The achievements which China’s Xinjiang Uygur Autonomous Region has made over the past seven decades demonstrate that the system of regional ethnic autonomy is a distinctive advantage of socialism with Chinese charac...The achievements which China’s Xinjiang Uygur Autonomous Region has made over the past seven decades demonstrate that the system of regional ethnic autonomy is a distinctive advantage of socialism with Chinese characteristics.展开更多
The cultivation of innovative talents has become the primary objective of talent development in colleges and universities and is also essential for the personal development of master's degree students.Ethnic medic...The cultivation of innovative talents has become the primary objective of talent development in colleges and universities and is also essential for the personal development of master's degree students.Ethnic medicine,a key discipline at Guangxi University of Chinese Medicine,aims to cultivate high-level master's degree talents who possess comprehensive qualities,strong innovative capabilities,and distinctive characteristics of Zhuang medicine.This program is designed to better serve the local economic development and social needs of Guangxi,thereby promoting the substantive advancement of higher education within traditional medical institutions.展开更多
BACKGROUND Regulatory agencies are increasingly recognizing that minority trial repres-entation is inadequate,contributing to healthcare disparities.The scope of min-ority population disparities in clinical trial part...BACKGROUND Regulatory agencies are increasingly recognizing that minority trial repres-entation is inadequate,contributing to healthcare disparities.The scope of min-ority population disparities in clinical trial participation remains unclear,as previous studies have compiled enrollment data from published trials,which AIM To evaluate sex,racial and ethnic inequities in liver transplantation(LT)trials participation in the United States.METHODS We used data from completed United States liver transplant clinical trials registered and reported on the National Institute of Health(NIH)website(clincaltrials.gov).Demographic data,including race,ethnicity,sex,and age were collected.To make inferences to a larger population,95%CIs were computed for estimates in each demographic group using the Wilson method for binomial proportions.We also computed the simultaneous 95%CIs by applying a Bonferroni correction to reflect the multinomial distribution of race proportions.The numbers and percentages of racial/ethnic minority and female individuals compared with United States census data from 2010 and 2018.Secondary outcome measures were inclusion by trial funding source and year of completion.RESULTS A total of 69 United States based clinical trials involving 6990 participants were included in the analysis.Of these,35 trials(51%)were randomized,and 26(38%)were conducted across multiple United States regions.All trials reported sex,while 42(61%)reported race and 27(39%)reported ethnicity.Compared to United States census data,Asian individuals were overrepresented(9.3%;95%CI:8.1%-10.5%),whereas African American(7.8%;95%CI:6.7%-8.9%)and American Indian or Alaska Native individuals(0.4%;95%CI:0.1%-0.6%)were underrepresented.The proportion of White participants(75.9%;95%CI:74.1%-77.7%)was consistent with census estimates.Hispanic participants were underrepresented(13.3%;95%CI:12.2%-14.5%)regardless of the census year referenced.In industry-sponsored trials,Asian representation was three times higher than in the general population(15%).NIH funded trials showed overrepresentation of White participants(83.8%)and underrepresentation of Black participants(4.1%)relative to census data.Women comprised 31.1%of all participants(95%CI:30.0%-32.2%),in-dicating underrepresentation.Among trials that reported racial data,62(90%)did not include participants of American Indian or Alaska Native,Native Hawaiian,or Pacific Islander descent.CONCLUSION Our analysis indicates that women,African Americans,and Hispanic individuals are underrepresented in LT clinical trials compared to the general United States population.These results highlight the need for regulatory initiatives aimed at enhancing the inclusion of historically marginalized racial and ethnic groups in clinical re-search.展开更多
Based on deep realization in relationship between human beings and environment,Yi people gradually formed high level ecological wisdom,which not only protects the environment very well where they are living in,but als...Based on deep realization in relationship between human beings and environment,Yi people gradually formed high level ecological wisdom,which not only protects the environment very well where they are living in,but also maintains their survival and development.Importantly,such traditional ecological wisdom will be very helpful for environmental protection and sustainable development of human beings,especially in the background of modern industrial civilization.展开更多
