On September 25 2003, ZTE Corporation, thelargest listed telecom equipment manufacturer inChina, and Microsoft(China)Co. Ltd., the globalleading software supplier, signed a memo forstrategie cooperation in Beijing.The...On September 25 2003, ZTE Corporation, thelargest listed telecom equipment manufacturer inChina, and Microsoft(China)Co. Ltd., the globalleading software supplier, signed a memo forstrategie cooperation in Beijing.The cooperation focuses on setting up a ZTE-Microsoft Software Teehnology Lab at ZTE. It willmake use of advanced technologies and products ofMicrosoft in the software platform field and ZTE’sample communication product lines to conduct co-operation in multiple communication product展开更多
ZTE Corporation announced on April 16, 2009 that it has partnered with Sichuan Telecom to successfully establish the first IMS-based EV-DO Video Telephony (VT) call in China.
Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for sign...Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.展开更多
Tsinghua University＇s Center unveiled its Center for Engineering Education （CEE）, a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January ...Tsinghua University＇s Center unveiled its Center for Engineering Education （CEE）, a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.展开更多
Tsinghua University unveiled its Center for Engineering Education （CEE）, a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.
Kenya Airways,one of the best and most respected airline companies in Africa, recently officially announced its intent to fly to Ouagadougou, capital of Burkina Faso, starting July 15,
HIRING a fitness consultant for one year is as easy as filling in a form and paying 10 yuan to get a membership. You will receive a bulletin entitled Fitness Guide and therefore after the bulletin provides free
IN July, 1993, an international seminar titled "Chinese Women and Development—Status, Health and Employment" was sponsored by the Women’s Studies Center at Tianjin Normal University. More than 100 internat...IN July, 1993, an international seminar titled "Chinese Women and Development—Status, Health and Employment" was sponsored by the Women’s Studies Center at Tianjin Normal University. More than 100 international and domestic specialists and workers who deal with women’s issues attended. At the conference, the Women’s Research Institute of the All-China Women’s Federation disclosed the results of an investigation about the status of women in China, which was launched in the early 1990s on a nationwide scale. The results showed that China’s economic reform has greatly affected women. As a result, many researchers who began their research by considering China’s present economic situation, tried to determine the influences the展开更多
Northern Rare Earth and Xiamen Tungsten announced on the evening of November 1 that they have signed a Strategic Cooperation Framework Agreement in Baotou,Inner Mongolia and will cooperate in a number of areas includi...Northern Rare Earth and Xiamen Tungsten announced on the evening of November 1 that they have signed a Strategic Cooperation Framework Agreement in Baotou,Inner Mongolia and will cooperate in a number of areas including guarantee for the supply of rare earth products,hydrogen storage展开更多
In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratifi...In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratification,prevention,intervention,and management framework for hypertension tailored to the unique characteristics of the Chinese population.Over the past two decades,these guidelines have been widely implemented in clinical practice across China and have played a significant role in the management of hypertension and chronic diseases,the development of grassroots guidelines,the formulation of clinical pathways,and the implementation of health insurance policies.展开更多
Digital technology and the digital economy are at the forefront of the global technological revolution and industrial transformation.They are profoundly reshaping the international landscape of competition and restruc...Digital technology and the digital economy are at the forefront of the global technological revolution and industrial transformation.They are profoundly reshaping the international landscape of competition and restructuring the world economy.Major countries and economies around the globe are increasingly competing on digital technology and the digital economy,striving to secure a strategic advantage in the new round of international competition and establish a strong position in the evolving international order.展开更多
Background Clinical brain-computer interface(BCI)for mental disorders is an emerging interdisciplinary research field,posing new ethical concerns and challenges,yet lacking practical ethical governance guidelines for ...Background Clinical brain-computer interface(BCI)for mental disorders is an emerging interdisciplinary research field,posing new ethical concerns and challenges,yet lacking practical ethical governance guidelines for stakeholders and the entire community.Aims This study aims to establish a multidisciplinary consensus of principles for ethical governance of clinical BCI research for mental disorders and offer practical ethical guidance to stakeholders involved.Methods A systematic literature review,symposium and roundtable discussions,and a pre-Delphi(round 0)survey were conducted to form the questionnaire for the three-round modified Delphi study.Two rounds of surveys,followed by a third round of independent interviews of 25 experts from