Teachers' in-class evaluative speech is an indispensable part in English language teaching and also a is an indispensable and a weak point in English teaching. When using in-class evaluative speeches, the teacher ...Teachers' in-class evaluative speech is an indispensable part in English language teaching and also a is an indispensable and a weak point in English teaching. When using in-class evaluative speeches, the teacher made mistakes with a high frequency and failed to reach the purpose of it. This study attempts to investigate and analyze the meaning of teachers' in- class evaluative speeches, discusses some of the problems existing in teachers' evaluation in English classroom teaching and proposes countermeasures to improve the quality of it. It aims at causing the teachers' attention and correcting the mistakes of using inclass evaluative speeches.展开更多
Homologous recombination deficiency(HRD)has emerged as a critical prognostic and predictive biomarker in oncology.However,current test-ing methods,especially those reliant on targeted panels,are plagued by inconsisten...Homologous recombination deficiency(HRD)has emerged as a critical prognostic and predictive biomarker in oncology.However,current test-ing methods,especially those reliant on targeted panels,are plagued by inconsistent results from the same samples.This highlights the urgent need for standardized benchmarks to evaluate HRD assay performance.In phases lla and Ilb of the Chinese HRD Harmonization Project,we de-veloped ten pairs of well-characterized DNA reference materials derived from lung,breast,and melanoma cancer cell lines and their matched normal cell lines,keeping each paired with seven cancer-to-normal mass ratios.Reference datasets for allele-specific copy number variations(AsCNVs)and HRD scores were established and validated using three sequencing methods and nine analytical pipelines.The genomic instabil-ity scores(GISs)of the reference materials ranged from 11 to 96,enabling validation across various thresholds.The AsCNV reference datasets covered a genomic span of 2340 to 2749 Mb,equivalent to 81.2%to 95.4%of the autosomes in the 37d5 reference genome.These bench-marks were subsequently utilized to assess the accuracy and reproducibility of four HRD panel assays,revealing significant variability in both ASCNV detection and HRD scores.The concordance between panel-detected GISs and reference GISs ranged from 0.81 to 0.94,with only two assays exhibiting high overall agreement with Myriad MyChoice CDx for HRD classification.This study also identified specific challenges in ASCNV detection in HRD-related regions and the profound impact of high ploidy on consistency.The established HRD reference materials and datasets providea robust toolkit forobjective evaluation of HRD testing.展开更多
With the improvement of living standards and the shift in societal consumption attitudes,consumers demand for the quality of aquatic products is increasingly stringent.Freshness and quality have become primary factors...With the improvement of living standards and the shift in societal consumption attitudes,consumers demand for the quality of aquatic products is increasingly stringent.Freshness and quality have become primary factors determining consumers purchasing decisions.However,due to the high moisture content,active endogenous enzymes,and rich nutrients in aquatic products,both fresh and processed products are highly susceptible to quality deterioration during procurement,distribution,and storage,which leads to a significant decline in sensory quality and nutritional value,while also compromising safety.Today,the consumption of high-quality aquatic products has become a prevailing trend.This paper reviewed the methods for freshness evaluation and quality grading of aquatic products in terms of sensory and nutritional aspects,aiming to support the market circulation principle of"higher price for better quality"and"price based on quality",and better meeting consumer demands.Therefore,it is imperative to enhance the analysis and evaluation of aquatic product quality and to continuously refine assessment systems and methods,which is crucial for promoting industry transformation and fostering a healthy market-consumer economic cycle.展开更多
It is well recognized that Structural Health Monitoring(SHM)reliability evaluation is a key aspect that needs to be urgently addressed to promote the wide application of SHM methods.However,the existing studies typica...It is well recognized that Structural Health Monitoring(SHM)reliability evaluation is a key aspect that needs to be urgently addressed to promote the wide application of SHM methods.However,the existing studies typically transfer the Non-Destructive Testing/Evaluation(NDT/E)reliability metrics to SHM without a systematic analysis of where these metrics originated.Seldom attentions are paid to the evaluation conditions which are very important to apply these metrics.Aimed at this issue,a new condition control-based Dual-Reliability Evaluation(Dual-RE)method for SHM is proposed.This new method is proposed based on a systematic analysis of the whole framework of reliability evaluation from instrument to NDT,and emphasis is paid to the evaluation condition control.Based on these analyses,considering the special online application scenario of SHM,the proposed Dual-RE method contains two key components:Integrated Sensor-based SHM-RE(IS-SHM-RE)and Critical Service Condition-based SHM-RE(CSC-SHM-RE).ISSHM-RE evaluates the reliability of integrated SHM sensor and system themselves under approximate repeatability conditions,while CSC-SHM-RE assesses SHM reliability under the dominant uncertainties during service,namely intermediate conditions.To demonstrate the Dual-RE,crack monitoring by using the Guided Wave-based-SHM(GW-SHM)on aircraft lug structures is taken as a case study.Both the crack detection and sizing performance are evaluated from accuracy and uncertainty.展开更多
Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces ...Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces a visual evaluation index named confidence centroid skewing quadrilateral,which is based on a classification confidence-based confusion matrix,offering a quantitative and visual comparison of the adversarial robustness among different classification algorithms,and enhances intuitiveness and interpretability of attack impacts.We first conduct a validity test and sensitive analysis of the method.Then,prove its effectiveness through the experiments of five classification algorithms including artificial neural network(ANN),logistic regression(LR),support vector machine(SVM),convolutional neural network(CNN)and transformer against three adversarial attacks such as fast gradient sign method(FGSM),DeepFool,and projected gradient descent(PGD)attack.展开更多
In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation ...In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade.展开更多
