China's High Performance Computer Standard Commission was established on March 28, 2007, under the guidance of the Science and Technology Bureau of the Ministry of Information Industry. It will prepare relevan... China's High Performance Computer Standard Commission was established on March 28, 2007, under the guidance of the Science and Technology Bureau of the Ministry of Information Industry. It will prepare relevant professional standards on high performance computers to break through the monopoly in the field by foreign manufacturers and vendors.……展开更多
ForewordDue to the variety of international tradeand specialty difference of each individualnegotiator as well as their differentunderstanding about contract, each foreigntrade contract has its different emphasis andc...ForewordDue to the variety of international tradeand specialty difference of each individualnegotiator as well as their differentunderstanding about contract, each foreigntrade contract has its different emphasis andcharacter. Even for the same contractobjective, terms of payment andtransportation, if the contract was given bydifferent people in different period, thedifference will always exist. Thisphenomenon is rather common in foreigntrade business.展开更多
On November 30, 2007, the China Association for Standardization (CAS) held a press conference at Beijing Diaoyutai State vip House. Leaders from the China Household Electric Appliance Research Institute, the Chi... On November 30, 2007, the China Association for Standardization (CAS) held a press conference at Beijing Diaoyutai State vip House. Leaders from the China Household Electric Appliance Research Institute, the China Household Electric Appliance Association, and the China Consumers' Association attended and made speeches.……展开更多
Automotive experts from the European Commission and European Industry met on 29/30 June 1995 in Beijing with representatives from Chinese Ministries and testing and certification agencies to exchange views on the regu...Automotive experts from the European Commission and European Industry met on 29/30 June 1995 in Beijing with representatives from Chinese Ministries and testing and certification agencies to exchange views on the regulatory regime applicable to the automotive sector in China now and in the future and to discuss the latest development in this sector in Europe. The Chinese delegation was headed by Mr. Li Zhongzhou, Deputy Director展开更多
Chimeric antigen receptor(CAR)-T cell therapy has become a crucial treatment modality for hematopoietic malignancies.Because of the complex treatment procedures of CAR-T cell therapy and its specific severe immune-rel...Chimeric antigen receptor(CAR)-T cell therapy has become a crucial treatment modality for hematopoietic malignancies.Because of the complex treatment procedures of CAR-T cell therapy and its specific severe immune-related adverse events,a multidisciplinary integrated case management approach is necessary.Focusing on how to improve the efficacy and safety of CAR-T cell therapy,we developed this consensus to establish a standardized approach for managing and applying the multidisciplinary teams(MDT)model in CAR-T cell therapy for B-cell non-Hodgkin lymphoma.Full-length version of the consensus can be seen in supplementary file,http://links.lww.com/CM9/B961.展开更多
Objective:Alveolar macrophages(AMs)are involved in the development and progression of a variety of lung diseases.It is of great significance to explore the pathogenesis of diseases and evaluate the efficacy of drugs.H...Objective:Alveolar macrophages(AMs)are involved in the development and progression of a variety of lung diseases.It is of great significance to explore the pathogenesis of diseases and evaluate the efficacy of drugs.However,there is no standard process for extracting primary AM.Nitidine chloride(NC)is an alkaloid extracted from Zanthoxylum nitidum(Roxb.)DC.,which has an antitumour pharmacological effect.However,there is no evidence that NC has a direct effect on colorectal cancer cell lung metastasis.The purpose of this study was to establish a standard for the extraction of primary AM from mice and to investigate the pharmacodynamics of NC in mice with lung metastases to colorectal cancer.Methods:The standard for the extraction of mouse primary AM by lavage was established.Western blot and polymerase chain reaction were used to detect the regulatory mechanism of NC in the treatment of lung metastasis in mice by macrophage phenotype and glycolysis level.Results:The results showed that sufficient quantity and quality of primary AM could be obtained by optimizing extraction steps,and AM obtained by this method could accurately reflect disease progression.At the same time,NC can effectively reduce colorectal cancer lung metastasis in mice.From the mechanism,NC can inhibit the expression of M2 macrophage markers and the levels of mRNA and proteins of the glycolysis-limiting enzyme.Conclusions:Our results show that primary AM that accurately reflects disease and assesses pharmacological effects can be obtained using our established criteria.The inhibitory effect of NC on colorectal cancer lung metastasis may be attributed to its regulation of macrophage phenotype and glycolysis.展开更多
文摘 China's High Performance Computer Standard Commission was established on March 28, 2007, under the guidance of the Science and Technology Bureau of the Ministry of Information Industry. It will prepare relevant professional standards on high performance computers to break through the monopoly in the field by foreign manufacturers and vendors.……
文摘ForewordDue to the variety of international tradeand specialty difference of each individualnegotiator as well as their differentunderstanding about contract, each foreigntrade contract has its different emphasis andcharacter. Even for the same contractobjective, terms of payment andtransportation, if the contract was given bydifferent people in different period, thedifference will always exist. Thisphenomenon is rather common in foreigntrade business.