With the rapid development of China's economy and the government's issuance of a series of rural revitalization strategies,the design of rural landscapes has garnered increasing attention.However,some rural la...With the rapid development of China's economy and the government's issuance of a series of rural revitalization strategies,the design of rural landscapes has garnered increasing attention.However,some rural landscape designs have become more urbanized,neglecting the natural ecology,distinctive characteristics,and cultural heritage of rural areas,leading to a homogenized phenomenon.To address issues such as landscape homogenization and cultural erosion in traditional villages,this paper analyzes the current status of ethnic minority village landscapes and integrates landscape design principles to propose design strategies for rural landscapes in traditional ethnic minority villages in Hunan Province.It is intended to better achieve the construction of rural landscapes in traditional ethnic minority villages in Hunan Province.展开更多
BACKGROUND Septic shock,the most severe form of sepsis,remains a major global health challenge with high mortality.The coronavirus disease 2019(COVID-19)pandemic has exacerbated this burden,as severe acute respiratory...BACKGROUND Septic shock,the most severe form of sepsis,remains a major global health challenge with high mortality.The coronavirus disease 2019(COVID-19)pandemic has exacerbated this burden,as severe acute respiratory syndrome coronavirus 2 infection often leads to sepsis and septic shock.Racial and ethnic differences in critical illness outcomes are well-documented,but their impact on COVID-19 associated septic shock remains unclear.AIM To examine epidemiologic data to explore racial and ethnic differences in outcomes in COVID-19 associated septic shock.METHODS Using the National Inpatient Sample(2020–2021),we conducted a retrospective cohort study to assess racial and ethnic disparities in septic shock outcomes among adults(≥18 years)with concurrent COVID-19.Primary and secondary outcomes included in-hospital mortality,acute kidney injury(AKI),AKI requiring dialysis,and mechanical ventilation.Adjusted multivariable logistic regression accounted for demographics,comorbidities,hospital characteristics,and inhospital events.RESULTS Among 396795 weighted hospitalizations,Non-Hispanic Black(NHB)(25.3%)and Hispanic(30.4%)populations were younger and had greater comorbidity burdens than Non-Hispanic White(NHW)patients.Compared to NHW,adjusted analyses showed higher in-hospital mortality[adjusted odds ratio(aOR)=1.21,95%CI:1.15-1.27],mechanical ventilation use(aOR=1.19,95%CI:1.12-1.27)and AKI requiring dialysis(aOR=1.16,95%CI:1.07-1.25,P<0.001)among Hispanic patients.NHB patients had similar mortality to NHWs but had higher risk of mechanical ventilation(aOR=1.15,95%CI:1.09-1.22)and AKI requiring dialysis(aOR=1.65,95%CI:1.54-1.76).Mean length of stay and cost were longest and highest for Hispanic patients.CONCLUSION Our study showed that there was higher mortality in Hispanic patients,and higher renal and respiratory complication in both NHB and Hispanic groups compared to NHW group.Future research identifying the causes of the observed differences in complications are required to inform targeted strategies that may mitigate modifiable risk factors and optimize early detection of organ failure to optimize outcomes in this population.展开更多
Mountainous minority regions in China,characterized by abundant natural and cultural resources,ecologically fragile environments,and often geographically remote locations,pose distinct developmental challenges and opp...Mountainous minority regions in China,characterized by abundant natural and cultural resources,ecologically fragile environments,and often geographically remote locations,pose distinct developmental challenges and opportunities.Despite the complexity and typicality of Chinese mountainous ethnic minority regions in terms of eco-cultural tourism and land use dynamics,the interplay among tourism development,land use changes,and landscape ecological risk in these specific contexts has received insufficient attention.To explore how eco-cultural tourism development in ethnic minority mountainous regions affects land use and landscape ecology,this study investigates the evolution of land use in Southeast Guizhou Province from 1980-2020,integrating GIS spatial analysis,the landscape pattern index and landscape ecological risk index analysis.Over the past four decades(1980-2020),eco-cultural tourism has driven significant land use transformations characterized by substantial expansion of building land,growth of ecological land(notably forest land and water areas),and reduction of cultivated land.Concurrently,landscape ecological risk evolved through distinct phases-showing an overall increase during 1980-2000 with expanding medium-risk zones,followed by stabilization from 2000-2020.Tourism development accelerated these land transitions while fostering multifunctional compound land uses,enhancing both land value and utilization efficiency.Crucially,eco-cultural tourism in ethnic regions demonstrates capacity to reconcile ecological conservation with economic development,providing transferable models for similar regions globally.展开更多