Zearalenone(ZEN),a mycotoxin present in cereals,poses significant health risks to animals and humans due to its estrogenic effects.Numerous studies on the enzymatic detoxification of ZEN have predominantly focused on ...Zearalenone(ZEN),a mycotoxin present in cereals,poses significant health risks to animals and humans due to its estrogenic effects.Numerous studies on the enzymatic detoxification of ZEN have predominantly focused on reducing the parent toxin to assess the enzyme’s efficacy,yet there is limited research on the identification and toxicity evaluation of the enzymatic degradation products.This study investigated the enzymatic degradation mechanisms of ZEN using commercial peroxidase(POD)and laccase(LC),with a focus on identifying degradation products and assessing their hepatotoxicity effects.Molecular docking and dynamics simulations elucidated the binding mechanisms between these enzymes and ZEN,revealing strong interactions that facilitate efficient detoxification.Subsequent analysis employing ultra-high performance liquid chromatography-high resolution mass spectrometry(UHPLC-HRMS)successfully identified crucial degradation products.Hepatic toxicity of the enzymatic degradation products was comprehensively assessed in HepaRG liver cells through systematic measurements of cell viability,oxidative stress,apoptosis,mitochondrial membrane potential,and molecular metabolic profiles.Our findings demonstrate that both POD and LC exhibit significant efficacy in mitigating hepatocyte toxicity induced by ZEN,thereby highlighting their potential utility in enhancing food safety.This research provides essential data for safety evaluation regarding enzymatic detoxification of ZEN while offering theoretical and technical resources for risk assessment related to mycotoxin enzymatic detoxification.展开更多
Rock brittleness is a critical property in geotechnical and energy engineering,as it directly influences the prediction of rock failure and stability assessment.Although numerous methods have been developed to evaluat...Rock brittleness is a critical property in geotechnical and energy engineering,as it directly influences the prediction of rock failure and stability assessment.Although numerous methods have been developed to evaluate brittleness,many fail to comprehensively account for the impacts of microstructural changes,mineralogical characteristics,and stress conditions on energy evolution during failure.This study proposes a novel approach for brittleness evaluation based on the energy evolution throughout the post-peak failure process,integrating two micromechanical mechanisms:crack propagation and frictional sliding.A new brittleness index is defined as the ratio of generated surface energy to released elastic energy,providing a unified framework for assessing both Class I and Class II mechanical behaviors.The brittleness of cyan,white,and gray sandstones was investigated under various confining pressures and moisture conditions using X-ray diffraction(XRD),scanning electron microscopy(SEM),and conventional triaxial compression(CTC)tests.The results demonstrate that brittleness decreases with increasing confining pressure,due to suppressed crack propagation,and increases under saturated conditions,as moisture enhances crack propagation.By establishing connections between mineral composition,microstructural features,and stress-induced responses,the proposed method overcame limitations of previous approaches and offered a more precise tool for evaluating rock brittleness under diverse environmental scenarios.展开更多
Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both g...Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.展开更多
[Objectives]To develop an HPLC fingerprint analysis method for the medicinal material of Lysimachia foenum-graecum Hance,thereby providing a foundation for its quality control.[Methods]Samples of L.foenum-graecum coll...[Objectives]To develop an HPLC fingerprint analysis method for the medicinal material of Lysimachia foenum-graecum Hance,thereby providing a foundation for its quality control.[Methods]Samples of L.foenum-graecum collected from 10 distinct locations in Guangxi were analyzed using HPLC,and chromatographic fingerprints were established.The Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine(2012 Edition)was employed for common peak calibration and similarity evaluation.Additionally,principal component analysis was performed on the common peak area data.[Results]An HPLC fingerprint of L.foenum-graecum was developed,identifying a total of 13 common peaks.Among these,four characteristic components were specifically identified:chlorogenic acid,myricetin,quercetin,and kaempferol.The kaempferol chromatographic peak,exhibiting good resolution and a stable peak shape,was selected as the reference peak.The similarity indices between the fingerprints of the 10 sample batches and the reference fingerprint ranged from 0.954 to 0.995,indicating a relatively high consistency in the chemical composition of L.foenum-graecum from different origins.Principal component analysis identified two principal components,which together accounted for 89.45%of the cumulative variance,effectively capturing the primary chemical differences among the samples.[Conclusions]The established HPLC fingerprint method is straightforward to implement,stable,reliable,and exhibits high specificity.When combined with similarity evaluation and principal component analysis,it offers a scientific basis for developing quality standards for L.foenum-graecum medicinal materials.展开更多
BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an e...BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.展开更多
Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core functi...Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core function is to characterize the complexity of the induced fracture network and the resulting effective stimulated volume.In this study,we quantified fracture area and geometric complexity using true triaxial fracturing experiments and computed tomography three-dimensional(3D)reconstruction technology,combined with the box-counting method to calculate the 3D fractal dimension of the fracture surfaces.The results revealed that the total fracture surface area per unit volume of the stimulated reservoir effectively characterized reservoir fracability;specifically,both a larger total fracture surface area and a higher fractal dimension corresponded to better reservoir fracability.Fracture complexity was enhanced by a decrease in the horizontal principal stress difference or an increase in the injection rate.Under optimal conditions of a 3 MPa stress difference and an injection rate of 60 mL/min,fracability improved by 27.6%.Furthermore,liquid carbon dioxide(CO_(2))improved fracability by 50.7%compared to using water as the fracturing fluid,a result attributed to its low viscosity and strong diffusion capacity,which activated a greater number of natural fractures.A fracability evaluation model integrating brittleness,fracture toughness,and dimensionless net pressure was developed using regression analysis,which demonstrated high reliability with a strong determination coefficient(R^(2))of 0.9019.This study clarifies the logical relationships among fracture area,complexity,and fractal dimension,providing a novel method for evaluating the fracability of coal reservoirs.展开更多
Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult t...Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult to compare their research results.Methods:The time for wound closure was evaluated and recorded through gross observation.The regression equation between the healing time and the diameter of skin defect was established,which can be used to predict the healing time for a certain skin defect size in rats.Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages,and the functional skin repair was quantitatively scored.Results:The critical-size defect of rats was determined based on the maximum capacity of structural skin repair,and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages.The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter.The concept of structural repair and the category of functional repair of injured skin are put forward.The regression equation between the structural skin healing time and defect diameters is established.Conclusion:The allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter.The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats.展开更多
Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage....Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage.Understanding the damage characteristics in soaked sandstones is essential for ensuring the stability and longevity of these energy storage systems.This study involved multi-stage cyclic loading tests conducted on soaked sandstone to explore the damage evolution throughout the loading process.The findingsreveal several important insights:(1)The plastic hysteresis loops observed during multi-stage cyclic loading evolved from dense to sparse.An increase in stress level led to greater damage in the rock,as evidenced by an increase in accumulated peak/plastic strains.(2)Energy density and stress level are related by quadratic polynomial relationships.The elastic and dissipated energy densities are related by a linear law.The average energy storage coefficientdecreased by up to 24.1%with increasing stress amplitude,reflectingchanges in energy dynamics within the samples.(3)AE counts,amplitude,and frequency provided critical insights into rock damage and fracture patterns.The greater the loading rate and stress amplitude,the lower the proportion of high-amplitude,high-peak frequency,and shear-type fractures.Increasing stress amplitude caused a maximum 16.63%reduction in the AE bvalue,indicating shifts in fracture behavior under varying stress conditions.(4)The increase in loading rate and stress amplitude promotes the transformation of micropores and mesopores to macropores/microcracks.(5)Damage variables,definedin terms of cumulative dissipation energy,aligned closely with the fatigue damage model under multi-stage cyclic loading.Accelerated damage primarily occurred during the finalstages of fatigue loading,highlighting critical periods in the degradation of soaked sandstones.This study can offer guidance for designing operational parameters for energy storage geological bodies dominated by soaked sandstones.展开更多
Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation...Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation-integrated multimodal photoacoustic/ultrasound(PA/US)imaging framework designed to quantify entheseal oxygen saturation(SO_(2))for assessing entheseal disease activity in PsA.In this cross-sectional study,25 PsA patients underwent bilateral PA/US imaging of 12 entheses,where ultrasound lesions were scored using the Outcome Measures in Rheumatology scoring system,and PA-derived SO_(2) levels,quantified via dual-wavelength PA imaging,were classified into hyperoxia or hypoxia groups using k-means clustering.This approach provides metabolic insights complementary to conventional ultrasonic assessment.A composite score integrating hypoxia with US parameters was validated against clinical disease activity indices(Disease Activity Score 28-C-reactive protein,DAS28-CRP;Disease Activity Index for Psoriatic Arthritis,DAPSA).Among 300 entheses,103(34.3%)exhibited PA positivity,with 40(38.8%)classified as hypoxia.Hypoxia scores independently predicted DAS28-CRP(β=0.618,p=0.001)and DAPSA(β=0.612,p<0:001).The hypoxia-optimized PAUS score demonstrated superior correlation with disease activity indices compared to conventional US(DAS28-CRP:r=0.615,p=0.001 versus r=0.474,p=0.017;DAPSA:r=0.743,p<0:001 versus r=0.567,p=0.003),alongside superior diagnostic accuracy for minimal disease activity(area under the curve,AUC 0.776 versus 0.614,p=0.008)and low disease activity(AUC 0.853 versus 0.772,p=0.009).This multimodal scoring system enhances the stratification of PsA disease activity by providing unique metabolic insights,offering a potential tool for therapeutic monitoring and guiding treat-to-target strategies.展开更多
Although lead(Pb)-based perovskite solar cells(PSCs)have garnered intense attention for their remarkable photovoltaic conversion efficiency,their commercial process is urgently in need of an effective damage-evaluatio...Although lead(Pb)-based perovskite solar cells(PSCs)have garnered intense attention for their remarkable photovoltaic conversion efficiency,their commercial process is urgently in need of an effective damage-evaluation system for the early diagnosis of faulty PSCs.The main cause of microdamage in perovskite films is the outflow of Pb,which significantly impacts device performance.However,no reliable correlation has been established between classical damage detection techniques and Pb detection,resulting in limited detection sensitivity.Here,we report an in situ visual microdamage evaluation method of PSCs by coating the device surface with a silica gel encapsulation layer containing porphyrin molecules.This detection technology enables high selectivity and sensitivity based on the strong complexation between the porphyrin ring and trace Pb outflow from degraded PSCs.By establishing the linear relationship between the fluorescence intensity and Pb concentration in PSCs,trace Pb outflow is pinpointed and quantified with a low detection limit of 0.65μg cm^(-2).An applet is developed for the insitu visual fluorescence detection method to facilitate the continuous real-time monitoring of series-type PSCs,thereby enabling the prompt identification and replacement of damaged PSCs and ensuring the swift restoration of high efficiency.展开更多
Ground penetrating radar(GPR)offers a rapid and non-destructive approach to evaluating asphalt mixtures by capturing variations in their dielectric constant.As a critical electromagnetic parameter,the dielectric const...Ground penetrating radar(GPR)offers a rapid and non-destructive approach to evaluating asphalt mixtures by capturing variations in their dielectric constant.As a critical electromagnetic parameter,the dielectric constant demonstrates significant potential for assessing the material composition and mechanical properties of asphalt mixtures.However,the relationship between the dielectric constant and mechanical properties remains unclear.To investigate the factors affecting the dielectric constant and its correlation with the mechanical properties of asphalt mixtures,a systematic analysis of the influencing parameters was conducted.Fitting equations were established to quantify the relationships between the dielectric constant and mechanical properties.Firstly,the effects of compaction state,testing frequency,and testing temperature on the dielectric constant were evaluated.Subsequently,forward simulations of GPR were executed on asphalt pavements with diverse air voids and detection frequencies.Finally,a fitting analysis was performed to determine the correlation between the dielectric constant and the dynamic modulus,compressive strength,and splitting tensile strength.The results indicated that the dielectric constant increased with the compaction state,decreased with increasing testing frequency until stabilized,and was insignificantly affected by changes in testing temperature.The change of air void in asphalt pavement has significantly affected the amplitude and timing of electromagnetic wave reflection.A linear positive correlation was identified between the dielectric constant and dynamic modulus as well as compressive strength,while a quadratic positive correlation existed with splitting tensile strength.This study provided theoretical and practical foundations for enhancing the reliability and accuracy of non-destructive testing in asphalt pavement.展开更多
Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urolo...Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urology,First Affiliated Hospital of Jinan University,were selected and treated with electrophysiological therapy.They were randomly divided into three groups:the fixed-parameter AA7 treatment group,the P2+P4 treatment group,and the precision treatment group(individualized parameter treatment).Pain scores of patients in each group were compared before and after treatment,with a pain score of 0 indicating cure.The cure rate of each group was observed.Results:The average ages of the AA7 group,P2+P4 group,and precision treatment group were 34±14.17 years,35.58±12.57 years,and 35.5±11.27 years,respectively.There was no significant difference in age among the three groups(p>0.05).Before treatment,the pain scores of the AA7 group,P2+P4 group,and precision treatment group were 4.14±1.74,4.64±1.72,and 3.50±1.89,respectively,with no significant differences among the groups(p>0.05).After treatment,the pain scores were 0.71±0.99 for the AA7 group(cure rate:57%),0.49±0.79 for the P2+P4 group(cure rate:67%),and 0.50±0.77 for the precision treatment group(cure rate:64%),with no significant differences among the groups(p>0.05).The cure rates for different pain locations were as follows:83%for lower abdominal pain,74%for perineal pain,62%for dysuria,49%for testicular pain,and 75%for inguinal pain.Conclusion:The pathogenesis of CPPS is complex and diverse,with numerous treatment options and uncertain efficacy,posing significant challenges to clinical practice.This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment,indicating significant therapeutic effects on CPPS.All three modes demonstrated good cure rates.Individualized precision treatment and fixed-mode P2+P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting.Fixed-mode P2+P4 and AA7,due to their easier standardization of parameters and patch modes,reduced the learning curve and had better potential for widespread application.展开更多
The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention a...The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.展开更多
Crassostrea gigas has good taste and high nutritional value;however,there are few assessments of comprehensive and panoramic analyses of the nutritional quality of the northern oyster.To study the nutritional characte...Crassostrea gigas has good taste and high nutritional value;however,there are few assessments of comprehensive and panoramic analyses of the nutritional quality of the northern oyster.To study the nutritional characteristics of C.gigas from different sources(ploidy,region,size,and culture mode),C.gigas from various ploidy(diploid and triploid),regions(Rushan,Off-site fattening,and Rongcheng),sizes(small,medium,and large)and culture modes(nearshore and offshore)were selected for comparative analyses.The nutritional components(moisture,protein,fat,and mineral),flavor substances(taste amino acids,nucleotides,and succinic acid),and functional indices(eicosapentaenoic acid(EPA),docosahexaenoic acid(DHA),and taurine)of C.gigas were determined.Principal component analysis(PCA)was used to comprehensively evaluate the oysters and investigate the variations in nutritional quality.The PCA results indicate that protein,essential fatty acids,selenium,zinc,taste amino acids,taurine,EPA,and DHA were core components contributing to 82.25%of the cumulative variance,providing a more comprehensive reflection of the nutrient composition of C.gigas.The extensive quality rankings for the C.gigas were as follows:diploid>triploid,Rushan>fattening>Rongcheng,medium>large>small,and offshore>nearshore.The score rank revealed that diploid oysters of medium-size from Rushan demonstrated superior nutritional quality compared to other tested samples.This is the first comprehensive and systematic investigation of C.gigas in northern China to reveal the feature of nutrients,flavor,and functional components.The study provided data support for the culture,consumption,processing,research,and nutritional quality improvement of oyster industry.展开更多
文摘Teachers' in-class evaluative speech is an indispensable part in English language teaching and also a is an indispensable and a weak point in English teaching. When using in-class evaluative speeches, the teacher made mistakes with a high frequency and failed to reach the purpose of it. This study attempts to investigate and analyze the meaning of teachers' in- class evaluative speeches, discusses some of the problems existing in teachers' evaluation in English classroom teaching and proposes countermeasures to improve the quality of it. It aims at causing the teachers' attention and correcting the mistakes of using inclass evaluative speeches.
基金supported by the National Key R&D Program of China(Grant No.2022YFF1202203)the NIFDC Fund for Key Technology Research,China(Grant No.GJJS-2022-2-1).
文摘Homologous recombination deficiency(HRD)has emerged as a critical prognostic and predictive biomarker in oncology.However,current test-ing methods,especially those reliant on targeted panels,are plagued by inconsistent results from the same samples.This highlights the urgent need for standardized benchmarks to evaluate HRD assay performance.In phases lla and Ilb of the Chinese HRD Harmonization Project,we de-veloped ten pairs of well-characterized DNA reference materials derived from lung,breast,and melanoma cancer cell lines and their matched normal cell lines,keeping each paired with seven cancer-to-normal mass ratios.Reference datasets for allele-specific copy number variations(AsCNVs)and HRD scores were established and validated using three sequencing methods and nine analytical pipelines.The genomic instabil-ity scores(GISs)of the reference materials ranged from 11 to 96,enabling validation across various thresholds.The AsCNV reference datasets covered a genomic span of 2340 to 2749 Mb,equivalent to 81.2%to 95.4%of the autosomes in the 37d5 reference genome.These bench-marks were subsequently utilized to assess the accuracy and reproducibility of four HRD panel assays,revealing significant variability in both ASCNV detection and HRD scores.The concordance between panel-detected GISs and reference GISs ranged from 0.81 to 0.94,with only two assays exhibiting high overall agreement with Myriad MyChoice CDx for HRD classification.This study also identified specific challenges in ASCNV detection in HRD-related regions and the profound impact of high ploidy on consistency.The established HRD reference materials and datasets providea robust toolkit forobjective evaluation of HRD testing.
基金Supported by Tangshan Talent Funding Project in 2025(B202304018).
文摘With the improvement of living standards and the shift in societal consumption attitudes,consumers demand for the quality of aquatic products is increasingly stringent.Freshness and quality have become primary factors determining consumers purchasing decisions.However,due to the high moisture content,active endogenous enzymes,and rich nutrients in aquatic products,both fresh and processed products are highly susceptible to quality deterioration during procurement,distribution,and storage,which leads to a significant decline in sensory quality and nutritional value,while also compromising safety.Today,the consumption of high-quality aquatic products has become a prevailing trend.This paper reviewed the methods for freshness evaluation and quality grading of aquatic products in terms of sensory and nutritional aspects,aiming to support the market circulation principle of"higher price for better quality"and"price based on quality",and better meeting consumer demands.Therefore,it is imperative to enhance the analysis and evaluation of aquatic product quality and to continuously refine assessment systems and methods,which is crucial for promoting industry transformation and fostering a healthy market-consumer economic cycle.