文摘 On November 30, 2007, the China Association for Standardization (CAS) held a press conference at Beijing Diaoyutai State vip House. Leaders from the China Household Electric Appliance Research Institute, the China Household Electric Appliance Association, and the China Consumers' Association attended and made speeches.……
文摘Automotive experts from the European Commission and European Industry met on 29/30 June 1995 in Beijing with representatives from Chinese Ministries and testing and certification agencies to exchange views on the regulatory regime applicable to the automotive sector in China now and in the future and to discuss the latest development in this sector in Europe. The Chinese delegation was headed by Mr. Li Zhongzhou, Deputy Director
基金supported by funds from the National Natural Science Foundation of China(Nos.82270233,81830004,and 82070168)National Natural Science Foundation of China Youth Science Foundation Project(No.82200246)+2 种基金Translational Research Grant of NCRCH(No.2020ZKZC04)National Key R&D Program of China(No.2021YFA1100800)Shanghai Municipal Health Commission(No.2020CXJQ02).
文摘Chimeric antigen receptor(CAR)-T cell therapy has become a crucial treatment modality for hematopoietic malignancies.Because of the complex treatment procedures of CAR-T cell therapy and its specific severe immune-related adverse events,a multidisciplinary integrated case management approach is necessary.Focusing on how to improve the efficacy and safety of CAR-T cell therapy,we developed this consensus to establish a standardized approach for managing and applying the multidisciplinary teams(MDT)model in CAR-T cell therapy for B-cell non-Hodgkin lymphoma.Full-length version of the consensus can be seen in supplementary file,http://links.lww.com/CM9/B961.
基金China Postdoctoral Science Foundation(No.2023M732627 and No.2024T170657)Natural Science Foundation of Tianjin Municipality(No:23JCZXJC00150 and 23JCJQJC00040)supported this work。
文摘Objective:Alveolar macrophages(AMs)are involved in the development and progression of a variety of lung diseases.It is of great significance to explore the pathogenesis of diseases and evaluate the efficacy of drugs.However,there is no standard process for extracting primary AM.Nitidine chloride(NC)is an alkaloid extracted from Zanthoxylum nitidum(Roxb.)DC.,which has an antitumour pharmacological effect.However,there is no evidence that NC has a direct effect on colorectal cancer cell lung metastasis.The purpose of this study was to establish a standard for the extraction of primary AM from mice and to investigate the pharmacodynamics of NC in mice with lung metastases to colorectal cancer.Methods:The standard for the extraction of mouse primary AM by lavage was established.Western blot and polymerase chain reaction were used to detect the regulatory mechanism of NC in the treatment of lung metastasis in mice by macrophage phenotype and glycolysis level.Results:The results showed that sufficient quantity and quality of primary AM could be obtained by optimizing extraction steps,and AM obtained by this method could accurately reflect disease progression.At the same time,NC can effectively reduce colorectal cancer lung metastasis in mice.From the mechanism,NC can inhibit the expression of M2 macrophage markers and the levels of mRNA and proteins of the glycolysis-limiting enzyme.Conclusions:Our results show that primary AM that accurately reflects disease and assesses pharmacological effects can be obtained using our established criteria.The inhibitory effect of NC on colorectal cancer lung metastasis may be attributed to its regulation of macrophage phenotype and glycolysis.
