B》 SCIE EI CAS CSCD 2016年第5期487-492,共6页
This paper investigates the consensus tracking problems of second-order multi-agent systems with a virtual leader via event-triggered control. A novel distributed event-triggered transmission scheme is proposed, which... This paper investigates the consensus tracking problems of second-order multi-agent systems with a virtual leader via event-triggered control. A novel distributed event-triggered transmission scheme is proposed, which is intermittently examined at constant sampling instants. Only partial neighbor information and local measurements are required for event detection. Then the corresponding event-triggered consensus tracking protocol is presented to guarantee second-order multi-agent systems to achieve consensus tracking. Numerical simulations are given to illustrate the effectiveness of the proposed strategy. 展开更多
关键词 consensus tracking event-triggered control SAMPLED-data second-order multi-agent systems
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Construction and Implementation of the Online Data Analysis System on EAST
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作者 杨飞 肖炳甲 张睿瑞 《Plasma Science and Technology》 SCIE EI CAS CSCD 2014年第5期521-526,共6页
In order to obtain diagnostic data with physical meaning,the acquired raw data must be processed through a series of physical formulas or processing algorithms.Some diagnostic data are acquired and processed by the di... In order to obtain diagnostic data with physical meaning,the acquired raw data must be processed through a series of physical formulas or processing algorithms.Some diagnostic data are acquired and processed by the diagnostic systems themselves.The data processing programs are specific and usually run manually,and the processed results of the analytical data are stored in their local disk,which is unshared and unsafe.Thus,it is necessary to integrate all the specific process programs and build an automatic and unified data analysis system with shareable data storage.This paper introduces the design and implementation of the online analysis system.Based on the MDSplus event mechanism,this system deploys synchronous operations for different processing programs.According to the computational complexity and real-time requirements,combined with the programmability of parallel algorithms and hardware costs,the OpenMP parallel processing technology is applied to the EAST analysis system,and significantly enhances the processing efficiency. 展开更多
关键词 EAST MDSPLUS OPENMP event data processing
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Sub Farm Interface of the ATLAS Dataflow System
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作者 刘尉悦 安琪 Maria Lorenza FERRER 《Plasma Science and Technology》 SCIE EI CAS CSCD 2006年第3期355-357,共3页
Sub Farm Interface is the event builder of the ATLAS(A Toroidal LHC ApparatuS) Dataflow System. It receives event fragments from the Read Out System, builds full events and sends complete events to the Event Filter ... Sub Farm Interface is the event builder of the ATLAS(A Toroidal LHC ApparatuS) Dataflow System. It receives event fragments from the Read Out System, builds full events and sends complete events to the Event Filter for high level event selection. This paper describes the implementation of the Sub Farm Interface. Furthermore, this paper introduces some issues on SFI(Sub Farm Interface) optimization and the monitoring service inside SFI. 展开更多
关键词 nuclear physics event building data acquisition MONITORING dataFLOW
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READA: Redundancy Elimination for Accurate Data Aggregation in Wireless Sensor Networks 被引量:1
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作者 Kavi Khedo Rubeena Doomun Sonum Aucharuz 《Wireless Sensor Network》 2010年第4期300-308,共9页