基金the support from National Natural Science Foundation of China(No.52275153)the Frontier Technologies R&D Program of Jiangsu,China(No.BF2024068)+1 种基金The Fund of Prospective Layout of Scientific Research for Nanjing University of Aeronautics and Astronautics,ChinaResearch Fund of State Key Laboratory of Mechanics and Control for Aerospace Structures(Nanjing University of Aeronautics and Astronautics),China(Nos.MCAS-I-0425K01,MCAS-I-0423G01)。
文摘It is well recognized that Structural Health Monitoring(SHM)reliability evaluation is a key aspect that needs to be urgently addressed to promote the wide application of SHM methods.However,the existing studies typically transfer the Non-Destructive Testing/Evaluation(NDT/E)reliability metrics to SHM without a systematic analysis of where these metrics originated.Seldom attentions are paid to the evaluation conditions which are very important to apply these metrics.Aimed at this issue,a new condition control-based Dual-Reliability Evaluation(Dual-RE)method for SHM is proposed.This new method is proposed based on a systematic analysis of the whole framework of reliability evaluation from instrument to NDT,and emphasis is paid to the evaluation condition control.Based on these analyses,considering the special online application scenario of SHM,the proposed Dual-RE method contains two key components:Integrated Sensor-based SHM-RE(IS-SHM-RE)and Critical Service Condition-based SHM-RE(CSC-SHM-RE).ISSHM-RE evaluates the reliability of integrated SHM sensor and system themselves under approximate repeatability conditions,while CSC-SHM-RE assesses SHM reliability under the dominant uncertainties during service,namely intermediate conditions.To demonstrate the Dual-RE,crack monitoring by using the Guided Wave-based-SHM(GW-SHM)on aircraft lug structures is taken as a case study.Both the crack detection and sizing performance are evaluated from accuracy and uncertainty.
文摘Evaluating the adversarial robustness of classification algorithms in machine learning is a crucial domain.However,current methods lack measurable and interpretable metrics.To address this issue,this paper introduces a visual evaluation index named confidence centroid skewing quadrilateral,which is based on a classification confidence-based confusion matrix,offering a quantitative and visual comparison of the adversarial robustness among different classification algorithms,and enhances intuitiveness and interpretability of attack impacts.We first conduct a validity test and sensitive analysis of the method.Then,prove its effectiveness through the experiments of five classification algorithms including artificial neural network(ANN),logistic regression(LR),support vector machine(SVM),convolutional neural network(CNN)and transformer against three adversarial attacks such as fast gradient sign method(FGSM),DeepFool,and projected gradient descent(PGD)attack.
文摘In their recent paper Pereira et al.(2025)claim that validation is overlooked in mapping and modelling of ecosystem services(ES).They state that“many studies lack critical evaluation of the results and no validation is provided”and that“the validation step is largely overlooked”.This assertion may have been true several years ago,for example,when Ochoa and Urbina-Cardona(2017)made a similar observation.However,there has been much work on ES model validation over the last decade.
基金financially supported by the National Key Research and Development Program of China(2022YFF1102500)the Key Research and Development Projects in Hubei Province,China(2021BCA113).
文摘Zearalenone(ZEN),a mycotoxin present in cereals,poses significant health risks to animals and humans due to its estrogenic effects.Numerous studies on the enzymatic detoxification of ZEN have predominantly focused on reducing the parent toxin to assess the enzyme’s efficacy,yet there is limited research on the identification and toxicity evaluation of the enzymatic degradation products.This study investigated the enzymatic degradation mechanisms of ZEN using commercial peroxidase(POD)and laccase(LC),with a focus on identifying degradation products and assessing their hepatotoxicity effects.Molecular docking and dynamics simulations elucidated the binding mechanisms between these enzymes and ZEN,revealing strong interactions that facilitate efficient detoxification.Subsequent analysis employing ultra-high performance liquid chromatography-high resolution mass spectrometry(UHPLC-HRMS)successfully identified crucial degradation products.Hepatic toxicity of the enzymatic degradation products was comprehensively assessed in HepaRG liver cells through systematic measurements of cell viability,oxidative stress,apoptosis,mitochondrial membrane potential,and molecular metabolic profiles.Our findings demonstrate that both POD and LC exhibit significant efficacy in mitigating hepatocyte toxicity induced by ZEN,thereby highlighting their potential utility in enhancing food safety.This research provides essential data for safety evaluation regarding enzymatic detoxification of ZEN while offering theoretical and technical resources for risk assessment related to mycotoxin enzymatic detoxification.
基金supported by the National Natural Science Foundation of China(Grant No.42277147)Ningbo Public Welfare Research Program(Grant No.2024S081)Ningbo Natural Science Foundation(Grant No.2024J186).
文摘Rock brittleness is a critical property in geotechnical and energy engineering,as it directly influences the prediction of rock failure and stability assessment.Although numerous methods have been developed to evaluate brittleness,many fail to comprehensively account for the impacts of microstructural changes,mineralogical characteristics,and stress conditions on energy evolution during failure.This study proposes a novel approach for brittleness evaluation based on the energy evolution throughout the post-peak failure process,integrating two micromechanical mechanisms:crack propagation and frictional sliding.A new brittleness index is defined as the ratio of generated surface energy to released elastic energy,providing a unified framework for assessing both Class I and Class II mechanical behaviors.The brittleness of cyan,white,and gray sandstones was investigated under various confining pressures and moisture conditions using X-ray diffraction(XRD),scanning electron microscopy(SEM),and conventional triaxial compression(CTC)tests.The results demonstrate that brittleness decreases with increasing confining pressure,due to suppressed crack propagation,and increases under saturated conditions,as moisture enhances crack propagation.By establishing connections between mineral composition,microstructural features,and stress-induced responses,the proposed method overcame limitations of previous approaches and offered a more precise tool for evaluating rock brittleness under diverse environmental scenarios.
基金supported by the National Natural Science Foundation of China(Grant Nos.U2342210 and 42275043)the National Institute of Natural Hazards,Ministry of Emergency Management of China(Grant Nos.J2223806,ZDJ2024-25 and ZDJ2025-34)。
文摘Climate models are essential for understanding past,present,and future changes in atmospheric circulation,with circulation modes providing key sources of seasonal predictability and prediction uncertainties for both global and regional climates.This study assesses the performance of models participating in phase 6 of the Coupled Model Intercomparison Project in simulating interannual variability modes of Northern Hemisphere 500-hPa geopotential height during winter and summer,distinguishing predictable(potentially predictable on seasonal or longer timescales)and unpredictable(intraseasonal and essentially unpredictable at long range)components,using reanalysis data and a variance decomposition method.Although most models effectively capture unpredictable modes in reanalysis,their ability to reproduce dominant predictable modes-specifically the Pacific-North American pattern,Arctic Oscillation,and Western Pacific Oscillation in winter,and the East Atlantic and North Atlantic Oscillations in summer-varies notably.An optimal ensemble is identified to distinguish(a)predictable-external modes,dominated by external forcing,and(b)predictable-internal modes,associated with slow internal variability,during the historical period(1950-2014)and the SSP5-8.5 scenario(2036-2100).Under increased radiative forcing,the leading winter/summer predictable-external mode exhibits a more uniform spatial distribution,remarkably larger trend and annual variance,and enhanced height-sea surface temperature(SST)covariance under SSP5-8.5 compared to historical conditions.The dominant winter/summer predictable-internal modes also exhibit increased variance and height-SST covariance under SSP5-8.5,along with localized changes in spatial configuration.Minimal changes are observed in spatial distribution or variance for dominant winter/summer unpredictable modes under SSP5-8.5.This study,from a predictive perspective,deepens our understanding of model uncertainties and projected changes in circulations.
