To the Editor:Essential tremor(ET)is a common movement disorder with significant clinical heterogeneity.[1]Following the proposal of“ET-plus”,the cross-sectional investigation of ET has increased.However,the charact...To the Editor:Essential tremor(ET)is a common movement disorder with significant clinical heterogeneity.[1]Following the proposal of“ET-plus”,the cross-sectional investigation of ET has increased.However,the characteristics of pure ET vs.ET-plus remain unclear.Herein,we present a longitudinal follow-up study of pure ET and ET-plus patients that aimed to clarify disease progression and outcome,to determine the annual incidence rates of pure ET to ET-plus,and ET to Parkinson’s disease(ETPD),and to investigate the clinical biomarkers influencing disease outcomes.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.U20A20355,82171256,and 82202051)the Hunan Natural Science Foundation of China(No.2021SK53501).
文摘To the Editor:Essential tremor(ET)is a common movement disorder with significant clinical heterogeneity.[1]Following the proposal of“ET-plus”,the cross-sectional investigation of ET has increased.However,the characteristics of pure ET vs.ET-plus remain unclear.Herein,we present a longitudinal follow-up study of pure ET and ET-plus patients that aimed to clarify disease progression and outcome,to determine the annual incidence rates of pure ET to ET-plus,and ET to Parkinson’s disease(ETPD),and to investigate the clinical biomarkers influencing disease outcomes.