In monitoring systems, multiple sensor nodes can detect a single target of interest simultaneously and the data collected are usually highly correlated and redundant. If each node sends data to the base station, energ... In monitoring systems, multiple sensor nodes can detect a single target of interest simultaneously and the data collected are usually highly correlated and redundant. If each node sends data to the base station, energy will be wasted and thus the network energy will be depleted quickly. Data aggregation is an important paradigm for compressing data so that the energy of the network is spent efficiently. In this paper, a novel data aggregation algorithm called Redundancy Elimination for Accurate Data Aggregation (READA) has been proposed. By exploiting the range of spatial correlations of data in the network, READA applies a grouping and compression mechanism to remove duplicate data in the aggregated set of data to be sent to the base station without largely losing the accuracy of the final aggregated data. One peculiarity of READA is that it uses a prediction model derived from cached values to confirm whether any outlier is actually an event which has occurred. From the various simulations conducted, it was observed that in READA the accuracy of data has been highly preserved taking into consideration the energy dissipated for aggregating the 展开更多
关键词 Sensor Networks data AGGREGATION data Compression event Detection REDUNDANCY ELIMINATION
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大数据时代我国大型体育赛事的数据治理研究
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作者 王烁 《沈阳体育学院学报》 北大核心 2025年第4期102-108,共7页
为破解大数据时代我国大型体育赛事数字化转型中“数据孤岛”现象严重、数据安全问题凸显等数据治理难题,亟待构建规范、安全、高效的赛事数据治理体系。本研究运用文献资料法、案例分析法和逻辑分析法解析大数据时代我国大型体育赛事... 为破解大数据时代我国大型体育赛事数字化转型中“数据孤岛”现象严重、数据安全问题凸显等数据治理难题,亟待构建规范、安全、高效的赛事数据治理体系。本研究运用文献资料法、案例分析法和逻辑分析法解析大数据时代我国大型体育赛事数据治理的生成逻辑,探究其治理困境,并提出切实可行的行动路向。研究认为:大数据时代我国大型体育赛事数据治理面临数据治理设备落后、平台缺位、场景受限等基础薄弱问题,数据治理战略模糊、标准未定、人才匮乏等体系不完善问题,数据治理权属不清、安全薄弱、协同不足等机制不健全问题。据此提出行动路向:优化系统、整合平台、拓展场景,以多维度夯实数据治理基础设施;规划战略、统一标准、培养人才,以多层次构建数据治理体系;确权分利、保障安全、促进共享,以多方位健全数据治理机制。 展开更多
关键词 大数据时代 大型体育赛事 数据治理 赛事数据 高质量发展
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A Processing Approach for Event-Based Location Aware Queries in Hybrid Wireless Sensor Networks
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作者 HONG Liang,LU Yansheng College of Computer Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,Hubei,China 《Wuhan University Journal of Natural Sciences》 CAS 2009年第4期327-332,共6页
In hybrid wireless sensor networks, sensor mobility causes the query areas to change dynamically. Aiming at the problem of inefficiency in processing the data aggregation queries in dynamic query areas, this paper pro... In hybrid wireless sensor networks, sensor mobility causes the query areas to change dynamically. Aiming at the problem of inefficiency in processing the data aggregation queries in dynamic query areas, this paper proposes a processing approach for event-based location aware queries (ELAQ), which includes query dissemination algorithm, maximum distance projection proxy selection algorithm, in-network query propagation, and aggregation algorithm. ELAQs are triggered by the events and the query results are dependent on mobile sensors' location, which are the characteristics of ELAQ model. The results show that compared with the TinyDB query processing approach, ELAQ processing approach increases the accuracy of the query result and decreases the query response time. 展开更多
关键词 query processing wireless sensor network MOBILITY data aggregation event
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基于美国FAERS数据库多黏菌素B不良事件信号挖掘研究 被引量:1
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作者 李菁 张金红 冯鑫 《天津药学》 2025年第1期102-108,共7页
目的基于美国食品药品监督管理局不良事件报告系统(FAERS)数据库,挖掘并研究多黏菌素B的药物不良事件(ADE),为临床合理用药提供参考。方法检索并下载FAERS数据库2004年第一季度至2023年第四季度的数据,筛选出多黏菌素B的ADE报告,采用报... 目的基于美国食品药品监督管理局不良事件报告系统(FAERS)数据库,挖掘并研究多黏菌素B的药物不良事件(ADE),为临床合理用药提供参考。方法检索并下载FAERS数据库2004年第一季度至2023年第四季度的数据,筛选出多黏菌素B的ADE报告,采用报告比值比法(ROR)、比例报告比值比法(PRR)和综合标准法(MHRA)对多黏菌素B的ADE报告进行分析研究。结果FAERS数据库中共收录294份多黏菌素B为首要怀疑药物的ADE,经过筛选,共挖掘出有效信号21个,ADE报告128份,共涉及12个系统器官分类(SOC),报告数量前三位分别为肾脏及泌尿系统疾病、各类神经系统疾病、各类损伤和中毒及操作并发症,信号强度最强的ADE是皮肤色素沉着过度,同时还挖掘出说明书未说明的ADE,如:皮肤色素沉着过度、医院内感染、横纹肌溶解、低钾血症、感染性休克等。结论在应用多黏菌素B时,要重点关注肾脏及泌尿系统疾病、各类神经系统疾病、各类损伤和中毒及操作并发症、感染及侵染类疾病等ADE,及时采取防治措施,降低临床用药风险。 展开更多