BCI-related research domains,were involved.We conducted quantitative analysis of responses and agreements among experts to reveal the consensus and differences regarding the ethical governance of mental BCI research from a multidisciplinary perspective.Results The Delphi panel emphasised important concerns of ethical review practices and ethical principles within the BCI context,identified qualified and highly influential institutions and personnel in conducting and advancing clinical BCI research,and recognised prioritised aspects in the risk-benefit evaluation.Experts expressed diverse opinions on specific ethical concerns,including concerns about invasive technology,its impact on humanity and potential social consequences.Agreement was reached that the practices of ethical governance of clinical BCI for mental disorders should focus on patient voluntariness,autonomy,long-term effects and related assessments of BCI interventions,as well as privacy protection,transparent reporting and ensuring that the research is conducted in qualified institutions with strong data security.Conclusions Ethical governance of clinical research on BCI for mental disorders should include interdisciplinary experts to balance various needs and incorporate the expertise of different stakeholders to avoid serious ethical issues.It requires scientifically grounded approaches,continuous monitoring and interdisciplinary collaboration to ensure evidence-based policies,comprehensive risk assessments and transparency,thereby promoting responsible innovations and protecting patient rights and well-being.展开更多
The visual noise of each light intensity area is different when the image is drawn by Monte Carlo method.However,the existing denoising algorithms have limited denoising performance under complex lighting conditions a...The visual noise of each light intensity area is different when the image is drawn by Monte Carlo method.However,the existing denoising algorithms have limited denoising performance under complex lighting conditions and are easy to lose detailed information.So we propose a rendered image denoising method with filtering guided by lighting information.First,we design an image segmentation algorithm based on lighting information to segment the image into different illumination areas.Then,we establish the parameter prediction model guided by lighting information for filtering(PGLF)to predict the filtering parameters of different illumination areas.For different illumination areas,we use these filtering parameters to construct area filters,and the filters are guided by the lighting information to perform sub-area filtering.Finally,the filtering results are fused with auxiliary features to output denoised images for improving the overall denoising effect of the image.Under the physically based rendering tool(PBRT)scene and Tungsten dataset,the experimental results show that compared with other guided filtering denoising methods,our method improves the peak signal-to-noise ratio(PSNR)metrics by 4.2164 dB on average and the structural similarity index(SSIM)metrics by 7.8%on average.This shows that our method can better reduce the noise in complex lighting scenesand improvethe imagequality.展开更多
Establishing Consensus with Users of Research Irradiator Devices to Facilitate Source Type Replacement Danette R.Fennesy1,Janet M.Gutiérrez1,2,Scott J.Patlovich1,Robert J.Emery1(1.The University of Texas Health S...Establishing Consensus with Users of Research Irradiator Devices to Facilitate Source Type Replacement Danette R.Fennesy1,Janet M.Gutiérrez1,2,Scott J.Patlovich1,Robert J.Emery1(1.The University of Texas Health Science Center at Houston,Environmental Health&Safety,6431 Fannin St,CYF G.102,Houston,TX,77030;2.Corresponding author)Abstract:The ability to irradiate cells,tissues,and other biological materials with high-energy photons has been an essential tool in the discovery of numerous biomedical research advancements.展开更多
I.This year marks the 50th anniversary of the establishment of diplomatic relations between China and the European Union(EU).Fifty years ago,the elder generation of Chinese and European leaders,with a keen grasp of th...I.This year marks the 50th anniversary of the establishment of diplomatic relations between China and the European Union(EU).Fifty years ago,the elder generation of Chinese and European leaders,with a keen grasp of the trend of the times and extraordinary political courage and strategic vision,broke through the barriers of the Cold War,transcended ideological differences,and made the historic decision to establish diplomatic ties between the two sides.展开更多
It’s a great honor for me to talk about ethics applied to artificial intelligence here.Most of the problems that we are facing today come from a strong misunderstanding of what ethics means.We tend to think ethics ar...It’s a great honor for me to talk about ethics applied to artificial intelligence here.Most of the problems that we are facing today come from a strong misunderstanding of what ethics means.We tend to think ethics are merely about establishing principles that would help us mitigate risks and secure benefits expected from AI systems.We are on the wrong path.Ethics are much more complex than that.Ethics are about philosophy,not about politics.Ethics are more about asking questions to enlighten decision-making processes,then to provide one-size-fit-all solutions.We are doing what I call cosmetics,which is a makeup using ethics-related vocabulary,notions and concepts to communicate and influence users and consumers,and to send messages to the market.展开更多