基金Supported by 2023 Self-funded Research Project of the Guangxi Zhuang Autonomous Region Administration of Traditional Chinese Medicine(GXZYL20230369)2022 Internal Talent Research Project of Affiliated Hospital of Youjiang Medical University for Nationalities(Y202210319).
文摘[Objectives]To develop an HPLC fingerprint analysis method for the medicinal material of Lysimachia foenum-graecum Hance,thereby providing a foundation for its quality control.[Methods]Samples of L.foenum-graecum collected from 10 distinct locations in Guangxi were analyzed using HPLC,and chromatographic fingerprints were established.The Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine(2012 Edition)was employed for common peak calibration and similarity evaluation.Additionally,principal component analysis was performed on the common peak area data.[Results]An HPLC fingerprint of L.foenum-graecum was developed,identifying a total of 13 common peaks.Among these,four characteristic components were specifically identified:chlorogenic acid,myricetin,quercetin,and kaempferol.The kaempferol chromatographic peak,exhibiting good resolution and a stable peak shape,was selected as the reference peak.The similarity indices between the fingerprints of the 10 sample batches and the reference fingerprint ranged from 0.954 to 0.995,indicating a relatively high consistency in the chemical composition of L.foenum-graecum from different origins.Principal component analysis identified two principal components,which together accounted for 89.45%of the cumulative variance,effectively capturing the primary chemical differences among the samples.[Conclusions]The established HPLC fingerprint method is straightforward to implement,stable,reliable,and exhibits high specificity.When combined with similarity evaluation and principal component analysis,it offers a scientific basis for developing quality standards for L.foenum-graecum medicinal materials.
基金Supported by Inter Disciplinary Direction Cultivation Project of Hunan University of Chinese Medicine,No.2025JC01032025 Hunan Province Science and Technology Innovation Plan Project,No.2025RC9012+2 种基金2022"Unveiling and Leading"Project of Discipline Construction at Hunan University of Chinese Medicine,No.22JBZ044Changsha Municipal Natural Science Foundation,No.kq2402174Hunan Provincial Science Popularization Fund Project,No.2025ZK4223.
文摘BACKGROUND Timely and accurate evaluation of mental disorders in adolescents using appropriate mental health literacy assessment tools is essential for improving their mental health literacy levels.AIM To develop an evaluation index system for the mental health literacy of adolescent patients with mental disorders,providing a scientific,comprehensive,and reliable tool for the monitoring and intervention of mental health literacy of such patients.METHODS From December 2022 to June 2023,the evaluation index system for mental health literacy of adolescents with mental disorders was developed through literature reviews,semi-structured interviews,expert letter consultations,and the analytic hierarchy process.Based on this index system,a self-assessment questionnaire was compiled and administered to 305 adolescents with mental disorders to test the reliability and validity of the index system.RESULTS The final evaluation index system for mental health literacy of adolescents with mental disorders included 4 first-level indicators,10 second-level indicators,and 52 third-level indicators.The overall Cronbach’sαcoefficient of the index system was 0.957,with a partial reliability of 0.826 and a content validity index of 0.975.The cumulative variance contribution rate of 10 common factors was 66.491%.The correlation coefficients between each dimension and the total questionnaire ranged from 0.672 to 0.724,while the correlation coefficients in each dimension ranged from 0.389 to 0.705.CONCLUSION The evaluation index system for mental health literacy of adolescents with mental disorders,developed in this study,demonstrated notable reliability and validity,making it a valuable tool for evaluating mental health literacy in this population.
基金supported by the Natural Science Foundation of China(Grant No.52574047 and Grant No.52374045)Key Project of Sichuan Provincial Joint Fund for Science Technology and Education,China(Grant No.2025NSFSC2008).
文摘Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core function is to characterize the complexity of the induced fracture network and the resulting effective stimulated volume.In this study,we quantified fracture area and geometric complexity using true triaxial fracturing experiments and computed tomography three-dimensional(3D)reconstruction technology,combined with the box-counting method to calculate the 3D fractal dimension of the fracture surfaces.The results revealed that the total fracture surface area per unit volume of the stimulated reservoir effectively characterized reservoir fracability;specifically,both a larger total fracture surface area and a higher fractal dimension corresponded to better reservoir fracability.Fracture complexity was enhanced by a decrease in the horizontal principal stress difference or an increase in the injection rate.Under optimal conditions of a 3 MPa stress difference and an injection rate of 60 mL/min,fracability improved by 27.6%.Furthermore,liquid carbon dioxide(CO_(2))improved fracability by 50.7%compared to using water as the fracturing fluid,a result attributed to its low viscosity and strong diffusion capacity,which activated a greater number of natural fractures.A fracability evaluation model integrating brittleness,fracture toughness,and dimensionless net pressure was developed using regression analysis,which demonstrated high reliability with a strong determination coefficient(R^(2))of 0.9019.This study clarifies the logical relationships among fracture area,complexity,and fractal dimension,providing a novel method for evaluating the fracability of coal reservoirs.