关键词 多黏菌素B FAERS 不良事件 信号挖掘 首要怀疑药物
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Evaluation of the Impact of Queue Trucks with Navigation Alerts Using Connected Vehicle Data 被引量:1
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作者 Rahul Suryakant Sakhare Jairaj C. Desai +5 位作者 Justin Mahlberg Jijo K. Mathew Woosung Kim Howell Li John D. McGregor Darcy M. Bullock 《Journal of Transportation Technologies》 2021年第4期561-576,共16页
Back of queue crashes on Interstates are a major concern for all state transportation departments. In 2020, Indiana DOT begin deploying queue warning trucks with message boards, flashers and digital alerts that could ... Back of queue crashes on Interstates are a major concern for all state transportation departments. In 2020, Indiana DOT begin deploying queue warning trucks with message boards, flashers and digital alerts that could be transmitted to navigation systems such as Waze. This study reports on the deployment and impact evaluation of digital alerts on motorist’s assistance patrols and 19 Queue trucks in Indiana. The motorist assistance patrol evaluation is provided qualitatively. A novel analysis of queue warning trucks equipped with digital alerts was conducted during the months of May-July in 2021 using connected vehicle data. This new data set reports locations of anonymous hard-braking events from connected vehicles on the Interstate. Hard-braking events were tabulated for when queueing occurred with and without the presence of a queue warning truck. Approximately 370 hours of queueing with queue trucks present and 58 hours of queueing without queue truck<span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> present were evaluated. Hard-braking events were found to decrease approximately 80% when queue warning trucks were used to alert motorists of impending queues.</span> 展开更多
关键词 Queue Trucks Navigation Alerts Connected Vehicle data Hard-Braking events Motorists’ Safety
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Discrete Event Simulation-Based Evaluation of a Single-Lane Synchronized Dual-Traffic Light Intersections
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作者 Chimezie Calistus Ogharandukun Martin +1 位作者 Abdullahi Monday Essien Joe 《Journal of Computer and Communications》 2023年第10期82-100,共19页
This research involved an exploratory evaluation of the dynamics of vehicular traffic on a road network across two traffic light-controlled junctions. The study uses the case study of a one-kilometer road system model... This research involved an exploratory evaluation of the dynamics of vehicular traffic on a road network across two traffic light-controlled junctions. The study uses the case study of a one-kilometer road system modelled on Anylogic version 8.8.4. Anylogic is a multi-paradigm simulation tool that supports three main simulation methodologies: discrete event simulation, agent-based modeling, and system dynamics modeling. The system is used to evaluate the implication of stochastic time-based vehicle variables on the general efficiency of road use. Road use efficiency as reflected in this model is based on the percentage of entry vehicles to exit the model within a one-hour simulation period. The study deduced that for the model under review, an increase in entry point time delay has a domineering influence on the efficiency of road use far beyond any other consideration. This study therefore presents a novel approach that leverages Discrete Events Simulation to facilitate efficient road management with a focus on optimum road use efficiency. The study also determined that the inclusion of appropriate random parameters to reflect road use activities at critical event points in a simulation can help in the effective representation of authentic traffic models. The Anylogic simulation software leverages the Classic DEVS and Parallel DEVS formalisms to achieve these objectives. 展开更多
关键词 Multi-Core Processing Distributed Computing event-Driven Modelling Discrete event Simulation data Analysis and Visualization