Direct seeding of rice(DS)has been widely adopted due to reduced labor cost and simpler cultivation practices.However,anaerobic flooding conditions reduce seed germination and seedling establishment.Here,a genome-wide...Direct seeding of rice(DS)has been widely adopted due to reduced labor cost and simpler cultivation practices.However,anaerobic flooding conditions reduce seed germination and seedling establishment.Here,a genome-wide association study(GWAS)of four coleoptile traits using 572 rice accessions subjected to 3 d of anaerobic conditions was conducted.The traits were coleoptile length(CL),coleoptile surface area(CSA),coleoptile volume(CV),and coleoptile diameter(CD).Ninety two QTL were identified,with 59 overlapping with previously reported loci.Two rice varieties(C126 and C261)with contrasting coleoptile lengths were selected for multi-omics analyses.A specific anaerobic-responsive blue module was identified by weighted gene co-expression network analysis(WGCNA).Thirty six candidate genes were screened,including OsMYB48 that was predominantly localized in the nucleus.Loss-of-function OsMYB48 mutants exhibited significantly increased coleoptile length relative to the control under 4 d of anaerobic conditions.Endogenous hormone measurements revealed that the content of 1-aminocyclopropanecarboxylic acid(ACC),the ethylene precursor,was significantly increased in the ko-osmyb48-1 mutants.Ethylene-related genes OsACS1 and OsACO2 were also upregulated in the mutants.OsMYB48 DAP-seq identified 31 potential target genes,including WB1 and OsBURP16.Hence,anaerobic-responsive gene OsMYB48 likely acts as a transcriptional repressor of coleoptile elongation under anaerobic germination conditions,probably via the ethylene signaling pathway.This work provides a theoretical basis and genetic resources for breeding rice lines with high germination when directly sown.展开更多
Objective:This study aims to outline the background of advanced nursing practice(ANP),potential issues,and the prospects for its establishment in the Moroccan health care system.Methods:A review was performed with dat...Objective:This study aims to outline the background of advanced nursing practice(ANP),potential issues,and the prospects for its establishment in the Moroccan health care system.Methods:A review was performed with databases that included articles published between 2016 and 2023.Results:The study found 14 articles agreeing that ANP is a solution to the shortage of medical and nursing staff.Moreover,its establishment in the Moroccan health care system is subject to many challenges,which require an in-depth study.Conclusions:The training of advanced practice nurse(APN)is needed to meet the requirements of the national health care system.It can be incorporated if the context is examined,considering all the challenges that may arise when implementing this program.展开更多
Supportive policies and generational skills change lives in remote villages of Xizang.AAGQU,the city with the highest average altitude in China and a gateway to Xizang Autonomous Region,is an important transportation ...Supportive policies and generational skills change lives in remote villages of Xizang.AAGQU,the city with the highest average altitude in China and a gateway to Xizang Autonomous Region,is an important transportation hub along two national highways.It is also a focus of the local government’s rural revitalization drive to improve the lives of local residents,who are mostly farmers and herdsmen,by promoting traditional crafts and establishing local brands.展开更多
Patch-clamp technique serve as a powerful tool for precisely measuring and characterizing ion channel currents,offering critical molecular-level insights essential for drug screening and optimization.By enabling a dee...Patch-clamp technique serve as a powerful tool for precisely measuring and characterizing ion channel currents,offering critical molecular-level insights essential for drug screening and optimization.By enabling a deeper understanding of ion channel behavior,these techniques significantly accelerate the process of drug discovery and development.In recent years,automated patch-clamp technique has undergone substantial advancements,surpassing traditional manual methods with its high throughput,improved data consistency,and automation.However,fully harnessing these advantages requires meticulous optimization of experimental conditions tailored to specific targets.Without such refinement,the high cost of consumables and operational expenses could severely hinder the widespread adoption of this technique.This study focused on the TRPV1 channel,detailing the establishment of an automated patch-clamp detection system for TRPV1 currents,optimization of experimental parameters,and a comparative evaluation of the results against manual patch-clamp techniques.展开更多
文摘On September 25 2003, ZTE Corporation, thelargest listed telecom equipment manufacturer inChina, and Microsoft(China)Co. Ltd., the globalleading software supplier, signed a memo forstrategie cooperation in Beijing.The cooperation focuses on setting up a ZTE-Microsoft Software Teehnology Lab at ZTE. It willmake use of advanced technologies and products ofMicrosoft in the software platform field and ZTE’sample communication product lines to conduct co-operation in multiple communication product
文摘ZTE Corporation announced on April 16, 2009 that it has partnered with Sichuan Telecom to successfully establish the first IMS-based EV-DO Video Telephony (VT) call in China.