基金National Key Research and Development Program of China,Grant/Award Number:2023YFC2410403。
文摘Background:Rats are often used to prepare skin defect models.However,the skin defect sizes of the models prepared by researchers are different,and the lack of consensus on the critical-size defect makes it difficult to compare their research results.Methods:The time for wound closure was evaluated and recorded through gross observation.The regression equation between the healing time and the diameter of skin defect was established,which can be used to predict the healing time for a certain skin defect size in rats.Histochemical and immunohistochemical staining was used to observe the regeneration and reconstruction of skin appendages,and the functional skin repair was quantitatively scored.Results:The critical-size defect of rats was determined based on the maximum capacity of structural skin repair,and the functional skin repair was quantitatively scored based on the regeneration and reconstruction of skin appendages.The allowable range of critical-size skin defect of SD rats lies between 45 and 50 mm in diameter.The concept of structural repair and the category of functional repair of injured skin are put forward.The regression equation between the structural skin healing time and defect diameters is established.Conclusion:The allowable range of skin critical-size defect of SD rats lies between 45 and 50 mm in diameter.The regression equation between the structural skin healing time and defect diameters can be used to predict the healing time for a certain skin defect size in rats.
基金sponsored by National Natural Science Foundation of China(Grant Nos.U22B6003 and 52304070)Key Laboratory of Geomechanics and Geotechnical Engineering Safety,Chinese Academy of Sciences(Grant No.SKLGME-JBGS2404).
文摘Large-scale geological energy storage plays a crucial role in balancing the intermittency of renewable energy.As an energy storage medium,soaked sandstone has a wide range of applications in geological energy storage.Understanding the damage characteristics in soaked sandstones is essential for ensuring the stability and longevity of these energy storage systems.This study involved multi-stage cyclic loading tests conducted on soaked sandstone to explore the damage evolution throughout the loading process.The findingsreveal several important insights:(1)The plastic hysteresis loops observed during multi-stage cyclic loading evolved from dense to sparse.An increase in stress level led to greater damage in the rock,as evidenced by an increase in accumulated peak/plastic strains.(2)Energy density and stress level are related by quadratic polynomial relationships.The elastic and dissipated energy densities are related by a linear law.The average energy storage coefficientdecreased by up to 24.1%with increasing stress amplitude,reflectingchanges in energy dynamics within the samples.(3)AE counts,amplitude,and frequency provided critical insights into rock damage and fracture patterns.The greater the loading rate and stress amplitude,the lower the proportion of high-amplitude,high-peak frequency,and shear-type fractures.Increasing stress amplitude caused a maximum 16.63%reduction in the AE bvalue,indicating shifts in fracture behavior under varying stress conditions.(4)The increase in loading rate and stress amplitude promotes the transformation of micropores and mesopores to macropores/microcracks.(5)Damage variables,definedin terms of cumulative dissipation energy,aligned closely with the fatigue damage model under multi-stage cyclic loading.Accelerated damage primarily occurred during the finalstages of fatigue loading,highlighting critical periods in the degradation of soaked sandstones.This study can offer guidance for designing operational parameters for energy storage geological bodies dominated by soaked sandstones.
基金supported by the National Natural Science Foundation of China(62325112)the National Key Research and Development Program of China(2023YFC2411700,2023YFC2411705)+2 种基金the National Natural Science Foundation of China(U22A2023)the National High-Level Hospital Clinical Research Funding(2022-PUMCH-C-009,2022-PUMCH-B-064,2022-PUMCH-D-002)the National Basic Research Program of China(973 Program,2014CB541801).
文摘Conventional ultrasound(US)evaluation of enthesitis in psoriatic arthritis(PsA)is limited by its inability to quantify metabolic alterations such as hypoxia,a key driver of disease activity.We introduce an oxygenation-integrated multimodal photoacoustic/ultrasound(PA/US)imaging framework designed to quantify entheseal oxygen saturation(SO_(2))for assessing entheseal disease activity in PsA.In this cross-sectional study,25 PsA patients underwent bilateral PA/US imaging of 12 entheses,where ultrasound lesions were scored using the Outcome Measures in Rheumatology scoring system,and PA-derived SO_(2) levels,quantified via dual-wavelength PA imaging,were classified into hyperoxia or hypoxia groups using k-means clustering.This approach provides metabolic insights complementary to conventional ultrasonic assessment.A composite score integrating hypoxia with US parameters was validated against clinical disease activity indices(Disease Activity Score 28-C-reactive protein,DAS28-CRP;Disease Activity Index for Psoriatic Arthritis,DAPSA).Among 300 entheses,103(34.3%)exhibited PA positivity,with 40(38.8%)classified as hypoxia.Hypoxia scores independently predicted DAS28-CRP(β=0.618,p=0.001)and DAPSA(β=0.612,p<0:001).The hypoxia-optimized PAUS score demonstrated superior correlation with disease activity indices compared to conventional US(DAS28-CRP:r=0.615,p=0.001 versus r=0.474,p=0.017;DAPSA:r=0.743,p<0:001 versus r=0.567,p=0.003),alongside superior diagnostic accuracy for minimal disease activity(area under the curve,AUC 0.776 versus 0.614,p=0.008)and low disease activity(AUC 0.853 versus 0.772,p=0.009).This multimodal scoring system enhances the stratification of PsA disease activity by providing unique metabolic insights,offering a potential tool for therapeutic monitoring and guiding treat-to-target strategies.
基金financial support from the Shccig-Qinling Program(SMYJY202300294C)the Science,Technology,and Innovation Commission of Shenzhen Municipality(GJHZ20220913143204008,JCYJ20220818103417036)+1 种基金the National Natural Science Foundation of China(22261142666,52172237,52372225)the Shaanxi Science Fund for Distinguished Young Scholars(2022JC-21)。
文摘Although lead(Pb)-based perovskite solar cells(PSCs)have garnered intense attention for their remarkable photovoltaic conversion efficiency,their commercial process is urgently in need of an effective damage-evaluation system for the early diagnosis of faulty PSCs.The main cause of microdamage in perovskite films is the outflow of Pb,which significantly impacts device performance.However,no reliable correlation has been established between classical damage detection techniques and Pb detection,resulting in limited detection sensitivity.Here,we report an in situ visual microdamage evaluation method of PSCs by coating the device surface with a silica gel encapsulation layer containing porphyrin molecules.This detection technology enables high selectivity and sensitivity based on the strong complexation between the porphyrin ring and trace Pb outflow from degraded PSCs.By establishing the linear relationship between the fluorescence intensity and Pb concentration in PSCs,trace Pb outflow is pinpointed and quantified with a low detection limit of 0.65μg cm^(-2).An applet is developed for the insitu visual fluorescence detection method to facilitate the continuous real-time monitoring of series-type PSCs,thereby enabling the prompt identification and replacement of damaged PSCs and ensuring the swift restoration of high efficiency.