Against the strategic backdrop of forging and strengthening the consciousness of the Chinese national community in the new era,universities in border areas,as crucial platforms for the integration of multi-ethnic cult...Against the strategic backdrop of forging and strengthening the consciousness of the Chinese national community in the new era,universities in border areas,as crucial platforms for the integration of multi-ethnic cultures,shoulder the significant mission of enhancing ethnic unity and promoting outstanding traditional Chinese culture.As an important carrier of Chinese culture,ethnic music not only contains profound historical memories and emotional identities but also demonstrates a powerful cultural and educational function in the teaching of border universities.Based on the actual situation of universities in border areas,this paper analyzes the unique value of ethnic music in cultivating students’national identity,cultural identity,and emotional identity,and explores effective paths for it to empower the forging and strengthening of the consciousness of the Chinese national community in teaching practice.By combining policy orientations and teaching status quo,the paper points out the main dilemmas such as single curriculum content,insufficient integration of ideological and political education,and a lack of practical resources,and proposes countermeasures such as strengthening the integration of ideological and political education,optimizing the curriculum structure,and expanding practical platforms.Through the deepening and innovation of ethnic music education,border universities can effectively enhance students’cultural consciousness and cultural confidence,providing solid educational support for forging and strengthening the consciousness of the Chinese national community.This paper has positive significance for promoting the high-quality development of education in border universities and constructing a new-era ethnic unity and progress education system.展开更多
Against the backdrop of globalization and regional economic integration,border tourism,as a unique form of tourism,is increasingly emerging as a significant driving force for promoting economic development in border r...Against the backdrop of globalization and regional economic integration,border tourism,as a unique form of tourism,is increasingly emerging as a significant driving force for promoting economic development in border regions,fostering cultural exchange,and strengthening international cooperation.The northwestern Yunnan region,located in China’s Southwestern frontier,is a key area bordering Southeast and South Asian countries,endowed with abundant border tourism resources.This article delves into the border tourism models and pathways for border development and prosperity in ethnic regions,using a case study of the Northwest Yunnan region to analyze the mechanisms and influencing factors of border tourism in promoting local economic development,social progress,and cultural heritage.This provides empirical evidence for further understanding the development patterns of border tourism and also contributes to strengthening ethnic unity and maintaining harmony and stability in border regions.This study addresses the current research gap in exploring the development models and pathways of border tourism in specific regions,offering valuable references and insights for future related research.展开更多
Along the ancient Tea-Horse Road of thousands of miles between Sichuan and Xizang in Southwest China lies a centuries old courtyard.Commonly called the"Jiang Family Compound"or"Yu Xing Tea Store",t...Along the ancient Tea-Horse Road of thousands of miles between Sichuan and Xizang in Southwest China lies a centuries old courtyard.Commonly called the"Jiang Family Compound"or"Yu Xing Tea Store",this architecture situated in the old downtown area of Yingjing County in Ya'an City,Sichuan Province,was once the residence of the local tea merchants-the Jiang family.展开更多
BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a cancer with a poor prognosis,characterized by distinct geographical distribution and family clustering.AIM To investigate if ethnic differences(Han vs Kazakh)cau...BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a cancer with a poor prognosis,characterized by distinct geographical distribution and family clustering.AIM To investigate if ethnic differences(Han vs Kazakh)cause molecular variations in ESCC patients via genomic sequencing 299 samples.METHODS Here,we sequenced samples from 299 ESCC patients collected from Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment,The First Affiliated Hospital of Zhengzhou University,including Han and Kazakh ethnic groups,and performed a genomic comparative analysis of these two ethnic cohorts.RESULTS ESCC patients of Kazakh ethnicity present with a later age of onset compared to Han.Kazakh patients exhibit a slightly higher tumor mutation burden compared to their Han counterparts.Three genes GIGYF1,CACNA1D,and ACOT11 exhibited mutation frequencies threefold higher in Kazakh patients than in Han.This enrichment may be associated with Kazakhs’adaptation to cold climates and consumption of high-calorie diets.Among Han patients,the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide(APOBEC)-associated single base substitutions(SBS)13 mutational signature is more prevalent,whereas SBS6,indicative of DNA mismatch repair deficiency,is more common in Kazakh patients.Additionally,Han Chinese patients with APOBEC-enriched tumors exhibit a significantly higher mutation load than those without.Moreover,patients lacking the APOBEC signature demonstrate superior survival probability compared to the APOBEC-enriched group.CONCLUSION Living environment and diet are major factors in the development of ESCC.Genomic difference may provide guidance for the formulation of clinical treatment plans for ESCC from different ethnics regions.展开更多
BACKGROUND Prevalence of the main rheumatic diseases in the Republic of Sakha(Yakutia)[RS(Y)],one of the regions of the Russian Federation,differs from the other regions of the Russian Federation due to its ethnic and...BACKGROUND Prevalence of the main rheumatic diseases in the Republic of Sakha(Yakutia)[RS(Y)],one of the regions of the Russian Federation,differs from the other regions of the Russian Federation due to its ethnic and geographic features.Knowledge regarding the prevalence and structure of juvenile idiopathic arthritis(JIA)allows us to shape the work of the pediatric rheumatology service in the region correctly,and optimize the healthcare system and the need for medica-tions.AIM To describe the epidemiological,demographic,clinical,and laboratory characteristics of children with JIA in the RS(Y)and evaluate the main outcomes.METHODS This retrospective cohort study assessed all the data from the medical histories of the patients(n=225)diagnosed with JIA(2016-2023)in the Cardiorheumatology Department of the M.E.Nikolaev National Center of Medicine.Pearson'sχ²test,Fisher's exact test,Mann–Whitney and Kruskal-Wallis tests were used for statistical analyses.RESULTS The ethnic prevalence of JIA is higher in Sakha than in Russian children at 110.1 per 100000 children and 69.4 per 100000 children,respectively.The prevalence of JIA among boys and girls in Sakha was similar,unlike in Russians,where the number of girls predominated.The JIA categories were as follows:(1)Systemic arthritis:3.5%;(2)Oligoarthritis(persistent and extended):33.8%;(3)Rheumatoid factor(RF)(+)polyarthritis:0.9%;(4)RF(-)polyarthritis:14.7%;(5)Enthesitis-related arthritis(ERA):44%;and(6)Psoriatic arthritis:3.1%.Prevalence of the ERA category was 4.4 times higher in Sakha children,but the prevalence of systemic arthritis was 2.9 times lower compared to Russians(P=0.0005).The frequency of uveitis was 10.2%,and the frequency of human leukocyte antigen(HLA)B27 was 39.6%in JIA children.Biologic treatment was received by 40.4%of JIA children and 45.3%achieved remission.CONCLUSION Higher JIA prevalence,male and ERA predominance,related to a higher frequency of HLA B27 are typical in RS(Y).These data might improve the pediatric rheumatology health service.展开更多
文摘The achievements which China’s Xinjiang Uygur Autonomous Region has made over the past seven decades demonstrate that the system of regional ethnic autonomy is a distinctive advantage of socialism with Chinese characteristics.
基金Supported by Innovation Project of Guangxi Graduate Education of Guangxi University of Chinese Medicine(YJSJG201602)Special Project on Innovation and Entrepreneurship Education in Colleges and Universities under the"14 th Five-Year Plan"of Guangxi Education Science(2022ZJY2965).
文摘The cultivation of innovative talents has become the primary objective of talent development in colleges and universities and is also essential for the personal development of master's degree students.Ethnic medicine,a key discipline at Guangxi University of Chinese Medicine,aims to cultivate high-level master's degree talents who possess comprehensive qualities,strong innovative capabilities,and distinctive characteristics of Zhuang medicine.This program is designed to better serve the local economic development and social needs of Guangxi,thereby promoting the substantive advancement of higher education within traditional medical institutions.