基金supported by the National Natural Science Foundation of China(NSFC/RGC/JRF N_HKU735/21)Research Grant Council of Hong Kong,China(17102120,17108821,17103922,C1024-22GF,C7074-21G)+1 种基金Health and Medical Research Fund(HMRF 09200966)(to CSWL)FRQS Postdoctoral Fellowship(to AHKF).
文摘Dendritic spines are small protrusions along dendrites that contain most of the excitatory synapses in principal neurons,playing a crucial role in neuronal function by creating a compartmentalized environment for signal transduction.The plasticity of spine morphologies provides a tunable handle to regulate calcium signal dynamics,allowing rapid regulation of protein expression necessary to establish and maintain synapses(Cornejo et al.,2022).If excitatory inputs were to be located primarily on dendritic shafts,dendrites would frequently short-circuit,preventing voltage signals from propagating(Cornejo et al.,2022).It is thus not surprising that the structural plasticity of dendritic spines is closely linked to synaptic plasticity and memory formation(Berry and Nedivi,2017).While comprehensive in vitro studies have been conducted,in vivo studies that directly tackle the mechanism of dendritic transport and translation in regulating spine plasticity spatiotemporally are limited.
文摘Tsinghua University＇s Center unveiled its Center for Engineering Education （CEE）, a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.
文摘Tsinghua University unveiled its Center for Engineering Education （CEE）, a cross-disciplinary research center for engineering education studies, at an inauguration ceremony in the Main Building on January 12, 2009.
文摘Kenya Airways,one of the best and most respected airline companies in Africa, recently officially announced its intent to fly to Ouagadougou, capital of Burkina Faso, starting July 15,
文摘HIRING a fitness consultant for one year is as easy as filling in a form and paying 10 yuan to get a membership. You will receive a bulletin entitled Fitness Guide and therefore after the bulletin provides free
文摘IN July, 1993, an international seminar titled "Chinese Women and Development—Status, Health and Employment" was sponsored by the Women’s Studies Center at Tianjin Normal University. More than 100 international and domestic specialists and workers who deal with women’s issues attended. At the conference, the Women’s Research Institute of the All-China Women’s Federation disclosed the results of an investigation about the status of women in China, which was launched in the early 1990s on a nationwide scale. The results showed that China’s economic reform has greatly affected women. As a result, many researchers who began their research by considering China’s present economic situation, tried to determine the influences the
文摘Northern Rare Earth and Xiamen Tungsten announced on the evening of November 1 that they have signed a Strategic Cooperation Framework Agreement in Baotou,Inner Mongolia and will cooperate in a number of areas including guarantee for the supply of rare earth products,hydrogen storage
文摘In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratification,prevention,intervention,and management framework for hypertension tailored to the unique characteristics of the Chinese population.Over the past two decades,these guidelines have been widely implemented in clinical practice across China and have played a significant role in the management of hypertension and chronic diseases,the development of grassroots guidelines,the formulation of clinical pathways,and the implementation of health insurance policies.
文摘Digital technology and the digital economy are at the forefront of the global technological revolution and industrial transformation.They are profoundly reshaping the international landscape of competition and restructuring the world economy.Major countries and economies around the globe are increasingly competing on digital technology and the digital economy,striving to secure a strategic advantage in the new round of international competition and establish a strong position in the evolving international order.
