Severe liver dysfunction in pregnancy（SLDP） is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ...Severe liver dysfunction in pregnancy（SLDP） is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients with SLD. A total of 55 patients with indications of labor induction were enrolled and analyzed by retrospective control analysis method. Twenty-three cases adopted Cook double balloon dilation as Cook group, and 32 cases received intra-amniotic injection of ethacridine lactate as EL group. The primary outcome was evaluated by successful abortion rate and the difference in the induction-to-abortion interval. Secondary outcomes included liver function recovery and the frequency of adverse events. Both Cook and EL regimens were effective, with successful abortion rate of 87.0% and 93.8%, respectively（P=0.639）. The induction-to-delivery interval was similar between Cook group and EL group（38.1±21.5 vs. 41.3±17.4, P=0.543）. The liver disease status was more severe in Cook group than in EL group, but it did not show any significant difference after pregnancy termination between the two groups and the improvement rate also did not show any significant difference. Both treatments were safe and there was no significant difference in bleeding and cervical laceration adverse events between the two groups. Our study firstly compared double-balloon catheter and ethacridine lactate for the induction of labor in women with SLD during second trimester pregnancy.展开更多
BACKGROUND The management of severe extravasation injuries is still controversial.Extravasation injuries can be treated in many ways.AIM To present a series of patients with severe extravasation injuries due to infusi...BACKGROUND The management of severe extravasation injuries is still controversial.Extravasation injuries can be treated in many ways.AIM To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and phototherapy.METHODS In this study,we evaluated the data of eight patients,including six from the Department of Burn,one(with colorectal carcinoma)from the Veteran Cadre Department,and one(with leukemia)from the Hematology Department.Of these,three patients were male and five were female.Age of the patients ranged from 10 mo to 72 years,including two children(10 and 19 mo of age).In this study,the infusion was stopped immediately when the extravasation was identified.The extravasation event was managed routinely using a blocking solution.A ring-shaped localized closure was performed using the blocking agents.Moreover,ethacridine lactate dressing and phototherapy were applied for 3-5 d.RESULTS In this study,the drugs contained in the infusates were iodixanol,norepinephrine,alprostadil,amino acids,fat emulsion,cefoselis,cefoxitin,and potassium chloride+concentrated sodium chloride.All of the patients achieved complete healing after treatment and no obvious adverse reactions were observed.CONCLUSION The treatment of severe extravasation injuries using a combination of localized closure,ethacridine lactate dressing,and phototherapy resulted in satisfactory outcomes in patients.展开更多
Objective: to analyze the clinical efficacy of etacridine combined with mifepristone (MFP) in the treatment of induced labor during middle pregnancy. Methods: from May 2015 to April 2020, 50 patients with midterm preg...Objective: to analyze the clinical efficacy of etacridine combined with mifepristone (MFP) in the treatment of induced labor during middle pregnancy. Methods: from May 2015 to April 2020, 50 patients with midterm pregnancy during labor induction period in our hospital were selected. The digital table was randomly divided into two groups with 25 cases in each group. Treatment was given to patients from a single drug group. The etazidine-bound group was treated with etazidine, acridine combined with MFP. The time, success rate, and incidence of complications were compared between the two groups from the start of dosing to embryo excretion. Results: the duration from initial administration to embryo expulsion in combination group was 36.21±2.45h shorter than that in single drug group, 56.13±5.01h, P < 0.05. The combined power was 100.00% higher than that of the single drug group (76.00%, P < 0.05). There were no serious complications in the two groups, including 2 cases of low fever in the monotherapy group and 3 cases of mild diarrhea and nausea in the combination group (P > 0.05). Conclusion: the clinical effect of ethacridine combined with MFP in the treatment of induced labor in the second trimester is better than ethacridine, which can improve the success rate and shorten the time of induced labor, with high safety.展开更多
基金supported by a grant from the National Natural Science Foundation of China(No.81372806)
文摘Severe liver dysfunction in pregnancy（SLDP） is rare but serious complications with high mortality rate. This study compared the effectiveness and safety of double-balloon catheter versus intra-amniotic injection of ethacridine lactate for the termination of second trimester pregnancy in patients with SLD. A total of 55 patients with indications of labor induction were enrolled and analyzed by retrospective control analysis method. Twenty-three cases adopted Cook double balloon dilation as Cook group, and 32 cases received intra-amniotic injection of ethacridine lactate as EL group. The primary outcome was evaluated by successful abortion rate and the difference in the induction-to-abortion interval. Secondary outcomes included liver function recovery and the frequency of adverse events. Both Cook and EL regimens were effective, with successful abortion rate of 87.0% and 93.8%, respectively（P=0.639）. The induction-to-delivery interval was similar between Cook group and EL group（38.1±21.5 vs. 41.3±17.4, P=0.543）. The liver disease status was more severe in Cook group than in EL group, but it did not show any significant difference after pregnancy termination between the two groups and the improvement rate also did not show any significant difference. Both treatments were safe and there was no significant difference in bleeding and cervical laceration adverse events between the two groups. Our study firstly compared double-balloon catheter and ethacridine lactate for the induction of labor in women with SLD during second trimester pregnancy.
基金Supported by Natural Science Foundation of Hunan Provincial Science and Technology Department,No.2019JJ40527.
文摘BACKGROUND The management of severe extravasation injuries is still controversial.Extravasation injuries can be treated in many ways.AIM To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and phototherapy.METHODS In this study,we evaluated the data of eight patients,including six from the Department of Burn,one(with colorectal carcinoma)from the Veteran Cadre Department,and one(with leukemia)from the Hematology Department.Of these,three patients were male and five were female.Age of the patients ranged from 10 mo to 72 years,including two children(10 and 19 mo of age).In this study,the infusion was stopped immediately when the extravasation was identified.The extravasation event was managed routinely using a blocking solution.A ring-shaped localized closure was performed using the blocking agents.Moreover,ethacridine lactate dressing and phototherapy were applied for 3-5 d.RESULTS In this study,the drugs contained in the infusates were iodixanol,norepinephrine,alprostadil,amino acids,fat emulsion,cefoselis,cefoxitin,and potassium chloride+concentrated sodium chloride.All of the patients achieved complete healing after treatment and no obvious adverse reactions were observed.CONCLUSION The treatment of severe extravasation injuries using a combination of localized closure,ethacridine lactate dressing,and phototherapy resulted in satisfactory outcomes in patients.
文摘Objective: to analyze the clinical efficacy of etacridine combined with mifepristone (MFP) in the treatment of induced labor during middle pregnancy. Methods: from May 2015 to April 2020, 50 patients with midterm pregnancy during labor induction period in our hospital were selected. The digital table was randomly divided into two groups with 25 cases in each group. Treatment was given to patients from a single drug group. The etazidine-bound group was treated with etazidine, acridine combined with MFP. The time, success rate, and incidence of complications were compared between the two groups from the start of dosing to embryo excretion. Results: the duration from initial administration to embryo expulsion in combination group was 36.21±2.45h shorter than that in single drug group, 56.13±5.01h, P < 0.05. The combined power was 100.00% higher than that of the single drug group (76.00%, P < 0.05). There were no serious complications in the two groups, including 2 cases of low fever in the monotherapy group and 3 cases of mild diarrhea and nausea in the combination group (P > 0.05). Conclusion: the clinical effect of ethacridine combined with MFP in the treatment of induced labor in the second trimester is better than ethacridine, which can improve the success rate and shorten the time of induced labor, with high safety.