文摘BACKGROUND Regulatory agencies are increasingly recognizing that minority trial repres-entation is inadequate,contributing to healthcare disparities.The scope of min-ority population disparities in clinical trial participation remains unclear,as previous studies have compiled enrollment data from published trials,which AIM To evaluate sex,racial and ethnic inequities in liver transplantation(LT)trials participation in the United States.METHODS We used data from completed United States liver transplant clinical trials registered and reported on the National Institute of Health(NIH)website(clincaltrials.gov).Demographic data,including race,ethnicity,sex,and age were collected.To make inferences to a larger population,95%CIs were computed for estimates in each demographic group using the Wilson method for binomial proportions.We also computed the simultaneous 95%CIs by applying a Bonferroni correction to reflect the multinomial distribution of race proportions.The numbers and percentages of racial/ethnic minority and female individuals compared with United States census data from 2010 and 2018.Secondary outcome measures were inclusion by trial funding source and year of completion.RESULTS A total of 69 United States based clinical trials involving 6990 participants were included in the analysis.Of these,35 trials(51%)were randomized,and 26(38%)were conducted across multiple United States regions.All trials reported sex,while 42(61%)reported race and 27(39%)reported ethnicity.Compared to United States census data,Asian individuals were overrepresented(9.3%;95%CI:8.1%-10.5%),whereas African American(7.8%;95%CI:6.7%-8.9%)and American Indian or Alaska Native individuals(0.4%;95%CI:0.1%-0.6%)were underrepresented.The proportion of White participants(75.9%;95%CI:74.1%-77.7%)was consistent with census estimates.Hispanic participants were underrepresented(13.3%;95%CI:12.2%-14.5%)regardless of the census year referenced.In industry-sponsored trials,Asian representation was three times higher than in the general population(15%).NIH funded trials showed overrepresentation of White participants(83.8%)and underrepresentation of Black participants(4.1%)relative to census data.Women comprised 31.1%of all participants(95%CI:30.0%-32.2%),in-dicating underrepresentation.Among trials that reported racial data,62(90%)did not include participants of American Indian or Alaska Native,Native Hawaiian,or Pacific Islander descent.CONCLUSION Our analysis indicates that women,African Americans,and Hispanic individuals are underrepresented in LT clinical trials compared to the general United States population.These results highlight the need for regulatory initiatives aimed at enhancing the inclusion of historically marginalized racial and ethnic groups in clinical re-search.
文摘Based on deep realization in relationship between human beings and environment,Yi people gradually formed high level ecological wisdom,which not only protects the environment very well where they are living in,but also maintains their survival and development.Importantly,such traditional ecological wisdom will be very helpful for environmental protection and sustainable development of human beings,especially in the background of modern industrial civilization.
基金Supported by Key Scientific Research Project of the Department of Education of Hunan Province in 2022"Research on Art and Design Strategies for Rural Revitalization in Ethnic Minority Traditional Villages of Hunan under the New Development Concept"(22A0396).
文摘With the rapid development of China's economy and the government's issuance of a series of rural revitalization strategies,the design of rural landscapes has garnered increasing attention.However,some rural landscape designs have become more urbanized,neglecting the natural ecology,distinctive characteristics,and cultural heritage of rural areas,leading to a homogenized phenomenon.To address issues such as landscape homogenization and cultural erosion in traditional villages,this paper analyzes the current status of ethnic minority village landscapes and integrates landscape design principles to propose design strategies for rural landscapes in traditional ethnic minority villages in Hunan Province.It is intended to better achieve the construction of rural landscapes in traditional ethnic minority villages in Hunan Province.
文摘BACKGROUND Septic shock,the most severe form of sepsis,remains a major global health challenge with high mortality.The coronavirus disease 2019(COVID-19)pandemic has exacerbated this burden,as severe acute respiratory syndrome coronavirus 2 infection often leads to sepsis and septic shock.Racial and ethnic differences in critical illness outcomes are well-documented,but their impact on COVID-19 associated septic shock remains unclear.AIM To examine epidemiologic data to explore racial and ethnic differences in outcomes in COVID-19 associated septic shock.METHODS Using the National Inpatient Sample(2020–2021),we conducted a retrospective cohort study to assess racial and ethnic disparities in septic shock outcomes among adults(≥18 years)with concurrent COVID-19.Primary and secondary outcomes included in-hospital mortality,acute kidney injury(AKI),AKI requiring dialysis,and mechanical ventilation.Adjusted multivariable logistic regression accounted for demographics,comorbidities,hospital characteristics,and inhospital events.RESULTS Among 396795 weighted hospitalizations,Non-Hispanic Black(NHB)(25.3%)and Hispanic(30.4%)populations were younger and had greater comorbidity burdens than Non-Hispanic White(NHW)patients.Compared to NHW,adjusted analyses showed higher in-hospital mortality[adjusted odds ratio(aOR)=1.21,95%CI:1.15-1.27],mechanical ventilation use(aOR=1.19,95%CI:1.12-1.27)and AKI requiring dialysis(aOR=1.16,95%CI:1.07-1.25,P<0.001)among Hispanic patients.NHB patients had similar mortality to NHWs but had higher risk of mechanical ventilation(aOR=1.15,95%CI:1.09-1.22)and AKI requiring dialysis(aOR=1.65,95%CI:1.54-1.76).Mean length of stay and cost were longest and highest for Hispanic patients.CONCLUSION Our study showed that there was higher mortality in Hispanic patients,and higher renal and respiratory complication in both NHB and Hispanic groups compared to NHW group.Future research identifying the causes of the observed differences in complications are required to inform targeted strategies that may mitigate modifiable risk factors and optimize early detection of organ failure to optimize outcomes in this population.