基金funded by the Shanghai Philosophy and Social Science Planning Project (2021BZX008)the National Social Science Foundation of China (23BZX110)the National Office for Philosophy and Social Science (20&ZD045).
文摘Background Clinical brain-computer interface(BCI)for mental disorders is an emerging interdisciplinary research field,posing new ethical concerns and challenges,yet lacking practical ethical governance guidelines for stakeholders and the entire community.Aims This study aims to establish a multidisciplinary consensus of principles for ethical governance of clinical BCI research for mental disorders and offer practical ethical guidance to stakeholders involved.Methods A systematic literature review,symposium and roundtable discussions,and a pre-Delphi(round 0)survey were conducted to form the questionnaire for the three-round modified Delphi study.Two rounds of surveys,followed by a third round of independent interviews of 25 experts from BCI-related research domains,were involved.We conducted quantitative analysis of responses and agreements among experts to reveal the consensus and differences regarding the ethical governance of mental BCI research from a multidisciplinary perspective.Results The Delphi panel emphasised important concerns of ethical review practices and ethical principles within the BCI context,identified qualified and highly influential institutions and personnel in conducting and advancing clinical BCI research,and recognised prioritised aspects in the risk-benefit evaluation.Experts expressed diverse opinions on specific ethical concerns,including concerns about invasive technology,its impact on humanity and potential social consequences.Agreement was reached that the practices of ethical governance of clinical BCI for mental disorders should focus on patient voluntariness,autonomy,long-term effects and related assessments of BCI interventions,as well as privacy protection,transparent reporting and ensuring that the research is conducted in qualified institutions with strong data security.Conclusions Ethical governance of clinical research on BCI for mental disorders should include interdisciplinary experts to balance various needs and incorporate the expertise of different stakeholders to avoid serious ethical issues.It requires scientifically grounded approaches,continuous monitoring and interdisciplinary collaboration to ensure evidence-based policies,comprehensive risk assessments and transparency,thereby promoting responsible innovations and protecting patient rights and well-being.
基金supported by the National Natural Science(No.U19A2063)the Jilin Provincial Development Program of Science and Technology (No.20230201080GX)the Jilin Province Education Department Scientific Research Project (No.JJKH20230851KJ)。
文摘The visual noise of each light intensity area is different when the image is drawn by Monte Carlo method.However,the existing denoising algorithms have limited denoising performance under complex lighting conditions and are easy to lose detailed information.So we propose a rendered image denoising method with filtering guided by lighting information.First,we design an image segmentation algorithm based on lighting information to segment the image into different illumination areas.Then,we establish the parameter prediction model guided by lighting information for filtering(PGLF)to predict the filtering parameters of different illumination areas.For different illumination areas,we use these filtering parameters to construct area filters,and the filters are guided by the lighting information to perform sub-area filtering.Finally,the filtering results are fused with auxiliary features to output denoised images for improving the overall denoising effect of the image.Under the physically based rendering tool(PBRT)scene and Tungsten dataset,the experimental results show that compared with other guided filtering denoising methods,our method improves the peak signal-to-noise ratio(PSNR)metrics by 4.2164 dB on average and the structural similarity index(SSIM)metrics by 7.8%on average.This shows that our method can better reduce the noise in complex lighting scenesand improvethe imagequality.
文摘Establishing Consensus with Users of Research Irradiator Devices to Facilitate Source Type Replacement Danette R.Fennesy1,Janet M.Gutiérrez1,2,Scott J.Patlovich1,Robert J.Emery1(1.The University of Texas Health Science Center at Houston,Environmental Health&Safety,6431 Fannin St,CYF G.102,Houston,TX,77030;2.Corresponding author)Abstract:The ability to irradiate cells,tissues,and other biological materials with high-energy photons has been an essential tool in the discovery of numerous biomedical research advancements.
文摘I.This year marks the 50th anniversary of the establishment of diplomatic relations between China and the European Union(EU).Fifty years ago,the elder generation of Chinese and European leaders,with a keen grasp of the trend of the times and extraordinary political courage and strategic vision,broke through the barriers of the Cold War,transcended ideological differences,and made the historic decision to establish diplomatic ties between the two sides.