基金supported by the Major Program of Xiangjiang Laboratory(No.22XJ01009)National Natural Science Foundation of China(Grant Nos.52227815,52078065,and 52178414)the Postgraduate Scientific Research Innovation Project of Hunan Province(Nos.CX20230852 and CX20230848).
文摘Ground penetrating radar(GPR)offers a rapid and non-destructive approach to evaluating asphalt mixtures by capturing variations in their dielectric constant.As a critical electromagnetic parameter,the dielectric constant demonstrates significant potential for assessing the material composition and mechanical properties of asphalt mixtures.However,the relationship between the dielectric constant and mechanical properties remains unclear.To investigate the factors affecting the dielectric constant and its correlation with the mechanical properties of asphalt mixtures,a systematic analysis of the influencing parameters was conducted.Fitting equations were established to quantify the relationships between the dielectric constant and mechanical properties.Firstly,the effects of compaction state,testing frequency,and testing temperature on the dielectric constant were evaluated.Subsequently,forward simulations of GPR were executed on asphalt pavements with diverse air voids and detection frequencies.Finally,a fitting analysis was performed to determine the correlation between the dielectric constant and the dynamic modulus,compressive strength,and splitting tensile strength.The results indicated that the dielectric constant increased with the compaction state,decreased with increasing testing frequency until stabilized,and was insignificantly affected by changes in testing temperature.The change of air void in asphalt pavement has significantly affected the amplitude and timing of electromagnetic wave reflection.A linear positive correlation was identified between the dielectric constant and dynamic modulus as well as compressive strength,while a quadratic positive correlation existed with splitting tensile strength.This study provided theoretical and practical foundations for enhancing the reliability and accuracy of non-destructive testing in asphalt pavement.
文摘Objective:To investigate the clinical efficacy of electrophysiological therapy under different parameter modes in chronic pelvic pain syndrome(CPPS).Methods:A total of 95patients with CPPS from the Department of Urology,First Affiliated Hospital of Jinan University,were selected and treated with electrophysiological therapy.They were randomly divided into three groups:the fixed-parameter AA7 treatment group,the P2+P4 treatment group,and the precision treatment group(individualized parameter treatment).Pain scores of patients in each group were compared before and after treatment,with a pain score of 0 indicating cure.The cure rate of each group was observed.Results:The average ages of the AA7 group,P2+P4 group,and precision treatment group were 34±14.17 years,35.58±12.57 years,and 35.5±11.27 years,respectively.There was no significant difference in age among the three groups(p>0.05).Before treatment,the pain scores of the AA7 group,P2+P4 group,and precision treatment group were 4.14±1.74,4.64±1.72,and 3.50±1.89,respectively,with no significant differences among the groups(p>0.05).After treatment,the pain scores were 0.71±0.99 for the AA7 group(cure rate:57%),0.49±0.79 for the P2+P4 group(cure rate:67%),and 0.50±0.77 for the precision treatment group(cure rate:64%),with no significant differences among the groups(p>0.05).The cure rates for different pain locations were as follows:83%for lower abdominal pain,74%for perineal pain,62%for dysuria,49%for testicular pain,and 75%for inguinal pain.Conclusion:The pathogenesis of CPPS is complex and diverse,with numerous treatment options and uncertain efficacy,posing significant challenges to clinical practice.This study showed that electrophysiological therapy under different parameter modes significantly reduced pain scores before and after treatment,indicating significant therapeutic effects on CPPS.All three modes demonstrated good cure rates.Individualized precision treatment and fixed-mode P2+P4 or AA7 treatment were safe and effective in CPPS treatment and are worth promoting.Fixed-mode P2+P4 and AA7,due to their easier standardization of parameters and patch modes,reduced the learning curve and had better potential for widespread application.
基金National Natural Science Foundation of China,Grant/Award Number:82000102 and 82270112。
文摘The incidence of benign airway stenosis(BAS)is on the rise,and current treatment options are associated with a significant risk of restenosis.Therefore,there is an urgent need to explore new and effective prevention and treatment methods.Animal models serve as essential tools for investigating disease mechanisms and assessing novel therapeutic strategies,and the scientific rigor of their construction and validation significantly impacts the reliability of research findings.This paper systematically reviews the research progress and evaluation systems of BAS animal models over the past decade,aiming to provide a robust foundation for the optimized construction of BAS models,intervention studies,and clinical translation.This effort is intended to facilitate the innovation and advancement in BAS prevention and treatment strategies.
基金Supported by the Central Public-interest Scientific Institution Basal Research Fund,YSFRI,CAFS(No.20603022024016)the Central Public-interest Scientific Institution Basal Research Fund,CAFS(Nos.2023TD52,2023TD76)the earmarked fund for CARS(No.CARS-49)。
文摘Crassostrea gigas has good taste and high nutritional value;however,there are few assessments of comprehensive and panoramic analyses of the nutritional quality of the northern oyster.To study the nutritional characteristics of C.gigas from different sources(ploidy,region,size,and culture mode),C.gigas from various ploidy(diploid and triploid),regions(Rushan,Off-site fattening,and Rongcheng),sizes(small,medium,and large)and culture modes(nearshore and offshore)were selected for comparative analyses.The nutritional components(moisture,protein,fat,and mineral),flavor substances(taste amino acids,nucleotides,and succinic acid),and functional indices(eicosapentaenoic acid(EPA),docosahexaenoic acid(DHA),and taurine)of C.gigas were determined.Principal component analysis(PCA)was used to comprehensively evaluate the oysters and investigate the variations in nutritional quality.The PCA results indicate that protein,essential fatty acids,selenium,zinc,taste amino acids,taurine,EPA,and DHA were core components contributing to 82.25%of the cumulative variance,providing a more comprehensive reflection of the nutrient composition of C.gigas.The extensive quality rankings for the C.gigas were as follows:diploid>triploid,Rushan>fattening>Rongcheng,medium>large>small,and offshore>nearshore.The score rank revealed that diploid oysters of medium-size from Rushan demonstrated superior nutritional quality compared to other tested samples.This is the first comprehensive and systematic investigation of C.gigas in northern China to reveal the feature of nutrients,flavor,and functional components.The study provided data support for the culture,consumption,processing,research,and nutritional quality improvement of oyster industry.