基金supported by the National Social Science Foundation of China(Grant No.20CMZ033)Fundamental Research Funds for the Central Universities(CCNU24ZZ125).
文摘Mountainous minority regions in China,characterized by abundant natural and cultural resources,ecologically fragile environments,and often geographically remote locations,pose distinct developmental challenges and opportunities.Despite the complexity and typicality of Chinese mountainous ethnic minority regions in terms of eco-cultural tourism and land use dynamics,the interplay among tourism development,land use changes,and landscape ecological risk in these specific contexts has received insufficient attention.To explore how eco-cultural tourism development in ethnic minority mountainous regions affects land use and landscape ecology,this study investigates the evolution of land use in Southeast Guizhou Province from 1980-2020,integrating GIS spatial analysis,the landscape pattern index and landscape ecological risk index analysis.Over the past four decades(1980-2020),eco-cultural tourism has driven significant land use transformations characterized by substantial expansion of building land,growth of ecological land(notably forest land and water areas),and reduction of cultivated land.Concurrently,landscape ecological risk evolved through distinct phases-showing an overall increase during 1980-2000 with expanding medium-risk zones,followed by stabilization from 2000-2020.Tourism development accelerated these land transitions while fostering multifunctional compound land uses,enhancing both land value and utilization efficiency.Crucially,eco-cultural tourism in ethnic regions demonstrates capacity to reconcile ecological conservation with economic development,providing transferable models for similar regions globally.
基金This paper is the research result of the 2023 Undergraduate Teaching Reform Project of Higher Education in Guangxi,“Research on the Teaching Practice Model of Minority Music in Universities under the Background of Forging and Strengthening the Consciousness of the Chinese National Community”(2023JGA234).
文摘Against the strategic backdrop of forging and strengthening the consciousness of the Chinese national community in the new era,universities in border areas,as crucial platforms for the integration of multi-ethnic cultures,shoulder the significant mission of enhancing ethnic unity and promoting outstanding traditional Chinese culture.As an important carrier of Chinese culture,ethnic music not only contains profound historical memories and emotional identities but also demonstrates a powerful cultural and educational function in the teaching of border universities.Based on the actual situation of universities in border areas,this paper analyzes the unique value of ethnic music in cultivating students’national identity,cultural identity,and emotional identity,and explores effective paths for it to empower the forging and strengthening of the consciousness of the Chinese national community in teaching practice.By combining policy orientations and teaching status quo,the paper points out the main dilemmas such as single curriculum content,insufficient integration of ideological and political education,and a lack of practical resources,and proposes countermeasures such as strengthening the integration of ideological and political education,optimizing the curriculum structure,and expanding practical platforms.Through the deepening and innovation of ethnic music education,border universities can effectively enhance students’cultural consciousness and cultural confidence,providing solid educational support for forging and strengthening the consciousness of the Chinese national community.This paper has positive significance for promoting the high-quality development of education in border universities and constructing a new-era ethnic unity and progress education system.
文摘Against the backdrop of globalization and regional economic integration,border tourism,as a unique form of tourism,is increasingly emerging as a significant driving force for promoting economic development in border regions,fostering cultural exchange,and strengthening international cooperation.The northwestern Yunnan region,located in China’s Southwestern frontier,is a key area bordering Southeast and South Asian countries,endowed with abundant border tourism resources.This article delves into the border tourism models and pathways for border development and prosperity in ethnic regions,using a case study of the Northwest Yunnan region to analyze the mechanisms and influencing factors of border tourism in promoting local economic development,social progress,and cultural heritage.This provides empirical evidence for further understanding the development patterns of border tourism and also contributes to strengthening ethnic unity and maintaining harmony and stability in border regions.This study addresses the current research gap in exploring the development models and pathways of border tourism in specific regions,offering valuable references and insights for future related research.