文摘It’s a great honor for me to talk about ethics applied to artificial intelligence here.Most of the problems that we are facing today come from a strong misunderstanding of what ethics means.We tend to think ethics are merely about establishing principles that would help us mitigate risks and secure benefits expected from AI systems.We are on the wrong path.Ethics are much more complex than that.Ethics are about philosophy,not about politics.Ethics are more about asking questions to enlighten decision-making processes,then to provide one-size-fit-all solutions.We are doing what I call cosmetics,which is a makeup using ethics-related vocabulary,notions and concepts to communicate and influence users and consumers,and to send messages to the market.
基金supported by the Construction of Cosmic Particle Directed Mutagenesis Technology System and Creation of New Germplasm in Rice(2022YFD1200703)China Agriculture Research System(CARS-01-06).
文摘Direct seeding of rice(DS)has been widely adopted due to reduced labor cost and simpler cultivation practices.However,anaerobic flooding conditions reduce seed germination and seedling establishment.Here,a genome-wide association study(GWAS)of four coleoptile traits using 572 rice accessions subjected to 3 d of anaerobic conditions was conducted.The traits were coleoptile length(CL),coleoptile surface area(CSA),coleoptile volume(CV),and coleoptile diameter(CD).Ninety two QTL were identified,with 59 overlapping with previously reported loci.Two rice varieties(C126 and C261)with contrasting coleoptile lengths were selected for multi-omics analyses.A specific anaerobic-responsive blue module was identified by weighted gene co-expression network analysis(WGCNA).Thirty six candidate genes were screened,including OsMYB48 that was predominantly localized in the nucleus.Loss-of-function OsMYB48 mutants exhibited significantly increased coleoptile length relative to the control under 4 d of anaerobic conditions.Endogenous hormone measurements revealed that the content of 1-aminocyclopropanecarboxylic acid(ACC),the ethylene precursor,was significantly increased in the ko-osmyb48-1 mutants.Ethylene-related genes OsACS1 and OsACO2 were also upregulated in the mutants.OsMYB48 DAP-seq identified 31 potential target genes,including WB1 and OsBURP16.Hence,anaerobic-responsive gene OsMYB48 likely acts as a transcriptional repressor of coleoptile elongation under anaerobic germination conditions,probably via the ethylene signaling pathway.This work provides a theoretical basis and genetic resources for breeding rice lines with high germination when directly sown.
文摘Objective:This study aims to outline the background of advanced nursing practice(ANP),potential issues,and the prospects for its establishment in the Moroccan health care system.Methods:A review was performed with databases that included articles published between 2016 and 2023.Results:The study found 14 articles agreeing that ANP is a solution to the shortage of medical and nursing staff.Moreover,its establishment in the Moroccan health care system is subject to many challenges,which require an in-depth study.Conclusions:The training of advanced practice nurse(APN)is needed to meet the requirements of the national health care system.It can be incorporated if the context is examined,considering all the challenges that may arise when implementing this program.
文摘Supportive policies and generational skills change lives in remote villages of Xizang.AAGQU,the city with the highest average altitude in China and a gateway to Xizang Autonomous Region,is an important transportation hub along two national highways.It is also a focus of the local government’s rural revitalization drive to improve the lives of local residents,who are mostly farmers and herdsmen,by promoting traditional crafts and establishing local brands.
基金The National Natural Science Foundation of China(Grant No.32000674).
文摘Patch-clamp technique serve as a powerful tool for precisely measuring and characterizing ion channel currents,offering critical molecular-level insights essential for drug screening and optimization.By enabling a deeper understanding of ion channel behavior,these techniques significantly accelerate the process of drug discovery and development.In recent years,automated patch-clamp technique has undergone substantial advancements,surpassing traditional manual methods with its high throughput,improved data consistency,and automation.However,fully harnessing these advantages requires meticulous optimization of experimental conditions tailored to specific targets.Without such refinement,the high cost of consumables and operational expenses could severely hinder the widespread adoption of this technique.This study focused on the TRPV1 channel,detailing the establishment of an automated patch-clamp detection system for TRPV1 currents,optimization of experimental parameters,and a comparative evaluation of the results against manual patch-clamp techniques.