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Asymptotic Extremal Distribution for Non-Stationary, Strongly-Dependent Data
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作者 Carolina Crisci Gonzalo Perera 《Advances in Pure Mathematics》 2022年第8期479-489,共11页
Fisher-Tippet-Gnedenko classical theory shows that the normalized maximum of n iid random variables with distribution F belonging to a very wide class of functions, converges in law to an extremal distribution H, that... Fisher-Tippet-Gnedenko classical theory shows that the normalized maximum of n iid random variables with distribution F belonging to a very wide class of functions, converges in law to an extremal distribution H, that is determined by the tail of F. Extensions of this theory from the iid case to stationary and weak dependent sequences are well known from the work of Leadbetter, Lindgreen and Rootzén. In this paper, we present a very simple class of random processes that runs from iid sequences to non-stationary and strongly dependent processes, and we study the asymptotic behavior of its normalized maximum. More interesting, we show that when the process is strongly dependent, the asymptotic distribution is no longer an extremal one, but a mixture of extremal distributions. We present very simple theoretical and simulated examples of this result. This provides a simple framework to asymptotic approximations of extremes values not covered by classical extremal theory and its well-known extensions. 展开更多
关键词 Extreme events Strongly Dependent data Fisher-Tippet-Gnedenko Theory
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Multi-bit soft error tolerable L1 data cache based on characteristic of data value
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作者 王党辉 刘合朋 陈怡然 《Journal of Central South University》 SCIE EI CAS CSCD 2015年第5期1769-1775,共7页
Due to continuous decreasing feature size and increasing device density, on-chip caches have been becoming susceptible to single event upsets, which will result in multi-bit soft errors. The increasing rate of multi-b... Due to continuous decreasing feature size and increasing device density, on-chip caches have been becoming susceptible to single event upsets, which will result in multi-bit soft errors. The increasing rate of multi-bit errors could result in high risk of data corruption and even application program crashing. Traditionally, L1 D-caches have been protected from soft errors using simple parity to detect errors, and recover errors by reading correct data from L2 cache, which will induce performance penalty. This work proposes to exploit the redundancy based on the characteristic of data values. In the case of a small data value, the replica is stored in the upper half of the word. The replica of a big data value is stored in a dedicated cache line, which will sacrifice some capacity of the data cache. Experiment results show that the reliability of L1 D-cache has been improved by 65% at the cost of 1% in performance. 展开更多
关键词 data cache RELIABILITY REPLICA data value single event upset(SEU)
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基于美国FAERS数据库儿童药源性血小板减少症的警戒信号挖掘
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作者 张静 郝丽娜 《药物评价研究》 北大核心 2025年第4期964-970,共7页
目的 基于美国食品药品监督管理局不良事件呈报系统(FAERS),挖掘药物在0~18岁儿童临床使用中引起血小板减少症的警戒信号,为判断和治疗临床不明原因血小板减少提供参考。方法 用Open Vigil 2.1软件对FAERS数据库进行药源性血小板减少症... 目的 基于美国食品药品监督管理局不良事件呈报系统(FAERS),挖掘药物在0~18岁儿童临床使用中引起血小板减少症的警戒信号,为判断和治疗临床不明原因血小板减少提供参考。方法 用Open Vigil 2.1软件对FAERS数据库进行药源性血小板减少症不良反应数据挖掘,以“thrombocytopenia”为首选术语进行检索,采用比例报告比(PRR)和报告比值比法(ROR)对药源性血小板减少症警戒信号进行数据分析和处置。结果 根据预定义的纳入标准,2 510例不良事件(ADE)报告涉及鉴定出435种疑似药物,经过数据挖掘,生成54种药源性血小板减少症的阳性风险信号,其中36种是抗肿瘤药物。报告最多的药物是甲氨蝶呤(n=113)、其次是丙戊酸(n=67)、多柔比星(n=52)、阿糖胞苷(n=51)和依托泊苷(n=46)。地西他滨(PRR=27.18,ROR=32.5)、硫鸟嘌呤(PRR=22.96,ROR=26.62)、吉西他滨(PRR=17.85,ROR=19.94),和奥沙利铂(PRR=16.79,ROR=18.63)与血小板减少的关系比其余的药物更强。结论 引起儿童药源性血小板减少症的药物主要包括抗肿瘤药物、神经系统药物及抗感染药物3大类,关注其引起儿童药源性血小板减少症的特点,对相关药物风险进行识别与比较,持续监测该ADE,进而有效降低临床用药风险。 展开更多
关键词 药源性血小板减少症 不良事件 信号挖掘 儿童 安全 抗肿瘤药物
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