文摘Along the ancient Tea-Horse Road of thousands of miles between Sichuan and Xizang in Southwest China lies a centuries old courtyard.Commonly called the"Jiang Family Compound"or"Yu Xing Tea Store",this architecture situated in the old downtown area of Yingjing County in Ya'an City,Sichuan Province,was once the residence of the local tea merchants-the Jiang family.
基金Supported by the National Natural Science Foundation of China,No.U1301227National Major Science and Technology Projects,No.2024ZD05209060Henan Province Jointly Built Science and Technology Key Projects,No.LHGJ20210337.
文摘BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a cancer with a poor prognosis,characterized by distinct geographical distribution and family clustering.AIM To investigate if ethnic differences(Han vs Kazakh)cause molecular variations in ESCC patients via genomic sequencing 299 samples.METHODS Here,we sequenced samples from 299 ESCC patients collected from Henan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolic Dysregulation and Esophageal Cancer Prevention and Treatment,The First Affiliated Hospital of Zhengzhou University,including Han and Kazakh ethnic groups,and performed a genomic comparative analysis of these two ethnic cohorts.RESULTS ESCC patients of Kazakh ethnicity present with a later age of onset compared to Han.Kazakh patients exhibit a slightly higher tumor mutation burden compared to their Han counterparts.Three genes GIGYF1,CACNA1D,and ACOT11 exhibited mutation frequencies threefold higher in Kazakh patients than in Han.This enrichment may be associated with Kazakhs’adaptation to cold climates and consumption of high-calorie diets.Among Han patients,the apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide(APOBEC)-associated single base substitutions(SBS)13 mutational signature is more prevalent,whereas SBS6,indicative of DNA mismatch repair deficiency,is more common in Kazakh patients.Additionally,Han Chinese patients with APOBEC-enriched tumors exhibit a significantly higher mutation load than those without.Moreover,patients lacking the APOBEC signature demonstrate superior survival probability compared to the APOBEC-enriched group.CONCLUSION Living environment and diet are major factors in the development of ESCC.Genomic difference may provide guidance for the formulation of clinical treatment plans for ESCC from different ethnics regions.
文摘BACKGROUND Prevalence of the main rheumatic diseases in the Republic of Sakha(Yakutia)[RS(Y)],one of the regions of the Russian Federation,differs from the other regions of the Russian Federation due to its ethnic and geographic features.Knowledge regarding the prevalence and structure of juvenile idiopathic arthritis(JIA)allows us to shape the work of the pediatric rheumatology service in the region correctly,and optimize the healthcare system and the need for medica-tions.AIM To describe the epidemiological,demographic,clinical,and laboratory characteristics of children with JIA in the RS(Y)and evaluate the main outcomes.METHODS This retrospective cohort study assessed all the data from the medical histories of the patients(n=225)diagnosed with JIA(2016-2023)in the Cardiorheumatology Department of the M.E.Nikolaev National Center of Medicine.Pearson'sχ²test,Fisher's exact test,Mann–Whitney and Kruskal-Wallis tests were used for statistical analyses.RESULTS The ethnic prevalence of JIA is higher in Sakha than in Russian children at 110.1 per 100000 children and 69.4 per 100000 children,respectively.The prevalence of JIA among boys and girls in Sakha was similar,unlike in Russians,where the number of girls predominated.The JIA categories were as follows:(1)Systemic arthritis:3.5%;(2)Oligoarthritis(persistent and extended):33.8%;(3)Rheumatoid factor(RF)(+)polyarthritis:0.9%;(4)RF(-)polyarthritis:14.7%;(5)Enthesitis-related arthritis(ERA):44%;and(6)Psoriatic arthritis:3.1%.Prevalence of the ERA category was 4.4 times higher in Sakha children,but the prevalence of systemic arthritis was 2.9 times lower compared to Russians(P=0.0005).The frequency of uveitis was 10.2%,and the frequency of human leukocyte antigen(HLA)B27 was 39.6%in JIA children.Biologic treatment was received by 40.4%of JIA children and 45.3%achieved remission.CONCLUSION Higher JIA prevalence,male and ERA predominance,related to a higher frequency of HLA B27 are typical in RS(Y).These data might improve the pediatric rheumatology health service.
